Shedding light on the hidden benefit of Porphyridium cruentum culture

Detalhes bibliográficos
Autor(a) principal: Liberti, Davide
Data de Publicação: 2023
Outros Autores: Imbimbo, Paola, Giustino, Enrica, D’Elia, Luigi, Silva, Mélanie, Barreira, Luísa, Monti, Daria Maria
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: http://hdl.handle.net/10400.1/19131
Resumo: Microalgae can represent a reliable source of natural compounds with different activities. Here, we evaluated the antioxidant and anti-inflammatory activity of sulfated exopolysaccharides (s-EPSs) and phycoerythrin (PE), two molecules naturally produced by the red marine microalga Porphyridium cruentum (CCALA415). In vitro and cell-based assays were performed to assess the biological activities of these compounds. The s-EPSs, owing to the presence of sulfate groups, showed biocompatibility on immortalized eukaryotic cell lines and a high antioxidant activity on cell-based systems. PE showed powerful antioxidant activity both in vitro and on cell-based systems, but purification is mandatory for its safe use. Finally, both molecules showed anti-inflammatory activity comparable to that of ibuprofen and helped tissue regeneration. Thus, the isolated molecules from microalgae represent an excellent source of antioxidants to be used in different fields.
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spelling Shedding light on the hidden benefit of Porphyridium cruentum cultureMicroalgaeExopolysaccharidesPhycoerythrinAntioxidant activityAnti-inflammatory activityBiocompatibilityWound healingMicroalgae can represent a reliable source of natural compounds with different activities. Here, we evaluated the antioxidant and anti-inflammatory activity of sulfated exopolysaccharides (s-EPSs) and phycoerythrin (PE), two molecules naturally produced by the red marine microalga Porphyridium cruentum (CCALA415). In vitro and cell-based assays were performed to assess the biological activities of these compounds. The s-EPSs, owing to the presence of sulfate groups, showed biocompatibility on immortalized eukaryotic cell lines and a high antioxidant activity on cell-based systems. PE showed powerful antioxidant activity both in vitro and on cell-based systems, but purification is mandatory for its safe use. Finally, both molecules showed anti-inflammatory activity comparable to that of ibuprofen and helped tissue regeneration. Thus, the isolated molecules from microalgae represent an excellent source of antioxidants to be used in different fields.UIDP/0436/2020LA/P/0101/2020MDPISapientiaLiberti, DavideImbimbo, PaolaGiustino, EnricaD’Elia, LuigiSilva, MélanieBarreira, LuísaMonti, Daria Maria2023-02-27T10:08:51Z2023-01-312023-02-24T14:08:02Z2023-01-31T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10400.1/19131engAntioxidants 12 (2): 337 (2023)10.3390/antiox120203372076-3921info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-07-24T10:31:33Zoai:sapientia.ualg.pt:10400.1/19131Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T20:08:47.489949Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv Shedding light on the hidden benefit of Porphyridium cruentum culture
title Shedding light on the hidden benefit of Porphyridium cruentum culture
spellingShingle Shedding light on the hidden benefit of Porphyridium cruentum culture
Liberti, Davide
Microalgae
Exopolysaccharides
Phycoerythrin
Antioxidant activity
Anti-inflammatory activity
Biocompatibility
Wound healing
title_short Shedding light on the hidden benefit of Porphyridium cruentum culture
title_full Shedding light on the hidden benefit of Porphyridium cruentum culture
title_fullStr Shedding light on the hidden benefit of Porphyridium cruentum culture
title_full_unstemmed Shedding light on the hidden benefit of Porphyridium cruentum culture
title_sort Shedding light on the hidden benefit of Porphyridium cruentum culture
author Liberti, Davide
author_facet Liberti, Davide
Imbimbo, Paola
Giustino, Enrica
D’Elia, Luigi
Silva, Mélanie
Barreira, Luísa
Monti, Daria Maria
author_role author
author2 Imbimbo, Paola
Giustino, Enrica
D’Elia, Luigi
Silva, Mélanie
Barreira, Luísa
Monti, Daria Maria
author2_role author
author
author
author
author
author
dc.contributor.none.fl_str_mv Sapientia
dc.contributor.author.fl_str_mv Liberti, Davide
Imbimbo, Paola
Giustino, Enrica
D’Elia, Luigi
Silva, Mélanie
Barreira, Luísa
Monti, Daria Maria
dc.subject.por.fl_str_mv Microalgae
Exopolysaccharides
Phycoerythrin
Antioxidant activity
Anti-inflammatory activity
Biocompatibility
Wound healing
topic Microalgae
Exopolysaccharides
Phycoerythrin
Antioxidant activity
Anti-inflammatory activity
Biocompatibility
Wound healing
description Microalgae can represent a reliable source of natural compounds with different activities. Here, we evaluated the antioxidant and anti-inflammatory activity of sulfated exopolysaccharides (s-EPSs) and phycoerythrin (PE), two molecules naturally produced by the red marine microalga Porphyridium cruentum (CCALA415). In vitro and cell-based assays were performed to assess the biological activities of these compounds. The s-EPSs, owing to the presence of sulfate groups, showed biocompatibility on immortalized eukaryotic cell lines and a high antioxidant activity on cell-based systems. PE showed powerful antioxidant activity both in vitro and on cell-based systems, but purification is mandatory for its safe use. Finally, both molecules showed anti-inflammatory activity comparable to that of ibuprofen and helped tissue regeneration. Thus, the isolated molecules from microalgae represent an excellent source of antioxidants to be used in different fields.
publishDate 2023
dc.date.none.fl_str_mv 2023-02-27T10:08:51Z
2023-01-31
2023-02-24T14:08:02Z
2023-01-31T00:00:00Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/10400.1/19131
url http://hdl.handle.net/10400.1/19131
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv Antioxidants 12 (2): 337 (2023)
10.3390/antiox12020337
2076-3921
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv MDPI
publisher.none.fl_str_mv MDPI
dc.source.none.fl_str_mv reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron:RCAAP
instname_str Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
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