Low-dose Colchicine in coronary artery disease : systematic review and meta-analysis

Detalhes bibliográficos
Autor(a) principal: Abrantes, Ana Mafalda
Data de Publicação: 2021
Outros Autores: Nogueira Garcia, Beatriz, Alves, Mariana, Passos, Dúlio Teixeira, Brito, Dulce, Pinto, Fausto J., Caldeira, Daniel
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: http://hdl.handle.net/10451/49509
Resumo: © 2021, The Japanese Circulation Society. This article is licensed under a Creative Commons [Attribution-NonCommercial-NoDerivatives 4.0 International] license. https://creativecommons.org/licenses/by-nc-nd/4.0/
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spelling Low-dose Colchicine in coronary artery disease : systematic review and meta-analysisAtherosclerosisColchicineCoronary artery diseaseInflammation© 2021, The Japanese Circulation Society. This article is licensed under a Creative Commons [Attribution-NonCommercial-NoDerivatives 4.0 International] license. https://creativecommons.org/licenses/by-nc-nd/4.0/Background: Recent studies have revealed the benefits of using colchicine, a drug with anti-inflammatory properties, in coronary artery disease (CAD). This study systematically reviewed the benefits and risks of low-dose colchicine in patients with CAD. Methods and Results: We searched for randomized controlled trials (RCTs) in MEDLINE, the Cochrane Central Register of Controlled Trials (CENTRAL), and Web of Science databases (March 2020). Efficacy and safety outcomes were evaluated. Estimates are expressed as risk ratios (RRs) and 95% confidence intervals (95% CIs). Heterogeneity was assessed with I2 test. Confidence in the pooled evidence was appraised using the GRADE framework. Colchicine reduced the rate of major adverse cardiovascular events (RR 0.65; 95% CI 0.49-0.86; 6 RCTs; I2=50%; 11,718 patients; GRADE, moderate confidence), acute coronary syndrome (RR 0.64; 95% CI 0.46-0.90; I2=47%; 7 RCTs; 11,955 patients; GRADE, very low confidence), stroke (RR 0.49; 95% CI 0.30-0.78; I2=0%; 6 RCTs; 11,896 patients; GRADE, moderate confidence), and cardiovascular interventions (RR 0.61; 95% CI 0.42-0.89; I2=40%; 4 RCTs; 11,284 patients; GRADE, high confidence). Colchicine did not increase the risk of adverse events, except for gastrointestinal events (RR 1.54; 95% CI 1.11-2.13; I2=72%; 9 RCTs; 12,374 patients; GRADE, very low confidence). Conclusions: Low-dose colchicine in patients with CAD is associated with beneficial effects on prognosis, although an increased risk of gastrointestinal events was confirmed.The Japanese Circulation SocietyRepositório da Universidade de LisboaAbrantes, Ana MafaldaNogueira Garcia, BeatrizAlves, MarianaPassos, Dúlio TeixeiraBrito, DulcePinto, Fausto J.Caldeira, Daniel2021-09-13T16:56:34Z20212021-01-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10451/49509engCirc Rep. 2021 Jul 15;3(8):457-46410.1253/circrep.CR-21-00652434-0790info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-11-08T16:53:19Zoai:repositorio.ul.pt:10451/49509Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T22:01:07.781589Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv Low-dose Colchicine in coronary artery disease : systematic review and meta-analysis
title Low-dose Colchicine in coronary artery disease : systematic review and meta-analysis
spellingShingle Low-dose Colchicine in coronary artery disease : systematic review and meta-analysis
Abrantes, Ana Mafalda
Atherosclerosis
Colchicine
Coronary artery disease
Inflammation
title_short Low-dose Colchicine in coronary artery disease : systematic review and meta-analysis
title_full Low-dose Colchicine in coronary artery disease : systematic review and meta-analysis
title_fullStr Low-dose Colchicine in coronary artery disease : systematic review and meta-analysis
title_full_unstemmed Low-dose Colchicine in coronary artery disease : systematic review and meta-analysis
title_sort Low-dose Colchicine in coronary artery disease : systematic review and meta-analysis
author Abrantes, Ana Mafalda
author_facet Abrantes, Ana Mafalda
Nogueira Garcia, Beatriz
Alves, Mariana
Passos, Dúlio Teixeira
Brito, Dulce
Pinto, Fausto J.
Caldeira, Daniel
author_role author
author2 Nogueira Garcia, Beatriz
Alves, Mariana
Passos, Dúlio Teixeira
Brito, Dulce
Pinto, Fausto J.
Caldeira, Daniel
author2_role author
author
author
author
author
author
dc.contributor.none.fl_str_mv Repositório da Universidade de Lisboa
dc.contributor.author.fl_str_mv Abrantes, Ana Mafalda
Nogueira Garcia, Beatriz
Alves, Mariana
Passos, Dúlio Teixeira
Brito, Dulce
Pinto, Fausto J.
Caldeira, Daniel
dc.subject.por.fl_str_mv Atherosclerosis
Colchicine
Coronary artery disease
Inflammation
topic Atherosclerosis
Colchicine
Coronary artery disease
Inflammation
description © 2021, The Japanese Circulation Society. This article is licensed under a Creative Commons [Attribution-NonCommercial-NoDerivatives 4.0 International] license. https://creativecommons.org/licenses/by-nc-nd/4.0/
publishDate 2021
dc.date.none.fl_str_mv 2021-09-13T16:56:34Z
2021
2021-01-01T00:00:00Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/10451/49509
url http://hdl.handle.net/10451/49509
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv Circ Rep. 2021 Jul 15;3(8):457-464
10.1253/circrep.CR-21-0065
2434-0790
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv The Japanese Circulation Society
publisher.none.fl_str_mv The Japanese Circulation Society
dc.source.none.fl_str_mv reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron:RCAAP
instname_str Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron_str RCAAP
institution RCAAP
reponame_str Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
collection Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
repository.name.fl_str_mv Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
repository.mail.fl_str_mv
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