Phenotypic analysis of urothelial exfoliated cells in bladder cancer via microfluidic immunoassays: Sialyl-Tn as a novel biomarker in liquid biopsies

Detalhes bibliográficos
Autor(a) principal: Carvalho, Sandra
Data de Publicação: 2020
Outros Autores: Abreu, Catarina M., Ferreira, Dylan, Lima, Luís, Santos, Lúcio L., Ribeiro, Ricardo, Grenha, Vânia, Martínez-Fernández, Mónica, Duenas, Marta, Suárez-Cabrera, Cristian, Paramio, Jesus M., Diéguez, Lorena, Freitas, Paulo P., Oliveira, Marta I.
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: http://hdl.handle.net/10400.22/16517
Resumo: Bladder cancer is the most common malignancy of the urinary tract, having one of the highest recurrence rates and progression from non-muscle to muscle invasive bladder cancer that commonly leads to metastasis. Cystoscopy and urine cytology are the standard procedures for its detection but have limited clinical sensitivity and specificity. Herein, a microfluidic device, the UriChip, was developed for the enrichment of urothelial exfoliated cells from fresh and frozen urine, based on deformability and size, and the cancer-associated glycan Sialyl-Tn explored as a putative bladder cancer urinary biomarker.
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spelling Phenotypic analysis of urothelial exfoliated cells in bladder cancer via microfluidic immunoassays: Sialyl-Tn as a novel biomarker in liquid biopsiesBladder cancerMicrofluidicsLiquid biopsyUrineSialyl-TnMMBladder cancer is the most common malignancy of the urinary tract, having one of the highest recurrence rates and progression from non-muscle to muscle invasive bladder cancer that commonly leads to metastasis. Cystoscopy and urine cytology are the standard procedures for its detection but have limited clinical sensitivity and specificity. Herein, a microfluidic device, the UriChip, was developed for the enrichment of urothelial exfoliated cells from fresh and frozen urine, based on deformability and size, and the cancer-associated glycan Sialyl-Tn explored as a putative bladder cancer urinary biomarker.Frontiers MediaRepositório Científico do Instituto Politécnico do PortoCarvalho, SandraAbreu, Catarina M.Ferreira, DylanLima, LuísSantos, Lúcio L.Ribeiro, RicardoGrenha, VâniaMartínez-Fernández, MónicaDuenas, MartaSuárez-Cabrera, CristianParamio, Jesus M.Diéguez, LorenaFreitas, Paulo P.Oliveira, Marta I.2020-12-03T10:23:05Z20202020-01-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10400.22/16517engCarvalho, S., Abreu, C. M., Ferreira, D., Lima, L., Ferreira, J. A., Santos, L. L., Ribeiro, R., Grenha, V., Martínez-Fernández, M., Duenas, M., Suárez-Cabrera, C., Paramio, J. M., Diéguez, L., Freitas, P. P., & Oliveira, M. I. (2020). Phenotypic Analysis of Urothelial Exfoliated Cells in Bladder Cancer via Microfluidic Immunoassays: Sialyl-Tn as a Novel Biomarker in Liquid Biopsies. Frontiers in Oncology, 10, 1774. https://doi.org/10.3389/fonc.2020.0177410.3389/fonc.2020.01774info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2024-03-13T01:47:31Zoai:recipp.ipp.pt:10400.22/16517Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T17:36:10.582286Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv Phenotypic analysis of urothelial exfoliated cells in bladder cancer via microfluidic immunoassays: Sialyl-Tn as a novel biomarker in liquid biopsies
title Phenotypic analysis of urothelial exfoliated cells in bladder cancer via microfluidic immunoassays: Sialyl-Tn as a novel biomarker in liquid biopsies
spellingShingle Phenotypic analysis of urothelial exfoliated cells in bladder cancer via microfluidic immunoassays: Sialyl-Tn as a novel biomarker in liquid biopsies
Carvalho, Sandra
Bladder cancer
Microfluidics
Liquid biopsy
Urine
Sialyl-TnMM
title_short Phenotypic analysis of urothelial exfoliated cells in bladder cancer via microfluidic immunoassays: Sialyl-Tn as a novel biomarker in liquid biopsies
title_full Phenotypic analysis of urothelial exfoliated cells in bladder cancer via microfluidic immunoassays: Sialyl-Tn as a novel biomarker in liquid biopsies
title_fullStr Phenotypic analysis of urothelial exfoliated cells in bladder cancer via microfluidic immunoassays: Sialyl-Tn as a novel biomarker in liquid biopsies
title_full_unstemmed Phenotypic analysis of urothelial exfoliated cells in bladder cancer via microfluidic immunoassays: Sialyl-Tn as a novel biomarker in liquid biopsies
title_sort Phenotypic analysis of urothelial exfoliated cells in bladder cancer via microfluidic immunoassays: Sialyl-Tn as a novel biomarker in liquid biopsies
author Carvalho, Sandra
author_facet Carvalho, Sandra
Abreu, Catarina M.
Ferreira, Dylan
Lima, Luís
Santos, Lúcio L.
Ribeiro, Ricardo
Grenha, Vânia
Martínez-Fernández, Mónica
Duenas, Marta
Suárez-Cabrera, Cristian
Paramio, Jesus M.
Diéguez, Lorena
Freitas, Paulo P.
Oliveira, Marta I.
author_role author
author2 Abreu, Catarina M.
Ferreira, Dylan
Lima, Luís
Santos, Lúcio L.
Ribeiro, Ricardo
Grenha, Vânia
Martínez-Fernández, Mónica
Duenas, Marta
Suárez-Cabrera, Cristian
Paramio, Jesus M.
Diéguez, Lorena
Freitas, Paulo P.
Oliveira, Marta I.
author2_role author
author
author
author
author
author
author
author
author
author
author
author
author
dc.contributor.none.fl_str_mv Repositório Científico do Instituto Politécnico do Porto
dc.contributor.author.fl_str_mv Carvalho, Sandra
Abreu, Catarina M.
Ferreira, Dylan
Lima, Luís
Santos, Lúcio L.
Ribeiro, Ricardo
Grenha, Vânia
Martínez-Fernández, Mónica
Duenas, Marta
Suárez-Cabrera, Cristian
Paramio, Jesus M.
Diéguez, Lorena
Freitas, Paulo P.
Oliveira, Marta I.
dc.subject.por.fl_str_mv Bladder cancer
Microfluidics
Liquid biopsy
Urine
Sialyl-TnMM
topic Bladder cancer
Microfluidics
Liquid biopsy
Urine
Sialyl-TnMM
description Bladder cancer is the most common malignancy of the urinary tract, having one of the highest recurrence rates and progression from non-muscle to muscle invasive bladder cancer that commonly leads to metastasis. Cystoscopy and urine cytology are the standard procedures for its detection but have limited clinical sensitivity and specificity. Herein, a microfluidic device, the UriChip, was developed for the enrichment of urothelial exfoliated cells from fresh and frozen urine, based on deformability and size, and the cancer-associated glycan Sialyl-Tn explored as a putative bladder cancer urinary biomarker.
publishDate 2020
dc.date.none.fl_str_mv 2020-12-03T10:23:05Z
2020
2020-01-01T00:00:00Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/10400.22/16517
url http://hdl.handle.net/10400.22/16517
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv Carvalho, S., Abreu, C. M., Ferreira, D., Lima, L., Ferreira, J. A., Santos, L. L., Ribeiro, R., Grenha, V., Martínez-Fernández, M., Duenas, M., Suárez-Cabrera, C., Paramio, J. M., Diéguez, L., Freitas, P. P., & Oliveira, M. I. (2020). Phenotypic Analysis of Urothelial Exfoliated Cells in Bladder Cancer via Microfluidic Immunoassays: Sialyl-Tn as a Novel Biomarker in Liquid Biopsies. Frontiers in Oncology, 10, 1774. https://doi.org/10.3389/fonc.2020.01774
10.3389/fonc.2020.01774
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Frontiers Media
publisher.none.fl_str_mv Frontiers Media
dc.source.none.fl_str_mv reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron:RCAAP
instname_str Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron_str RCAAP
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reponame_str Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
collection Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
repository.name.fl_str_mv Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
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