Environmental Tobacco Smoke in Occupational Settings

Detalhes bibliográficos
Autor(a) principal: Vital, Nádia
Data de Publicação: 2021
Outros Autores: Antunes, Susana, Louro, Henriqueta, Vaz, Fátima, Simões, Tânia, Penque, Deborah, Silva, Maria João
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: http://hdl.handle.net/10362/120609
Resumo: Funding: This work was funded by the Portuguese institutions Fundação Calouste Gulbenkian, Administração Central do Sistema de Saúde (ACSS) and FCT/MCTES through funding to ToxOmics (UIDB/00009/2020; UIDP/00009/2020).
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spelling Environmental Tobacco Smoke in Occupational SettingsEffect and Susceptibility Biomarkers in Workers From Lisbon Restaurants and Barschallenge assaygenotoxicityhuman biomonitoringoccupational exposuresecond-hand smokePublic Health, Environmental and Occupational HealthSDG 3 - Good Health and Well-beingFunding: This work was funded by the Portuguese institutions Fundação Calouste Gulbenkian, Administração Central do Sistema de Saúde (ACSS) and FCT/MCTES through funding to ToxOmics (UIDB/00009/2020; UIDP/00009/2020).Environmental tobacco smoke (ETS) has been recognized as a major health hazard by environmental and public health authorities worldwide. In Portugal, smoke-free laws are in force for some years, banning smoking in most indoor public spaces. However, in hospitality venues such as restaurants and bars, owners can still choose between a total smoke-free policy or a partial smoking restriction with designated smoking areas, if adequate reinforced ventilation systems are implemented. Despite that, a previous study showed that workers remained continuously exposed to higher ETS pollution in Lisbon restaurants and bars where smoking was still allowed, comparatively to total smoke-free venues. This was assessed by measurements of indoor PM2.5 and urinary cotinine, a biomarkers of tobacco smoke exposure, demonstrating that partial smoking restrictions do not effectively protect workers from ETS. The aim of the present work was to characterize effect and susceptibility biomarkers in non-smokers from those hospitality venues occupationally exposed to ETS comparatively to non-exposed ones. A group of smokers was also included for comparison. The sister chromatid exchange (SCE), micronucleus (MN) and comet assays in whole peripheral blood lymphocytes (PBLs) and the micronucleus assay in exfoliated buccal cells, were used as biomarkers of genotoxicity. Furthermore, a comet assay after ex vivo challenge of leukocytes with an alkylating agent, ethyl methanesulfonate (EMS), was used to analyze the repair capacity of those cells. Genetic polymorphisms in genes associated with metabolism and DNA repair were also included. The results showed no clear association between occupational exposure to ETS and the induction of genotoxicity. Interestingly, the leukocytes from non-smoking ETS-exposed individuals displayed lower DNA damage levels in response to the ex vivo EMS challenge, in comparison to those from non-exposed workers, suggesting a possible adaptive response. The contribution of individual susceptibility to the effect biomarkers studied was unclear, deserving further investigation.Centre for Toxicogenomics and Human Health (ToxOmics)NOVA Medical School|Faculdade de Ciências Médicas (NMS|FCM)RUNVital, NádiaAntunes, SusanaLouro, HenriquetaVaz, FátimaSimões, TâniaPenque, DeborahSilva, Maria João2021-07-06T22:18:06Z2021-06-042021-06-04T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10362/120609eng2296-2565PURE: 32181367https://doi.org/10.3389/fpubh.2021.674142info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2024-05-22T17:54:27Zoai:run.unl.pt:10362/120609Portal AgregadorONGhttps://www.rcaap.pt/oai/openairemluisa.alvim@gmail.comopendoar:71602024-05-22T17:54:27Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv Environmental Tobacco Smoke in Occupational Settings
Effect and Susceptibility Biomarkers in Workers From Lisbon Restaurants and Bars
title Environmental Tobacco Smoke in Occupational Settings
spellingShingle Environmental Tobacco Smoke in Occupational Settings
Vital, Nádia
challenge assay
genotoxicity
human biomonitoring
occupational exposure
second-hand smoke
Public Health, Environmental and Occupational Health
SDG 3 - Good Health and Well-being
title_short Environmental Tobacco Smoke in Occupational Settings
title_full Environmental Tobacco Smoke in Occupational Settings
title_fullStr Environmental Tobacco Smoke in Occupational Settings
title_full_unstemmed Environmental Tobacco Smoke in Occupational Settings
title_sort Environmental Tobacco Smoke in Occupational Settings
author Vital, Nádia
author_facet Vital, Nádia
Antunes, Susana
Louro, Henriqueta
Vaz, Fátima
Simões, Tânia
Penque, Deborah
Silva, Maria João
author_role author
author2 Antunes, Susana
Louro, Henriqueta
Vaz, Fátima
Simões, Tânia
Penque, Deborah
Silva, Maria João
author2_role author
author
author
author
author
author
dc.contributor.none.fl_str_mv Centre for Toxicogenomics and Human Health (ToxOmics)
NOVA Medical School|Faculdade de Ciências Médicas (NMS|FCM)
RUN
dc.contributor.author.fl_str_mv Vital, Nádia
Antunes, Susana
Louro, Henriqueta
Vaz, Fátima
Simões, Tânia
Penque, Deborah
Silva, Maria João
dc.subject.por.fl_str_mv challenge assay
genotoxicity
human biomonitoring
occupational exposure
second-hand smoke
Public Health, Environmental and Occupational Health
SDG 3 - Good Health and Well-being
topic challenge assay
genotoxicity
human biomonitoring
occupational exposure
second-hand smoke
Public Health, Environmental and Occupational Health
SDG 3 - Good Health and Well-being
description Funding: This work was funded by the Portuguese institutions Fundação Calouste Gulbenkian, Administração Central do Sistema de Saúde (ACSS) and FCT/MCTES through funding to ToxOmics (UIDB/00009/2020; UIDP/00009/2020).
publishDate 2021
dc.date.none.fl_str_mv 2021-07-06T22:18:06Z
2021-06-04
2021-06-04T00:00:00Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/10362/120609
url http://hdl.handle.net/10362/120609
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 2296-2565
PURE: 32181367
https://doi.org/10.3389/fpubh.2021.674142
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.source.none.fl_str_mv reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron:RCAAP
instname_str Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron_str RCAAP
institution RCAAP
reponame_str Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
collection Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
repository.name.fl_str_mv Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
repository.mail.fl_str_mv mluisa.alvim@gmail.com
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