The Use of Human Biomonitoring to Assess Occupational Exposure to PAHs in Europe
| Autor(a) principal: | |
|---|---|
| Data de Publicação: | 2022 |
| Outros Autores: | , , , , , , , , , , , , , , , |
| Tipo de documento: | Outros |
| Idioma: | eng |
| Título da fonte: | Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
| Texto Completo: | http://hdl.handle.net/10362/143634 |
Resumo: | Funding: This project has received funding from the European Unions’ Horizon 2020 research and innovation Programme under grant agreement No 733032. HBM4EU. |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
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7160 |
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The Use of Human Biomonitoring to Assess Occupational Exposure to PAHs in EuropeA Comprehensive Revieweffect biomarkerexposure biomarkerhuman biomonitoringoccupational exposurepolycyclic aromatic hydrocarbonsSDG 3 - Good Health and Well-beingFunding: This project has received funding from the European Unions’ Horizon 2020 research and innovation Programme under grant agreement No 733032. HBM4EU.Polycyclic aromatic hydrocarbons (PAHs) are among the chemicals with proven impact on workers' health. The use of human biomonitoring (HBM) to assess occupational exposure to PAHs has become more common in recent years, but the data generated need an overall view to make them more usable by regulators and policymakers. This comprehensive review, developed under the Human Biomonitoring for Europe (HBM4EU) Initiative, was based on the literature available from 2008-2022, aiming to present and discuss the information on occupational exposure to PAHs, in order to identify the strengths and limitations of exposure and effect biomarkers and the knowledge needs for regulation in the workplace. The most frequently used exposure biomarker is urinary 1-hydroxypyrene (1-OH-PYR), a metabolite of pyrene. As effect biomarkers, those based on the measurement of oxidative stress (urinary 8-oxo-dG adducts) and genotoxicity (blood DNA strand-breaks) are the most common. Overall, a need to advance new harmonized approaches both in data and sample collection and in the use of appropriate biomarkers in occupational studies to obtain reliable and comparable data on PAH exposure in different industrial sectors, was noted. Moreover, the use of effect biomarkers can assist to identify work environments or activities of high risk, thus enabling preventive risk mitigation and management measures.Centre for Toxicogenomics and Human Health (ToxOmics)NOVA Medical School|Faculdade de Ciências Médicas (NMS|FCM)Escola Nacional de Saúde Pública (ENSP)Centro de Investigação em Saúde Pública (CISP/PHRC)Comprehensive Health Research Centre (CHRC) - Pólo ENSPRUNLouro, HenriquetaGomes, Bruno CostaSaber, Anne ThoustrupIamiceli, Anna LauraGöen, ThomasJones, KateKatsonouri, AndromachiNeophytou, Christiana MVogel, UllaVentura, CéliaOberemm, AxelDuca, Radu CorneliuFernandez, Mariana FOlea, NicolasSantonen, TiinaViegas, SusanaSilva, Maria João2022-09-09T22:42:10Z2022-08-172022-08-17T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/otherapplication/pdfhttp://hdl.handle.net/10362/143634eng2305-6304PURE: 46260253https://doi.org/10.3390/toxics10080480info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2024-05-22T18:05:00Zoai:run.unl.pt:10362/143634Portal AgregadorONGhttps://www.rcaap.pt/oai/openairemluisa.alvim@gmail.comopendoar:71602024-05-22T18:05Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse |
| dc.title.none.fl_str_mv |
The Use of Human Biomonitoring to Assess Occupational Exposure to PAHs in Europe A Comprehensive Review |
| title |
The Use of Human Biomonitoring to Assess Occupational Exposure to PAHs in Europe |
| spellingShingle |
The Use of Human Biomonitoring to Assess Occupational Exposure to PAHs in Europe Louro, Henriqueta effect biomarker exposure biomarker human biomonitoring occupational exposure polycyclic aromatic hydrocarbons SDG 3 - Good Health and Well-being |
| title_short |
The Use of Human Biomonitoring to Assess Occupational Exposure to PAHs in Europe |
| title_full |
The Use of Human Biomonitoring to Assess Occupational Exposure to PAHs in Europe |
| title_fullStr |
The Use of Human Biomonitoring to Assess Occupational Exposure to PAHs in Europe |
| title_full_unstemmed |
The Use of Human Biomonitoring to Assess Occupational Exposure to PAHs in Europe |
| title_sort |
The Use of Human Biomonitoring to Assess Occupational Exposure to PAHs in Europe |
| author |
Louro, Henriqueta |
| author_facet |
Louro, Henriqueta Gomes, Bruno Costa Saber, Anne Thoustrup Iamiceli, Anna Laura Göen, Thomas Jones, Kate Katsonouri, Andromachi Neophytou, Christiana M Vogel, Ulla Ventura, Célia Oberemm, Axel Duca, Radu Corneliu Fernandez, Mariana F Olea, Nicolas Santonen, Tiina Viegas, Susana Silva, Maria João |
| author_role |
author |
| author2 |
Gomes, Bruno Costa Saber, Anne Thoustrup Iamiceli, Anna Laura Göen, Thomas Jones, Kate Katsonouri, Andromachi Neophytou, Christiana M Vogel, Ulla Ventura, Célia Oberemm, Axel Duca, Radu Corneliu Fernandez, Mariana F Olea, Nicolas Santonen, Tiina Viegas, Susana Silva, Maria João |
| author2_role |
author author author author author author author author author author author author author author author author |
| dc.contributor.none.fl_str_mv |
Centre for Toxicogenomics and Human Health (ToxOmics) NOVA Medical School|Faculdade de Ciências Médicas (NMS|FCM) Escola Nacional de Saúde Pública (ENSP) Centro de Investigação em Saúde Pública (CISP/PHRC) Comprehensive Health Research Centre (CHRC) - Pólo ENSP RUN |
| dc.contributor.author.fl_str_mv |
Louro, Henriqueta Gomes, Bruno Costa Saber, Anne Thoustrup Iamiceli, Anna Laura Göen, Thomas Jones, Kate Katsonouri, Andromachi Neophytou, Christiana M Vogel, Ulla Ventura, Célia Oberemm, Axel Duca, Radu Corneliu Fernandez, Mariana F Olea, Nicolas Santonen, Tiina Viegas, Susana Silva, Maria João |
| dc.subject.por.fl_str_mv |
effect biomarker exposure biomarker human biomonitoring occupational exposure polycyclic aromatic hydrocarbons SDG 3 - Good Health and Well-being |
| topic |
effect biomarker exposure biomarker human biomonitoring occupational exposure polycyclic aromatic hydrocarbons SDG 3 - Good Health and Well-being |
| description |
Funding: This project has received funding from the European Unions’ Horizon 2020 research and innovation Programme under grant agreement No 733032. HBM4EU. |
| publishDate |
2022 |
| dc.date.none.fl_str_mv |
2022-09-09T22:42:10Z 2022-08-17 2022-08-17T00:00:00Z |
| dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
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info:eu-repo/semantics/other |
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other |
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publishedVersion |
| dc.identifier.uri.fl_str_mv |
http://hdl.handle.net/10362/143634 |
| url |
http://hdl.handle.net/10362/143634 |
| dc.language.iso.fl_str_mv |
eng |
| language |
eng |
| dc.relation.none.fl_str_mv |
2305-6304 PURE: 46260253 https://doi.org/10.3390/toxics10080480 |
| dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
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openAccess |
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application/pdf |
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reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação instacron:RCAAP |
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Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
| instacron_str |
RCAAP |
| institution |
RCAAP |
| reponame_str |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
| collection |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
| repository.name.fl_str_mv |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
| repository.mail.fl_str_mv |
mluisa.alvim@gmail.com |
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1817545885669654528 |