Cancer traps: implantable and on-chip solutions for early cancer detection and treatment
Autor(a) principal: | |
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Data de Publicação: | 2023 |
Outros Autores: | , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
Texto Completo: | https://hdl.handle.net/1822/85091 |
Resumo: | Cancer continues to be a major global health issue causing millions of deaths annually. While traditional therapeutic methods may be effective in many cases, they may not be suitable for highly metastatic cancers. Moreover, the late detection of tumors, when they have already spread and are harder to treat, further exacerbates the challenge in managing this disease. As a result, there is a growing interest in developing complementary tissue-engineered approaches for early cancer diagnosis and treatment to enhance patient recovery. Bioengineered cancer traps have gained significant attention due to their efficacy and ease of use. These trapping systems employ (bio)chemical and mechanical strategies to selectively capture and limit the spread of cancer cells, leading to their eradication from the body. Furthermore, when integrated into microfluidic devices, these cancer traps-on-a-chip can be used for liquid biopsy and the early detection of circulating tumor cells and other tumor-derived material, allowing for precision medicine treatments. Herein, this innovative approach to cancer theranostics, including its mechanism of action, current stage of development, and potential advantages and limitations is discussed. |
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Cancer traps: implantable and on-chip solutions for early cancer detection and treatmentBiophysicsCancer trapLiquid biopsyMetastasisMicrofluidicsTheranosticsbiomaterialscancer trapsCancer continues to be a major global health issue causing millions of deaths annually. While traditional therapeutic methods may be effective in many cases, they may not be suitable for highly metastatic cancers. Moreover, the late detection of tumors, when they have already spread and are harder to treat, further exacerbates the challenge in managing this disease. As a result, there is a growing interest in developing complementary tissue-engineered approaches for early cancer diagnosis and treatment to enhance patient recovery. Bioengineered cancer traps have gained significant attention due to their efficacy and ease of use. These trapping systems employ (bio)chemical and mechanical strategies to selectively capture and limit the spread of cancer cells, leading to their eradication from the body. Furthermore, when integrated into microfluidic devices, these cancer traps-on-a-chip can be used for liquid biopsy and the early detection of circulating tumor cells and other tumor-derived material, allowing for precision medicine treatments. Herein, this innovative approach to cancer theranostics, including its mechanism of action, current stage of development, and potential advantages and limitations is discussed.This work was supported by the Portuguese Foundation for Science and Technology (FCT) under the program CEEC Individual 2017 (CEECIND/00352/2017) and RECOVER IC&DT project (2022.02260.PTDC) attributed to D.CWileyUniversidade do MinhoCaballero, DavidReis, R. L.Kundu, Subhas C2023-062023-06-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttps://hdl.handle.net/1822/85091engCaballero D., Reis R. L., Kundu S. C. Cancer Traps: Implantable and On-Chip Solutions for Early Cancer Detection and Treatment, Advanced Materials Technologies, pp. 2300491, doi:10.1002/admt.202300491, 20232365-709X10.1002/admt.202300491https://onlinelibrary.wiley.com/doi/abs/10.1002/admt.202300491info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-12-02T01:19:24Zoai:repositorium.sdum.uminho.pt:1822/85091Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T18:54:29.592089Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse |
dc.title.none.fl_str_mv |
Cancer traps: implantable and on-chip solutions for early cancer detection and treatment |
title |
Cancer traps: implantable and on-chip solutions for early cancer detection and treatment |
spellingShingle |
Cancer traps: implantable and on-chip solutions for early cancer detection and treatment Caballero, David Biophysics Cancer trap Liquid biopsy Metastasis Microfluidics Theranostics biomaterials cancer traps |
title_short |
Cancer traps: implantable and on-chip solutions for early cancer detection and treatment |
title_full |
Cancer traps: implantable and on-chip solutions for early cancer detection and treatment |
title_fullStr |
Cancer traps: implantable and on-chip solutions for early cancer detection and treatment |
title_full_unstemmed |
Cancer traps: implantable and on-chip solutions for early cancer detection and treatment |
title_sort |
Cancer traps: implantable and on-chip solutions for early cancer detection and treatment |
author |
Caballero, David |
author_facet |
Caballero, David Reis, R. L. Kundu, Subhas C |
author_role |
author |
author2 |
Reis, R. L. Kundu, Subhas C |
author2_role |
author author |
dc.contributor.none.fl_str_mv |
Universidade do Minho |
dc.contributor.author.fl_str_mv |
Caballero, David Reis, R. L. Kundu, Subhas C |
dc.subject.por.fl_str_mv |
Biophysics Cancer trap Liquid biopsy Metastasis Microfluidics Theranostics biomaterials cancer traps |
topic |
Biophysics Cancer trap Liquid biopsy Metastasis Microfluidics Theranostics biomaterials cancer traps |
description |
Cancer continues to be a major global health issue causing millions of deaths annually. While traditional therapeutic methods may be effective in many cases, they may not be suitable for highly metastatic cancers. Moreover, the late detection of tumors, when they have already spread and are harder to treat, further exacerbates the challenge in managing this disease. As a result, there is a growing interest in developing complementary tissue-engineered approaches for early cancer diagnosis and treatment to enhance patient recovery. Bioengineered cancer traps have gained significant attention due to their efficacy and ease of use. These trapping systems employ (bio)chemical and mechanical strategies to selectively capture and limit the spread of cancer cells, leading to their eradication from the body. Furthermore, when integrated into microfluidic devices, these cancer traps-on-a-chip can be used for liquid biopsy and the early detection of circulating tumor cells and other tumor-derived material, allowing for precision medicine treatments. Herein, this innovative approach to cancer theranostics, including its mechanism of action, current stage of development, and potential advantages and limitations is discussed. |
publishDate |
2023 |
dc.date.none.fl_str_mv |
2023-06 2023-06-01T00:00:00Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
https://hdl.handle.net/1822/85091 |
url |
https://hdl.handle.net/1822/85091 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
Caballero D., Reis R. L., Kundu S. C. Cancer Traps: Implantable and On-Chip Solutions for Early Cancer Detection and Treatment, Advanced Materials Technologies, pp. 2300491, doi:10.1002/admt.202300491, 2023 2365-709X 10.1002/admt.202300491 https://onlinelibrary.wiley.com/doi/abs/10.1002/admt.202300491 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.publisher.none.fl_str_mv |
Wiley |
publisher.none.fl_str_mv |
Wiley |
dc.source.none.fl_str_mv |
reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação instacron:RCAAP |
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Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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RCAAP |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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1799132327217987584 |