Obesity or diet? Levels and determinants of phthalate body burden – A case study on Portuguese children

Detalhes bibliográficos
Autor(a) principal: Correia-Sá, Luísa
Data de Publicação: 2018
Outros Autores: Kasper-Sonnenberg, Monika, Pälmke, Claudia, Schütze, André, Norberto, Sónia, Calhau, Conceição, Domingues, Valentina F., Koch, Holger M.
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: http://hdl.handle.net/10400.22/14716
Resumo: In this study we analyzed one of the most comprehensive sets of 21 urinary phthalate metabolites representing exposure to 11 parent phthalates (DEP, DMP, DiBP, DnBP, BBzP, DEHP, DiNP, DiDP, DCHP, DnPeP, DnOP) in first morning urine samples of 112 Portuguese children (4-18 years) sampled in 2014/15. The study population consisted of two groups: group 1 with normal weight/underweight children (N = 43) following their regular diet and group 2 with obese/overweight children (N = 69) following a healthy diet (with nutritional counselling). Most of the metabolites were above the limits quantification (81-100%) except for MCHP, MnPEP and MnOP. Metabolite levels were generally comparable to other recent child and general populations sampled worldwide, confirming the steady decline in exposures to most phthalates. Compared to Portuguese children sampled in 2011/2012, median urinary metabolite levels decreased by approximately 50% for DEHP, DnBP, DiBP and BBzP. Risk assessments for individual phthalates and the sum of the anti-androgenic phthalates did not indicate to attributable health risks, also at the upper percentiles of exposure. In the healthy diet group the median concentration of the DEHP metabolites was significant lower, while all phthalate metabolites except MEP tended to be lower compared to the regular diet group. Multiple log-linear regression analyses revealed significantly lower daily intakes (DIs) for all phthalates in the healthy diet group compared to the regular diet group (geometric mean ratios (gMR) between 0.510-0.618; p ≤ 0.05), except for DEP (gMR: 0.811; p = 0.273). The same analyses with the continuous variable body mass index instead of the diet groups also showed effects on the DIs (gMRs between 0.926-0.951; p ≤ 0.05), however much smaller than the effects of the diet. The results indicate that obese children following a healthy diet composed of fresh and less packaged/processed food can considerably reduce their intake for most phthalates and can have lower phthalate intakes than regular weight/regular diet children.
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spelling Obesity or diet? Levels and determinants of phthalate body burden – A case study on Portuguese childrenAdolescentBody BurdenBody WeightChild, PreschoolDibutyl PhthalateDietDiethylhexyl PhthalateEnvironmental ExposureEnvironmental PollutantsFeeding BehaviorHumansObesityPhthalic AcidsPortugalRisk FactorsBody Mass IndexPlasticizersIn this study we analyzed one of the most comprehensive sets of 21 urinary phthalate metabolites representing exposure to 11 parent phthalates (DEP, DMP, DiBP, DnBP, BBzP, DEHP, DiNP, DiDP, DCHP, DnPeP, DnOP) in first morning urine samples of 112 Portuguese children (4-18 years) sampled in 2014/15. The study population consisted of two groups: group 1 with normal weight/underweight children (N = 43) following their regular diet and group 2 with obese/overweight children (N = 69) following a healthy diet (with nutritional counselling). Most of the metabolites were above the limits quantification (81-100%) except for MCHP, MnPEP and MnOP. Metabolite levels were generally comparable to other recent child and general populations sampled worldwide, confirming the steady decline in exposures to most phthalates. Compared to Portuguese children sampled in 2011/2012, median urinary metabolite levels decreased by approximately 50% for DEHP, DnBP, DiBP and BBzP. Risk assessments for individual phthalates and the sum of the anti-androgenic phthalates did not indicate to attributable health risks, also at the upper percentiles of exposure. In the healthy diet group the median concentration of the DEHP metabolites was significant lower, while all phthalate metabolites except MEP tended to be lower compared to the regular diet group. Multiple log-linear regression analyses revealed significantly lower daily intakes (DIs) for all phthalates in the healthy diet group compared to the regular diet group (geometric mean ratios (gMR) between 0.510-0.618; p ≤ 0.05), except for DEP (gMR: 0.811; p = 0.273). The same analyses with the continuous variable body mass index instead of the diet groups also showed effects on the DIs (gMRs between 0.926-0.951; p ≤ 0.05), however much smaller than the effects of the diet. The results indicate that obese children following a healthy diet composed of fresh and less packaged/processed food can considerably reduce their intake for most phthalates and can have lower phthalate intakes than regular weight/regular diet children.Luísa Correia-Sá is grateful to Fundação para a Ciência e a Tecnologia (FCT) by the grant (SFRH/BD/87019/2012), financed by POCH, subsidized by Fundo Social Europeu and Ministério da Ciência, Tecnologia e Ensino Superior. The authors are thankful to the project Qualidade e Segurança Alimentar – uma abordagem (nano)tecnológica, reference NORTE-01-0145-FEDER-000011.ElsevierRepositório Científico do Instituto Politécnico do PortoCorreia-Sá, LuísaKasper-Sonnenberg, MonikaPälmke, ClaudiaSchütze, AndréNorberto, SóniaCalhau, ConceiçãoDomingues, Valentina F.Koch, Holger M.2019-10-07T15:28:01Z20182018-01-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10400.22/14716eng1438-463910.1016/j.ijheh.2018.02.001info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-03-13T12:57:44Zoai:recipp.ipp.pt:10400.22/14716Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T17:34:14.335999Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv Obesity or diet? Levels and determinants of phthalate body burden – A case study on Portuguese children
title Obesity or diet? Levels and determinants of phthalate body burden – A case study on Portuguese children
spellingShingle Obesity or diet? Levels and determinants of phthalate body burden – A case study on Portuguese children
Correia-Sá, Luísa
Adolescent
Body Burden
Body Weight
Child, Preschool
Dibutyl Phthalate
Diet
Diethylhexyl Phthalate
Environmental Exposure
Environmental Pollutants
Feeding Behavior
Humans
Obesity
Phthalic Acids
Portugal
Risk Factors
Body Mass Index
Plasticizers
title_short Obesity or diet? Levels and determinants of phthalate body burden – A case study on Portuguese children
title_full Obesity or diet? Levels and determinants of phthalate body burden – A case study on Portuguese children
title_fullStr Obesity or diet? Levels and determinants of phthalate body burden – A case study on Portuguese children
title_full_unstemmed Obesity or diet? Levels and determinants of phthalate body burden – A case study on Portuguese children
title_sort Obesity or diet? Levels and determinants of phthalate body burden – A case study on Portuguese children
author Correia-Sá, Luísa
author_facet Correia-Sá, Luísa
Kasper-Sonnenberg, Monika
Pälmke, Claudia
Schütze, André
Norberto, Sónia
Calhau, Conceição
Domingues, Valentina F.
Koch, Holger M.
author_role author
author2 Kasper-Sonnenberg, Monika
Pälmke, Claudia
Schütze, André
Norberto, Sónia
Calhau, Conceição
Domingues, Valentina F.
Koch, Holger M.
author2_role author
author
author
author
author
author
author
dc.contributor.none.fl_str_mv Repositório Científico do Instituto Politécnico do Porto
dc.contributor.author.fl_str_mv Correia-Sá, Luísa
Kasper-Sonnenberg, Monika
Pälmke, Claudia
Schütze, André
Norberto, Sónia
Calhau, Conceição
Domingues, Valentina F.
Koch, Holger M.
dc.subject.por.fl_str_mv Adolescent
Body Burden
Body Weight
Child, Preschool
Dibutyl Phthalate
Diet
Diethylhexyl Phthalate
Environmental Exposure
Environmental Pollutants
Feeding Behavior
Humans
Obesity
Phthalic Acids
Portugal
Risk Factors
Body Mass Index
Plasticizers
topic Adolescent
Body Burden
Body Weight
Child, Preschool
Dibutyl Phthalate
Diet
Diethylhexyl Phthalate
Environmental Exposure
Environmental Pollutants
Feeding Behavior
Humans
Obesity
Phthalic Acids
Portugal
Risk Factors
Body Mass Index
Plasticizers
description In this study we analyzed one of the most comprehensive sets of 21 urinary phthalate metabolites representing exposure to 11 parent phthalates (DEP, DMP, DiBP, DnBP, BBzP, DEHP, DiNP, DiDP, DCHP, DnPeP, DnOP) in first morning urine samples of 112 Portuguese children (4-18 years) sampled in 2014/15. The study population consisted of two groups: group 1 with normal weight/underweight children (N = 43) following their regular diet and group 2 with obese/overweight children (N = 69) following a healthy diet (with nutritional counselling). Most of the metabolites were above the limits quantification (81-100%) except for MCHP, MnPEP and MnOP. Metabolite levels were generally comparable to other recent child and general populations sampled worldwide, confirming the steady decline in exposures to most phthalates. Compared to Portuguese children sampled in 2011/2012, median urinary metabolite levels decreased by approximately 50% for DEHP, DnBP, DiBP and BBzP. Risk assessments for individual phthalates and the sum of the anti-androgenic phthalates did not indicate to attributable health risks, also at the upper percentiles of exposure. In the healthy diet group the median concentration of the DEHP metabolites was significant lower, while all phthalate metabolites except MEP tended to be lower compared to the regular diet group. Multiple log-linear regression analyses revealed significantly lower daily intakes (DIs) for all phthalates in the healthy diet group compared to the regular diet group (geometric mean ratios (gMR) between 0.510-0.618; p ≤ 0.05), except for DEP (gMR: 0.811; p = 0.273). The same analyses with the continuous variable body mass index instead of the diet groups also showed effects on the DIs (gMRs between 0.926-0.951; p ≤ 0.05), however much smaller than the effects of the diet. The results indicate that obese children following a healthy diet composed of fresh and less packaged/processed food can considerably reduce their intake for most phthalates and can have lower phthalate intakes than regular weight/regular diet children.
publishDate 2018
dc.date.none.fl_str_mv 2018
2018-01-01T00:00:00Z
2019-10-07T15:28:01Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
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status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/10400.22/14716
url http://hdl.handle.net/10400.22/14716
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 1438-4639
10.1016/j.ijheh.2018.02.001
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dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Elsevier
publisher.none.fl_str_mv Elsevier
dc.source.none.fl_str_mv reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
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collection Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
repository.name.fl_str_mv Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
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