Characterization of phenolic compounds in tincture of edible Nepeta nuda: development of antimicrobial mouthwash
Autor(a) principal: | |
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Data de Publicação: | 2018 |
Outros Autores: | , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
Texto Completo: | http://hdl.handle.net/10198/18695 |
Resumo: | The activity of edible Nepeta nuda L. (Lamiaceae) tincture and Listerine towards a selected group of oral pathogenic microorganisms (4 bacterial and 9 fungal strains) has been explored. Their potentials to inhibit the formation of biofilm and to diminish established biofilm have been compared. The amount of N. nuda tincture and swishing time necessary for reaching better or equivalent antimicrobial effect than that of Listerine have been predicted. Phenolic compounds in N. nuda tincture are determined by LC-DAD/ ESI-MSn. Both Listerine and N. nuda tincture possess good antimicrobial potentials (MIC in the range of 0.8–15 µL per well) including inhibition of biofilms. Rosmarinic acid and verminoside are the most dominant phenolic compounds present in the N. nuda tincture. Based on in vitro results, we infer that it is more desirable to swish 20 mL of mouthwashes (Listerine and N. nuda tincture, 100 mg mL−1) for 30 s when dealing with selected microorganisms in general and for 60 s (N. nuda tincture) when dealing with bacterial biofilms. |
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Characterization of phenolic compounds in tincture of edible Nepeta nuda: development of antimicrobial mouthwashThe activity of edible Nepeta nuda L. (Lamiaceae) tincture and Listerine towards a selected group of oral pathogenic microorganisms (4 bacterial and 9 fungal strains) has been explored. Their potentials to inhibit the formation of biofilm and to diminish established biofilm have been compared. The amount of N. nuda tincture and swishing time necessary for reaching better or equivalent antimicrobial effect than that of Listerine have been predicted. Phenolic compounds in N. nuda tincture are determined by LC-DAD/ ESI-MSn. Both Listerine and N. nuda tincture possess good antimicrobial potentials (MIC in the range of 0.8–15 µL per well) including inhibition of biofilms. Rosmarinic acid and verminoside are the most dominant phenolic compounds present in the N. nuda tincture. Based on in vitro results, we infer that it is more desirable to swish 20 mL of mouthwashes (Listerine and N. nuda tincture, 100 mg mL−1) for 30 s when dealing with selected microorganisms in general and for 60 s (N. nuda tincture) when dealing with bacterial biofilms.This work has been supported by the Serbian Ministry of Education, Science and Technological Development for financial support (Grant number 173032 and 173029). The authors are grateful to the Foundation for Science and Technology (FCT) of Portugal and FEDER under Programme PT2020 for financial support to CIMO (UID/AGR/00690/2013) and L. Barros research contract. The authors are grateful to FEDER-Interreg España-Portugal programme for financial support through the project 0377_Iberphenol_6_E.Biblioteca Digital do IPBSmiljković, MarijaDias, Maria InêsStojković, DejanBarros, LillianBukvički, DankaFerreira, Isabel C.F.R.Soković, Marina2018-01-19T10:00:00Z20182018-01-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10198/18695engSmiljković, Marija; Dias, Maria Inês; Stojkovic, Dejan; Barros, Lillian; Bukvički, Danka; Ferreira, Isabel C.F.R.; Sokovic, Marina (2018). Characterization of phenolic compounds in tincture of edible Nepeta nuda: development of antimicrobial mouthwash. Food and Function. ISSN 2042-6496. 9, p. 5417-54252042-649610.1039/c8fo01466cinfo:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-11-21T10:42:53Zoai:bibliotecadigital.ipb.pt:10198/18695Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T23:09:03.717310Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse |
dc.title.none.fl_str_mv |
Characterization of phenolic compounds in tincture of edible Nepeta nuda: development of antimicrobial mouthwash |
title |
Characterization of phenolic compounds in tincture of edible Nepeta nuda: development of antimicrobial mouthwash |
spellingShingle |
Characterization of phenolic compounds in tincture of edible Nepeta nuda: development of antimicrobial mouthwash Smiljković, Marija |
title_short |
Characterization of phenolic compounds in tincture of edible Nepeta nuda: development of antimicrobial mouthwash |
title_full |
Characterization of phenolic compounds in tincture of edible Nepeta nuda: development of antimicrobial mouthwash |
title_fullStr |
Characterization of phenolic compounds in tincture of edible Nepeta nuda: development of antimicrobial mouthwash |
title_full_unstemmed |
Characterization of phenolic compounds in tincture of edible Nepeta nuda: development of antimicrobial mouthwash |
title_sort |
Characterization of phenolic compounds in tincture of edible Nepeta nuda: development of antimicrobial mouthwash |
author |
Smiljković, Marija |
author_facet |
Smiljković, Marija Dias, Maria Inês Stojković, Dejan Barros, Lillian Bukvički, Danka Ferreira, Isabel C.F.R. Soković, Marina |
author_role |
author |
author2 |
Dias, Maria Inês Stojković, Dejan Barros, Lillian Bukvički, Danka Ferreira, Isabel C.F.R. Soković, Marina |
author2_role |
author author author author author author |
dc.contributor.none.fl_str_mv |
Biblioteca Digital do IPB |
dc.contributor.author.fl_str_mv |
Smiljković, Marija Dias, Maria Inês Stojković, Dejan Barros, Lillian Bukvički, Danka Ferreira, Isabel C.F.R. Soković, Marina |
description |
The activity of edible Nepeta nuda L. (Lamiaceae) tincture and Listerine towards a selected group of oral pathogenic microorganisms (4 bacterial and 9 fungal strains) has been explored. Their potentials to inhibit the formation of biofilm and to diminish established biofilm have been compared. The amount of N. nuda tincture and swishing time necessary for reaching better or equivalent antimicrobial effect than that of Listerine have been predicted. Phenolic compounds in N. nuda tincture are determined by LC-DAD/ ESI-MSn. Both Listerine and N. nuda tincture possess good antimicrobial potentials (MIC in the range of 0.8–15 µL per well) including inhibition of biofilms. Rosmarinic acid and verminoside are the most dominant phenolic compounds present in the N. nuda tincture. Based on in vitro results, we infer that it is more desirable to swish 20 mL of mouthwashes (Listerine and N. nuda tincture, 100 mg mL−1) for 30 s when dealing with selected microorganisms in general and for 60 s (N. nuda tincture) when dealing with bacterial biofilms. |
publishDate |
2018 |
dc.date.none.fl_str_mv |
2018-01-19T10:00:00Z 2018 2018-01-01T00:00:00Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://hdl.handle.net/10198/18695 |
url |
http://hdl.handle.net/10198/18695 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
Smiljković, Marija; Dias, Maria Inês; Stojkovic, Dejan; Barros, Lillian; Bukvički, Danka; Ferreira, Isabel C.F.R.; Sokovic, Marina (2018). Characterization of phenolic compounds in tincture of edible Nepeta nuda: development of antimicrobial mouthwash. Food and Function. ISSN 2042-6496. 9, p. 5417-5425 2042-6496 10.1039/c8fo01466c |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.source.none.fl_str_mv |
reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação instacron:RCAAP |
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Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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RCAAP |
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RCAAP |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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