Preliminary evaluation of zeolite-based platforms as potential dual drug delivery systems against microbial infections in the tumor microenvironment
Autor(a) principal: | |
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Data de Publicação: | 2024 |
Outros Autores: | , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
Texto Completo: | https://hdl.handle.net/1822/87176 |
Resumo: | Several zeolite-based delivery systems (ZDS) built with faujasite structure were prepared containing silver (Ag+) and 5-Fluorouracil (5-FU) as antimicrobial and antineoplastic agents, respectively. The idea behind this drug combination is an answer to the increasing evidence of colonization of tumor microenvironments by pathogenic microorganisms and their active role in tumor growth. Two ZDS with a fixed load of 5-FU and different silver loads, Ag7(5-FU). |
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Preliminary evaluation of zeolite-based platforms as potential dual drug delivery systems against microbial infections in the tumor microenvironmentZeolite5-FluorouracilSilverMicrobial infectionsTumor microenvironmentSeveral zeolite-based delivery systems (ZDS) built with faujasite structure were prepared containing silver (Ag+) and 5-Fluorouracil (5-FU) as antimicrobial and antineoplastic agents, respectively. The idea behind this drug combination is an answer to the increasing evidence of colonization of tumor microenvironments by pathogenic microorganisms and their active role in tumor growth. Two ZDS with a fixed load of 5-FU and different silver loads, Ag7(5-FU).FCT -Fundação para a Ciência e a Tecnologia(UID/QUI/0686/2020)info:eu-repo/semantics/publishedVersionElsevierUniversidade do MinhoBertão, Ana RaquelIvasiv, ViktoriyaAlmeida Aguiar, CristinaCorreia, Patrícia R.Fonseca, António M.Bañobre-López, ManuelBaltazar, FátimaNeves, Isabel C.2024-01-152024-01-15T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttps://hdl.handle.net/1822/87176engBertão, Ana Raquel; Ivasiv, Viktoriya; Almeida-Aguiar, Cristina; Correia, Patricia R.; Fonseca, António; Bañobre-López, Manuel; Baltazar, Fátima; Neves, Isabel C., Preliminary evaluation of zeolite-based platforms as potential dual drug delivery systems against microbial infections in the tumor microenvironment. Microporous and Mesoporous Materials, 364(112871), 20241387-181110.1016/j.micromeso.2023.112871https://www.journals.elsevier.com/microporous-and-mesoporous-materialsinfo:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2024-02-24T01:22:58Zoai:repositorium.sdum.uminho.pt:1822/87176Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T22:37:54.394890Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse |
dc.title.none.fl_str_mv |
Preliminary evaluation of zeolite-based platforms as potential dual drug delivery systems against microbial infections in the tumor microenvironment |
title |
Preliminary evaluation of zeolite-based platforms as potential dual drug delivery systems against microbial infections in the tumor microenvironment |
spellingShingle |
Preliminary evaluation of zeolite-based platforms as potential dual drug delivery systems against microbial infections in the tumor microenvironment Bertão, Ana Raquel Zeolite 5-Fluorouracil Silver Microbial infections Tumor microenvironment |
title_short |
Preliminary evaluation of zeolite-based platforms as potential dual drug delivery systems against microbial infections in the tumor microenvironment |
title_full |
Preliminary evaluation of zeolite-based platforms as potential dual drug delivery systems against microbial infections in the tumor microenvironment |
title_fullStr |
Preliminary evaluation of zeolite-based platforms as potential dual drug delivery systems against microbial infections in the tumor microenvironment |
title_full_unstemmed |
Preliminary evaluation of zeolite-based platforms as potential dual drug delivery systems against microbial infections in the tumor microenvironment |
title_sort |
Preliminary evaluation of zeolite-based platforms as potential dual drug delivery systems against microbial infections in the tumor microenvironment |
author |
Bertão, Ana Raquel |
author_facet |
Bertão, Ana Raquel Ivasiv, Viktoriya Almeida Aguiar, Cristina Correia, Patrícia R. Fonseca, António M. Bañobre-López, Manuel Baltazar, Fátima Neves, Isabel C. |
author_role |
author |
author2 |
Ivasiv, Viktoriya Almeida Aguiar, Cristina Correia, Patrícia R. Fonseca, António M. Bañobre-López, Manuel Baltazar, Fátima Neves, Isabel C. |
author2_role |
author author author author author author author |
dc.contributor.none.fl_str_mv |
Universidade do Minho |
dc.contributor.author.fl_str_mv |
Bertão, Ana Raquel Ivasiv, Viktoriya Almeida Aguiar, Cristina Correia, Patrícia R. Fonseca, António M. Bañobre-López, Manuel Baltazar, Fátima Neves, Isabel C. |
dc.subject.por.fl_str_mv |
Zeolite 5-Fluorouracil Silver Microbial infections Tumor microenvironment |
topic |
Zeolite 5-Fluorouracil Silver Microbial infections Tumor microenvironment |
description |
Several zeolite-based delivery systems (ZDS) built with faujasite structure were prepared containing silver (Ag+) and 5-Fluorouracil (5-FU) as antimicrobial and antineoplastic agents, respectively. The idea behind this drug combination is an answer to the increasing evidence of colonization of tumor microenvironments by pathogenic microorganisms and their active role in tumor growth. Two ZDS with a fixed load of 5-FU and different silver loads, Ag7(5-FU). |
publishDate |
2024 |
dc.date.none.fl_str_mv |
2024-01-15 2024-01-15T00:00:00Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
https://hdl.handle.net/1822/87176 |
url |
https://hdl.handle.net/1822/87176 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
Bertão, Ana Raquel; Ivasiv, Viktoriya; Almeida-Aguiar, Cristina; Correia, Patricia R.; Fonseca, António; Bañobre-López, Manuel; Baltazar, Fátima; Neves, Isabel C., Preliminary evaluation of zeolite-based platforms as potential dual drug delivery systems against microbial infections in the tumor microenvironment. Microporous and Mesoporous Materials, 364(112871), 2024 1387-1811 10.1016/j.micromeso.2023.112871 https://www.journals.elsevier.com/microporous-and-mesoporous-materials |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.publisher.none.fl_str_mv |
Elsevier |
publisher.none.fl_str_mv |
Elsevier |
dc.source.none.fl_str_mv |
reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação instacron:RCAAP |
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Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
instacron_str |
RCAAP |
institution |
RCAAP |
reponame_str |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
collection |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
repository.name.fl_str_mv |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
repository.mail.fl_str_mv |
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1799134937972998144 |