Orange thyme: Phytochemical profiling, in vitro bioactivities of extracts and potential health benefits

Detalhes bibliográficos
Autor(a) principal: Silva, Amélia M.
Data de Publicação: 2021
Outros Autores: Félix, Luís M, Teixeira, Isabel, Martins-Gomes, Carlos, Schäfer, Judith, Souto, Eliana B., Santos, Dario J, Bunzel, Mirko, Nunes, Fernando M
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: http://hdl.handle.net/10316/103950
https://doi.org/10.1016/j.fochx.2021.100171
Resumo: Orange thyme (Thymus fragrantissimus) is becoming widely used in food as a condiment and herbal tea, nevertheless its chemical composition and potential bioactivities are largely unknown. Thus the objective of this work is to obtain a detailed phytochemical profile of T. fragrantissimus by exhaustive ethanolic extraction and by aqueous decoction mimicking its consumption. Extracts showed high content in rosmarinic acid, luteolin-O-hexuronide and eriodictyol-O-hexuronide; these were the main phenolic compounds present in orange thyme accounting for 85% of the total phenolic compounds. Orange thyme extracts presented high scavenging activity against nitric oxide and superoxide radicals. Both extracts presented significant inhibitory effect of tyrosinase activity and moderate anti-acetylcholinesterase activity. Both extracts showed a good in vitro anti-inflammatory activity and a weak anti-proliferative/cytotoxic activity against Caco-2 and HepG2 cell lines supporting its safe use. Orange thyme is a very good source of bioactive compounds with potential use in different food and nutraceutical industries.
id RCAP_4dcdd69d0a056f923a8e0b8ce5c70a64
oai_identifier_str oai:estudogeral.uc.pt:10316/103950
network_acronym_str RCAP
network_name_str Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
repository_id_str 7160
spelling Orange thyme: Phytochemical profiling, in vitro bioactivities of extracts and potential health benefitsOrange thymePhenolic compositionAntioxidant activityAnti-proliferativeAnti-inflammatory activityAqueous extractHydroethanolic extractRadical scavenging activitiesOrange thyme (Thymus fragrantissimus) is becoming widely used in food as a condiment and herbal tea, nevertheless its chemical composition and potential bioactivities are largely unknown. Thus the objective of this work is to obtain a detailed phytochemical profile of T. fragrantissimus by exhaustive ethanolic extraction and by aqueous decoction mimicking its consumption. Extracts showed high content in rosmarinic acid, luteolin-O-hexuronide and eriodictyol-O-hexuronide; these were the main phenolic compounds present in orange thyme accounting for 85% of the total phenolic compounds. Orange thyme extracts presented high scavenging activity against nitric oxide and superoxide radicals. Both extracts presented significant inhibitory effect of tyrosinase activity and moderate anti-acetylcholinesterase activity. Both extracts showed a good in vitro anti-inflammatory activity and a weak anti-proliferative/cytotoxic activity against Caco-2 and HepG2 cell lines supporting its safe use. Orange thyme is a very good source of bioactive compounds with potential use in different food and nutraceutical industries.Elsevier2021-12-30info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articlehttp://hdl.handle.net/10316/103950http://hdl.handle.net/10316/103950https://doi.org/10.1016/j.fochx.2021.100171eng25901575Silva, Amélia M.Félix, Luís MTeixeira, IsabelMartins-Gomes, CarlosSchäfer, JudithSouto, Eliana B.Santos, Dario JBunzel, MirkoNunes, Fernando Minfo:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2022-12-12T21:37:54Zoai:estudogeral.uc.pt:10316/103950Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T21:20:41.784059Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv Orange thyme: Phytochemical profiling, in vitro bioactivities of extracts and potential health benefits
title Orange thyme: Phytochemical profiling, in vitro bioactivities of extracts and potential health benefits
spellingShingle Orange thyme: Phytochemical profiling, in vitro bioactivities of extracts and potential health benefits
Silva, Amélia M.
Orange thyme
Phenolic composition
Antioxidant activity
Anti-proliferative
Anti-inflammatory activity
Aqueous extract
Hydroethanolic extract
Radical scavenging activities
title_short Orange thyme: Phytochemical profiling, in vitro bioactivities of extracts and potential health benefits
title_full Orange thyme: Phytochemical profiling, in vitro bioactivities of extracts and potential health benefits
title_fullStr Orange thyme: Phytochemical profiling, in vitro bioactivities of extracts and potential health benefits
title_full_unstemmed Orange thyme: Phytochemical profiling, in vitro bioactivities of extracts and potential health benefits
title_sort Orange thyme: Phytochemical profiling, in vitro bioactivities of extracts and potential health benefits
author Silva, Amélia M.
author_facet Silva, Amélia M.
Félix, Luís M
Teixeira, Isabel
Martins-Gomes, Carlos
Schäfer, Judith
Souto, Eliana B.
Santos, Dario J
Bunzel, Mirko
Nunes, Fernando M
author_role author
author2 Félix, Luís M
Teixeira, Isabel
Martins-Gomes, Carlos
Schäfer, Judith
Souto, Eliana B.
Santos, Dario J
Bunzel, Mirko
Nunes, Fernando M
author2_role author
author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Silva, Amélia M.
Félix, Luís M
Teixeira, Isabel
Martins-Gomes, Carlos
Schäfer, Judith
Souto, Eliana B.
Santos, Dario J
Bunzel, Mirko
Nunes, Fernando M
dc.subject.por.fl_str_mv Orange thyme
Phenolic composition
Antioxidant activity
Anti-proliferative
Anti-inflammatory activity
Aqueous extract
Hydroethanolic extract
Radical scavenging activities
topic Orange thyme
Phenolic composition
Antioxidant activity
Anti-proliferative
Anti-inflammatory activity
Aqueous extract
Hydroethanolic extract
Radical scavenging activities
description Orange thyme (Thymus fragrantissimus) is becoming widely used in food as a condiment and herbal tea, nevertheless its chemical composition and potential bioactivities are largely unknown. Thus the objective of this work is to obtain a detailed phytochemical profile of T. fragrantissimus by exhaustive ethanolic extraction and by aqueous decoction mimicking its consumption. Extracts showed high content in rosmarinic acid, luteolin-O-hexuronide and eriodictyol-O-hexuronide; these were the main phenolic compounds present in orange thyme accounting for 85% of the total phenolic compounds. Orange thyme extracts presented high scavenging activity against nitric oxide and superoxide radicals. Both extracts presented significant inhibitory effect of tyrosinase activity and moderate anti-acetylcholinesterase activity. Both extracts showed a good in vitro anti-inflammatory activity and a weak anti-proliferative/cytotoxic activity against Caco-2 and HepG2 cell lines supporting its safe use. Orange thyme is a very good source of bioactive compounds with potential use in different food and nutraceutical industries.
publishDate 2021
dc.date.none.fl_str_mv 2021-12-30
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/10316/103950
http://hdl.handle.net/10316/103950
https://doi.org/10.1016/j.fochx.2021.100171
url http://hdl.handle.net/10316/103950
https://doi.org/10.1016/j.fochx.2021.100171
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 25901575
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Elsevier
publisher.none.fl_str_mv Elsevier
dc.source.none.fl_str_mv reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron:RCAAP
instname_str Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron_str RCAAP
institution RCAAP
reponame_str Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
collection Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
repository.name.fl_str_mv Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
repository.mail.fl_str_mv
_version_ 1817552187962687488