Orange thyme: Phytochemical profiling, in vitro bioactivities of extracts and potential health benefits
Autor(a) principal: | |
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Data de Publicação: | 2021 |
Outros Autores: | , , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
Texto Completo: | http://hdl.handle.net/10316/103950 https://doi.org/10.1016/j.fochx.2021.100171 |
Resumo: | Orange thyme (Thymus fragrantissimus) is becoming widely used in food as a condiment and herbal tea, nevertheless its chemical composition and potential bioactivities are largely unknown. Thus the objective of this work is to obtain a detailed phytochemical profile of T. fragrantissimus by exhaustive ethanolic extraction and by aqueous decoction mimicking its consumption. Extracts showed high content in rosmarinic acid, luteolin-O-hexuronide and eriodictyol-O-hexuronide; these were the main phenolic compounds present in orange thyme accounting for 85% of the total phenolic compounds. Orange thyme extracts presented high scavenging activity against nitric oxide and superoxide radicals. Both extracts presented significant inhibitory effect of tyrosinase activity and moderate anti-acetylcholinesterase activity. Both extracts showed a good in vitro anti-inflammatory activity and a weak anti-proliferative/cytotoxic activity against Caco-2 and HepG2 cell lines supporting its safe use. Orange thyme is a very good source of bioactive compounds with potential use in different food and nutraceutical industries. |
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Orange thyme: Phytochemical profiling, in vitro bioactivities of extracts and potential health benefitsOrange thymePhenolic compositionAntioxidant activityAnti-proliferativeAnti-inflammatory activityAqueous extractHydroethanolic extractRadical scavenging activitiesOrange thyme (Thymus fragrantissimus) is becoming widely used in food as a condiment and herbal tea, nevertheless its chemical composition and potential bioactivities are largely unknown. Thus the objective of this work is to obtain a detailed phytochemical profile of T. fragrantissimus by exhaustive ethanolic extraction and by aqueous decoction mimicking its consumption. Extracts showed high content in rosmarinic acid, luteolin-O-hexuronide and eriodictyol-O-hexuronide; these were the main phenolic compounds present in orange thyme accounting for 85% of the total phenolic compounds. Orange thyme extracts presented high scavenging activity against nitric oxide and superoxide radicals. Both extracts presented significant inhibitory effect of tyrosinase activity and moderate anti-acetylcholinesterase activity. Both extracts showed a good in vitro anti-inflammatory activity and a weak anti-proliferative/cytotoxic activity against Caco-2 and HepG2 cell lines supporting its safe use. Orange thyme is a very good source of bioactive compounds with potential use in different food and nutraceutical industries.Elsevier2021-12-30info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articlehttp://hdl.handle.net/10316/103950http://hdl.handle.net/10316/103950https://doi.org/10.1016/j.fochx.2021.100171eng25901575Silva, Amélia M.Félix, Luís MTeixeira, IsabelMartins-Gomes, CarlosSchäfer, JudithSouto, Eliana B.Santos, Dario JBunzel, MirkoNunes, Fernando Minfo:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2022-12-12T21:37:54Zoai:estudogeral.uc.pt:10316/103950Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T21:20:41.784059Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse |
dc.title.none.fl_str_mv |
Orange thyme: Phytochemical profiling, in vitro bioactivities of extracts and potential health benefits |
title |
Orange thyme: Phytochemical profiling, in vitro bioactivities of extracts and potential health benefits |
spellingShingle |
Orange thyme: Phytochemical profiling, in vitro bioactivities of extracts and potential health benefits Silva, Amélia M. Orange thyme Phenolic composition Antioxidant activity Anti-proliferative Anti-inflammatory activity Aqueous extract Hydroethanolic extract Radical scavenging activities |
title_short |
Orange thyme: Phytochemical profiling, in vitro bioactivities of extracts and potential health benefits |
title_full |
Orange thyme: Phytochemical profiling, in vitro bioactivities of extracts and potential health benefits |
title_fullStr |
Orange thyme: Phytochemical profiling, in vitro bioactivities of extracts and potential health benefits |
title_full_unstemmed |
Orange thyme: Phytochemical profiling, in vitro bioactivities of extracts and potential health benefits |
title_sort |
Orange thyme: Phytochemical profiling, in vitro bioactivities of extracts and potential health benefits |
author |
Silva, Amélia M. |
author_facet |
Silva, Amélia M. Félix, Luís M Teixeira, Isabel Martins-Gomes, Carlos Schäfer, Judith Souto, Eliana B. Santos, Dario J Bunzel, Mirko Nunes, Fernando M |
author_role |
author |
author2 |
Félix, Luís M Teixeira, Isabel Martins-Gomes, Carlos Schäfer, Judith Souto, Eliana B. Santos, Dario J Bunzel, Mirko Nunes, Fernando M |
author2_role |
author author author author author author author author |
dc.contributor.author.fl_str_mv |
Silva, Amélia M. Félix, Luís M Teixeira, Isabel Martins-Gomes, Carlos Schäfer, Judith Souto, Eliana B. Santos, Dario J Bunzel, Mirko Nunes, Fernando M |
dc.subject.por.fl_str_mv |
Orange thyme Phenolic composition Antioxidant activity Anti-proliferative Anti-inflammatory activity Aqueous extract Hydroethanolic extract Radical scavenging activities |
topic |
Orange thyme Phenolic composition Antioxidant activity Anti-proliferative Anti-inflammatory activity Aqueous extract Hydroethanolic extract Radical scavenging activities |
description |
Orange thyme (Thymus fragrantissimus) is becoming widely used in food as a condiment and herbal tea, nevertheless its chemical composition and potential bioactivities are largely unknown. Thus the objective of this work is to obtain a detailed phytochemical profile of T. fragrantissimus by exhaustive ethanolic extraction and by aqueous decoction mimicking its consumption. Extracts showed high content in rosmarinic acid, luteolin-O-hexuronide and eriodictyol-O-hexuronide; these were the main phenolic compounds present in orange thyme accounting for 85% of the total phenolic compounds. Orange thyme extracts presented high scavenging activity against nitric oxide and superoxide radicals. Both extracts presented significant inhibitory effect of tyrosinase activity and moderate anti-acetylcholinesterase activity. Both extracts showed a good in vitro anti-inflammatory activity and a weak anti-proliferative/cytotoxic activity against Caco-2 and HepG2 cell lines supporting its safe use. Orange thyme is a very good source of bioactive compounds with potential use in different food and nutraceutical industries. |
publishDate |
2021 |
dc.date.none.fl_str_mv |
2021-12-30 |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://hdl.handle.net/10316/103950 http://hdl.handle.net/10316/103950 https://doi.org/10.1016/j.fochx.2021.100171 |
url |
http://hdl.handle.net/10316/103950 https://doi.org/10.1016/j.fochx.2021.100171 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
25901575 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.publisher.none.fl_str_mv |
Elsevier |
publisher.none.fl_str_mv |
Elsevier |
dc.source.none.fl_str_mv |
reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação instacron:RCAAP |
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Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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RCAAP |
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RCAAP |
reponame_str |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
collection |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
repository.name.fl_str_mv |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
repository.mail.fl_str_mv |
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1817552187962687488 |