Orange thyme: phytochemical profiling, in vitro bioactivities of extracts and potential health benefits

Detalhes bibliográficos
Autor(a) principal: Silva, Amélia M.
Data de Publicação: 2021
Outros Autores: Félix, Luís M., Teixeira, Isabel, Martins-Gomes, Carlos, Schäfer, Judith, Souto, Eliana B., Santos, Dario J., Bunzel, Mirko, Nunes, Fernando M.
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: http://hdl.handle.net/1822/74813
Resumo: Orange thyme (Thymus fragrantissimus) is becoming widely used in food as a condiment and herbal tea, nevertheless its chemical composition and potential bioactivities are largely unknown. Thus the objective of this work is to obtain a detailed phytochemical profile of T. fragrantissimus by exhaustive ethanolic extraction and by aqueous decoction mimicking its consumption. Extracts showed high content in rosmarinic acid, luteolin-O-hexuronide and eriodictyol-O-hexuronide; these were the main phenolic compounds present in orange thyme accounting for 85% of the total phenolic compounds. Orange thyme extracts presented high scavenging activity against nitric oxide and superoxide radicals. Both extracts presented significant inhibitory effect of tyrosinase activity and moderate anti-acetylcholinesterase activity. Both extracts showed a good in vitro anti-inflammatory activity and a weak anti-proliferative/cytotoxic activity against Caco-2 and HepG2 cell lines supporting its safe use. Orange thyme is a very good source of bioactive compounds with potential use in different food and nutraceutical industries.
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spelling Orange thyme: phytochemical profiling, in vitro bioactivities of extracts and potential health benefitsOrange thymePhenolic compositionAntioxidant activityAnti-proliferativeAnti-inflammatory activityAqueous extractHydroethanolic extractRadical scavenging activitiesApigenin (PubChem CID: 5280443)Eriodictyol (Pubchem CID 440735)Luteolin (PubChem CID: 5280445)Rosmarinic acid (PubChem CID: 5281792)Salvianolic acid I (Pubchem CID 10459878)Salvianolic acid K (Pubchem CID 10482829)Science & TechnologyOrange thyme (Thymus fragrantissimus) is becoming widely used in food as a condiment and herbal tea, nevertheless its chemical composition and potential bioactivities are largely unknown. Thus the objective of this work is to obtain a detailed phytochemical profile of T. fragrantissimus by exhaustive ethanolic extraction and by aqueous decoction mimicking its consumption. Extracts showed high content in rosmarinic acid, luteolin-O-hexuronide and eriodictyol-O-hexuronide; these were the main phenolic compounds present in orange thyme accounting for 85% of the total phenolic compounds. Orange thyme extracts presented high scavenging activity against nitric oxide and superoxide radicals. Both extracts presented significant inhibitory effect of tyrosinase activity and moderate anti-acetylcholinesterase activity. Both extracts showed a good in vitro anti-inflammatory activity and a weak anti-proliferative/cytotoxic activity against Caco-2 and HepG2 cell lines supporting its safe use. Orange thyme is a very good source of bioactive compounds with potential use in different food and nutraceutical industries.This research was supported by INTERACT project–“Integrative Research in Environment, Agro-Chains and Technology”, no. NORTE 01-0145-FEDER-000017, in its line of research entitled ISAC, co financed by the European Regional Development Fund (ERDF) through NORTE 2020 (North Regional Operational Program 2014/ 2020). By funds from the Portuguese Science and Technology Founda tion (FCT), Ministry of Science and Education (FCT/MEC) through na tional funds, and co-financed by FEDER/COMPETE/POCI, under the projects UIDB/04033/2020 (CITAB) and UIDB/00616/2020 and UIDP/ 00616/2020 (CQ-VR). The authors would like to thank the grants from INTERACT project: BI/UTAD/INTERACT/ISAC/203/2016 to L.F and BIM/UTAD/30/2018 to C.M.G.info:eu-repo/semantics/publishedVersionElsevierUniversidade do MinhoSilva, Amélia M.Félix, Luís M.Teixeira, IsabelMartins-Gomes, CarlosSchäfer, JudithSouto, Eliana B.Santos, Dario J.Bunzel, MirkoNunes, Fernando M.2021-12-302021-12-30T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/1822/74813engSilva, Amélia M.; Félix, Luís M.; Teixeira, Isabel; Martins-Gomes, Carlos; Schäfer, Judith; Souto, Eliana B.; Santos, Dario J.; Bunzel, Mirko; Nunes, Fernando M., Orange thyme: phytochemical profiling, in vitro bioactivities of extracts and potential health benefits. Food Chemistry: X, 12(100171), 20212590-157510.1016/j.fochx.2021.100171https://www.sciencedirect.com/journal/food-chemistry-xinfo:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-07-21T12:05:04Zoai:repositorium.sdum.uminho.pt:1822/74813Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T18:55:27.334727Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv Orange thyme: phytochemical profiling, in vitro bioactivities of extracts and potential health benefits
title Orange thyme: phytochemical profiling, in vitro bioactivities of extracts and potential health benefits
spellingShingle Orange thyme: phytochemical profiling, in vitro bioactivities of extracts and potential health benefits
Silva, Amélia M.
Orange thyme
Phenolic composition
Antioxidant activity
Anti-proliferative
Anti-inflammatory activity
Aqueous extract
Hydroethanolic extract
Radical scavenging activities
Apigenin (PubChem CID: 5280443)
Eriodictyol (Pubchem CID 440735)
Luteolin (PubChem CID: 5280445)
Rosmarinic acid (PubChem CID: 5281792)
Salvianolic acid I (Pubchem CID 10459878)
Salvianolic acid K (Pubchem CID 10482829)
Science & Technology
title_short Orange thyme: phytochemical profiling, in vitro bioactivities of extracts and potential health benefits
title_full Orange thyme: phytochemical profiling, in vitro bioactivities of extracts and potential health benefits
title_fullStr Orange thyme: phytochemical profiling, in vitro bioactivities of extracts and potential health benefits
title_full_unstemmed Orange thyme: phytochemical profiling, in vitro bioactivities of extracts and potential health benefits
title_sort Orange thyme: phytochemical profiling, in vitro bioactivities of extracts and potential health benefits
author Silva, Amélia M.
author_facet Silva, Amélia M.
Félix, Luís M.
Teixeira, Isabel
Martins-Gomes, Carlos
Schäfer, Judith
Souto, Eliana B.
Santos, Dario J.
Bunzel, Mirko
Nunes, Fernando M.
author_role author
author2 Félix, Luís M.
Teixeira, Isabel
Martins-Gomes, Carlos
Schäfer, Judith
Souto, Eliana B.
Santos, Dario J.
Bunzel, Mirko
Nunes, Fernando M.
author2_role author
author
author
author
author
author
author
author
dc.contributor.none.fl_str_mv Universidade do Minho
dc.contributor.author.fl_str_mv Silva, Amélia M.
Félix, Luís M.
Teixeira, Isabel
Martins-Gomes, Carlos
Schäfer, Judith
Souto, Eliana B.
Santos, Dario J.
Bunzel, Mirko
Nunes, Fernando M.
dc.subject.por.fl_str_mv Orange thyme
Phenolic composition
Antioxidant activity
Anti-proliferative
Anti-inflammatory activity
Aqueous extract
Hydroethanolic extract
Radical scavenging activities
Apigenin (PubChem CID: 5280443)
Eriodictyol (Pubchem CID 440735)
Luteolin (PubChem CID: 5280445)
Rosmarinic acid (PubChem CID: 5281792)
Salvianolic acid I (Pubchem CID 10459878)
Salvianolic acid K (Pubchem CID 10482829)
Science & Technology
topic Orange thyme
Phenolic composition
Antioxidant activity
Anti-proliferative
Anti-inflammatory activity
Aqueous extract
Hydroethanolic extract
Radical scavenging activities
Apigenin (PubChem CID: 5280443)
Eriodictyol (Pubchem CID 440735)
Luteolin (PubChem CID: 5280445)
Rosmarinic acid (PubChem CID: 5281792)
Salvianolic acid I (Pubchem CID 10459878)
Salvianolic acid K (Pubchem CID 10482829)
Science & Technology
description Orange thyme (Thymus fragrantissimus) is becoming widely used in food as a condiment and herbal tea, nevertheless its chemical composition and potential bioactivities are largely unknown. Thus the objective of this work is to obtain a detailed phytochemical profile of T. fragrantissimus by exhaustive ethanolic extraction and by aqueous decoction mimicking its consumption. Extracts showed high content in rosmarinic acid, luteolin-O-hexuronide and eriodictyol-O-hexuronide; these were the main phenolic compounds present in orange thyme accounting for 85% of the total phenolic compounds. Orange thyme extracts presented high scavenging activity against nitric oxide and superoxide radicals. Both extracts presented significant inhibitory effect of tyrosinase activity and moderate anti-acetylcholinesterase activity. Both extracts showed a good in vitro anti-inflammatory activity and a weak anti-proliferative/cytotoxic activity against Caco-2 and HepG2 cell lines supporting its safe use. Orange thyme is a very good source of bioactive compounds with potential use in different food and nutraceutical industries.
publishDate 2021
dc.date.none.fl_str_mv 2021-12-30
2021-12-30T00:00:00Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/1822/74813
url http://hdl.handle.net/1822/74813
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv Silva, Amélia M.; Félix, Luís M.; Teixeira, Isabel; Martins-Gomes, Carlos; Schäfer, Judith; Souto, Eliana B.; Santos, Dario J.; Bunzel, Mirko; Nunes, Fernando M., Orange thyme: phytochemical profiling, in vitro bioactivities of extracts and potential health benefits. Food Chemistry: X, 12(100171), 2021
2590-1575
10.1016/j.fochx.2021.100171
https://www.sciencedirect.com/journal/food-chemistry-x
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Elsevier
publisher.none.fl_str_mv Elsevier
dc.source.none.fl_str_mv reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron:RCAAP
instname_str Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron_str RCAAP
institution RCAAP
reponame_str Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
collection Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
repository.name.fl_str_mv Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
repository.mail.fl_str_mv
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