Plasmodium falciparum K13 expression associated with parasite clearance during artemisinin-based combination therapy
Autor(a) principal: | |
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Data de Publicação: | 2019 |
Outros Autores: | , , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
Texto Completo: | https://hdl.handle.net/1822/62313 |
Resumo: | Delayed parasite clearance and, consequently, reduced efficacy of artemisinin-based combination therapies have been linked with Plasmodium falciparum K13 gene SNPs in Southeast Asia. In Africa, significantly prolonged clearance has not yet been observed and the presently restricted variation in parasite clearance cannot be explained by K13 polymorphisms. |
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Plasmodium falciparum K13 expression associated with parasite clearance during artemisinin-based combination therapyCiências Médicas::Medicina BásicaScience & TechnologyDelayed parasite clearance and, consequently, reduced efficacy of artemisinin-based combination therapies have been linked with Plasmodium falciparum K13 gene SNPs in Southeast Asia. In Africa, significantly prolonged clearance has not yet been observed and the presently restricted variation in parasite clearance cannot be explained by K13 polymorphisms.Swedish Research Council (VR-2014-3134); the Swedish International Development Cooperation Agency(SWE-200-165); the Northern Portugal Regional Operational Programme(NORTE 2020), under the Portugal 2020 Partnership Agreement, throughthe European Regional Development Fund (NORTE-01-0145-FEDER-000013); and the Fundac ̧~ao para a Cieˆ ncia e Tecnologia (FCT) (SFRH/BD/129769/2017 to M. S., IF/00143/2015 to P. E. F., PD/BD/127826/2016 toC. C. and SFRH/BPD/76614/2011 to M. I. V.Oxford University PressUniversidade do MinhoSilva, M.Ferreira, P. E.Otienoburu, S. D.Calçada, Carla Sofia MartinsNgasala, B.Björkman, A.Mårtensson, A.Gil, J. P.Veiga, Maria Isabel Mendes20192019-01-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttps://hdl.handle.net/1822/62313engSilva, M., Ferreira, P. E., Otienoburu, S. D., Calçada, C., et. al. (2019). Plasmodium falciparum K13 expression associated with parasite clearance during artemisinin-based combination therapy. Journal of Antimicrobial Chemotherapy, 74(7), 1890-18930305-74531460-209110.1093/jac/dkz09830869127https://academic.oup.com/jac/article-abstract/74/7/1890/5380571info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-07-21T12:15:00Zoai:repositorium.sdum.uminho.pt:1822/62313Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T19:07:22.415668Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse |
dc.title.none.fl_str_mv |
Plasmodium falciparum K13 expression associated with parasite clearance during artemisinin-based combination therapy |
title |
Plasmodium falciparum K13 expression associated with parasite clearance during artemisinin-based combination therapy |
spellingShingle |
Plasmodium falciparum K13 expression associated with parasite clearance during artemisinin-based combination therapy Silva, M. Ciências Médicas::Medicina Básica Science & Technology |
title_short |
Plasmodium falciparum K13 expression associated with parasite clearance during artemisinin-based combination therapy |
title_full |
Plasmodium falciparum K13 expression associated with parasite clearance during artemisinin-based combination therapy |
title_fullStr |
Plasmodium falciparum K13 expression associated with parasite clearance during artemisinin-based combination therapy |
title_full_unstemmed |
Plasmodium falciparum K13 expression associated with parasite clearance during artemisinin-based combination therapy |
title_sort |
Plasmodium falciparum K13 expression associated with parasite clearance during artemisinin-based combination therapy |
author |
Silva, M. |
author_facet |
Silva, M. Ferreira, P. E. Otienoburu, S. D. Calçada, Carla Sofia Martins Ngasala, B. Björkman, A. Mårtensson, A. Gil, J. P. Veiga, Maria Isabel Mendes |
author_role |
author |
author2 |
Ferreira, P. E. Otienoburu, S. D. Calçada, Carla Sofia Martins Ngasala, B. Björkman, A. Mårtensson, A. Gil, J. P. Veiga, Maria Isabel Mendes |
author2_role |
author author author author author author author author |
dc.contributor.none.fl_str_mv |
Universidade do Minho |
dc.contributor.author.fl_str_mv |
Silva, M. Ferreira, P. E. Otienoburu, S. D. Calçada, Carla Sofia Martins Ngasala, B. Björkman, A. Mårtensson, A. Gil, J. P. Veiga, Maria Isabel Mendes |
dc.subject.por.fl_str_mv |
Ciências Médicas::Medicina Básica Science & Technology |
topic |
Ciências Médicas::Medicina Básica Science & Technology |
description |
Delayed parasite clearance and, consequently, reduced efficacy of artemisinin-based combination therapies have been linked with Plasmodium falciparum K13 gene SNPs in Southeast Asia. In Africa, significantly prolonged clearance has not yet been observed and the presently restricted variation in parasite clearance cannot be explained by K13 polymorphisms. |
publishDate |
2019 |
dc.date.none.fl_str_mv |
2019 2019-01-01T00:00:00Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
https://hdl.handle.net/1822/62313 |
url |
https://hdl.handle.net/1822/62313 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
Silva, M., Ferreira, P. E., Otienoburu, S. D., Calçada, C., et. al. (2019). Plasmodium falciparum K13 expression associated with parasite clearance during artemisinin-based combination therapy. Journal of Antimicrobial Chemotherapy, 74(7), 1890-1893 0305-7453 1460-2091 10.1093/jac/dkz098 30869127 https://academic.oup.com/jac/article-abstract/74/7/1890/5380571 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.publisher.none.fl_str_mv |
Oxford University Press |
publisher.none.fl_str_mv |
Oxford University Press |
dc.source.none.fl_str_mv |
reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação instacron:RCAAP |
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Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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RCAAP |
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RCAAP |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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1799132492336201728 |