The Application and Interpretation of IgG Avidity and IgA ELISA Tests to Characterize Zika Virus Infections

• Autor(a) principal: Amaro, F.
• Data de Publicação: 2019
• Outros Autores: Sánchez-Seco, M.P., Vásquez, A., Alves, M.J., Zé-Zé, L., Luz, M.T., Minguito, T., De La Fuente, J, De Ory, F.
• Tipo de documento: Artigo
• Idioma: eng
• Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
• Texto Completo: http://hdl.handle.net/10400.18/6562
• topic: Zika Virus; Dengue Virus; Secondary Infections; Cross-reactions; IgA; IgG Avidity Tests; Infecções Sistémicas e Zoonoses

In the absence of viremia, the diagnostics of Zika virus (ZIKV) infections must rely on serologicaltechniques. InordertoimprovetheserologicaldiagnosisofZIKV,ZIKV-IgAandZIKV-IgG avidity assays were evaluated. Forty patients returning from ZIKV endemic areas, with confirmed or suspected ZIKV infections were studied. Samples were classified as early acute, acute and late acute according to the number of days post illness onset. Low avidity IgG was only detected at acute and late acute stages and IgA mostly at the early acute and acute stages. The date of sampling provides useful information and can help to choose the best technique to use at a determined moment in time and to interpret low avidity IgG and IgA results, improving the serological diagnosis of ZIKV.