A glycine ruthenium trithiacyclononane complex and its molecular encapsulation using cyclodextrins

• Autor(a) principal: Marques, Joana
• Data de Publicação: 2009
• Outros Autores: Santos, Teresa M., Marques, Maria Paula, Braga, Susana S.
• Tipo de documento: Artigo
• Idioma: eng
• Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
• Texto Completo: http://hdl.handle.net/10316/45111; https://doi.org/10.1039/b915839a
• topic: Antineoplastic Agents; Bone Neoplasms; Cell Line, Tumor; Cell Proliferation; Coordination Complexes; Glycine; Humans; Osteosarcoma; beta-Cyclodextrins

The complex Ru([9]aneS(3))(gly)Cl (gly = glycine) was obtained from the reaction of the precursor Ru([9]aneS(3))dmsoCl(2) with glycine and encapsulated into native beta-CD, a hydroxypropylated derivative HPbetaCD, and the methylated cyclodextrins TRIMEB and CRYSMEB. All four inclusion compounds were obtained with a 1:1 host:guest stoichiometry and characterised in the solid-state by powder X-ray diffraction, thermogravimetric analysis (TGA), and (13)C{(1)H} CP/MAS NMR and FTIR spectroscopies. The cytostatic and antiproliferative activity of the complex Ru([9]aneS(3))(gly)Cl and its four CD inclusion compounds was tested on the human osteosarcoma MG-63 cell line and the results compared to the inhibitory effect exerted by the pure cyclodextrins.