A glycine ruthenium trithiacyclononane complex and its molecular encapsulation using cyclodextrins
Autor(a) principal: | |
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Data de Publicação: | 2009 |
Outros Autores: | , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
Texto Completo: | http://hdl.handle.net/10316/45111 https://doi.org/10.1039/b915839a |
Resumo: | The complex Ru([9]aneS(3))(gly)Cl (gly = glycine) was obtained from the reaction of the precursor Ru([9]aneS(3))dmsoCl(2) with glycine and encapsulated into native beta-CD, a hydroxypropylated derivative HPbetaCD, and the methylated cyclodextrins TRIMEB and CRYSMEB. All four inclusion compounds were obtained with a 1:1 host:guest stoichiometry and characterised in the solid-state by powder X-ray diffraction, thermogravimetric analysis (TGA), and (13)C{(1)H} CP/MAS NMR and FTIR spectroscopies. The cytostatic and antiproliferative activity of the complex Ru([9]aneS(3))(gly)Cl and its four CD inclusion compounds was tested on the human osteosarcoma MG-63 cell line and the results compared to the inhibitory effect exerted by the pure cyclodextrins. |
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A glycine ruthenium trithiacyclononane complex and its molecular encapsulation using cyclodextrinsAntineoplastic AgentsBone NeoplasmsCell Line, TumorCell ProliferationCoordination ComplexesGlycineHumansOsteosarcomabeta-CyclodextrinsThe complex Ru([9]aneS(3))(gly)Cl (gly = glycine) was obtained from the reaction of the precursor Ru([9]aneS(3))dmsoCl(2) with glycine and encapsulated into native beta-CD, a hydroxypropylated derivative HPbetaCD, and the methylated cyclodextrins TRIMEB and CRYSMEB. All four inclusion compounds were obtained with a 1:1 host:guest stoichiometry and characterised in the solid-state by powder X-ray diffraction, thermogravimetric analysis (TGA), and (13)C{(1)H} CP/MAS NMR and FTIR spectroscopies. The cytostatic and antiproliferative activity of the complex Ru([9]aneS(3))(gly)Cl and its four CD inclusion compounds was tested on the human osteosarcoma MG-63 cell line and the results compared to the inhibitory effect exerted by the pure cyclodextrins.2009info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articlehttp://hdl.handle.net/10316/45111http://hdl.handle.net/10316/45111https://doi.org/10.1039/b915839ahttps://doi.org/10.1039/b915839aengMarques, JoanaSantos, Teresa M.Marques, Maria PaulaBraga, Susana S.info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2021-06-29T10:03:09Zoai:estudogeral.uc.pt:10316/45111Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T20:56:09.396969Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse |
dc.title.none.fl_str_mv |
A glycine ruthenium trithiacyclononane complex and its molecular encapsulation using cyclodextrins |
title |
A glycine ruthenium trithiacyclononane complex and its molecular encapsulation using cyclodextrins |
spellingShingle |
A glycine ruthenium trithiacyclononane complex and its molecular encapsulation using cyclodextrins Marques, Joana Antineoplastic Agents Bone Neoplasms Cell Line, Tumor Cell Proliferation Coordination Complexes Glycine Humans Osteosarcoma beta-Cyclodextrins |
title_short |
A glycine ruthenium trithiacyclononane complex and its molecular encapsulation using cyclodextrins |
title_full |
A glycine ruthenium trithiacyclononane complex and its molecular encapsulation using cyclodextrins |
title_fullStr |
A glycine ruthenium trithiacyclononane complex and its molecular encapsulation using cyclodextrins |
title_full_unstemmed |
A glycine ruthenium trithiacyclononane complex and its molecular encapsulation using cyclodextrins |
title_sort |
A glycine ruthenium trithiacyclononane complex and its molecular encapsulation using cyclodextrins |
author |
Marques, Joana |
author_facet |
Marques, Joana Santos, Teresa M. Marques, Maria Paula Braga, Susana S. |
author_role |
author |
author2 |
Santos, Teresa M. Marques, Maria Paula Braga, Susana S. |
author2_role |
author author author |
dc.contributor.author.fl_str_mv |
Marques, Joana Santos, Teresa M. Marques, Maria Paula Braga, Susana S. |
dc.subject.por.fl_str_mv |
Antineoplastic Agents Bone Neoplasms Cell Line, Tumor Cell Proliferation Coordination Complexes Glycine Humans Osteosarcoma beta-Cyclodextrins |
topic |
Antineoplastic Agents Bone Neoplasms Cell Line, Tumor Cell Proliferation Coordination Complexes Glycine Humans Osteosarcoma beta-Cyclodextrins |
description |
The complex Ru([9]aneS(3))(gly)Cl (gly = glycine) was obtained from the reaction of the precursor Ru([9]aneS(3))dmsoCl(2) with glycine and encapsulated into native beta-CD, a hydroxypropylated derivative HPbetaCD, and the methylated cyclodextrins TRIMEB and CRYSMEB. All four inclusion compounds were obtained with a 1:1 host:guest stoichiometry and characterised in the solid-state by powder X-ray diffraction, thermogravimetric analysis (TGA), and (13)C{(1)H} CP/MAS NMR and FTIR spectroscopies. The cytostatic and antiproliferative activity of the complex Ru([9]aneS(3))(gly)Cl and its four CD inclusion compounds was tested on the human osteosarcoma MG-63 cell line and the results compared to the inhibitory effect exerted by the pure cyclodextrins. |
publishDate |
2009 |
dc.date.none.fl_str_mv |
2009 |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://hdl.handle.net/10316/45111 http://hdl.handle.net/10316/45111 https://doi.org/10.1039/b915839a https://doi.org/10.1039/b915839a |
url |
http://hdl.handle.net/10316/45111 https://doi.org/10.1039/b915839a |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.source.none.fl_str_mv |
reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação instacron:RCAAP |
instname_str |
Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
instacron_str |
RCAAP |
institution |
RCAAP |
reponame_str |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
collection |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
repository.name.fl_str_mv |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
repository.mail.fl_str_mv |
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1799133846669623296 |