Strontium Doped Bioactive Glass Nanoparticles in Osteogenic Commitment
Autor(a) principal: | |
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Data de Publicação: | 2018 |
Outros Autores: | , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
Texto Completo: | http://hdl.handle.net/1822/58749 |
Resumo: | “Just Accepted” manuscript |
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Strontium Doped Bioactive Glass Nanoparticles in Osteogenic CommitmenthASCsosteogenic differentiationStrontiumnanoparticlesbioactivityosteogenic commitmentsol-gelsolâgelCiências Médicas::Biotecnologia MédicaEngenharia e Tecnologia::Biotecnologia IndustrialScience & Technology“Just Accepted” manuscriptThe present work has explored bioactive glass nanoparticles (BGNPs) and developed strontium-doped nanoparticles (BGNPsSr), envisioning orthopedic strategies compatible with vascularization. The nanoparticles were synthesized by the solâ gel method, achieving a diameter of 55 nm for BGNPs and 75 nm for BGNPsSr, and the inclusion of strontium caused no structural alteration. The nanoparticles exhibited high cytocompatibility for human umbilical vein endothelial cells (HUVECs) and SaOS-2. Additionally, the incorporation of strontium emphasized the tubule networking behavior of HUVECs. Our results demonstrate that the nanoparticle dissolution products encouraged the osteogenic differentiation of human adipose stem cells as it favored the expression of key genes and proteins associated with osteogenic lineage. This effect was markedly enhanced for BGNPsSr, which could prompt stem cell osteogenic differentiation without the typical osteogenic inducers. This study not only supports the hypothesis that BGNPs might play a significant role in osteogenic commitment but also highlights that the designed BGNPsSr is a valuable tool for stem cell â tune-upâ in bone tissue engineering applications.Portuguese Foundation for Science and Technology Foundation (FCT) through the doctoral grant SFRH/BD/73174/2010 of Álvaro Leite and FCT and Fundo Social Europeu através do Programa Operacional do Capital Humano (FSE/POCH), PD/59/2013, for the doctoral grant PD/BD/113802/2015info:eu-repo/semantics/publishedVersionACS PublicationsUniversidade do MinhoLeite, A. J.Gonçalves, A IRodrigues, M. T.Gomes, Manuela E.Mano, J. F.2018-062018-06-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/1822/58749engLeite A. J., Gonçalves A. I., Rodrigues M. T., Gomes M. E., Mano J. F. Strontium-Doped Bioactive Glass Nanoparticles in Osteogenic Commitment, ACS Appl. Mater. Interfaces, Vol. 10, Issue 27, pp. 23311–23320, doi:10.1021/acsami.8b06154, 20181944-82441944-825210.1021/acsami.8b0615429906095https://pubs.acs.org/doi/abs/10.1021/acsami.8b06154info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-07-21T12:23:46Zoai:repositorium.sdum.uminho.pt:1822/58749Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T19:17:35.052862Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse |
dc.title.none.fl_str_mv |
Strontium Doped Bioactive Glass Nanoparticles in Osteogenic Commitment |
title |
Strontium Doped Bioactive Glass Nanoparticles in Osteogenic Commitment |
spellingShingle |
Strontium Doped Bioactive Glass Nanoparticles in Osteogenic Commitment Leite, A. J. hASCs osteogenic differentiation Strontium nanoparticles bioactivity osteogenic commitment sol-gel solâgel Ciências Médicas::Biotecnologia Médica Engenharia e Tecnologia::Biotecnologia Industrial Science & Technology |
title_short |
Strontium Doped Bioactive Glass Nanoparticles in Osteogenic Commitment |
title_full |
Strontium Doped Bioactive Glass Nanoparticles in Osteogenic Commitment |
title_fullStr |
Strontium Doped Bioactive Glass Nanoparticles in Osteogenic Commitment |
title_full_unstemmed |
Strontium Doped Bioactive Glass Nanoparticles in Osteogenic Commitment |
title_sort |
Strontium Doped Bioactive Glass Nanoparticles in Osteogenic Commitment |
author |
Leite, A. J. |
author_facet |
Leite, A. J. Gonçalves, A I Rodrigues, M. T. Gomes, Manuela E. Mano, J. F. |
author_role |
author |
author2 |
Gonçalves, A I Rodrigues, M. T. Gomes, Manuela E. Mano, J. F. |
author2_role |
author author author author |
dc.contributor.none.fl_str_mv |
Universidade do Minho |
dc.contributor.author.fl_str_mv |
Leite, A. J. Gonçalves, A I Rodrigues, M. T. Gomes, Manuela E. Mano, J. F. |
dc.subject.por.fl_str_mv |
hASCs osteogenic differentiation Strontium nanoparticles bioactivity osteogenic commitment sol-gel solâgel Ciências Médicas::Biotecnologia Médica Engenharia e Tecnologia::Biotecnologia Industrial Science & Technology |
topic |
hASCs osteogenic differentiation Strontium nanoparticles bioactivity osteogenic commitment sol-gel solâgel Ciências Médicas::Biotecnologia Médica Engenharia e Tecnologia::Biotecnologia Industrial Science & Technology |
description |
“Just Accepted” manuscript |
publishDate |
2018 |
dc.date.none.fl_str_mv |
2018-06 2018-06-01T00:00:00Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://hdl.handle.net/1822/58749 |
url |
http://hdl.handle.net/1822/58749 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
Leite A. J., Gonçalves A. I., Rodrigues M. T., Gomes M. E., Mano J. F. Strontium-Doped Bioactive Glass Nanoparticles in Osteogenic Commitment, ACS Appl. Mater. Interfaces, Vol. 10, Issue 27, pp. 23311–23320, doi:10.1021/acsami.8b06154, 2018 1944-8244 1944-8252 10.1021/acsami.8b06154 29906095 https://pubs.acs.org/doi/abs/10.1021/acsami.8b06154 |
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info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.publisher.none.fl_str_mv |
ACS Publications |
publisher.none.fl_str_mv |
ACS Publications |
dc.source.none.fl_str_mv |
reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação instacron:RCAAP |
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Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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RCAAP |
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RCAAP |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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1799132628626964480 |