Characteristics and Outcomes of Pregnant women infected with SARS-CoV-2
Autor(a) principal: | |
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Data de Publicação: | 2021 |
Outros Autores: | , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
Texto Completo: | http://scielo.pt/scielo.php?script=sci_arttext&pid=S1646-58302021000300251 |
Resumo: | Abstract Overview and Aims: The impact of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection on maternal/fetal wellbeing remains unknown. Currently, epidemiological data regarding pregnant women infected in Portugal are scarse. Our aim was to describe the clinical characteristics and maternal-fetal outcomes of pregnant women infected with SARS-CoV-2 in a Portuguese hospital. Study design: Single-center, retrospective, cohort-study. Population: Pregnant women with SARS-CoV-2 infection between March-30 and July-31, 2020, in a tertiary referral center for obstetrical care. Methods: Pregnant and immediately postpartum women with positive RT-PCR test for SARS-CoV-2 were included. We reviewed mother and neonate medical records for demographics, medical history, disease severity and pregnancy and neonatal outcomes including newborn infection. Results: 75 women were included, the majority infected in the 3rd-trimester (66.7%). Most were asymptomatic or had mild disease, with fever, cough and headache being commonly found. Only 2 cases presented with severe disease. SARS-CoV-2 prevalence rate at delivery was 6.2% and most patients had a cesarean delivery (64%). Lymphopenia was associated with symptomatic disease (p<0.001) and preterm delivery (p=0.025). Preterm birth was also more frequent in symptomatic women (p=0.048). There were 2 confirmed cases of vertical transmission (4%), one of which died. Conclusion: SARS-CoV-2 infection in pregnancy was associated with higher caesarian rates and prematurity. Lymphopenia may be an important marker for fetal distress and consequent iatrogenic preterm delivery. Vertical transmission occurred in 4% and may lead to fetal death. |
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Characteristics and Outcomes of Pregnant women infected with SARS-CoV-2PregnancyCOVID-19SARS-CoV-2Premature birthMother-to-child transmission.Abstract Overview and Aims: The impact of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection on maternal/fetal wellbeing remains unknown. Currently, epidemiological data regarding pregnant women infected in Portugal are scarse. Our aim was to describe the clinical characteristics and maternal-fetal outcomes of pregnant women infected with SARS-CoV-2 in a Portuguese hospital. Study design: Single-center, retrospective, cohort-study. Population: Pregnant women with SARS-CoV-2 infection between March-30 and July-31, 2020, in a tertiary referral center for obstetrical care. Methods: Pregnant and immediately postpartum women with positive RT-PCR test for SARS-CoV-2 were included. We reviewed mother and neonate medical records for demographics, medical history, disease severity and pregnancy and neonatal outcomes including newborn infection. Results: 75 women were included, the majority infected in the 3rd-trimester (66.7%). Most were asymptomatic or had mild disease, with fever, cough and headache being commonly found. Only 2 cases presented with severe disease. SARS-CoV-2 prevalence rate at delivery was 6.2% and most patients had a cesarean delivery (64%). Lymphopenia was associated with symptomatic disease (p<0.001) and preterm delivery (p=0.025). Preterm birth was also more frequent in symptomatic women (p=0.048). There were 2 confirmed cases of vertical transmission (4%), one of which died. Conclusion: SARS-CoV-2 infection in pregnancy was associated with higher caesarian rates and prematurity. Lymphopenia may be an important marker for fetal distress and consequent iatrogenic preterm delivery. Vertical transmission occurred in 4% and may lead to fetal death.Euromédice, Edições Médicas Lda.2021-09-01info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articletext/htmlhttp://scielo.pt/scielo.php?script=sci_arttext&pid=S1646-58302021000300251Acta Obstétrica e Ginecológica Portuguesa v.15 n.3 2021reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAPenghttp://scielo.pt/scielo.php?script=sci_arttext&pid=S1646-58302021000300251Marques,Mariana CrespoBranco,RuteCarvalho,Margarida Meira deMatos,TeresaNazaré,Antóniainfo:eu-repo/semantics/openAccess2024-02-06T17:21:53Zoai:scielo:S1646-58302021000300251Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-20T02:28:45.072990Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse |
dc.title.none.fl_str_mv |
Characteristics and Outcomes of Pregnant women infected with SARS-CoV-2 |
title |
Characteristics and Outcomes of Pregnant women infected with SARS-CoV-2 |
spellingShingle |
Characteristics and Outcomes of Pregnant women infected with SARS-CoV-2 Marques,Mariana Crespo Pregnancy COVID-19 SARS-CoV-2 Premature birth Mother-to-child transmission. |
title_short |
Characteristics and Outcomes of Pregnant women infected with SARS-CoV-2 |
title_full |
Characteristics and Outcomes of Pregnant women infected with SARS-CoV-2 |
title_fullStr |
Characteristics and Outcomes of Pregnant women infected with SARS-CoV-2 |
title_full_unstemmed |
Characteristics and Outcomes of Pregnant women infected with SARS-CoV-2 |
title_sort |
Characteristics and Outcomes of Pregnant women infected with SARS-CoV-2 |
author |
Marques,Mariana Crespo |
author_facet |
Marques,Mariana Crespo Branco,Rute Carvalho,Margarida Meira de Matos,Teresa Nazaré,Antónia |
author_role |
author |
author2 |
Branco,Rute Carvalho,Margarida Meira de Matos,Teresa Nazaré,Antónia |
author2_role |
author author author author |
dc.contributor.author.fl_str_mv |
Marques,Mariana Crespo Branco,Rute Carvalho,Margarida Meira de Matos,Teresa Nazaré,Antónia |
dc.subject.por.fl_str_mv |
Pregnancy COVID-19 SARS-CoV-2 Premature birth Mother-to-child transmission. |
topic |
Pregnancy COVID-19 SARS-CoV-2 Premature birth Mother-to-child transmission. |
description |
Abstract Overview and Aims: The impact of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection on maternal/fetal wellbeing remains unknown. Currently, epidemiological data regarding pregnant women infected in Portugal are scarse. Our aim was to describe the clinical characteristics and maternal-fetal outcomes of pregnant women infected with SARS-CoV-2 in a Portuguese hospital. Study design: Single-center, retrospective, cohort-study. Population: Pregnant women with SARS-CoV-2 infection between March-30 and July-31, 2020, in a tertiary referral center for obstetrical care. Methods: Pregnant and immediately postpartum women with positive RT-PCR test for SARS-CoV-2 were included. We reviewed mother and neonate medical records for demographics, medical history, disease severity and pregnancy and neonatal outcomes including newborn infection. Results: 75 women were included, the majority infected in the 3rd-trimester (66.7%). Most were asymptomatic or had mild disease, with fever, cough and headache being commonly found. Only 2 cases presented with severe disease. SARS-CoV-2 prevalence rate at delivery was 6.2% and most patients had a cesarean delivery (64%). Lymphopenia was associated with symptomatic disease (p<0.001) and preterm delivery (p=0.025). Preterm birth was also more frequent in symptomatic women (p=0.048). There were 2 confirmed cases of vertical transmission (4%), one of which died. Conclusion: SARS-CoV-2 infection in pregnancy was associated with higher caesarian rates and prematurity. Lymphopenia may be an important marker for fetal distress and consequent iatrogenic preterm delivery. Vertical transmission occurred in 4% and may lead to fetal death. |
publishDate |
2021 |
dc.date.none.fl_str_mv |
2021-09-01 |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://scielo.pt/scielo.php?script=sci_arttext&pid=S1646-58302021000300251 |
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http://scielo.pt/scielo.php?script=sci_arttext&pid=S1646-58302021000300251 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
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http://scielo.pt/scielo.php?script=sci_arttext&pid=S1646-58302021000300251 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
text/html |
dc.publisher.none.fl_str_mv |
Euromédice, Edições Médicas Lda. |
publisher.none.fl_str_mv |
Euromédice, Edições Médicas Lda. |
dc.source.none.fl_str_mv |
Acta Obstétrica e Ginecológica Portuguesa v.15 n.3 2021 reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação instacron:RCAAP |
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Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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RCAAP |
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RCAAP |
reponame_str |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
collection |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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