The influence of DNA methylation on monoallelic expression

Detalhes bibliográficos
Autor(a) principal: da Rocha, Simão T.
Data de Publicação: 2019
Outros Autores: Gendrel, Anne-Valerie
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: http://hdl.handle.net/10451/50331
Resumo: © 2019 The Author(s). This is an open access article published by Portland Press Limited on behalf of the Biochemical Society and distributed under the Creative Commons Attribution License 4.0 (CC BY-NC-ND).
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spelling The influence of DNA methylation on monoallelic expressionDNA methylationX-chromosome inactivationEpigeneticsImprintingMonoallelic expression© 2019 The Author(s). This is an open access article published by Portland Press Limited on behalf of the Biochemical Society and distributed under the Creative Commons Attribution License 4.0 (CC BY-NC-ND).Monoallelic gene expression occurs in diploid cells when only one of the two alleles of a gene is active. There are three main classes of genes that display monoallelic expression in mammalian genomes: (1) imprinted genes that are monoallelically expressed in a parent-of-origin dependent manner; (2) X-linked genes that undergo random X-chromosome inactivation in female cells; (3) random monoallelically expressed single and clustered genes located on autosomes. The heritability of monoallelic expression patterns during cell divisions implies that epigenetic mechanisms are involved in the cellular memory of these expression states. Among these, methylation of CpG sites on DNA is one of the best described modification to explain somatic inheritance. Here, we discuss the relevance of DNA methylation for the establishment and maintenance of monoallelic expression patterns among these three groups of genes, and how this is intrinsically linked to development and cellular states.This work was supported by Fundação para a Ciência e Tecnologia (FCT)/Ministério da Ciência, Tecnologia e Ensino Superior (MCTES), Portugal, through the project grants PTDC/BEX-BCM/2612/2014 and PTDC/BIA-MOL/29320/2017 IC&DT. S.T.d.R. has a CEECUIND/01234/207 assistant research contract from FCT. A.-V.G. is supported by an INSERM investigator position. Publications costs were supported by UID/BIM/50005/2019, project funded by FCT/MCTES through Fundos do Orçamento de Estado.Portland PressRepositório da Universidade de Lisboada Rocha, Simão T.Gendrel, Anne-Valerie2021-12-10T14:10:00Z20192019-01-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10451/50331engEssays Biochem. 2019 Dec 20;63(6):663-6760071-136510.1042/EBC201900341744-1358info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-11-08T16:54:27Zoai:repositorio.ul.pt:10451/50331Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T22:01:48.735114Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv The influence of DNA methylation on monoallelic expression
title The influence of DNA methylation on monoallelic expression
spellingShingle The influence of DNA methylation on monoallelic expression
da Rocha, Simão T.
DNA methylation
X-chromosome inactivation
Epigenetics
Imprinting
Monoallelic expression
title_short The influence of DNA methylation on monoallelic expression
title_full The influence of DNA methylation on monoallelic expression
title_fullStr The influence of DNA methylation on monoallelic expression
title_full_unstemmed The influence of DNA methylation on monoallelic expression
title_sort The influence of DNA methylation on monoallelic expression
author da Rocha, Simão T.
author_facet da Rocha, Simão T.
Gendrel, Anne-Valerie
author_role author
author2 Gendrel, Anne-Valerie
author2_role author
dc.contributor.none.fl_str_mv Repositório da Universidade de Lisboa
dc.contributor.author.fl_str_mv da Rocha, Simão T.
Gendrel, Anne-Valerie
dc.subject.por.fl_str_mv DNA methylation
X-chromosome inactivation
Epigenetics
Imprinting
Monoallelic expression
topic DNA methylation
X-chromosome inactivation
Epigenetics
Imprinting
Monoallelic expression
description © 2019 The Author(s). This is an open access article published by Portland Press Limited on behalf of the Biochemical Society and distributed under the Creative Commons Attribution License 4.0 (CC BY-NC-ND).
publishDate 2019
dc.date.none.fl_str_mv 2019
2019-01-01T00:00:00Z
2021-12-10T14:10:00Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
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status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/10451/50331
url http://hdl.handle.net/10451/50331
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv Essays Biochem. 2019 Dec 20;63(6):663-676
0071-1365
10.1042/EBC20190034
1744-1358
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dc.publisher.none.fl_str_mv Portland Press
publisher.none.fl_str_mv Portland Press
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