YAP and TAZ regulate adherens junction dynamics and endothelial cell distribution during vascular development
Autor(a) principal: | |
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Data de Publicação: | 2018 |
Outros Autores: | , , , , , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
Texto Completo: | http://hdl.handle.net/10451/50248 |
Resumo: | © Copyright Neto et al. This article is distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use and redistribution provided that the original author and source are credited. |
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YAP and TAZ regulate adherens junction dynamics and endothelial cell distribution during vascular developmentBMPTAZVE-CadherinYAPCell biologyDevelopmental biologyMouseStem cellsVascular development© Copyright Neto et al. This article is distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use and redistribution provided that the original author and source are credited.Formation of blood vessel networks by sprouting angiogenesis is critical for tissue growth, homeostasis and regeneration. How endothelial cells arise in adequate numbers and arrange suitably to shape functional vascular networks is poorly understood. Here we show that YAP/TAZ promote stretch-induced proliferation and rearrangements of endothelial cells whilst preventing bleeding in developing vessels. Mechanistically, YAP/TAZ increase the turnover of VE-Cadherin and the formation of junction associated intermediate lamellipodia, promoting both cell migration and barrier function maintenance. This is achieved in part by lowering BMP signalling. Consequently, the loss of YAP/TAZ in the mouse leads to stunted sprouting with local aggregation as well as scarcity of endothelial cells, branching irregularities and junction defects. Forced nuclear activity of TAZ instead drives hypersprouting and vascular hyperplasia. We propose a new model in which YAP/TAZ integrate mechanical signals with BMP signaling to maintain junctional compliance and integrity whilst balancing endothelial cell rearrangements in angiogenic vessels.FN was financially supported by the Fundação para a Ciência e a Tecnologia (FCT), CRUK-CRICK and the MDC. ACV, AKB and EBK were supported by the DZHK (German Centre for Cardiovascular Research), AS was supported by the EMBO (European Molecular Biology Organization), JRC was supported by the FCT. CAF is supported by the FCT, EC-ERC Starting Grant, Portugal2020 program. MP is supported by the Max Planck Society, the ERC Starting Grant ANGIOMET, the Deutsche Forschungsgemeinschaft, the Excellence Cluster Cardiopulmonary System, the LOEWE grant Ub-Net, the DZHK, the Stiftung Charité and the EMBO Young Investigator Program. HG is supported by the DZHK and ERC Consolidator Grant Reshape 311719.eLife Sciences Publications Ltd.Repositório da Universidade de LisboaNeto, FilipaKlaus-Bergmann, AlexandraOng, Yu TingAlt, SilvanusVion, Anne-ClémenceSzymborska, AnnaCarvalho, Joana R.Hollfinger, IreneBartels-Klein, EireenFranco, ClaudioPotente, MichaelGerhardt, Holger2021-12-02T15:17:40Z20182018-01-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10451/50248engElife. 2018 Feb 5;7:e3103710.7554/eLife.310372050-084Xinfo:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-11-08T16:54:15Zoai:repositorio.ul.pt:10451/50248Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T22:01:41.650819Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse |
dc.title.none.fl_str_mv |
YAP and TAZ regulate adherens junction dynamics and endothelial cell distribution during vascular development |
title |
YAP and TAZ regulate adherens junction dynamics and endothelial cell distribution during vascular development |
spellingShingle |
YAP and TAZ regulate adherens junction dynamics and endothelial cell distribution during vascular development Neto, Filipa BMP TAZ VE-Cadherin YAP Cell biology Developmental biology Mouse Stem cells Vascular development |
title_short |
YAP and TAZ regulate adherens junction dynamics and endothelial cell distribution during vascular development |
title_full |
YAP and TAZ regulate adherens junction dynamics and endothelial cell distribution during vascular development |
title_fullStr |
YAP and TAZ regulate adherens junction dynamics and endothelial cell distribution during vascular development |
title_full_unstemmed |
YAP and TAZ regulate adherens junction dynamics and endothelial cell distribution during vascular development |
title_sort |
YAP and TAZ regulate adherens junction dynamics and endothelial cell distribution during vascular development |
author |
Neto, Filipa |
author_facet |
Neto, Filipa Klaus-Bergmann, Alexandra Ong, Yu Ting Alt, Silvanus Vion, Anne-Clémence Szymborska, Anna Carvalho, Joana R. Hollfinger, Irene Bartels-Klein, Eireen Franco, Claudio Potente, Michael Gerhardt, Holger |
author_role |
author |
author2 |
Klaus-Bergmann, Alexandra Ong, Yu Ting Alt, Silvanus Vion, Anne-Clémence Szymborska, Anna Carvalho, Joana R. Hollfinger, Irene Bartels-Klein, Eireen Franco, Claudio Potente, Michael Gerhardt, Holger |
author2_role |
author author author author author author author author author author author |
dc.contributor.none.fl_str_mv |
Repositório da Universidade de Lisboa |
dc.contributor.author.fl_str_mv |
Neto, Filipa Klaus-Bergmann, Alexandra Ong, Yu Ting Alt, Silvanus Vion, Anne-Clémence Szymborska, Anna Carvalho, Joana R. Hollfinger, Irene Bartels-Klein, Eireen Franco, Claudio Potente, Michael Gerhardt, Holger |
dc.subject.por.fl_str_mv |
BMP TAZ VE-Cadherin YAP Cell biology Developmental biology Mouse Stem cells Vascular development |
topic |
BMP TAZ VE-Cadherin YAP Cell biology Developmental biology Mouse Stem cells Vascular development |
description |
© Copyright Neto et al. This article is distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use and redistribution provided that the original author and source are credited. |
publishDate |
2018 |
dc.date.none.fl_str_mv |
2018 2018-01-01T00:00:00Z 2021-12-02T15:17:40Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://hdl.handle.net/10451/50248 |
url |
http://hdl.handle.net/10451/50248 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
Elife. 2018 Feb 5;7:e31037 10.7554/eLife.31037 2050-084X |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.publisher.none.fl_str_mv |
eLife Sciences Publications Ltd. |
publisher.none.fl_str_mv |
eLife Sciences Publications Ltd. |
dc.source.none.fl_str_mv |
reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação instacron:RCAAP |
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Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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RCAAP |
institution |
RCAAP |
reponame_str |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
repository.name.fl_str_mv |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
repository.mail.fl_str_mv |
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1799134565558648832 |