The inner fluctuations of the brain in presymptomatic frontotemporal dementia: the chronnectome fingerprint

Detalhes bibliográficos
Autor(a) principal: Premi, Enrico
Data de Publicação: 2019
Outros Autores: Calhoun, Vince D., Diano, Matteo, Gazzina, Stefano, Cosseddu, Maura, Alberici, Antonella, Archetti, Silvana, Paternicò, Donata, Gasparotti, Roberto, van Swieten, John, Galimberti, Daniela, Sanchez-Valle, Raquel, Laforce, Robert, Moreno, Fermin, Synofzik, Matthis, Graff, Caroline, Masellis, Mario, Tartaglia, Maria Carmela, Rowe, James, Vandenberghe, Rik, Finger, Elizabeth, Tagliavini, Fabrizio, De Mendonça, Alexandre, Santana, Isabel, Butler, Chris, Ducharme, Simon, Gerhard, Alex, Danek, Adrian, Levin, Johannes, Otto, Markus, Frisoni, Giovanni, Cappa, Stefano, Sorbi, Sandro, Padovani, Alessandro, Rohrer, Jonathan D., Borroni, Barbara, Almeida, Maria Rosario, Anderl-Straub, Sarah, Andersson, Christin, Antonell, Anna, Arighi, Andrea, Balasa, Mircea, Barandiaran, Myriam, Bargalló, Nuria, Bartha, Robart, Bender, Benjamin, Benussi, Luisa, Binetti, Giuliano, Black, Sandra, Bocchetta, Martina, Borrego-Ecija, Sergi, Bras, Jose, Bruffaerts, Rose, Caroppo, Paola, Cash, David, Castelo-Branco, Miguel, Convery, Rhian, Cope, Thomas, de Arriba, María, Di Fede, Giuseppe, Díaz, Zigor, Dick, Katrina M., Duro, Diana, Fenoglio, Chiara, Ferreira, Carlos, Ferreira, Catarina B., Flanagan, Toby, Fox, Nick, Freedman, Morris, Fumagalli, Giorgio, Gabilondo, Alazne, Gauthier, Serge, Ghidoni, Roberta, Giaccone, Giorgio, Gorostidi, Ana, Greaves, Caroline, Guerreiro, Rita, Heller, Carolin, Hoegen, Tobias, Indakoetxea, Begoña, Jelic, Vesna, Jiskoot, Lize, Karnath, Hans-Otto, Keren, Ron, Leitão, Maria João, Lladó, Albert, Lombardi, Gemma, Loosli, Sandra, Maruta, Carolina, Mead, Simon, Meeter, Lieke, Miltenberger-Miltenyi, Gabriel, van Minkelen, Rick, Mitchell, Sara, Nacmias, Benedetta, Neason, Mollie, Nicholas, Jennifer, Öijerstedt, Linn, Olives, Jaume, Panman, Jessica, Papma, Janne, Patzig, Maximilian, Pievani, Michela, Prioni, Sara, Prix, Catharina, Rademakers, Rosa, Redaelli, Veronica, Rittman, Tim, Rogaeva, Ekaterina, Rosa-Neto, Pedro, Rossi, Giacomina, Rossor, Martin, Santiago, Beatriz, Scarpini, Elio, Semler, Elisa, Shafei, Rachelle, Shoesmith, Christen, Tábuas-Pereira, Miguel, Tainta, Mikel, Tang-Wai, David, Thomas, David L., Thonberg, Hakan, Timberlake, Carolyn, Tiraboschi, Pietro, Vandamme, Philip, Vandenbulcke, Mathieu, Veldsman, Michele, Verdelho, Ana, Villanua, Jorge, Warren, Jason, Wilke, Carlo, Zetterberg, Henrik, Zulaica, Miren
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: http://hdl.handle.net/10451/52406
Resumo: © 2019 Published by Elsevier Inc. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/)
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spelling The inner fluctuations of the brain in presymptomatic frontotemporal dementia: the chronnectome fingerprintC9orf72ChronnectomeDynamic brain functional connectivityFrontotemporal dementiaGranulinMicrotuble associate protein tauMutationResting-state fMRI© 2019 Published by Elsevier Inc. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/)Frontotemporal Dementia (FTD) is preceded by a long period of subtle brain changes, occurring in the absence of overt cognitive symptoms, that need to be still fully characterized. Dynamic network analysis based on resting-state magnetic resonance imaging (rs-fMRI) is a potentially powerful tool for the study of preclinical FTD. In the present study, we employed a "chronnectome" approach (recurring, time-varying patterns of connectivity) to evaluate measures of dynamic connectivity in 472 at-risk FTD subjects from the Genetic Frontotemporal dementia research Initiative (GENFI) cohort. We considered 249 subjects with FTD-related pathogenetic mutations and 223 mutation non-carriers (HC). Dynamic connectivity was evaluated using independent component analysis and sliding-time window correlation to rs-fMRI data, and meta-state measures of global brain flexibility were extracted. Results show that presymptomatic FTD exhibits diminished dynamic fluidity, visiting less meta-states, shifting less often across them, and travelling through a narrowed meta-state distance, as compared to HC. Dynamic connectivity changes characterize preclinical FTD, arguing for the desynchronization of the inner fluctuations of the brain. These changes antedate clinical symptoms, and might represent an early signature of FTD to be used as a biomarker in clinical trials.This work was supported in part by grants from the NIH (R01REB020407, P20GM103472), NSF grant 1539067 and the Well- come Trust grant (JBR 103838).ElsevierRepositório da Universidade de LisboaPremi, EnricoCalhoun, Vince D.Diano, MatteoGazzina, StefanoCosseddu, MauraAlberici, AntonellaArchetti, SilvanaPaternicò, DonataGasparotti, Robertovan Swieten, JohnGalimberti, DanielaSanchez-Valle, RaquelLaforce, RobertMoreno, FerminSynofzik, MatthisGraff, CarolineMasellis, MarioTartaglia, Maria CarmelaRowe, JamesVandenberghe, RikFinger, ElizabethTagliavini, FabrizioDe Mendonça, AlexandreSantana, IsabelButler, ChrisDucharme, SimonGerhard, AlexDanek, AdrianLevin, JohannesOtto, MarkusFrisoni, GiovanniCappa, StefanoSorbi, SandroPadovani, AlessandroRohrer, Jonathan D.Borroni, BarbaraAlmeida, Maria RosarioAnderl-Straub, SarahAndersson, ChristinAntonell, AnnaArighi, AndreaBalasa, MirceaBarandiaran, MyriamBargalló, NuriaBartha, RobartBender, BenjaminBenussi, LuisaBinetti, GiulianoBlack, SandraBocchetta, MartinaBorrego-Ecija, SergiBras, JoseBruffaerts, RoseCaroppo, PaolaCash, DavidCastelo-Branco, MiguelConvery, RhianCope, Thomasde Arriba, MaríaDi Fede, GiuseppeDíaz, ZigorDick, Katrina M.Duro, DianaFenoglio, ChiaraFerreira, CarlosFerreira, Catarina B.Flanagan, TobyFox, NickFreedman, MorrisFumagalli, GiorgioGabilondo, AlazneGauthier, SergeGhidoni, RobertaGiaccone, GiorgioGorostidi, AnaGreaves, CarolineGuerreiro, RitaHeller, CarolinHoegen, TobiasIndakoetxea, BegoñaJelic, VesnaJiskoot, LizeKarnath, Hans-OttoKeren, RonLeitão, Maria JoãoLladó, AlbertLombardi, GemmaLoosli, SandraMaruta, CarolinaMead, SimonMeeter, LiekeMiltenberger-Miltenyi, Gabrielvan Minkelen, RickMitchell, SaraNacmias, BenedettaNeason, MollieNicholas, JenniferÖijerstedt, LinnOlives, JaumePanman, JessicaPapma, JannePatzig, MaximilianPievani, MichelaPrioni, SaraPrix, CatharinaRademakers, RosaRedaelli, VeronicaRittman, TimRogaeva, EkaterinaRosa-Neto, PedroRossi, GiacominaRossor, MartinSantiago, BeatrizScarpini, ElioSemler, ElisaShafei, RachelleShoesmith, ChristenTábuas-Pereira, MiguelTainta, MikelTang-Wai, DavidThomas, David L.Thonberg, HakanTimberlake, CarolynTiraboschi, PietroVandamme, PhilipVandenbulcke, MathieuVeldsman, MicheleVerdelho, AnaVillanua, JorgeWarren, JasonWilke, CarloZetterberg, HenrikZulaica, Miren2022-04-18T15:52:27Z20192019-01-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10451/52406engNeuroimage. 2019 Apr 1;189:645-6541053-811910.1016/j.neuroimage.2019.01.0801095-9572info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-11-08T16:57:36Zoai:repositorio.ul.pt:10451/52406Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T22:03:31.781135Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv The inner fluctuations of the brain in presymptomatic frontotemporal dementia: the chronnectome fingerprint
title The inner fluctuations of the brain in presymptomatic frontotemporal dementia: the chronnectome fingerprint
spellingShingle The inner fluctuations of the brain in presymptomatic frontotemporal dementia: the chronnectome fingerprint
Premi, Enrico
C9orf72
Chronnectome
Dynamic brain functional connectivity
Frontotemporal dementia
Granulin
Microtuble associate protein tau
Mutation
Resting-state fMRI
title_short The inner fluctuations of the brain in presymptomatic frontotemporal dementia: the chronnectome fingerprint
title_full The inner fluctuations of the brain in presymptomatic frontotemporal dementia: the chronnectome fingerprint
title_fullStr The inner fluctuations of the brain in presymptomatic frontotemporal dementia: the chronnectome fingerprint
title_full_unstemmed The inner fluctuations of the brain in presymptomatic frontotemporal dementia: the chronnectome fingerprint
title_sort The inner fluctuations of the brain in presymptomatic frontotemporal dementia: the chronnectome fingerprint
author Premi, Enrico
author_facet Premi, Enrico
Calhoun, Vince D.
Diano, Matteo
Gazzina, Stefano
Cosseddu, Maura
Alberici, Antonella
Archetti, Silvana
Paternicò, Donata
Gasparotti, Roberto
van Swieten, John
Galimberti, Daniela
Sanchez-Valle, Raquel
Laforce, Robert
Moreno, Fermin
Synofzik, Matthis
Graff, Caroline
Masellis, Mario
Tartaglia, Maria Carmela
Rowe, James
Vandenberghe, Rik
Finger, Elizabeth
Tagliavini, Fabrizio
De Mendonça, Alexandre
Santana, Isabel
Butler, Chris
Ducharme, Simon
Gerhard, Alex
Danek, Adrian
Levin, Johannes
Otto, Markus
Frisoni, Giovanni
Cappa, Stefano
Sorbi, Sandro
Padovani, Alessandro
Rohrer, Jonathan D.
Borroni, Barbara
Almeida, Maria Rosario
Anderl-Straub, Sarah
Andersson, Christin
Antonell, Anna
Arighi, Andrea
Balasa, Mircea
Barandiaran, Myriam
Bargalló, Nuria
Bartha, Robart
Bender, Benjamin
Benussi, Luisa
Binetti, Giuliano
Black, Sandra
Bocchetta, Martina
Borrego-Ecija, Sergi
Bras, Jose
Bruffaerts, Rose
Caroppo, Paola
Cash, David
Castelo-Branco, Miguel
Convery, Rhian
Cope, Thomas
de Arriba, María
Di Fede, Giuseppe
Díaz, Zigor
Dick, Katrina M.
Duro, Diana
Fenoglio, Chiara
Ferreira, Carlos
Ferreira, Catarina B.
Flanagan, Toby
Fox, Nick
Freedman, Morris
Fumagalli, Giorgio
Gabilondo, Alazne
Gauthier, Serge
Ghidoni, Roberta
Giaccone, Giorgio
Gorostidi, Ana
Greaves, Caroline
Guerreiro, Rita
Heller, Carolin
Hoegen, Tobias
Indakoetxea, Begoña
Jelic, Vesna
Jiskoot, Lize
Karnath, Hans-Otto
Keren, Ron
Leitão, Maria João
Lladó, Albert
Lombardi, Gemma
Loosli, Sandra
Maruta, Carolina
Mead, Simon
Meeter, Lieke
Miltenberger-Miltenyi, Gabriel
van Minkelen, Rick
Mitchell, Sara
Nacmias, Benedetta
Neason, Mollie
Nicholas, Jennifer
Öijerstedt, Linn
Olives, Jaume
Panman, Jessica
Papma, Janne
Patzig, Maximilian
Pievani, Michela
Prioni, Sara
Prix, Catharina
Rademakers, Rosa
Redaelli, Veronica
Rittman, Tim
Rogaeva, Ekaterina
Rosa-Neto, Pedro
Rossi, Giacomina
Rossor, Martin
Santiago, Beatriz
Scarpini, Elio
Semler, Elisa
Shafei, Rachelle
Shoesmith, Christen
Tábuas-Pereira, Miguel
Tainta, Mikel
Tang-Wai, David
Thomas, David L.
Thonberg, Hakan
Timberlake, Carolyn
Tiraboschi, Pietro
Vandamme, Philip
Vandenbulcke, Mathieu
Veldsman, Michele
Verdelho, Ana
Villanua, Jorge
Warren, Jason
Wilke, Carlo
Zetterberg, Henrik
Zulaica, Miren
author_role author
author2 Calhoun, Vince D.
Diano, Matteo
Gazzina, Stefano
Cosseddu, Maura
Alberici, Antonella
Archetti, Silvana
Paternicò, Donata
Gasparotti, Roberto
van Swieten, John
Galimberti, Daniela
Sanchez-Valle, Raquel
Laforce, Robert
Moreno, Fermin
Synofzik, Matthis
Graff, Caroline
Masellis, Mario
Tartaglia, Maria Carmela
Rowe, James
Vandenberghe, Rik
Finger, Elizabeth
Tagliavini, Fabrizio
De Mendonça, Alexandre
Santana, Isabel
Butler, Chris
Ducharme, Simon
Gerhard, Alex
Danek, Adrian
Levin, Johannes
Otto, Markus
Frisoni, Giovanni
Cappa, Stefano
Sorbi, Sandro
Padovani, Alessandro
Rohrer, Jonathan D.
Borroni, Barbara
Almeida, Maria Rosario
Anderl-Straub, Sarah
Andersson, Christin
Antonell, Anna
Arighi, Andrea
Balasa, Mircea
Barandiaran, Myriam
Bargalló, Nuria
Bartha, Robart
Bender, Benjamin
Benussi, Luisa
Binetti, Giuliano
Black, Sandra
Bocchetta, Martina
Borrego-Ecija, Sergi
Bras, Jose
Bruffaerts, Rose
Caroppo, Paola
Cash, David
Castelo-Branco, Miguel
Convery, Rhian
Cope, Thomas
de Arriba, María
Di Fede, Giuseppe
Díaz, Zigor
Dick, Katrina M.
Duro, Diana
Fenoglio, Chiara
Ferreira, Carlos
Ferreira, Catarina B.
Flanagan, Toby
Fox, Nick
Freedman, Morris
Fumagalli, Giorgio
Gabilondo, Alazne
Gauthier, Serge
Ghidoni, Roberta
Giaccone, Giorgio
Gorostidi, Ana
Greaves, Caroline
Guerreiro, Rita
Heller, Carolin
Hoegen, Tobias
Indakoetxea, Begoña
Jelic, Vesna
Jiskoot, Lize
Karnath, Hans-Otto
Keren, Ron
Leitão, Maria João
Lladó, Albert
Lombardi, Gemma
Loosli, Sandra
Maruta, Carolina
Mead, Simon
Meeter, Lieke
Miltenberger-Miltenyi, Gabriel
van Minkelen, Rick
Mitchell, Sara
Nacmias, Benedetta
Neason, Mollie
Nicholas, Jennifer
Öijerstedt, Linn
Olives, Jaume
Panman, Jessica
Papma, Janne
Patzig, Maximilian
Pievani, Michela
Prioni, Sara
Prix, Catharina
Rademakers, Rosa
Redaelli, Veronica
Rittman, Tim
Rogaeva, Ekaterina
Rosa-Neto, Pedro
Rossi, Giacomina
Rossor, Martin
Santiago, Beatriz
Scarpini, Elio
Semler, Elisa
Shafei, Rachelle
Shoesmith, Christen
Tábuas-Pereira, Miguel
Tainta, Mikel
Tang-Wai, David
Thomas, David L.
Thonberg, Hakan
Timberlake, Carolyn
Tiraboschi, Pietro
Vandamme, Philip
Vandenbulcke, Mathieu
Veldsman, Michele
Verdelho, Ana
Villanua, Jorge
Warren, Jason
Wilke, Carlo
Zetterberg, Henrik
Zulaica, Miren
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dc.contributor.none.fl_str_mv Repositório da Universidade de Lisboa
dc.contributor.author.fl_str_mv Premi, Enrico
Calhoun, Vince D.
Diano, Matteo
Gazzina, Stefano
Cosseddu, Maura
Alberici, Antonella
Archetti, Silvana
Paternicò, Donata
Gasparotti, Roberto
van Swieten, John
Galimberti, Daniela
Sanchez-Valle, Raquel
Laforce, Robert
Moreno, Fermin
Synofzik, Matthis
Graff, Caroline
Masellis, Mario
Tartaglia, Maria Carmela
Rowe, James
Vandenberghe, Rik
Finger, Elizabeth
Tagliavini, Fabrizio
De Mendonça, Alexandre
Santana, Isabel
Butler, Chris
Ducharme, Simon
Gerhard, Alex
Danek, Adrian
Levin, Johannes
Otto, Markus
Frisoni, Giovanni
Cappa, Stefano
Sorbi, Sandro
Padovani, Alessandro
Rohrer, Jonathan D.
Borroni, Barbara
Almeida, Maria Rosario
Anderl-Straub, Sarah
Andersson, Christin
Antonell, Anna
Arighi, Andrea
Balasa, Mircea
Barandiaran, Myriam
Bargalló, Nuria
Bartha, Robart
Bender, Benjamin
Benussi, Luisa
Binetti, Giuliano
Black, Sandra
Bocchetta, Martina
Borrego-Ecija, Sergi
Bras, Jose
Bruffaerts, Rose
Caroppo, Paola
Cash, David
Castelo-Branco, Miguel
Convery, Rhian
Cope, Thomas
de Arriba, María
Di Fede, Giuseppe
Díaz, Zigor
Dick, Katrina M.
Duro, Diana
Fenoglio, Chiara
Ferreira, Carlos
Ferreira, Catarina B.
Flanagan, Toby
Fox, Nick
Freedman, Morris
Fumagalli, Giorgio
Gabilondo, Alazne
Gauthier, Serge
Ghidoni, Roberta
Giaccone, Giorgio
Gorostidi, Ana
Greaves, Caroline
Guerreiro, Rita
Heller, Carolin
Hoegen, Tobias
Indakoetxea, Begoña
Jelic, Vesna
Jiskoot, Lize
Karnath, Hans-Otto
Keren, Ron
Leitão, Maria João
Lladó, Albert
Lombardi, Gemma
Loosli, Sandra
Maruta, Carolina
Mead, Simon
Meeter, Lieke
Miltenberger-Miltenyi, Gabriel
van Minkelen, Rick
Mitchell, Sara
Nacmias, Benedetta
Neason, Mollie
Nicholas, Jennifer
Öijerstedt, Linn
Olives, Jaume
Panman, Jessica
Papma, Janne
Patzig, Maximilian
Pievani, Michela
Prioni, Sara
Prix, Catharina
Rademakers, Rosa
Redaelli, Veronica
Rittman, Tim
Rogaeva, Ekaterina
Rosa-Neto, Pedro
Rossi, Giacomina
Rossor, Martin
Santiago, Beatriz
Scarpini, Elio
Semler, Elisa
Shafei, Rachelle
Shoesmith, Christen
Tábuas-Pereira, Miguel
Tainta, Mikel
Tang-Wai, David
Thomas, David L.
Thonberg, Hakan
Timberlake, Carolyn
Tiraboschi, Pietro
Vandamme, Philip
Vandenbulcke, Mathieu
Veldsman, Michele
Verdelho, Ana
Villanua, Jorge
Warren, Jason
Wilke, Carlo
Zetterberg, Henrik
Zulaica, Miren
dc.subject.por.fl_str_mv C9orf72
Chronnectome
Dynamic brain functional connectivity
Frontotemporal dementia
Granulin
Microtuble associate protein tau
Mutation
Resting-state fMRI
topic C9orf72
Chronnectome
Dynamic brain functional connectivity
Frontotemporal dementia
Granulin
Microtuble associate protein tau
Mutation
Resting-state fMRI
description © 2019 Published by Elsevier Inc. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/)
publishDate 2019
dc.date.none.fl_str_mv 2019
2019-01-01T00:00:00Z
2022-04-18T15:52:27Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/10451/52406
url http://hdl.handle.net/10451/52406
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv Neuroimage. 2019 Apr 1;189:645-654
1053-8119
10.1016/j.neuroimage.2019.01.080
1095-9572
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Elsevier
publisher.none.fl_str_mv Elsevier
dc.source.none.fl_str_mv reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
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