The inner fluctuations of the brain in presymptomatic frontotemporal dementia: the chronnectome fingerprint
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Data de Publicação: | 2019 |
Outros Autores: | , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
Texto Completo: | http://hdl.handle.net/10451/52406 |
Resumo: | © 2019 Published by Elsevier Inc. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/) |
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The inner fluctuations of the brain in presymptomatic frontotemporal dementia: the chronnectome fingerprintC9orf72ChronnectomeDynamic brain functional connectivityFrontotemporal dementiaGranulinMicrotuble associate protein tauMutationResting-state fMRI© 2019 Published by Elsevier Inc. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/)Frontotemporal Dementia (FTD) is preceded by a long period of subtle brain changes, occurring in the absence of overt cognitive symptoms, that need to be still fully characterized. Dynamic network analysis based on resting-state magnetic resonance imaging (rs-fMRI) is a potentially powerful tool for the study of preclinical FTD. In the present study, we employed a "chronnectome" approach (recurring, time-varying patterns of connectivity) to evaluate measures of dynamic connectivity in 472 at-risk FTD subjects from the Genetic Frontotemporal dementia research Initiative (GENFI) cohort. We considered 249 subjects with FTD-related pathogenetic mutations and 223 mutation non-carriers (HC). Dynamic connectivity was evaluated using independent component analysis and sliding-time window correlation to rs-fMRI data, and meta-state measures of global brain flexibility were extracted. Results show that presymptomatic FTD exhibits diminished dynamic fluidity, visiting less meta-states, shifting less often across them, and travelling through a narrowed meta-state distance, as compared to HC. Dynamic connectivity changes characterize preclinical FTD, arguing for the desynchronization of the inner fluctuations of the brain. These changes antedate clinical symptoms, and might represent an early signature of FTD to be used as a biomarker in clinical trials.This work was supported in part by grants from the NIH (R01REB020407, P20GM103472), NSF grant 1539067 and the Well- come Trust grant (JBR 103838).ElsevierRepositório da Universidade de LisboaPremi, EnricoCalhoun, Vince D.Diano, MatteoGazzina, StefanoCosseddu, MauraAlberici, AntonellaArchetti, SilvanaPaternicò, DonataGasparotti, Robertovan Swieten, JohnGalimberti, DanielaSanchez-Valle, RaquelLaforce, RobertMoreno, FerminSynofzik, MatthisGraff, CarolineMasellis, MarioTartaglia, Maria CarmelaRowe, JamesVandenberghe, RikFinger, ElizabethTagliavini, FabrizioDe Mendonça, AlexandreSantana, IsabelButler, ChrisDucharme, SimonGerhard, AlexDanek, AdrianLevin, JohannesOtto, MarkusFrisoni, GiovanniCappa, StefanoSorbi, SandroPadovani, AlessandroRohrer, Jonathan D.Borroni, BarbaraAlmeida, Maria RosarioAnderl-Straub, SarahAndersson, ChristinAntonell, AnnaArighi, AndreaBalasa, MirceaBarandiaran, MyriamBargalló, NuriaBartha, RobartBender, BenjaminBenussi, LuisaBinetti, GiulianoBlack, SandraBocchetta, MartinaBorrego-Ecija, SergiBras, JoseBruffaerts, RoseCaroppo, PaolaCash, DavidCastelo-Branco, MiguelConvery, RhianCope, Thomasde Arriba, MaríaDi Fede, GiuseppeDíaz, ZigorDick, Katrina M.Duro, DianaFenoglio, ChiaraFerreira, CarlosFerreira, Catarina B.Flanagan, TobyFox, NickFreedman, MorrisFumagalli, GiorgioGabilondo, AlazneGauthier, SergeGhidoni, RobertaGiaccone, GiorgioGorostidi, AnaGreaves, CarolineGuerreiro, RitaHeller, CarolinHoegen, TobiasIndakoetxea, BegoñaJelic, VesnaJiskoot, LizeKarnath, Hans-OttoKeren, RonLeitão, Maria JoãoLladó, AlbertLombardi, GemmaLoosli, SandraMaruta, CarolinaMead, SimonMeeter, LiekeMiltenberger-Miltenyi, Gabrielvan Minkelen, RickMitchell, SaraNacmias, BenedettaNeason, MollieNicholas, JenniferÖijerstedt, LinnOlives, JaumePanman, JessicaPapma, JannePatzig, MaximilianPievani, MichelaPrioni, SaraPrix, CatharinaRademakers, RosaRedaelli, VeronicaRittman, TimRogaeva, EkaterinaRosa-Neto, PedroRossi, GiacominaRossor, MartinSantiago, BeatrizScarpini, ElioSemler, ElisaShafei, RachelleShoesmith, ChristenTábuas-Pereira, MiguelTainta, MikelTang-Wai, DavidThomas, David L.Thonberg, HakanTimberlake, CarolynTiraboschi, PietroVandamme, PhilipVandenbulcke, MathieuVeldsman, MicheleVerdelho, AnaVillanua, JorgeWarren, JasonWilke, CarloZetterberg, HenrikZulaica, Miren2022-04-18T15:52:27Z20192019-01-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10451/52406engNeuroimage. 2019 Apr 1;189:645-6541053-811910.1016/j.neuroimage.2019.01.0801095-9572info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-11-08T16:57:36Zoai:repositorio.ul.pt:10451/52406Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T22:03:31.781135Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse |
dc.title.none.fl_str_mv |
The inner fluctuations of the brain in presymptomatic frontotemporal dementia: the chronnectome fingerprint |
title |
The inner fluctuations of the brain in presymptomatic frontotemporal dementia: the chronnectome fingerprint |
spellingShingle |
The inner fluctuations of the brain in presymptomatic frontotemporal dementia: the chronnectome fingerprint Premi, Enrico C9orf72 Chronnectome Dynamic brain functional connectivity Frontotemporal dementia Granulin Microtuble associate protein tau Mutation Resting-state fMRI |
title_short |
The inner fluctuations of the brain in presymptomatic frontotemporal dementia: the chronnectome fingerprint |
title_full |
The inner fluctuations of the brain in presymptomatic frontotemporal dementia: the chronnectome fingerprint |
title_fullStr |
The inner fluctuations of the brain in presymptomatic frontotemporal dementia: the chronnectome fingerprint |
title_full_unstemmed |
The inner fluctuations of the brain in presymptomatic frontotemporal dementia: the chronnectome fingerprint |
title_sort |
The inner fluctuations of the brain in presymptomatic frontotemporal dementia: the chronnectome fingerprint |
author |
Premi, Enrico |
author_facet |
Premi, Enrico Calhoun, Vince D. Diano, Matteo Gazzina, Stefano Cosseddu, Maura Alberici, Antonella Archetti, Silvana Paternicò, Donata Gasparotti, Roberto van Swieten, John Galimberti, Daniela Sanchez-Valle, Raquel Laforce, Robert Moreno, Fermin Synofzik, Matthis Graff, Caroline Masellis, Mario Tartaglia, Maria Carmela Rowe, James Vandenberghe, Rik Finger, Elizabeth Tagliavini, Fabrizio De Mendonça, Alexandre Santana, Isabel Butler, Chris Ducharme, Simon Gerhard, Alex Danek, Adrian Levin, Johannes Otto, Markus Frisoni, Giovanni Cappa, Stefano Sorbi, Sandro Padovani, Alessandro Rohrer, Jonathan D. Borroni, Barbara Almeida, Maria Rosario Anderl-Straub, Sarah Andersson, Christin Antonell, Anna Arighi, Andrea Balasa, Mircea Barandiaran, Myriam Bargalló, Nuria Bartha, Robart Bender, Benjamin Benussi, Luisa Binetti, Giuliano Black, Sandra Bocchetta, Martina Borrego-Ecija, Sergi Bras, Jose Bruffaerts, Rose Caroppo, Paola Cash, David Castelo-Branco, Miguel Convery, Rhian Cope, Thomas de Arriba, María Di Fede, Giuseppe Díaz, Zigor Dick, Katrina M. Duro, Diana Fenoglio, Chiara Ferreira, Carlos Ferreira, Catarina B. Flanagan, Toby Fox, Nick Freedman, Morris Fumagalli, Giorgio Gabilondo, Alazne Gauthier, Serge Ghidoni, Roberta Giaccone, Giorgio Gorostidi, Ana Greaves, Caroline Guerreiro, Rita Heller, Carolin Hoegen, Tobias Indakoetxea, Begoña Jelic, Vesna Jiskoot, Lize Karnath, Hans-Otto Keren, Ron Leitão, Maria João Lladó, Albert Lombardi, Gemma Loosli, Sandra Maruta, Carolina Mead, Simon Meeter, Lieke Miltenberger-Miltenyi, Gabriel van Minkelen, Rick Mitchell, Sara Nacmias, Benedetta Neason, Mollie Nicholas, Jennifer Öijerstedt, Linn Olives, Jaume Panman, Jessica Papma, Janne Patzig, Maximilian Pievani, Michela Prioni, Sara Prix, Catharina Rademakers, Rosa Redaelli, Veronica Rittman, Tim Rogaeva, Ekaterina Rosa-Neto, Pedro Rossi, Giacomina Rossor, Martin Santiago, Beatriz Scarpini, Elio Semler, Elisa Shafei, Rachelle Shoesmith, Christen Tábuas-Pereira, Miguel Tainta, Mikel Tang-Wai, David Thomas, David L. Thonberg, Hakan Timberlake, Carolyn Tiraboschi, Pietro Vandamme, Philip Vandenbulcke, Mathieu Veldsman, Michele Verdelho, Ana Villanua, Jorge Warren, Jason Wilke, Carlo Zetterberg, Henrik Zulaica, Miren |
author_role |
author |
author2 |
Calhoun, Vince D. Diano, Matteo Gazzina, Stefano Cosseddu, Maura Alberici, Antonella Archetti, Silvana Paternicò, Donata Gasparotti, Roberto van Swieten, John Galimberti, Daniela Sanchez-Valle, Raquel Laforce, Robert Moreno, Fermin Synofzik, Matthis Graff, Caroline Masellis, Mario Tartaglia, Maria Carmela Rowe, James Vandenberghe, Rik Finger, Elizabeth Tagliavini, Fabrizio De Mendonça, Alexandre Santana, Isabel Butler, Chris Ducharme, Simon Gerhard, Alex Danek, Adrian Levin, Johannes Otto, Markus Frisoni, Giovanni Cappa, Stefano Sorbi, Sandro Padovani, Alessandro Rohrer, Jonathan D. Borroni, Barbara Almeida, Maria Rosario Anderl-Straub, Sarah Andersson, Christin Antonell, Anna Arighi, Andrea Balasa, Mircea Barandiaran, Myriam Bargalló, Nuria Bartha, Robart Bender, Benjamin Benussi, Luisa Binetti, Giuliano Black, Sandra Bocchetta, Martina Borrego-Ecija, Sergi Bras, Jose Bruffaerts, Rose Caroppo, Paola Cash, David Castelo-Branco, Miguel Convery, Rhian Cope, Thomas de Arriba, María Di Fede, Giuseppe Díaz, Zigor Dick, Katrina M. Duro, Diana Fenoglio, Chiara Ferreira, Carlos Ferreira, Catarina B. Flanagan, Toby Fox, Nick Freedman, Morris Fumagalli, Giorgio Gabilondo, Alazne Gauthier, Serge Ghidoni, Roberta Giaccone, Giorgio Gorostidi, Ana Greaves, Caroline Guerreiro, Rita Heller, Carolin Hoegen, Tobias Indakoetxea, Begoña Jelic, Vesna Jiskoot, Lize Karnath, Hans-Otto Keren, Ron Leitão, Maria João Lladó, Albert Lombardi, Gemma Loosli, Sandra Maruta, Carolina Mead, Simon Meeter, Lieke Miltenberger-Miltenyi, Gabriel van Minkelen, Rick Mitchell, Sara Nacmias, Benedetta Neason, Mollie Nicholas, Jennifer Öijerstedt, Linn Olives, Jaume Panman, Jessica Papma, Janne Patzig, Maximilian Pievani, Michela Prioni, Sara Prix, Catharina Rademakers, Rosa Redaelli, Veronica Rittman, Tim Rogaeva, Ekaterina Rosa-Neto, Pedro Rossi, Giacomina Rossor, Martin Santiago, Beatriz Scarpini, Elio Semler, Elisa Shafei, Rachelle Shoesmith, Christen Tábuas-Pereira, Miguel Tainta, Mikel Tang-Wai, David Thomas, David L. Thonberg, Hakan Timberlake, Carolyn Tiraboschi, Pietro Vandamme, Philip Vandenbulcke, Mathieu Veldsman, Michele Verdelho, Ana Villanua, Jorge Warren, Jason Wilke, Carlo Zetterberg, Henrik Zulaica, Miren |
author2_role |
author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author |
dc.contributor.none.fl_str_mv |
Repositório da Universidade de Lisboa |
dc.contributor.author.fl_str_mv |
Premi, Enrico Calhoun, Vince D. Diano, Matteo Gazzina, Stefano Cosseddu, Maura Alberici, Antonella Archetti, Silvana Paternicò, Donata Gasparotti, Roberto van Swieten, John Galimberti, Daniela Sanchez-Valle, Raquel Laforce, Robert Moreno, Fermin Synofzik, Matthis Graff, Caroline Masellis, Mario Tartaglia, Maria Carmela Rowe, James Vandenberghe, Rik Finger, Elizabeth Tagliavini, Fabrizio De Mendonça, Alexandre Santana, Isabel Butler, Chris Ducharme, Simon Gerhard, Alex Danek, Adrian Levin, Johannes Otto, Markus Frisoni, Giovanni Cappa, Stefano Sorbi, Sandro Padovani, Alessandro Rohrer, Jonathan D. Borroni, Barbara Almeida, Maria Rosario Anderl-Straub, Sarah Andersson, Christin Antonell, Anna Arighi, Andrea Balasa, Mircea Barandiaran, Myriam Bargalló, Nuria Bartha, Robart Bender, Benjamin Benussi, Luisa Binetti, Giuliano Black, Sandra Bocchetta, Martina Borrego-Ecija, Sergi Bras, Jose Bruffaerts, Rose Caroppo, Paola Cash, David Castelo-Branco, Miguel Convery, Rhian Cope, Thomas de Arriba, María Di Fede, Giuseppe Díaz, Zigor Dick, Katrina M. Duro, Diana Fenoglio, Chiara Ferreira, Carlos Ferreira, Catarina B. Flanagan, Toby Fox, Nick Freedman, Morris Fumagalli, Giorgio Gabilondo, Alazne Gauthier, Serge Ghidoni, Roberta Giaccone, Giorgio Gorostidi, Ana Greaves, Caroline Guerreiro, Rita Heller, Carolin Hoegen, Tobias Indakoetxea, Begoña Jelic, Vesna Jiskoot, Lize Karnath, Hans-Otto Keren, Ron Leitão, Maria João Lladó, Albert Lombardi, Gemma Loosli, Sandra Maruta, Carolina Mead, Simon Meeter, Lieke Miltenberger-Miltenyi, Gabriel van Minkelen, Rick Mitchell, Sara Nacmias, Benedetta Neason, Mollie Nicholas, Jennifer Öijerstedt, Linn Olives, Jaume Panman, Jessica Papma, Janne Patzig, Maximilian Pievani, Michela Prioni, Sara Prix, Catharina Rademakers, Rosa Redaelli, Veronica Rittman, Tim Rogaeva, Ekaterina Rosa-Neto, Pedro Rossi, Giacomina Rossor, Martin Santiago, Beatriz Scarpini, Elio Semler, Elisa Shafei, Rachelle Shoesmith, Christen Tábuas-Pereira, Miguel Tainta, Mikel Tang-Wai, David Thomas, David L. Thonberg, Hakan Timberlake, Carolyn Tiraboschi, Pietro Vandamme, Philip Vandenbulcke, Mathieu Veldsman, Michele Verdelho, Ana Villanua, Jorge Warren, Jason Wilke, Carlo Zetterberg, Henrik Zulaica, Miren |
dc.subject.por.fl_str_mv |
C9orf72 Chronnectome Dynamic brain functional connectivity Frontotemporal dementia Granulin Microtuble associate protein tau Mutation Resting-state fMRI |
topic |
C9orf72 Chronnectome Dynamic brain functional connectivity Frontotemporal dementia Granulin Microtuble associate protein tau Mutation Resting-state fMRI |
description |
© 2019 Published by Elsevier Inc. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/) |
publishDate |
2019 |
dc.date.none.fl_str_mv |
2019 2019-01-01T00:00:00Z 2022-04-18T15:52:27Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://hdl.handle.net/10451/52406 |
url |
http://hdl.handle.net/10451/52406 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
Neuroimage. 2019 Apr 1;189:645-654 1053-8119 10.1016/j.neuroimage.2019.01.080 1095-9572 |
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info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.publisher.none.fl_str_mv |
Elsevier |
publisher.none.fl_str_mv |
Elsevier |
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Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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RCAAP |
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RCAAP |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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