Anomia is present pre-symptomatically in frontotemporal dementia due to MAPT mutations

Detalhes bibliográficos
Autor(a) principal: Bouzigues, Arabella
Data de Publicação: 2022
Outros Autores: Russell, Lucy L., Peakman, Georgia, Bocchetta, Martina, Greaves, Caroline V., Convery, Rhian S., Todd, Emily, Rowe, James B., Borroni, Barbara, Galimberti, Daniela, Tiraboschi, Pietro, Zetterberg, Henrik, Jiskoot, Lize, Sorbi, Sandro, Butler, Chris R., Graff, Caroline, Gerhard, Alexander, Langheinrich, Tobias, Laforce, Robert, Sanchez-Valle, Raquel, De Mendonça, Alexandre, Balasa, Mircea, Moreno, Fermin, Swift, Imogen J, Synofzik, Matthis, Vandenberghe, Rik, Ducharme, Simon, Le Ber, Isabelle, Levin, Johannes, Danek, Adrian, Otto, Markus, Pasquier, Florence, Tang-Wai, David, Santana, Isabel, Rohrer, Jonathan D., Nicholas, Jennifer, Esteve, Aitana Sogorb, Nelson, Annabel, Heller, Carolin, Greaves, Caroline V, Cash, David, Thomas, David L, Rogaeva, Ekaterina, Samra, Kiran, Russell, Lucy L, Shafei, Rachelle, Convery, Rhian S, Antonell, Anna, Timberlake, Carolyn, Cope, Thomas, Rittman, Timothy, Benussi, Alberto, Castelo-Branco, Miguel, Premi, Enrico, Gasparotti, Roberto, Archetti, Silvana, Gazzina, Stefano, Cantoni, Valentina, Arighi, Andrea, Olives, Jaume, Fenoglio, Chiara, Scarpini, Elio, Fumagalli, Giorgio, Keren, Ron, Borracci, Vittoria, Rossi, Giacomina, Giaccone, Giorgio, Caroppo, Paola, Prioni, Sara, Redaelli, Veronica, Black, Sandra, Mitchell, Sara, Shoesmith, Christen, Bartha, Robart, Rademakers, Rosa, Finger, Elizabeth, Poos, Jackie, Bargalló, Nuria, Papma, Janne M, Giannini, Lucia, Minkelen, Rick, Pijnenburg, Yolande, Nacmias, Benedetta, Ferrari, Camilla, Polito, Cristina, Lombardi, Gemma, Bertrand, Anne, Bessi, Valentina, Veldsman, Michele, Borrego-Ecija, Sergi, Andersson, Christin, Thonberg, Hakan, Öijerstedt, Linn, Jelic, Vesna, Thompson, Paul, Lladó, Albert, Funkiewiez, Aurélie, Verdelho, Ana, Maruta, Carolina, Ferreira, Catarina B., Miltenberger-Miltenyi, Gabriel, Simões Do Couto, Frederico, Masellis, Mario, Gabilondo, Alazne, Gorostidi, Ana, Villanua, Jorge, Cañada, Marta, Rinaldi, Daisy, Tainta, Mikel, Zulaica, Miren, Barandiaran, Myriam, Alves, Patricia, Bender, Benjamin, Wilke, Carlo, Tartaglia, Maria Carmela, Graf, Lisa, Vogels, Annick, Vandenbulcke, Mathieu, Saracino, Dario, Van Damme, Philip, Bruffaerts, Rose, Poesen, Koen, Rosa-Neto, Pedro, Gauthier, Serge, Camuzat, Agnès, Brice, Alexis, Colliot, Olivier, Sayah, Sabrina, Prix, Catharina, Wlasich, Elisabeth, Wagemann, Olivia, Loosli, Sandra, van Swieten, John C., Schönecker, Sonja, Hoegen, Tobias, Lombardi, Jolina, Anderl-Straub, Sarah, Rollin, Adeline, Kuchcinski, Gregory, Bertoux, Maxime, Lebouvier, Thibaud, Benotmane, Hanya, Deramecourt, Vincent, Santiago, Beatriz, Seelaar, Harro, Duro, Diana, Leitão, Maria João, Almeida, Maria Rosario, Tábuas-Pereira, Miguel, Afonso, Sónia, Engel, Annerose, Polyakova, Maryna
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: http://hdl.handle.net/10451/52184
Resumo: © The Author(s) 2022. Springer Nature Switzerland AG. Part of Springer Nature. Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.
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spelling Anomia is present pre-symptomatically in frontotemporal dementia due to MAPT mutationsC9orf72CognitionFrontotemporal dementiaNamingProgranulinTau© The Author(s) 2022. Springer Nature Switzerland AG. Part of Springer Nature. Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.Introduction: A third of frontotemporal dementia (FTD) is caused by an autosomal-dominant genetic mutation in one of three genes: microtubule-associated protein tau (MAPT), chromosome 9 open reading frame 72 (C9orf72) and progranulin (GRN). Prior studies of prodromal FTD have identified impaired executive function and social cognition early in the disease but few have studied naming in detail. Methods: We investigated performance on the Boston Naming Test (BNT) in the GENetic Frontotemporal dementia Initiative cohort of 499 mutation carriers and 248 mutation-negative controls divided across three genetic groups: C9orf72, MAPT and GRN. Mutation carriers were further divided into 3 groups according to their global CDR plus NACC FTLD score: 0 (asymptomatic), 0.5 (prodromal) and 1 + (fully symptomatic). Groups were compared using a bootstrapped linear regression model, adjusting for age, sex, language and education. Finally, we identified neural correlates of anomia within carriers of each genetic group using a voxel-based morphometry analysis. Results: All symptomatic groups performed worse on the BNT than controls with the MAPT symptomatic group scoring the worst. Furthermore, MAPT asymptomatic and prodromal groups performed significantly worse than controls. Correlates of anomia in MAPT mutation carriers included bilateral anterior temporal lobe regions and the anterior insula. Similar bilateral anterior temporal lobe involvement was seen in C9orf72 mutation carriers as well as more widespread left frontal atrophy. In GRN mutation carriers, neural correlates were limited to the left hemisphere, and involved frontal, temporal, insula and striatal regions. Conclusion: This study suggests the development of early anomia in MAPT mutation carriers, likely to be associated with impaired semantic knowledge. Clinical trials focused on the prodromal period within individuals with MAPT mutations should use language tasks, such as the BNT for patient stratification and as outcome measures.he Dementia Research Centre is supported by Alzheimer's Research UK, Alzheimer's Society, Brain Research UK, and The Wolfson Foundation. This work was supported by the NIHR UCL/H Biomedical Research Centre, the Leonard Wolfson Experimental Neurology Centre (LWENC) Clinical Research Facility, and the UK Dementia Research Institute, which receives its funding from UK DRI Ltd, funded by the UK Medical Research Council, Alzheimer's Society and Alzheimer's Research UK. JDR is supported by the Miriam Marks Brain Research UK Senior Fellowship and has received funding from an MRC Clinician Scientist Fellowship (MR/M008525/1) and the NIHR Rare Disease Translational Research Collaboration (BRC149/NS/MH). This work was also supported by the MRC UK GENFI grant (MR/M023664/1), the Bluefield Project and the JPND GENFI-PROX grant (2019-02248). This research was supported by the NIHR Cambridge Biomedical Research Centre (BRC-1215-20014). The views expressed are those of the authors and not necessarily those of the NIHR or the Department of Health and Social Care. MB is supported by a Fellowship award from the Alzheimer’s Society, UK (AS-JF-19a-004-517). MB’s work is also supported by the UK Dementia Research Institute which receives its funding from DRI Ltd, funded by the UK Medical Research Council, Alzheimer’s Society and Alzheimer’s Research UK. RC/CG are supported by a Frontotemporal Dementia Research Studentships in Memory of David Blechner funded through The National Brain Appeal (RCN 290173). Several authors of this publication are members of the European Reference Network for Rare Neurological Diseases—Project ID No 739510. This work was funded by the Deutsche Forschungsgemeinschaft (DFG, German Research Foundation) under Germany’s Excellence Strategy within the framework of the Munich Cluster for Systems Neurology (EXC 2145 SyNergy—ID 390857198).Springer NatureRepositório da Universidade de LisboaBouzigues, ArabellaRussell, Lucy L.Peakman, GeorgiaBocchetta, MartinaGreaves, Caroline V.Convery, Rhian S.Todd, EmilyRowe, James B.Borroni, BarbaraGalimberti, DanielaTiraboschi, PietroZetterberg, HenrikJiskoot, LizeSorbi, SandroButler, Chris R.Graff, CarolineGerhard, AlexanderLangheinrich, TobiasLaforce, RobertSanchez-Valle, RaquelDe Mendonça, AlexandreBalasa, MirceaMoreno, FerminSwift, Imogen JSynofzik, MatthisVandenberghe, RikDucharme, SimonLe Ber, IsabelleLevin, JohannesDanek, AdrianOtto, MarkusPasquier, FlorenceTang-Wai, DavidSantana, IsabelRohrer, Jonathan D.Nicholas, JenniferEsteve, Aitana SogorbNelson, AnnabelBouzigues, ArabellaHeller, CarolinGreaves, Caroline VCash, DavidThomas, David LRogaeva, EkaterinaSamra, KiranRussell, Lucy LBocchetta, MartinaShafei, RachelleConvery, Rhian SAntonell, AnnaTimberlake, CarolynCope, ThomasRittman, TimothyBenussi, AlbertoCastelo-Branco, MiguelPremi, EnricoGasparotti, RobertoArchetti, SilvanaGazzina, StefanoCantoni, ValentinaArighi, AndreaOlives, JaumeFenoglio, ChiaraScarpini, ElioFumagalli, GiorgioKeren, RonBorracci, VittoriaRossi, GiacominaGiaccone, GiorgioCaroppo, PaolaTiraboschi, PietroPrioni, SaraRedaelli, VeronicaBlack, SandraMitchell, SaraShoesmith, ChristenBartha, RobartRademakers, RosaFinger, ElizabethPoos, JackieBargalló, NuriaPapma, Janne MGiannini, LuciaMinkelen, RickPijnenburg, YolandeNacmias, BenedettaFerrari, CamillaPolito, CristinaLombardi, GemmaBertrand, AnneBessi, ValentinaVeldsman, MicheleBorrego-Ecija, SergiAndersson, ChristinThonberg, HakanÖijerstedt, LinnJelic, VesnaThompson, PaulLangheinrich, TobiasLladó, AlbertFunkiewiez, AurélieVerdelho, AnaMaruta, CarolinaFerreira, Catarina B.Miltenberger-Miltenyi, GabrielSimões Do Couto, FredericoMasellis, MarioGabilondo, AlazneGorostidi, AnaVillanua, JorgeCañada, MartaRinaldi, DaisyTainta, MikelZulaica, MirenBarandiaran, MyriamAlves, PatriciaBender, BenjaminWilke, CarloTartaglia, Maria CarmelaGraf, LisaVogels, AnnickVandenbulcke, MathieuSaracino, DarioVan Damme, PhilipBruffaerts, RosePoesen, KoenRosa-Neto, PedroGauthier, SergeCamuzat, AgnèsBrice, AlexisColliot, OlivierSayah, SabrinaPrix, CatharinaWlasich, ElisabethWagemann, OliviaTodd, EmilyLoosli, Sandravan Swieten, John C.Schönecker, SonjaHoegen, TobiasLombardi, JolinaAnderl-Straub, SarahRollin, AdelineKuchcinski, GregoryBertoux, MaximeLebouvier, ThibaudBenotmane, HanyaDeramecourt, VincentSantiago, BeatrizSeelaar, HarroDuro, DianaLeitão, Maria JoãoAlmeida, Maria RosarioTábuas-Pereira, MiguelAfonso, SóniaEngel, AnnerosePolyakova, Maryna2022-04-05T13:33:22Z20222022-01-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10451/52184engJ Neurol. 2022 Mar 290340-535410.1007/s00415-022-11068-01432-1459info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-11-08T16:57:17Zoai:repositorio.ul.pt:10451/52184Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T22:03:19.169047Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv Anomia is present pre-symptomatically in frontotemporal dementia due to MAPT mutations
title Anomia is present pre-symptomatically in frontotemporal dementia due to MAPT mutations
spellingShingle Anomia is present pre-symptomatically in frontotemporal dementia due to MAPT mutations
Bouzigues, Arabella
C9orf72
Cognition
Frontotemporal dementia
Naming
Progranulin
Tau
title_short Anomia is present pre-symptomatically in frontotemporal dementia due to MAPT mutations
title_full Anomia is present pre-symptomatically in frontotemporal dementia due to MAPT mutations
title_fullStr Anomia is present pre-symptomatically in frontotemporal dementia due to MAPT mutations
title_full_unstemmed Anomia is present pre-symptomatically in frontotemporal dementia due to MAPT mutations
title_sort Anomia is present pre-symptomatically in frontotemporal dementia due to MAPT mutations
author Bouzigues, Arabella
author_facet Bouzigues, Arabella
Russell, Lucy L.
Peakman, Georgia
Bocchetta, Martina
Greaves, Caroline V.
Convery, Rhian S.
Todd, Emily
Rowe, James B.
Borroni, Barbara
Galimberti, Daniela
Tiraboschi, Pietro
Zetterberg, Henrik
Jiskoot, Lize
Sorbi, Sandro
Butler, Chris R.
Graff, Caroline
Gerhard, Alexander
Langheinrich, Tobias
Laforce, Robert
Sanchez-Valle, Raquel
De Mendonça, Alexandre
Balasa, Mircea
Moreno, Fermin
Swift, Imogen J
Synofzik, Matthis
Vandenberghe, Rik
Ducharme, Simon
Le Ber, Isabelle
Levin, Johannes
Danek, Adrian
Otto, Markus
Pasquier, Florence
Tang-Wai, David
Santana, Isabel
Rohrer, Jonathan D.
Nicholas, Jennifer
Esteve, Aitana Sogorb
Nelson, Annabel
Heller, Carolin
Greaves, Caroline V
Cash, David
Thomas, David L
Rogaeva, Ekaterina
Samra, Kiran
Russell, Lucy L
Shafei, Rachelle
Convery, Rhian S
Antonell, Anna
Timberlake, Carolyn
Cope, Thomas
Rittman, Timothy
Benussi, Alberto
Castelo-Branco, Miguel
Premi, Enrico
Gasparotti, Roberto
Archetti, Silvana
Gazzina, Stefano
Cantoni, Valentina
Arighi, Andrea
Olives, Jaume
Fenoglio, Chiara
Scarpini, Elio
Fumagalli, Giorgio
Keren, Ron
Borracci, Vittoria
Rossi, Giacomina
Giaccone, Giorgio
Caroppo, Paola
Prioni, Sara
Redaelli, Veronica
Black, Sandra
Mitchell, Sara
Shoesmith, Christen
Bartha, Robart
Rademakers, Rosa
Finger, Elizabeth
Poos, Jackie
Bargalló, Nuria
Papma, Janne M
Giannini, Lucia
Minkelen, Rick
Pijnenburg, Yolande
Nacmias, Benedetta
Ferrari, Camilla
Polito, Cristina
Lombardi, Gemma
Bertrand, Anne
Bessi, Valentina
Veldsman, Michele
Borrego-Ecija, Sergi
Andersson, Christin
Thonberg, Hakan
Öijerstedt, Linn
Jelic, Vesna
Thompson, Paul
Lladó, Albert
Funkiewiez, Aurélie
Verdelho, Ana
Maruta, Carolina
Ferreira, Catarina B.
Miltenberger-Miltenyi, Gabriel
Simões Do Couto, Frederico
Masellis, Mario
Gabilondo, Alazne
Gorostidi, Ana
Villanua, Jorge
Cañada, Marta
Rinaldi, Daisy
Tainta, Mikel
Zulaica, Miren
Barandiaran, Myriam
Alves, Patricia
Bender, Benjamin
Wilke, Carlo
Tartaglia, Maria Carmela
Graf, Lisa
Vogels, Annick
Vandenbulcke, Mathieu
Saracino, Dario
Van Damme, Philip
Bruffaerts, Rose
Poesen, Koen
Rosa-Neto, Pedro
Gauthier, Serge
Camuzat, Agnès
Brice, Alexis
Colliot, Olivier
Sayah, Sabrina
Prix, Catharina
Wlasich, Elisabeth
Wagemann, Olivia
Loosli, Sandra
van Swieten, John C.
Schönecker, Sonja
Hoegen, Tobias
Lombardi, Jolina
Anderl-Straub, Sarah
Rollin, Adeline
Kuchcinski, Gregory
Bertoux, Maxime
Lebouvier, Thibaud
Benotmane, Hanya
Deramecourt, Vincent
Santiago, Beatriz
Seelaar, Harro
Duro, Diana
Leitão, Maria João
Almeida, Maria Rosario
Tábuas-Pereira, Miguel
Afonso, Sónia
Engel, Annerose
Polyakova, Maryna
author_role author
author2 Russell, Lucy L.
Peakman, Georgia
Bocchetta, Martina
Greaves, Caroline V.
Convery, Rhian S.
Todd, Emily
Rowe, James B.
Borroni, Barbara
Galimberti, Daniela
Tiraboschi, Pietro
Zetterberg, Henrik
Jiskoot, Lize
Sorbi, Sandro
Butler, Chris R.
Graff, Caroline
Gerhard, Alexander
Langheinrich, Tobias
Laforce, Robert
Sanchez-Valle, Raquel
De Mendonça, Alexandre
Balasa, Mircea
Moreno, Fermin
Swift, Imogen J
Synofzik, Matthis
Vandenberghe, Rik
Ducharme, Simon
Le Ber, Isabelle
Levin, Johannes
Danek, Adrian
Otto, Markus
Pasquier, Florence
Tang-Wai, David
Santana, Isabel
Rohrer, Jonathan D.
Nicholas, Jennifer
Esteve, Aitana Sogorb
Nelson, Annabel
Heller, Carolin
Greaves, Caroline V
Cash, David
Thomas, David L
Rogaeva, Ekaterina
Samra, Kiran
Russell, Lucy L
Shafei, Rachelle
Convery, Rhian S
Antonell, Anna
Timberlake, Carolyn
Cope, Thomas
Rittman, Timothy
Benussi, Alberto
Castelo-Branco, Miguel
Premi, Enrico
Gasparotti, Roberto
Archetti, Silvana
Gazzina, Stefano
Cantoni, Valentina
Arighi, Andrea
Olives, Jaume
Fenoglio, Chiara
Scarpini, Elio
Fumagalli, Giorgio
Keren, Ron
Borracci, Vittoria
Rossi, Giacomina
Giaccone, Giorgio
Caroppo, Paola
Prioni, Sara
Redaelli, Veronica
Black, Sandra
Mitchell, Sara
Shoesmith, Christen
Bartha, Robart
Rademakers, Rosa
Finger, Elizabeth
Poos, Jackie
Bargalló, Nuria
Papma, Janne M
Giannini, Lucia
Minkelen, Rick
Pijnenburg, Yolande
Nacmias, Benedetta
Ferrari, Camilla
Polito, Cristina
Lombardi, Gemma
Bertrand, Anne
Bessi, Valentina
Veldsman, Michele
Borrego-Ecija, Sergi
Andersson, Christin
Thonberg, Hakan
Öijerstedt, Linn
Jelic, Vesna
Thompson, Paul
Lladó, Albert
Funkiewiez, Aurélie
Verdelho, Ana
Maruta, Carolina
Ferreira, Catarina B.
Miltenberger-Miltenyi, Gabriel
Simões Do Couto, Frederico
Masellis, Mario
Gabilondo, Alazne
Gorostidi, Ana
Villanua, Jorge
Cañada, Marta
Rinaldi, Daisy
Tainta, Mikel
Zulaica, Miren
Barandiaran, Myriam
Alves, Patricia
Bender, Benjamin
Wilke, Carlo
Tartaglia, Maria Carmela
Graf, Lisa
Vogels, Annick
Vandenbulcke, Mathieu
Saracino, Dario
Van Damme, Philip
Bruffaerts, Rose
Poesen, Koen
Rosa-Neto, Pedro
Gauthier, Serge
Camuzat, Agnès
Brice, Alexis
Colliot, Olivier
Sayah, Sabrina
Prix, Catharina
Wlasich, Elisabeth
Wagemann, Olivia
Loosli, Sandra
van Swieten, John C.
Schönecker, Sonja
Hoegen, Tobias
Lombardi, Jolina
Anderl-Straub, Sarah
Rollin, Adeline
Kuchcinski, Gregory
Bertoux, Maxime
Lebouvier, Thibaud
Benotmane, Hanya
Deramecourt, Vincent
Santiago, Beatriz
Seelaar, Harro
Duro, Diana
Leitão, Maria João
Almeida, Maria Rosario
Tábuas-Pereira, Miguel
Afonso, Sónia
Engel, Annerose
Polyakova, Maryna
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dc.contributor.none.fl_str_mv Repositório da Universidade de Lisboa
dc.contributor.author.fl_str_mv Bouzigues, Arabella
Russell, Lucy L.
Peakman, Georgia
Bocchetta, Martina
Greaves, Caroline V.
Convery, Rhian S.
Todd, Emily
Rowe, James B.
Borroni, Barbara
Galimberti, Daniela
Tiraboschi, Pietro
Zetterberg, Henrik
Jiskoot, Lize
Sorbi, Sandro
Butler, Chris R.
Graff, Caroline
Gerhard, Alexander
Langheinrich, Tobias
Laforce, Robert
Sanchez-Valle, Raquel
De Mendonça, Alexandre
Balasa, Mircea
Moreno, Fermin
Swift, Imogen J
Synofzik, Matthis
Vandenberghe, Rik
Ducharme, Simon
Le Ber, Isabelle
Levin, Johannes
Danek, Adrian
Otto, Markus
Pasquier, Florence
Tang-Wai, David
Santana, Isabel
Rohrer, Jonathan D.
Nicholas, Jennifer
Esteve, Aitana Sogorb
Nelson, Annabel
Bouzigues, Arabella
Heller, Carolin
Greaves, Caroline V
Cash, David
Thomas, David L
Rogaeva, Ekaterina
Samra, Kiran
Russell, Lucy L
Bocchetta, Martina
Shafei, Rachelle
Convery, Rhian S
Antonell, Anna
Timberlake, Carolyn
Cope, Thomas
Rittman, Timothy
Benussi, Alberto
Castelo-Branco, Miguel
Premi, Enrico
Gasparotti, Roberto
Archetti, Silvana
Gazzina, Stefano
Cantoni, Valentina
Arighi, Andrea
Olives, Jaume
Fenoglio, Chiara
Scarpini, Elio
Fumagalli, Giorgio
Keren, Ron
Borracci, Vittoria
Rossi, Giacomina
Giaccone, Giorgio
Caroppo, Paola
Tiraboschi, Pietro
Prioni, Sara
Redaelli, Veronica
Black, Sandra
Mitchell, Sara
Shoesmith, Christen
Bartha, Robart
Rademakers, Rosa
Finger, Elizabeth
Poos, Jackie
Bargalló, Nuria
Papma, Janne M
Giannini, Lucia
Minkelen, Rick
Pijnenburg, Yolande
Nacmias, Benedetta
Ferrari, Camilla
Polito, Cristina
Lombardi, Gemma
Bertrand, Anne
Bessi, Valentina
Veldsman, Michele
Borrego-Ecija, Sergi
Andersson, Christin
Thonberg, Hakan
Öijerstedt, Linn
Jelic, Vesna
Thompson, Paul
Langheinrich, Tobias
Lladó, Albert
Funkiewiez, Aurélie
Verdelho, Ana
Maruta, Carolina
Ferreira, Catarina B.
Miltenberger-Miltenyi, Gabriel
Simões Do Couto, Frederico
Masellis, Mario
Gabilondo, Alazne
Gorostidi, Ana
Villanua, Jorge
Cañada, Marta
Rinaldi, Daisy
Tainta, Mikel
Zulaica, Miren
Barandiaran, Myriam
Alves, Patricia
Bender, Benjamin
Wilke, Carlo
Tartaglia, Maria Carmela
Graf, Lisa
Vogels, Annick
Vandenbulcke, Mathieu
Saracino, Dario
Van Damme, Philip
Bruffaerts, Rose
Poesen, Koen
Rosa-Neto, Pedro
Gauthier, Serge
Camuzat, Agnès
Brice, Alexis
Colliot, Olivier
Sayah, Sabrina
Prix, Catharina
Wlasich, Elisabeth
Wagemann, Olivia
Todd, Emily
Loosli, Sandra
van Swieten, John C.
Schönecker, Sonja
Hoegen, Tobias
Lombardi, Jolina
Anderl-Straub, Sarah
Rollin, Adeline
Kuchcinski, Gregory
Bertoux, Maxime
Lebouvier, Thibaud
Benotmane, Hanya
Deramecourt, Vincent
Santiago, Beatriz
Seelaar, Harro
Duro, Diana
Leitão, Maria João
Almeida, Maria Rosario
Tábuas-Pereira, Miguel
Afonso, Sónia
Engel, Annerose
Polyakova, Maryna
dc.subject.por.fl_str_mv C9orf72
Cognition
Frontotemporal dementia
Naming
Progranulin
Tau
topic C9orf72
Cognition
Frontotemporal dementia
Naming
Progranulin
Tau
description © The Author(s) 2022. Springer Nature Switzerland AG. Part of Springer Nature. Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.
publishDate 2022
dc.date.none.fl_str_mv 2022-04-05T13:33:22Z
2022
2022-01-01T00:00:00Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
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status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/10451/52184
url http://hdl.handle.net/10451/52184
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv J Neurol. 2022 Mar 29
0340-5354
10.1007/s00415-022-11068-0
1432-1459
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eu_rights_str_mv openAccess
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dc.publisher.none.fl_str_mv Springer Nature
publisher.none.fl_str_mv Springer Nature
dc.source.none.fl_str_mv reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
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