Properties of collagen/sodium alginate hydrogels for bioprinting of skin models
| Autor(a) principal: | |
|---|---|
| Data de Publicação: | 2023 |
| Outros Autores: | , , , , |
| Tipo de documento: | Artigo |
| Idioma: | eng |
| Título da fonte: | Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
| Texto Completo: | https://hdl.handle.net/1822/79493 |
Resumo: | Published: 07 September 2022 |
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Properties of collagen/sodium alginate hydrogels for bioprinting of skin modelsBioprintingCollagenskin modelsBioinksodium alginate hydrogelSkinWound healingBionicCollagen/sodium alginate hydrogelScience & TechnologyPublished: 07 September 20223D printing technology has great potential for the reconstruction of human skin. However, the reconstructed skin has some differences from natural skin, largely because the hydrogel used does not have the appropriate biological and physical properties to allow healing and regeneration. This study examines the swelling, degradability, microstructure and biological properties of Collagen/Sodium Alginate (Col/SA) hydrogels of differing compositions for the purposes of skin printing. Increasing the content of sodium alginate causes the hydrogel to exhibit stronger mechanical and swelling properties, a faster degradation ratio, smaller pore size, and less favorable biological properties. An optimal 1% collagen hydrogel was used to print bi-layer skin in which fibroblasts and keratinocytes showed improved spreading and proliferation as compared to other developed formulations. The Col/SA hydrogels presented suitable tunability and properties to be used as a bioink for bioprinting of skin aiming at finding applications as 3D models for wound healing research.This research was funded by the National Key R&D Program of China (2018YFE0207900), and People's Liberation Army (BWS17J036, 18-163-13-ZT-003-011-01) and the National Natural Science Foundation of China (51835010 and 51375371), and Xi’an Science and Technology Plan Project (21ZCZZHXJS-QCY6-0012). Shaanxi Science and Technology Project (2022KXJ-147). Thanks to Shi Changquan and Yang Chuncheng of Shaanxi Ketao-AM Technology Co., Ltd. for their technical support for printing equipment.SpringerUniversidade do MinhoTian Jiao, Q. L.Lian, W.Wang, Y.Li, D.Reis, R. L.Oliveira, Joaquim M.20232023-01-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttps://hdl.handle.net/1822/79493engJiao, T., Lian, Q., Lian, W. et al. Properties of Collagen/Sodium Alginate Hydrogels for Bioprinting of Skin Models. J Bionic Eng 20, 105–118 (2023). https://doi.org/10.1007/s42235-022-00251-82543-214110.1007/s42235-022-00251-8https://link.springer.com/article/10.1007/s42235-022-00251-8info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-12-23T01:29:54Zoai:repositorium.sdum.uminho.pt:1822/79493Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T19:08:39.381060Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse |
| dc.title.none.fl_str_mv |
Properties of collagen/sodium alginate hydrogels for bioprinting of skin models |
| title |
Properties of collagen/sodium alginate hydrogels for bioprinting of skin models |
| spellingShingle |
Properties of collagen/sodium alginate hydrogels for bioprinting of skin models Tian Jiao, Q. L. Bioprinting Collagen skin models Bioink sodium alginate hydrogel Skin Wound healing Bionic Collagen/sodium alginate hydrogel Science & Technology |
| title_short |
Properties of collagen/sodium alginate hydrogels for bioprinting of skin models |
| title_full |
Properties of collagen/sodium alginate hydrogels for bioprinting of skin models |
| title_fullStr |
Properties of collagen/sodium alginate hydrogels for bioprinting of skin models |
| title_full_unstemmed |
Properties of collagen/sodium alginate hydrogels for bioprinting of skin models |
| title_sort |
Properties of collagen/sodium alginate hydrogels for bioprinting of skin models |
| author |
Tian Jiao, Q. L. |
| author_facet |
Tian Jiao, Q. L. Lian, W. Wang, Y. Li, D. Reis, R. L. Oliveira, Joaquim M. |
| author_role |
author |
| author2 |
Lian, W. Wang, Y. Li, D. Reis, R. L. Oliveira, Joaquim M. |
| author2_role |
author author author author author |
| dc.contributor.none.fl_str_mv |
Universidade do Minho |
| dc.contributor.author.fl_str_mv |
Tian Jiao, Q. L. Lian, W. Wang, Y. Li, D. Reis, R. L. Oliveira, Joaquim M. |
| dc.subject.por.fl_str_mv |
Bioprinting Collagen skin models Bioink sodium alginate hydrogel Skin Wound healing Bionic Collagen/sodium alginate hydrogel Science & Technology |
| topic |
Bioprinting Collagen skin models Bioink sodium alginate hydrogel Skin Wound healing Bionic Collagen/sodium alginate hydrogel Science & Technology |
| description |
Published: 07 September 2022 |
| publishDate |
2023 |
| dc.date.none.fl_str_mv |
2023 2023-01-01T00:00:00Z |
| dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
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info:eu-repo/semantics/article |
| format |
article |
| status_str |
publishedVersion |
| dc.identifier.uri.fl_str_mv |
https://hdl.handle.net/1822/79493 |
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https://hdl.handle.net/1822/79493 |
| dc.language.iso.fl_str_mv |
eng |
| language |
eng |
| dc.relation.none.fl_str_mv |
Jiao, T., Lian, Q., Lian, W. et al. Properties of Collagen/Sodium Alginate Hydrogels for Bioprinting of Skin Models. J Bionic Eng 20, 105–118 (2023). https://doi.org/10.1007/s42235-022-00251-8 2543-2141 10.1007/s42235-022-00251-8 https://link.springer.com/article/10.1007/s42235-022-00251-8 |
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info:eu-repo/semantics/openAccess |
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openAccess |
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application/pdf |
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Springer |
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Springer |
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reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação instacron:RCAAP |
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Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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RCAAP |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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