Persistent Leprosy Reaction 8 Years After the End of Therapy: Challenges for Doctors and Patients

Detalhes bibliográficos
Autor(a) principal: Franco Ferraz Santino, Mariana
Data de Publicação: 2020
Outros Autores: Cuzzi, Tullia, Manta, Fernanda Saloum de Neves, Oliveira, Maria Leide W.
Tipo de documento: Artigo
Idioma: por
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: https://doi.org/10.29021/spdv.77.4.1097
Resumo: Introduction: In addition to infection with Mycobacterium leprae, type 1 and 2 reactions represent acute inflammatory events in the chronic course of multibacillary leprosy, which may persist for long periods. Case Report: A young woman presenting borderline lepromatous leprosy and persistent type 2 reaction with difficult clinical conduction. Discussion: The case illustrates the diagnostic challenge in leprosy with a systemic inflammatory response, more expressive than the dermato – neurological features. The clinical, histopathological and therapeutic implications, as well as risk factors for reaction and also polymerase chain reaction 8 years after being discharged from treatment of multidrug therapy are discussed.
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spelling Persistent Leprosy Reaction 8 Years After the End of Therapy: Challenges for Doctors and PatientsReação Hanseniásica Persistente 8 Anos Após Conclusão da Terapêutica: Desafio para Médicos e PacientesLeprosy/complicationsLeprosy/therapyPanniculitisLepra/complicaçõesLepra/tratamentoPaniculiteIntroduction: In addition to infection with Mycobacterium leprae, type 1 and 2 reactions represent acute inflammatory events in the chronic course of multibacillary leprosy, which may persist for long periods. Case Report: A young woman presenting borderline lepromatous leprosy and persistent type 2 reaction with difficult clinical conduction. Discussion: The case illustrates the diagnostic challenge in leprosy with a systemic inflammatory response, more expressive than the dermato – neurological features. The clinical, histopathological and therapeutic implications, as well as risk factors for reaction and also polymerase chain reaction 8 years after being discharged from treatment of multidrug therapy are discussed.Introdução: Para além da infecção pelo Mycobacterium leprae, as reações tipo 1 e 2 representam eventos inflama- tórios agudos, no curso crónico da hanseníase multibacilar, mas que podem ser recorrentes e tardias. Caso Clínico: Jovem com quadro de reação tipo 2 no contexto de hanseníase borderline lepromatosa, persistente e de difícil condução clínica. Discussão: O caso ilustra o desafio diagnóstico na hanseníase com resposta inflamatória sistémica, mais expressiva que o quadro dermato – neurológico. São discutidas as implicações clínicas, histopatológicas e terapêuticas, além de fatores de risco para reação e a positividade da reação em cadeia da polimerase 8 anos após a alta da poliquimioterapiaSociedade Portuguesa de Dermatologia e Venereologia2020-01-11T00:00:00Zjournal articleinfo:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://doi.org/10.29021/spdv.77.4.1097oai:ojs.revista.spdv.com.pt:article/1097Journal of the Portuguese Society of Dermatology and Venereology; Vol 77 No 4 (2019): October - December; 357-362Revista da Sociedade Portuguesa de Dermatologia e Venereologia; v. 77 n. 4 (2019): Outubro - Dezembro; 357-3622182-24092182-2395reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAPporhttps://revista.spdv.com.pt/index.php/spdv/article/view/1097https://doi.org/10.29021/spdv.77.4.1097https://revista.spdv.com.pt/index.php/spdv/article/view/1097/808Franco Ferraz Santino, MarianaCuzzi, TulliaManta, Fernanda Saloum de NevesOliveira, Maria Leide W.info:eu-repo/semantics/openAccess2022-10-06T12:35:12Zoai:ojs.revista.spdv.com.pt:article/1097Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T16:11:10.437481Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv Persistent Leprosy Reaction 8 Years After the End of Therapy: Challenges for Doctors and Patients
Reação Hanseniásica Persistente 8 Anos Após Conclusão da Terapêutica: Desafio para Médicos e Pacientes
title Persistent Leprosy Reaction 8 Years After the End of Therapy: Challenges for Doctors and Patients
spellingShingle Persistent Leprosy Reaction 8 Years After the End of Therapy: Challenges for Doctors and Patients
Franco Ferraz Santino, Mariana
Leprosy/complications
Leprosy/therapy
Panniculitis
Lepra/complicações
Lepra/tratamento
Paniculite
title_short Persistent Leprosy Reaction 8 Years After the End of Therapy: Challenges for Doctors and Patients
title_full Persistent Leprosy Reaction 8 Years After the End of Therapy: Challenges for Doctors and Patients
title_fullStr Persistent Leprosy Reaction 8 Years After the End of Therapy: Challenges for Doctors and Patients
title_full_unstemmed Persistent Leprosy Reaction 8 Years After the End of Therapy: Challenges for Doctors and Patients
title_sort Persistent Leprosy Reaction 8 Years After the End of Therapy: Challenges for Doctors and Patients
author Franco Ferraz Santino, Mariana
author_facet Franco Ferraz Santino, Mariana
Cuzzi, Tullia
Manta, Fernanda Saloum de Neves
Oliveira, Maria Leide W.
author_role author
author2 Cuzzi, Tullia
Manta, Fernanda Saloum de Neves
Oliveira, Maria Leide W.
author2_role author
author
author
dc.contributor.author.fl_str_mv Franco Ferraz Santino, Mariana
Cuzzi, Tullia
Manta, Fernanda Saloum de Neves
Oliveira, Maria Leide W.
dc.subject.por.fl_str_mv Leprosy/complications
Leprosy/therapy
Panniculitis
Lepra/complicações
Lepra/tratamento
Paniculite
topic Leprosy/complications
Leprosy/therapy
Panniculitis
Lepra/complicações
Lepra/tratamento
Paniculite
description Introduction: In addition to infection with Mycobacterium leprae, type 1 and 2 reactions represent acute inflammatory events in the chronic course of multibacillary leprosy, which may persist for long periods. Case Report: A young woman presenting borderline lepromatous leprosy and persistent type 2 reaction with difficult clinical conduction. Discussion: The case illustrates the diagnostic challenge in leprosy with a systemic inflammatory response, more expressive than the dermato – neurological features. The clinical, histopathological and therapeutic implications, as well as risk factors for reaction and also polymerase chain reaction 8 years after being discharged from treatment of multidrug therapy are discussed.
publishDate 2020
dc.date.none.fl_str_mv 2020-01-11T00:00:00Z
dc.type.driver.fl_str_mv journal article
info:eu-repo/semantics/article
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv https://doi.org/10.29021/spdv.77.4.1097
oai:ojs.revista.spdv.com.pt:article/1097
url https://doi.org/10.29021/spdv.77.4.1097
identifier_str_mv oai:ojs.revista.spdv.com.pt:article/1097
dc.language.iso.fl_str_mv por
language por
dc.relation.none.fl_str_mv https://revista.spdv.com.pt/index.php/spdv/article/view/1097
https://doi.org/10.29021/spdv.77.4.1097
https://revista.spdv.com.pt/index.php/spdv/article/view/1097/808
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
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dc.publisher.none.fl_str_mv Sociedade Portuguesa de Dermatologia e Venereologia
publisher.none.fl_str_mv Sociedade Portuguesa de Dermatologia e Venereologia
dc.source.none.fl_str_mv Journal of the Portuguese Society of Dermatology and Venereology; Vol 77 No 4 (2019): October - December; 357-362
Revista da Sociedade Portuguesa de Dermatologia e Venereologia; v. 77 n. 4 (2019): Outubro - Dezembro; 357-362
2182-2409
2182-2395
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instacron:RCAAP
instname_str Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron_str RCAAP
institution RCAAP
reponame_str Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
collection Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
repository.name.fl_str_mv Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
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