The TLR1 gene is associated with higher protection from leprosy in women

Detalhes bibliográficos
Autor(a) principal: Niitsuma, Eyleen Nabyla Alvarenga
Data de Publicação: 2018
Outros Autores: Fernandes, Gabriel da Rocha, Félix, Francisco Carlos
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://www.arca.fiocruz.br/handle/icict/33774
Resumo: Instituto Federal de Educação, Ciência e Tecnologia do Norte de Minas Gerais. Almenara, MG, Brasil.
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spelling Niitsuma, Eyleen Nabyla AlvarengaFernandes, Gabriel da RochaFélix, Francisco Carlos2019-07-02T14:17:44Z2019-07-02T14:17:44Z2018NIITSUMA, Eyleen Nabyla Alvarenga; FERNANDES, Gabriel da Rocha; FÉLIX, Francisco Carlos. The TLR1 gene is associated with higher protection from leprosy in women. PLoS One, v. 13, n. 10, p. 1-10, 2018.1932-6203https://www.arca.fiocruz.br/handle/icict/3377410.1371/journal.pone.0205234engPublic Library of ScienceLepraHanseníaseLeprosyThe TLR1 gene is associated with higher protection from leprosy in womeninfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleInstituto Federal de Educação, Ciência e Tecnologia do Norte de Minas Gerais. Almenara, MG, Brasil.Fundação Oswaldo Cruz. Instituto René Rachou. Belo Horizonte, MG, Brasil.Universidade Federal de Minas Gerais. Escola de Enfermagem. Departamento de Enfermagem Materna e Infantil e Saúde Pública. Belo Horizonte, MG, Brasil.Leprosy is an infectious disease with a complex genetic and immunological background. Polymorphisms in genes that encode cytokines and receptors involved in the immune response, such as the Toll-like receptor 1 (TLR1), may be associated with disease risk. We hypothesized that polymorphisms in innate immunity genes confer susceptibility to leprosy that differs between women and men. In this study, we investigate sex differences in the association between a single nucleotide polymorphism (SNP) in TLR1 and Nucleotide-binding oligomerization domain containing 2 (NOD2) genes and leprosy susceptibility in 256 clinically classified leprosy patients and 233 control subjects in a Brazilian population. Our results showed no association between the SNP rs8057341 in NOD2 and leprosy in this population. However, the heterozygous genotype of the TLR1 SNP (rs4833095) showed a statistically significant association in women (OR = 0.54, P = 0.02). Our findings suggest that the TLR1 polymorphism was associated with an increased protection from leprosy in women.info:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-83082https://www.arca.fiocruz.br/bitstream/icict/33774/1/license.txt9193a7c197bc67acd023525e72a03240MD51ORIGINALThe TLR1 gene is associated with higher protection from leprosy in women.pdfThe TLR1 gene is associated with higher protection from leprosy in women.pdfapplication/pdf132966https://www.arca.fiocruz.br/bitstream/icict/33774/2/The%20TLR1%20gene%20is%20associated%20with%20higher%20protection%20from%20leprosy%20in%20women.pdf8106f10f3e33e7c27e71f572c94223afMD52TEXTThe TLR1 gene is associated with higher protection from leprosy in women.pdf.txtThe TLR1 gene is associated with higher protection from leprosy in women.pdf.txtExtracted 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dc.title.pt_BR.fl_str_mv The TLR1 gene is associated with higher protection from leprosy in women
title The TLR1 gene is associated with higher protection from leprosy in women
spellingShingle The TLR1 gene is associated with higher protection from leprosy in women
Niitsuma, Eyleen Nabyla Alvarenga
Lepra
Hanseníase
Leprosy
title_short The TLR1 gene is associated with higher protection from leprosy in women
title_full The TLR1 gene is associated with higher protection from leprosy in women
title_fullStr The TLR1 gene is associated with higher protection from leprosy in women
title_full_unstemmed The TLR1 gene is associated with higher protection from leprosy in women
title_sort The TLR1 gene is associated with higher protection from leprosy in women
author Niitsuma, Eyleen Nabyla Alvarenga
author_facet Niitsuma, Eyleen Nabyla Alvarenga
Fernandes, Gabriel da Rocha
Félix, Francisco Carlos
author_role author
author2 Fernandes, Gabriel da Rocha
Félix, Francisco Carlos
author2_role author
author
dc.contributor.author.fl_str_mv Niitsuma, Eyleen Nabyla Alvarenga
Fernandes, Gabriel da Rocha
Félix, Francisco Carlos
dc.subject.other.pt_BR.fl_str_mv Lepra
Hanseníase
topic Lepra
Hanseníase
Leprosy
dc.subject.en.pt_BR.fl_str_mv Leprosy
description Instituto Federal de Educação, Ciência e Tecnologia do Norte de Minas Gerais. Almenara, MG, Brasil.
publishDate 2018
dc.date.issued.fl_str_mv 2018
dc.date.accessioned.fl_str_mv 2019-07-02T14:17:44Z
dc.date.available.fl_str_mv 2019-07-02T14:17:44Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
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status_str publishedVersion
dc.identifier.citation.fl_str_mv NIITSUMA, Eyleen Nabyla Alvarenga; FERNANDES, Gabriel da Rocha; FÉLIX, Francisco Carlos. The TLR1 gene is associated with higher protection from leprosy in women. PLoS One, v. 13, n. 10, p. 1-10, 2018.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/33774
dc.identifier.issn.pt_BR.fl_str_mv 1932-6203
dc.identifier.doi.none.fl_str_mv 10.1371/journal.pone.0205234
identifier_str_mv NIITSUMA, Eyleen Nabyla Alvarenga; FERNANDES, Gabriel da Rocha; FÉLIX, Francisco Carlos. The TLR1 gene is associated with higher protection from leprosy in women. PLoS One, v. 13, n. 10, p. 1-10, 2018.
1932-6203
10.1371/journal.pone.0205234
url https://www.arca.fiocruz.br/handle/icict/33774
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Public Library of Science
publisher.none.fl_str_mv Public Library of Science
dc.source.none.fl_str_mv reponame:Repositório Institucional da FIOCRUZ (ARCA)
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instacron_str FIOCRUZ
institution FIOCRUZ
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