Mycobacterium tuberculosis lineage 4 comprises globally distributed and geographically restricted sublineages

Detalhes bibliográficos
Autor(a) principal: Stucki, David
Data de Publicação: 2016
Outros Autores: Brites, Daniela, Jeljeli, Leila, Coscolla, Mireia, Liu, Qingyun, Trauner, Andrej, Fenner, Lukas, Rutaihwa, Liliana, Borrell, Sonia, Saraiva, Margarida
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: http://hdl.handle.net/1822/44899
Resumo: Generalist and specialist species differ in the breadth of their ecological niches. Little is known about the niche width of obligate human pathogens. Here we analyzed a global collection of Mycobacterium tuberculosis lineage 4 clinical isolates, the most geographically widespread cause of human tuberculosis. We show that lineage 4 comprises globally distributed and geographically restricted sublineages, suggesting a distinction between generalists and specialists. Population genomic analyses showed that, whereas the majority of human T cell epitopes were conserved in all sublineages, the proportion of variable epitopes was higher in generalists. Our data further support a European origin for the most common generalist sublineage. Hence, the global success of lineage 4 reflects distinct strategies adopted by different sublineages and the influence of human migration.
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spelling Mycobacterium tuberculosis lineage 4 comprises globally distributed and geographically restricted sublineagesScience & TechnologyGeneralist and specialist species differ in the breadth of their ecological niches. Little is known about the niche width of obligate human pathogens. Here we analyzed a global collection of Mycobacterium tuberculosis lineage 4 clinical isolates, the most geographically widespread cause of human tuberculosis. We show that lineage 4 comprises globally distributed and geographically restricted sublineages, suggesting a distinction between generalists and specialists. Population genomic analyses showed that, whereas the majority of human T cell epitopes were conserved in all sublineages, the proportion of variable epitopes was higher in generalists. Our data further support a European origin for the most common generalist sublineage. Hence, the global success of lineage 4 reflects distinct strategies adopted by different sublineages and the influence of human migration.We thank S. Lecher, S. Li and J. Zallet for technical support. Calculations were performed at the sciCORE scientific computing core facility at the University of Basel. This work was supported by the Swiss National Science Foundation (grants 310030_166687 (S.G.) and 320030_153442 (M.E.) and Swiss HIV Cohort Study grant 740 to L.F.), the European Research Council (309540-EVODRTB to S.G.), TB-PAN-NET (FP7-223681 to S.N.), PathoNgenTrace projects (FP7-278864-2 to S.N.), SystemsX.ch (S.G.), the German Center for Infection Research (DZIF; S.N.), the Novartis Foundation (S.G.), the Natural Science Foundation of China (91631301 to Q.G.), and the National Institute of Allergy and Infectious Diseases (5U01-AI069924-05) of the US National Institutes of Health (M.E.).Nature Publishing Group[et. al.]Universidade do MinhoStucki, DavidBrites, DanielaJeljeli, LeilaCoscolla, MireiaLiu, QingyunTrauner, AndrejFenner, LukasRutaihwa, LilianaBorrell, SoniaSaraiva, Margarida20162016-01-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/1822/44899eng1061-403610.1038/ng.370427798628http://www.nature.com/ng/index.htmlinfo:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-07-21T12:15:06Zoai:repositorium.sdum.uminho.pt:1822/44899Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T19:07:32.369258Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv Mycobacterium tuberculosis lineage 4 comprises globally distributed and geographically restricted sublineages
title Mycobacterium tuberculosis lineage 4 comprises globally distributed and geographically restricted sublineages
spellingShingle Mycobacterium tuberculosis lineage 4 comprises globally distributed and geographically restricted sublineages
Stucki, David
Science & Technology
title_short Mycobacterium tuberculosis lineage 4 comprises globally distributed and geographically restricted sublineages
title_full Mycobacterium tuberculosis lineage 4 comprises globally distributed and geographically restricted sublineages
title_fullStr Mycobacterium tuberculosis lineage 4 comprises globally distributed and geographically restricted sublineages
title_full_unstemmed Mycobacterium tuberculosis lineage 4 comprises globally distributed and geographically restricted sublineages
title_sort Mycobacterium tuberculosis lineage 4 comprises globally distributed and geographically restricted sublineages
author Stucki, David
author_facet Stucki, David
Brites, Daniela
Jeljeli, Leila
Coscolla, Mireia
Liu, Qingyun
Trauner, Andrej
Fenner, Lukas
Rutaihwa, Liliana
Borrell, Sonia
Saraiva, Margarida
author_role author
author2 Brites, Daniela
Jeljeli, Leila
Coscolla, Mireia
Liu, Qingyun
Trauner, Andrej
Fenner, Lukas
Rutaihwa, Liliana
Borrell, Sonia
Saraiva, Margarida
author2_role author
author
author
author
author
author
author
author
author
dc.contributor.none.fl_str_mv [et. al.]
Universidade do Minho
dc.contributor.author.fl_str_mv Stucki, David
Brites, Daniela
Jeljeli, Leila
Coscolla, Mireia
Liu, Qingyun
Trauner, Andrej
Fenner, Lukas
Rutaihwa, Liliana
Borrell, Sonia
Saraiva, Margarida
dc.subject.por.fl_str_mv Science & Technology
topic Science & Technology
description Generalist and specialist species differ in the breadth of their ecological niches. Little is known about the niche width of obligate human pathogens. Here we analyzed a global collection of Mycobacterium tuberculosis lineage 4 clinical isolates, the most geographically widespread cause of human tuberculosis. We show that lineage 4 comprises globally distributed and geographically restricted sublineages, suggesting a distinction between generalists and specialists. Population genomic analyses showed that, whereas the majority of human T cell epitopes were conserved in all sublineages, the proportion of variable epitopes was higher in generalists. Our data further support a European origin for the most common generalist sublineage. Hence, the global success of lineage 4 reflects distinct strategies adopted by different sublineages and the influence of human migration.
publishDate 2016
dc.date.none.fl_str_mv 2016
2016-01-01T00:00:00Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/1822/44899
url http://hdl.handle.net/1822/44899
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 1061-4036
10.1038/ng.3704
27798628
http://www.nature.com/ng/index.html
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Nature Publishing Group
publisher.none.fl_str_mv Nature Publishing Group
dc.source.none.fl_str_mv reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
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repository.name.fl_str_mv Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
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