Mycobacterium tuberculosis lineage 4 comprises globally distributed and geographically restricted sublineages

Stucki, David; Brites, Daniela; Jeljeli, Leïla; Coscolla, Mireia; Liu, Qingyun; Trauner, Andrej; Fenner, Lukas; Rutaihwa, Liliana; Borrell, Sonia; Luo, Tao; Gao, Qian; Kato-Maeda, Midori; Ballif, Marie; Egger, Matthias; Macedo, Rita; Mardassi, Helmi; Moreno, Milagros; Vilanova, Griselda Tudo; Fyfe, Janet; Globan, Maria; Thomas, Jackson; Jamieson, Frances; Guthrie, Jennifer L.; Asante-Poku, Adwoa; Yeboah-Manu, Dorothy; Wampande, Eddie; Ssengooba, Willy; Joloba, Moses; Boom, W. Henry; Basu, Indira; Bower, James; Saraiva, Margarida; Vasconcellos, Sidra E.G.; Suffys, Philip; Koch, Anastasia; Wilkinson, Robert; Gail-Bekker, Linda; Malla, Bijaya; Ley, Serej D.; Beck, Hans-Peter; de Jong, Bouke C.; Toit, Kadri; Sanchez-Padilla, Elisabeth; Bonnet, Maryline; Gil-Brusola, Ana; Frank, Matthias; Penlap Beng, Veronique N.; Eisenach, Kathleen; Alani, Issam; Ndung'u, Perpetual Wangui; Revathi, Gunturu; Gehre, Florian; Akter, Suriya; Ntoumi, Francine; Stewart-Isherwood, Lynsey; Ntinginya, Nyanda E.; Rachow, Andrea; Hoelscher, Michael; Cirillo, Daniela Maria; Skenders, Girts; Hoffner, Sven; Bakonyte, Daiva; Stakenas, Petras; Diel, Roland; Crudu, Valeriu; Moldovan, Olga; Al-Hajoj, Sahal; Otero, Larissa; Barletta, Francesca; Carter, E. Jane; Diero, Lameck; Supply, Philip; Comas, Iñaki; Niemann, Stefan; Gagneux, Sebastien

Mycobacterium tuberculosis lineage 4 comprises globally distributed and geographically restricted sublineages

Detalhes bibliográficos
Autor(a) principal:	Stucki, David
Data de Publicação:	2016
Outros Autores:	Brites, Daniela, Jeljeli, Leïla, Coscolla, Mireia, Liu, Qingyun, Trauner, Andrej, Fenner, Lukas, Rutaihwa, Liliana, Borrell, Sonia, Luo, Tao, Gao, Qian, Kato-Maeda, Midori, Ballif, Marie, Egger, Matthias, Macedo, Rita, Mardassi, Helmi, Moreno, Milagros, Vilanova, Griselda Tudo, Fyfe, Janet, Globan, Maria, Thomas, Jackson, Jamieson, Frances, Guthrie, Jennifer L., Asante-Poku, Adwoa, Yeboah-Manu, Dorothy, Wampande, Eddie, Ssengooba, Willy, Joloba, Moses, Boom, W. Henry, Basu, Indira, Bower, James, Saraiva, Margarida, Vasconcellos, Sidra E.G., Suffys, Philip, Koch, Anastasia, Wilkinson, Robert, Gail-Bekker, Linda, Malla, Bijaya, Ley, Serej D., Beck, Hans-Peter, de Jong, Bouke C., Toit, Kadri, Sanchez-Padilla, Elisabeth, Bonnet, Maryline, Gil-Brusola, Ana, Frank, Matthias, Penlap Beng, Veronique N., Eisenach, Kathleen, Alani, Issam, Ndung'u, Perpetual Wangui, Revathi, Gunturu, Gehre, Florian, Akter, Suriya, Ntoumi, Francine, Stewart-Isherwood, Lynsey, Ntinginya, Nyanda E., Rachow, Andrea, Hoelscher, Michael, Cirillo, Daniela Maria, Skenders, Girts, Hoffner, Sven, Bakonyte, Daiva, Stakenas, Petras, Diel, Roland, Crudu, Valeriu, Moldovan, Olga, Al-Hajoj, Sahal, Otero, Larissa, Barletta, Francesca, Carter, E. Jane, Diero, Lameck, Supply, Philip, Comas, Iñaki, Niemann, Stefan, Gagneux, Sebastien
Tipo de documento:	Artigo
Idioma:	eng
Título da fonte:	Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo:	http://hdl.handle.net/10400.18/7943
Resumo:	Rita Macedo - INSA

Metadados do item

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network_name_str	Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
repository_id_str	7160
spelling	Mycobacterium tuberculosis lineage 4 comprises globally distributed and geographically restricted sublineagesDNA, BacterialGenomicsGenotypeGlobal HealthHumansMycobacterium tuberculosisPhylogeographyPolymorphism, GeneticTuberculosisInfecções RespiratóriasRita Macedo - INSAGeneralist and specialist species differ in the breadth of their ecological niches. Little is known about the niche width of obligate human pathogens. Here we analyzed a global collection of Mycobacterium tuberculosis lineage 4 clinical isolates, the most geographically widespread cause of human tuberculosis. We show that lineage 4 comprises globally distributed and geographically restricted sublineages, suggesting a distinction between generalists and specialists. Population genomic analyses showed that, whereas the majority of human T cell epitopes were conserved in all sublineages, the proportion of variable epitopes was higher in generalists. Our data further support a European origin for the most common generalist sublineage. Hence, the global success of lineage 4 reflects distinct strategies adopted by different sublineages and the influence of human migration.This work was supported by the Swiss National Science Foundation (grants 310030_166687 (S.G.) and 320030_153442 (M.E.), Swiss HIV Cohort Study grant 740 (L.F.)), the European Research Council (309540-EVODRTB, S.G.), TB-PAN-NET (FP7-223681, S.N.), PathoNgenTrace (FP7- 278864-2, S.N.) projects, SystemsX.ch (S.G.), the German Center for Infection Research (DZIF, S.N.), the Novartis Foundation (S.G.), and the Natural Science Foundation of China (91631301, Q.G.).Nature ResearchRepositório Científico do Instituto Nacional de SaúdeStucki, DavidBrites, DanielaJeljeli, LeïlaCoscolla, MireiaLiu, QingyunTrauner, AndrejFenner, LukasRutaihwa, LilianaBorrell, SoniaLuo, TaoGao, QianKato-Maeda, MidoriBallif, MarieEgger, MatthiasMacedo, RitaMardassi, HelmiMoreno, MilagrosVilanova, Griselda TudoFyfe, JanetGloban, MariaThomas, JacksonJamieson, FrancesGuthrie, Jennifer L.Asante-Poku, AdwoaYeboah-Manu, DorothyWampande, EddieSsengooba, WillyJoloba, MosesBoom, W. HenryBasu, IndiraBower, JamesSaraiva, MargaridaVasconcellos, Sidra E.G.Suffys, PhilipKoch, AnastasiaWilkinson, RobertGail-Bekker, LindaMalla, BijayaLey, Serej D.Beck, Hans-Peterde Jong, Bouke C.Toit, KadriSanchez-Padilla, ElisabethBonnet, MarylineGil-Brusola, AnaFrank, MatthiasPenlap Beng, Veronique N.Eisenach, KathleenAlani, IssamNdung'u, Perpetual WanguiRevathi, GunturuGehre, FlorianAkter, SuriyaNtoumi, FrancineStewart-Isherwood, LynseyNtinginya, Nyanda E.Rachow, AndreaHoelscher, MichaelCirillo, Daniela MariaSkenders, GirtsHoffner, SvenBakonyte, DaivaStakenas, PetrasDiel, RolandCrudu, ValeriuMoldovan, OlgaAl-Hajoj, SahalOtero, LarissaBarletta, FrancescaCarter, E. JaneDiero, LameckSupply, PhilipComas, IñakiNiemann, StefanGagneux, Sebastien2022-02-09T15:20:00Z2016-10-312016-10-31T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10400.18/7943engNat Genet. 2016 Dec;48(12):1535-1543. doi: 10.1038/ng.3704. Epub 2016 Oct 311061-403610.1038/ng.3704info:eu-repo/semantics/embargoedAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-07-20T15:41:18Zoai:repositorio.insa.pt:10400.18/7943Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T18:40:53.872975Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv	Mycobacterium tuberculosis lineage 4 comprises globally distributed and geographically restricted sublineages
title	Mycobacterium tuberculosis lineage 4 comprises globally distributed and geographically restricted sublineages
spellingShingle	Mycobacterium tuberculosis lineage 4 comprises globally distributed and geographically restricted sublineages Stucki, David DNA, Bacterial Genomics Genotype Global Health Humans Mycobacterium tuberculosis Phylogeography Polymorphism, Genetic Tuberculosis Infecções Respiratórias
title_short	Mycobacterium tuberculosis lineage 4 comprises globally distributed and geographically restricted sublineages
title_full	Mycobacterium tuberculosis lineage 4 comprises globally distributed and geographically restricted sublineages
title_fullStr	Mycobacterium tuberculosis lineage 4 comprises globally distributed and geographically restricted sublineages
title_full_unstemmed	Mycobacterium tuberculosis lineage 4 comprises globally distributed and geographically restricted sublineages
title_sort	Mycobacterium tuberculosis lineage 4 comprises globally distributed and geographically restricted sublineages
author	Stucki, David
author_facet	Stucki, David Brites, Daniela Jeljeli, Leïla Coscolla, Mireia Liu, Qingyun Trauner, Andrej Fenner, Lukas Rutaihwa, Liliana Borrell, Sonia Luo, Tao Gao, Qian Kato-Maeda, Midori Ballif, Marie Egger, Matthias Macedo, Rita Mardassi, Helmi Moreno, Milagros Vilanova, Griselda Tudo Fyfe, Janet Globan, Maria Thomas, Jackson Jamieson, Frances Guthrie, Jennifer L. Asante-Poku, Adwoa Yeboah-Manu, Dorothy Wampande, Eddie Ssengooba, Willy Joloba, Moses Boom, W. Henry Basu, Indira Bower, James Saraiva, Margarida Vasconcellos, Sidra E.G. Suffys, Philip Koch, Anastasia Wilkinson, Robert Gail-Bekker, Linda Malla, Bijaya Ley, Serej D. Beck, Hans-Peter de Jong, Bouke C. Toit, Kadri Sanchez-Padilla, Elisabeth Bonnet, Maryline Gil-Brusola, Ana Frank, Matthias Penlap Beng, Veronique N. Eisenach, Kathleen Alani, Issam Ndung'u, Perpetual Wangui Revathi, Gunturu Gehre, Florian Akter, Suriya Ntoumi, Francine Stewart-Isherwood, Lynsey Ntinginya, Nyanda E. Rachow, Andrea Hoelscher, Michael Cirillo, Daniela Maria Skenders, Girts Hoffner, Sven Bakonyte, Daiva Stakenas, Petras Diel, Roland Crudu, Valeriu Moldovan, Olga Al-Hajoj, Sahal Otero, Larissa Barletta, Francesca Carter, E. Jane Diero, Lameck Supply, Philip Comas, Iñaki Niemann, Stefan Gagneux, Sebastien
author_role	author
author2	Brites, Daniela Jeljeli, Leïla Coscolla, Mireia Liu, Qingyun Trauner, Andrej Fenner, Lukas Rutaihwa, Liliana Borrell, Sonia Luo, Tao Gao, Qian Kato-Maeda, Midori Ballif, Marie Egger, Matthias Macedo, Rita Mardassi, Helmi Moreno, Milagros Vilanova, Griselda Tudo Fyfe, Janet Globan, Maria Thomas, Jackson Jamieson, Frances Guthrie, Jennifer L. Asante-Poku, Adwoa Yeboah-Manu, Dorothy Wampande, Eddie Ssengooba, Willy Joloba, Moses Boom, W. Henry Basu, Indira Bower, James Saraiva, Margarida Vasconcellos, Sidra E.G. Suffys, Philip Koch, Anastasia Wilkinson, Robert Gail-Bekker, Linda Malla, Bijaya Ley, Serej D. Beck, Hans-Peter de Jong, Bouke C. Toit, Kadri Sanchez-Padilla, Elisabeth Bonnet, Maryline Gil-Brusola, Ana Frank, Matthias Penlap Beng, Veronique N. Eisenach, Kathleen Alani, Issam Ndung'u, Perpetual Wangui Revathi, Gunturu Gehre, Florian Akter, Suriya Ntoumi, Francine Stewart-Isherwood, Lynsey Ntinginya, Nyanda E. Rachow, Andrea Hoelscher, Michael Cirillo, Daniela Maria Skenders, Girts Hoffner, Sven Bakonyte, Daiva Stakenas, Petras Diel, Roland Crudu, Valeriu Moldovan, Olga Al-Hajoj, Sahal Otero, Larissa Barletta, Francesca Carter, E. Jane Diero, Lameck Supply, Philip Comas, Iñaki Niemann, Stefan Gagneux, Sebastien
author2_role	author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author
dc.contributor.none.fl_str_mv	Repositório Científico do Instituto Nacional de Saúde
dc.contributor.author.fl_str_mv	Stucki, David Brites, Daniela Jeljeli, Leïla Coscolla, Mireia Liu, Qingyun Trauner, Andrej Fenner, Lukas Rutaihwa, Liliana Borrell, Sonia Luo, Tao Gao, Qian Kato-Maeda, Midori Ballif, Marie Egger, Matthias Macedo, Rita Mardassi, Helmi Moreno, Milagros Vilanova, Griselda Tudo Fyfe, Janet Globan, Maria Thomas, Jackson Jamieson, Frances Guthrie, Jennifer L. Asante-Poku, Adwoa Yeboah-Manu, Dorothy Wampande, Eddie Ssengooba, Willy Joloba, Moses Boom, W. Henry Basu, Indira Bower, James Saraiva, Margarida Vasconcellos, Sidra E.G. Suffys, Philip Koch, Anastasia Wilkinson, Robert Gail-Bekker, Linda Malla, Bijaya Ley, Serej D. Beck, Hans-Peter de Jong, Bouke C. Toit, Kadri Sanchez-Padilla, Elisabeth Bonnet, Maryline Gil-Brusola, Ana Frank, Matthias Penlap Beng, Veronique N. Eisenach, Kathleen Alani, Issam Ndung'u, Perpetual Wangui Revathi, Gunturu Gehre, Florian Akter, Suriya Ntoumi, Francine Stewart-Isherwood, Lynsey Ntinginya, Nyanda E. Rachow, Andrea Hoelscher, Michael Cirillo, Daniela Maria Skenders, Girts Hoffner, Sven Bakonyte, Daiva Stakenas, Petras Diel, Roland Crudu, Valeriu Moldovan, Olga Al-Hajoj, Sahal Otero, Larissa Barletta, Francesca Carter, E. Jane Diero, Lameck Supply, Philip Comas, Iñaki Niemann, Stefan Gagneux, Sebastien
dc.subject.por.fl_str_mv	DNA, Bacterial Genomics Genotype Global Health Humans Mycobacterium tuberculosis Phylogeography Polymorphism, Genetic Tuberculosis Infecções Respiratórias
topic	DNA, Bacterial Genomics Genotype Global Health Humans Mycobacterium tuberculosis Phylogeography Polymorphism, Genetic Tuberculosis Infecções Respiratórias
description	Rita Macedo - INSA
publishDate	2016
dc.date.none.fl_str_mv	2016-10-31 2016-10-31T00:00:00Z 2022-02-09T15:20:00Z
dc.type.status.fl_str_mv	info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv	info:eu-repo/semantics/article
format	article
status_str	publishedVersion
dc.identifier.uri.fl_str_mv	http://hdl.handle.net/10400.18/7943
url	http://hdl.handle.net/10400.18/7943
dc.language.iso.fl_str_mv	eng
language	eng
dc.relation.none.fl_str_mv	Nat Genet. 2016 Dec;48(12):1535-1543. doi: 10.1038/ng.3704. Epub 2016 Oct 31 1061-4036 10.1038/ng.3704
dc.rights.driver.fl_str_mv	info:eu-repo/semantics/embargoedAccess
eu_rights_str_mv	embargoedAccess
dc.format.none.fl_str_mv	application/pdf
dc.publisher.none.fl_str_mv	Nature Research
publisher.none.fl_str_mv	Nature Research
dc.source.none.fl_str_mv	reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação instacron:RCAAP
instname_str	Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron_str	RCAAP
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repository.name.fl_str_mv	Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
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Mycobacterium tuberculosis lineage 4 comprises globally distributed and geographically restricted sublineages

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