Extracellular vesicles in CNS developmental disorders

Detalhes bibliográficos
Autor(a) principal: Gomes, Ana Rita
Data de Publicação: 2020
Outros Autores: Sangani, Nasim Bahram, Fernandes, Tiago G., Diogo, Maria Margarida, Curfs, Leopold M. G., Reutelingsperger, Chris P.
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: http://hdl.handle.net/10451/47166
Resumo: © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
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spelling Extracellular vesicles in CNS developmental disordersCNSAstrocytesExosomesExtracellular vesiclesGliaMicrovesiclesNeurodevelopmental disordersNeurons© 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).The central nervous system (CNS) is the most complex structure in the body, consisting of multiple cell types with distinct morphology and function. Development of the neuronal circuit and its function rely on a continuous crosstalk between neurons and non-neural cells. It has been widely accepted that extracellular vesicles (EVs), mainly exosomes, are effective entities responsible for intercellular CNS communication. They contain membrane and cytoplasmic proteins, lipids, non-coding RNAs, microRNAs and mRNAs. Their cargo modulates gene and protein expression in recipient cells. Several lines of evidence indicate that EVs play a role in modifying signal transduction with subsequent physiological changes in neurogenesis, gliogenesis, synaptogenesis and network circuit formation and activity, as well as synaptic pruning and myelination. Several studies demonstrate that neural and non-neural EVs play an important role in physiological and pathological neurodevelopment. The present review discusses the role of EVs in various neurodevelopmental disorders and the prospects of using EVs as disease biomarkers and therapeutics.MDPIRepositório da Universidade de LisboaGomes, Ana RitaSangani, Nasim BahramFernandes, Tiago G.Diogo, Maria MargaridaCurfs, Leopold M. G.Reutelingsperger, Chris P.2021-03-30T15:57:07Z20202020-01-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10451/47166engInt J Mol Sci. 2020 Dec 11;21(24):94281661-659610.3390/ijms212494281422-0067info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-11-08T16:49:52Zoai:repositorio.ul.pt:10451/47166Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T21:59:14.953879Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv Extracellular vesicles in CNS developmental disorders
title Extracellular vesicles in CNS developmental disorders
spellingShingle Extracellular vesicles in CNS developmental disorders
Gomes, Ana Rita
CNS
Astrocytes
Exosomes
Extracellular vesicles
Glia
Microvesicles
Neurodevelopmental disorders
Neurons
title_short Extracellular vesicles in CNS developmental disorders
title_full Extracellular vesicles in CNS developmental disorders
title_fullStr Extracellular vesicles in CNS developmental disorders
title_full_unstemmed Extracellular vesicles in CNS developmental disorders
title_sort Extracellular vesicles in CNS developmental disorders
author Gomes, Ana Rita
author_facet Gomes, Ana Rita
Sangani, Nasim Bahram
Fernandes, Tiago G.
Diogo, Maria Margarida
Curfs, Leopold M. G.
Reutelingsperger, Chris P.
author_role author
author2 Sangani, Nasim Bahram
Fernandes, Tiago G.
Diogo, Maria Margarida
Curfs, Leopold M. G.
Reutelingsperger, Chris P.
author2_role author
author
author
author
author
dc.contributor.none.fl_str_mv Repositório da Universidade de Lisboa
dc.contributor.author.fl_str_mv Gomes, Ana Rita
Sangani, Nasim Bahram
Fernandes, Tiago G.
Diogo, Maria Margarida
Curfs, Leopold M. G.
Reutelingsperger, Chris P.
dc.subject.por.fl_str_mv CNS
Astrocytes
Exosomes
Extracellular vesicles
Glia
Microvesicles
Neurodevelopmental disorders
Neurons
topic CNS
Astrocytes
Exosomes
Extracellular vesicles
Glia
Microvesicles
Neurodevelopmental disorders
Neurons
description © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
publishDate 2020
dc.date.none.fl_str_mv 2020
2020-01-01T00:00:00Z
2021-03-30T15:57:07Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
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status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/10451/47166
url http://hdl.handle.net/10451/47166
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv Int J Mol Sci. 2020 Dec 11;21(24):9428
1661-6596
10.3390/ijms21249428
1422-0067
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
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publisher.none.fl_str_mv MDPI
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