Extracellular vesicle interactions with the external and internal exposome in mediating carcinogenesis
Autor(a) principal: | |
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Data de Publicação: | 2021 |
Outros Autores: | , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UNESP |
Texto Completo: | http://dx.doi.org/10.1016/j.mam.2021.101039 http://hdl.handle.net/11449/222603 |
Resumo: | The influence of environmental factors on an individual, from conception onwards, is defined as the exposome. It can be categorized into the external exposome, which includes external factors such as air pollution, chemical contaminants, and diet, and the internal exposome, which is unique to an individual, and involves age, physiology, and their genetic profile. The effect of external exposures on the internal exposome, or genetic profile, can be determined through omics analyses. However, this is often compromised due to low sample quantity and cost. Therefore, identification of other factors that can provide an insight into the cellular profile of an individual, provides an exciting avenue, and an emerging field is that of extracellular vesicles (EVs). Recently, our understanding of how cells can communicate with each other has shifted to recognise the role of EVs. EVs are secreted by all living cells, and have been identified in all biological fluids studied so far. They transport bioactive molecules (e.g., proteins, miRNAs, and DNA), and their release can be regulated by the cellular microenvironment. Analysis of EVs in respond to environmental factors might provide novel insights into the role of tumour EVs in carcinogenesis. Not only will EVs give some insight into the tumour cells themselves but they will also provide a better understanding of how cells communicate with one another, contributing to cancer progression. Moreover, characterising the content and functions of tumour-derived EVs has the potential to overcome the current challenges to improve cancer patient outcomes. For example, the identification of EVs targets for therapeutic interventions and tumour EVs biomarkers could facilitate the development of early screening for several cancers. The aim of this review, thus, is to discuss the overall role of EVs in response to the various external and internal signals in cancer. We will specifically highlight the biogenesis, secretion, and content of EVs in response to oncogenic transformation and metabolic regulators in cancer. |
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Extracellular vesicle interactions with the external and internal exposome in mediating carcinogenesisCancerExosomesExposomeExtracellular vesiclesThe influence of environmental factors on an individual, from conception onwards, is defined as the exposome. It can be categorized into the external exposome, which includes external factors such as air pollution, chemical contaminants, and diet, and the internal exposome, which is unique to an individual, and involves age, physiology, and their genetic profile. The effect of external exposures on the internal exposome, or genetic profile, can be determined through omics analyses. However, this is often compromised due to low sample quantity and cost. Therefore, identification of other factors that can provide an insight into the cellular profile of an individual, provides an exciting avenue, and an emerging field is that of extracellular vesicles (EVs). Recently, our understanding of how cells can communicate with each other has shifted to recognise the role of EVs. EVs are secreted by all living cells, and have been identified in all biological fluids studied so far. They transport bioactive molecules (e.g., proteins, miRNAs, and DNA), and their release can be regulated by the cellular microenvironment. Analysis of EVs in respond to environmental factors might provide novel insights into the role of tumour EVs in carcinogenesis. Not only will EVs give some insight into the tumour cells themselves but they will also provide a better understanding of how cells communicate with one another, contributing to cancer progression. Moreover, characterising the content and functions of tumour-derived EVs has the potential to overcome the current challenges to improve cancer patient outcomes. For example, the identification of EVs targets for therapeutic interventions and tumour EVs biomarkers could facilitate the development of early screening for several cancers. The aim of this review, thus, is to discuss the overall role of EVs in response to the various external and internal signals in cancer. We will specifically highlight the biogenesis, secretion, and content of EVs in response to oncogenic transformation and metabolic regulators in cancer.Fondo Nacional de Desarrollo Científico y TecnológicoNational Health and Medical Research CouncilOvarian Cancer Research FoundationMedical Research FoundationWilson FoundationExosome Biology Laboratory Centre for Clinical Diagnostics University of Queensland Centre for Clinical Research Royal Brisbane and Women's Hospital The University of QueenslandCellular and Molecular Physiology Laboratory (CMPL) Department of Obstetrics Division of Obstetrics and Gynaecology School of Medicine Faculty of Medicine Pontificia Universidad Católica de ChileDepartment of Physiology Faculty of Pharmacy Universidad de Sevilla, E-41012Medical School (Faculty of Medicine) São Paulo State University (UNESP)University of Queensland Centre for Clinical Research (UQCCR) Faculty of Medicine and Biomedical Sciences University of QueenslandDepartment of Pathology and Medical Biology Division of Pathology University of Groningen University Medical Center Groningen (UMCG)Departamento de Investigación Postgrado y Educación Continua (DIPEC) Facultad de Ciencias de la Salud Universidad del AlbaMedical School (Faculty of Medicine) São Paulo State University (UNESP)The University of QueenslandPontificia Universidad Católica de ChileUniversidad de SevillaUniversidade Estadual Paulista (UNESP)University of QueenslandUniversity Medical Center Groningen (UMCG)Universidad del AlbaKalita-de Croft, PriyakshiSharma, ShaynaSobrevia, Luis [UNESP]Salomon, Carlos2022-04-28T19:45:45Z2022-04-28T19:45:45Z2021-01-01info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articlehttp://dx.doi.org/10.1016/j.mam.2021.101039Molecular Aspects of Medicine.1872-94520098-2997http://hdl.handle.net/11449/22260310.1016/j.mam.2021.1010392-s2.0-85116765113Scopusreponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengMolecular Aspects of Medicineinfo:eu-repo/semantics/openAccess2022-04-28T19:45:45Zoai:repositorio.unesp.br:11449/222603Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestopendoar:29462022-04-28T19:45:45Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false |
dc.title.none.fl_str_mv |
Extracellular vesicle interactions with the external and internal exposome in mediating carcinogenesis |
title |
Extracellular vesicle interactions with the external and internal exposome in mediating carcinogenesis |
spellingShingle |
Extracellular vesicle interactions with the external and internal exposome in mediating carcinogenesis Kalita-de Croft, Priyakshi Cancer Exosomes Exposome Extracellular vesicles |
title_short |
Extracellular vesicle interactions with the external and internal exposome in mediating carcinogenesis |
title_full |
Extracellular vesicle interactions with the external and internal exposome in mediating carcinogenesis |
title_fullStr |
Extracellular vesicle interactions with the external and internal exposome in mediating carcinogenesis |
title_full_unstemmed |
Extracellular vesicle interactions with the external and internal exposome in mediating carcinogenesis |
title_sort |
Extracellular vesicle interactions with the external and internal exposome in mediating carcinogenesis |
author |
Kalita-de Croft, Priyakshi |
author_facet |
Kalita-de Croft, Priyakshi Sharma, Shayna Sobrevia, Luis [UNESP] Salomon, Carlos |
author_role |
author |
author2 |
Sharma, Shayna Sobrevia, Luis [UNESP] Salomon, Carlos |
author2_role |
author author author |
dc.contributor.none.fl_str_mv |
The University of Queensland Pontificia Universidad Católica de Chile Universidad de Sevilla Universidade Estadual Paulista (UNESP) University of Queensland University Medical Center Groningen (UMCG) Universidad del Alba |
dc.contributor.author.fl_str_mv |
Kalita-de Croft, Priyakshi Sharma, Shayna Sobrevia, Luis [UNESP] Salomon, Carlos |
dc.subject.por.fl_str_mv |
Cancer Exosomes Exposome Extracellular vesicles |
topic |
Cancer Exosomes Exposome Extracellular vesicles |
description |
The influence of environmental factors on an individual, from conception onwards, is defined as the exposome. It can be categorized into the external exposome, which includes external factors such as air pollution, chemical contaminants, and diet, and the internal exposome, which is unique to an individual, and involves age, physiology, and their genetic profile. The effect of external exposures on the internal exposome, or genetic profile, can be determined through omics analyses. However, this is often compromised due to low sample quantity and cost. Therefore, identification of other factors that can provide an insight into the cellular profile of an individual, provides an exciting avenue, and an emerging field is that of extracellular vesicles (EVs). Recently, our understanding of how cells can communicate with each other has shifted to recognise the role of EVs. EVs are secreted by all living cells, and have been identified in all biological fluids studied so far. They transport bioactive molecules (e.g., proteins, miRNAs, and DNA), and their release can be regulated by the cellular microenvironment. Analysis of EVs in respond to environmental factors might provide novel insights into the role of tumour EVs in carcinogenesis. Not only will EVs give some insight into the tumour cells themselves but they will also provide a better understanding of how cells communicate with one another, contributing to cancer progression. Moreover, characterising the content and functions of tumour-derived EVs has the potential to overcome the current challenges to improve cancer patient outcomes. For example, the identification of EVs targets for therapeutic interventions and tumour EVs biomarkers could facilitate the development of early screening for several cancers. The aim of this review, thus, is to discuss the overall role of EVs in response to the various external and internal signals in cancer. We will specifically highlight the biogenesis, secretion, and content of EVs in response to oncogenic transformation and metabolic regulators in cancer. |
publishDate |
2021 |
dc.date.none.fl_str_mv |
2021-01-01 2022-04-28T19:45:45Z 2022-04-28T19:45:45Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://dx.doi.org/10.1016/j.mam.2021.101039 Molecular Aspects of Medicine. 1872-9452 0098-2997 http://hdl.handle.net/11449/222603 10.1016/j.mam.2021.101039 2-s2.0-85116765113 |
url |
http://dx.doi.org/10.1016/j.mam.2021.101039 http://hdl.handle.net/11449/222603 |
identifier_str_mv |
Molecular Aspects of Medicine. 1872-9452 0098-2997 10.1016/j.mam.2021.101039 2-s2.0-85116765113 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
Molecular Aspects of Medicine |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.source.none.fl_str_mv |
Scopus reponame:Repositório Institucional da UNESP instname:Universidade Estadual Paulista (UNESP) instacron:UNESP |
instname_str |
Universidade Estadual Paulista (UNESP) |
instacron_str |
UNESP |
institution |
UNESP |
reponame_str |
Repositório Institucional da UNESP |
collection |
Repositório Institucional da UNESP |
repository.name.fl_str_mv |
Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP) |
repository.mail.fl_str_mv |
|
_version_ |
1799965202618253312 |