Chiral separation by SMB chromatography
Autor(a) principal: | |
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Data de Publicação: | 2000 |
Outros Autores: | , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
Texto Completo: | http://hdl.handle.net/10198/1152 |
Resumo: | The paper deals with chiral separation by simulated moving bed (SMB) chromatography. A model for the prediction of the cyclic steady-state performance of the SMB, based on the analogy with the true moving bed (TMB), is developed assuming multicomponent adsorption equilibria, axial dispersion flow and the linear driving force approximation to describe the intraparticle mass transfer rate. The simulation package is used to predict the effect of operating variables on the process performance and to define the regions for enantiomers separation. The influence of mass transfer resistance in the separation region is analyzed. A practical tool for choosing the better SMB operating conditions as a function of the feed flow-rate is proposed. The experimental operation of a pilot unit of SMB, Licosep 12-26 (Novasep, France), is carried out for the separation of enantiomers and illustrated with two systems: the bi-naphthol and the chiral epoxide enantiomers. Experimental results and model predictions are compared in terms of process performance and internal concentration profiles. |
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Chiral separation by SMB chromatographySimulated moving bed chromatographyComputer simulation and optimizationChiral separationBi-naphthol enantiomersChiral epoxide enantiomersThe paper deals with chiral separation by simulated moving bed (SMB) chromatography. A model for the prediction of the cyclic steady-state performance of the SMB, based on the analogy with the true moving bed (TMB), is developed assuming multicomponent adsorption equilibria, axial dispersion flow and the linear driving force approximation to describe the intraparticle mass transfer rate. The simulation package is used to predict the effect of operating variables on the process performance and to define the regions for enantiomers separation. The influence of mass transfer resistance in the separation region is analyzed. A practical tool for choosing the better SMB operating conditions as a function of the feed flow-rate is proposed. The experimental operation of a pilot unit of SMB, Licosep 12-26 (Novasep, France), is carried out for the separation of enantiomers and illustrated with two systems: the bi-naphthol and the chiral epoxide enantiomers. Experimental results and model predictions are compared in terms of process performance and internal concentration profiles.ElsevierBiblioteca Digital do IPBPais, Luís S.Loureiro, José M.Rodrigues, Alírio200020002000-01-01T00:00:00Z2000-01-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10198/1152engengPais, L.S.; Loureiro, J.M.; Rodrigues, A.E. (2000). Chiral separation by SMB chromatography. Separation and Purification Technology. ISSN 1383-5866. 20:1, p.67-771383-5866Sep. Purif. Technology10.1016/S1383-5866(00)00063-0info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-11-21T10:04:29Zoai:bibliotecadigital.ipb.pt:10198/1152Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T22:54:43.032643Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse |
dc.title.none.fl_str_mv |
Chiral separation by SMB chromatography |
title |
Chiral separation by SMB chromatography |
spellingShingle |
Chiral separation by SMB chromatography Pais, Luís S. Simulated moving bed chromatography Computer simulation and optimization Chiral separation Bi-naphthol enantiomers Chiral epoxide enantiomers |
title_short |
Chiral separation by SMB chromatography |
title_full |
Chiral separation by SMB chromatography |
title_fullStr |
Chiral separation by SMB chromatography |
title_full_unstemmed |
Chiral separation by SMB chromatography |
title_sort |
Chiral separation by SMB chromatography |
author |
Pais, Luís S. |
author_facet |
Pais, Luís S. Loureiro, José M. Rodrigues, Alírio |
author_role |
author |
author2 |
Loureiro, José M. Rodrigues, Alírio |
author2_role |
author author |
dc.contributor.none.fl_str_mv |
Biblioteca Digital do IPB |
dc.contributor.author.fl_str_mv |
Pais, Luís S. Loureiro, José M. Rodrigues, Alírio |
dc.subject.por.fl_str_mv |
Simulated moving bed chromatography Computer simulation and optimization Chiral separation Bi-naphthol enantiomers Chiral epoxide enantiomers |
topic |
Simulated moving bed chromatography Computer simulation and optimization Chiral separation Bi-naphthol enantiomers Chiral epoxide enantiomers |
description |
The paper deals with chiral separation by simulated moving bed (SMB) chromatography. A model for the prediction of the cyclic steady-state performance of the SMB, based on the analogy with the true moving bed (TMB), is developed assuming multicomponent adsorption equilibria, axial dispersion flow and the linear driving force approximation to describe the intraparticle mass transfer rate. The simulation package is used to predict the effect of operating variables on the process performance and to define the regions for enantiomers separation. The influence of mass transfer resistance in the separation region is analyzed. A practical tool for choosing the better SMB operating conditions as a function of the feed flow-rate is proposed. The experimental operation of a pilot unit of SMB, Licosep 12-26 (Novasep, France), is carried out for the separation of enantiomers and illustrated with two systems: the bi-naphthol and the chiral epoxide enantiomers. Experimental results and model predictions are compared in terms of process performance and internal concentration profiles. |
publishDate |
2000 |
dc.date.none.fl_str_mv |
2000 2000 2000-01-01T00:00:00Z 2000-01-01T00:00:00Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://hdl.handle.net/10198/1152 |
url |
http://hdl.handle.net/10198/1152 |
dc.language.iso.fl_str_mv |
eng eng |
language |
eng |
dc.relation.none.fl_str_mv |
Pais, L.S.; Loureiro, J.M.; Rodrigues, A.E. (2000). Chiral separation by SMB chromatography. Separation and Purification Technology. ISSN 1383-5866. 20:1, p.67-77 1383-5866 Sep. Purif. Technology 10.1016/S1383-5866(00)00063-0 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.publisher.none.fl_str_mv |
Elsevier |
publisher.none.fl_str_mv |
Elsevier |
dc.source.none.fl_str_mv |
reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação instacron:RCAAP |
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Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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RCAAP |
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RCAAP |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
repository.name.fl_str_mv |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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1817552212713275392 |