Chiral separation by SMB chromatography

Detalhes bibliográficos
Autor(a) principal: Pais, Luís S.
Data de Publicação: 2000
Outros Autores: Loureiro, José M., Rodrigues, Alírio
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: http://hdl.handle.net/10198/1152
Resumo: The paper deals with chiral separation by simulated moving bed (SMB) chromatography. A model for the prediction of the cyclic steady-state performance of the SMB, based on the analogy with the true moving bed (TMB), is developed assuming multicomponent adsorption equilibria, axial dispersion flow and the linear driving force approximation to describe the intraparticle mass transfer rate. The simulation package is used to predict the effect of operating variables on the process performance and to define the regions for enantiomers separation. The influence of mass transfer resistance in the separation region is analyzed. A practical tool for choosing the better SMB operating conditions as a function of the feed flow-rate is proposed. The experimental operation of a pilot unit of SMB, Licosep 12-26 (Novasep, France), is carried out for the separation of enantiomers and illustrated with two systems: the bi-naphthol and the chiral epoxide enantiomers. Experimental results and model predictions are compared in terms of process performance and internal concentration profiles.
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spelling Chiral separation by SMB chromatographySimulated moving bed chromatographyComputer simulation and optimizationChiral separationBi-naphthol enantiomersChiral epoxide enantiomersThe paper deals with chiral separation by simulated moving bed (SMB) chromatography. A model for the prediction of the cyclic steady-state performance of the SMB, based on the analogy with the true moving bed (TMB), is developed assuming multicomponent adsorption equilibria, axial dispersion flow and the linear driving force approximation to describe the intraparticle mass transfer rate. The simulation package is used to predict the effect of operating variables on the process performance and to define the regions for enantiomers separation. The influence of mass transfer resistance in the separation region is analyzed. A practical tool for choosing the better SMB operating conditions as a function of the feed flow-rate is proposed. The experimental operation of a pilot unit of SMB, Licosep 12-26 (Novasep, France), is carried out for the separation of enantiomers and illustrated with two systems: the bi-naphthol and the chiral epoxide enantiomers. Experimental results and model predictions are compared in terms of process performance and internal concentration profiles.ElsevierBiblioteca Digital do IPBPais, Luís S.Loureiro, José M.Rodrigues, Alírio200020002000-01-01T00:00:00Z2000-01-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10198/1152engengPais, L.S.; Loureiro, J.M.; Rodrigues, A.E. (2000). Chiral separation by SMB chromatography. Separation and Purification Technology. ISSN 1383-5866. 20:1, p.67-771383-5866Sep. Purif. Technology10.1016/S1383-5866(00)00063-0info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-06-21T01:18:28ZPortal AgregadorONG
dc.title.none.fl_str_mv Chiral separation by SMB chromatography
title Chiral separation by SMB chromatography
spellingShingle Chiral separation by SMB chromatography
Pais, Luís S.
Simulated moving bed chromatography
Computer simulation and optimization
Chiral separation
Bi-naphthol enantiomers
Chiral epoxide enantiomers
title_short Chiral separation by SMB chromatography
title_full Chiral separation by SMB chromatography
title_fullStr Chiral separation by SMB chromatography
title_full_unstemmed Chiral separation by SMB chromatography
title_sort Chiral separation by SMB chromatography
author Pais, Luís S.
author_facet Pais, Luís S.
Loureiro, José M.
Rodrigues, Alírio
author_role author
author2 Loureiro, José M.
Rodrigues, Alírio
author2_role author
author
dc.contributor.none.fl_str_mv Biblioteca Digital do IPB
dc.contributor.author.fl_str_mv Pais, Luís S.
Loureiro, José M.
Rodrigues, Alírio
dc.subject.por.fl_str_mv Simulated moving bed chromatography
Computer simulation and optimization
Chiral separation
Bi-naphthol enantiomers
Chiral epoxide enantiomers
topic Simulated moving bed chromatography
Computer simulation and optimization
Chiral separation
Bi-naphthol enantiomers
Chiral epoxide enantiomers
description The paper deals with chiral separation by simulated moving bed (SMB) chromatography. A model for the prediction of the cyclic steady-state performance of the SMB, based on the analogy with the true moving bed (TMB), is developed assuming multicomponent adsorption equilibria, axial dispersion flow and the linear driving force approximation to describe the intraparticle mass transfer rate. The simulation package is used to predict the effect of operating variables on the process performance and to define the regions for enantiomers separation. The influence of mass transfer resistance in the separation region is analyzed. A practical tool for choosing the better SMB operating conditions as a function of the feed flow-rate is proposed. The experimental operation of a pilot unit of SMB, Licosep 12-26 (Novasep, France), is carried out for the separation of enantiomers and illustrated with two systems: the bi-naphthol and the chiral epoxide enantiomers. Experimental results and model predictions are compared in terms of process performance and internal concentration profiles.
publishDate 2000
dc.date.none.fl_str_mv 2000
2000
2000-01-01T00:00:00Z
2000-01-01T00:00:00Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/10198/1152
url http://hdl.handle.net/10198/1152
dc.language.iso.fl_str_mv eng
eng
language eng
dc.relation.none.fl_str_mv Pais, L.S.; Loureiro, J.M.; Rodrigues, A.E. (2000). Chiral separation by SMB chromatography. Separation and Purification Technology. ISSN 1383-5866. 20:1, p.67-77
1383-5866
Sep. Purif. Technology
10.1016/S1383-5866(00)00063-0
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Elsevier
publisher.none.fl_str_mv Elsevier
dc.source.none.fl_str_mv reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron:RCAAP
instname_str Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron_str RCAAP
institution RCAAP
reponame_str Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
collection Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
repository.name.fl_str_mv
repository.mail.fl_str_mv
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