Separation of enantiomers of 1a,2,7,7a-tetrahydro-3-methoxynaphtha-(2,3b)-oxirane by liquid chromatography: laboratory-scale elution chromatography and modelling of simulated moving bed

Detalhes bibliográficos
Autor(a) principal: Rodrigues, Alírio
Data de Publicação: 1995
Outros Autores: Lu, Z.P., Loureiro, José M., Pais, Luís S.
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: http://hdl.handle.net/10198/1146
Resumo: The separation of enantiomers of la,2,7,7a-tetrahydro-3-methoxynaphtha-(2,3b)-oxirane (Sandoz epoxide) on cellulose triacetate HPLC columns was investigated on the laboratory scale. The performance of the columns was calculated by HEPT measurements and the slopes of the adsorption equilibrium isotherms and effective diffusivities were calculated from elution chromatographic experiments. Multi-component adsorption equilibrium isotherms were calculated from single isotherms by using the ideal adsorbed solution (IAS) model. Simulation of continuous chromatographic separation of the racemic mixture of Sandoz epoxide in a simulated moving bed was carried out and the effect of mass transfer coefficient on process performance was analysed.
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spelling Separation of enantiomers of 1a,2,7,7a-tetrahydro-3-methoxynaphtha-(2,3b)-oxirane by liquid chromatography: laboratory-scale elution chromatography and modelling of simulated moving bedChiral epoxideChiral separationThe separation of enantiomers of la,2,7,7a-tetrahydro-3-methoxynaphtha-(2,3b)-oxirane (Sandoz epoxide) on cellulose triacetate HPLC columns was investigated on the laboratory scale. The performance of the columns was calculated by HEPT measurements and the slopes of the adsorption equilibrium isotherms and effective diffusivities were calculated from elution chromatographic experiments. Multi-component adsorption equilibrium isotherms were calculated from single isotherms by using the ideal adsorbed solution (IAS) model. Simulation of continuous chromatographic separation of the racemic mixture of Sandoz epoxide in a simulated moving bed was carried out and the effect of mass transfer coefficient on process performance was analysed.ElsevierBiblioteca Digital do IPBRodrigues, AlírioLu, Z.P.Loureiro, José M.Pais, Luís S.199519951995-01-01T00:00:00Z1995-01-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10198/1146engengRodrigues, A.E.; Lu, Z.P.; Loureiro, J.M.; Pais, L.S. (1995). Separation of enantiomers of 1a,2,7,7a-tetrahydro-3-methoxynaphtha-(2,3b)-oxirane by liquid chromatography: laboratory-scale elution chromatography and modelling of simulated moving bed. Journal of Chromatography A. ISSN 0021-9673. 702:1-2, p.223-2310021-9673Journal of Chromatography A10.1016/0021-9673(94)01037-Finfo:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-11-21T10:04:28Zoai:bibliotecadigital.ipb.pt:10198/1146Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T22:54:42.752835Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv Separation of enantiomers of 1a,2,7,7a-tetrahydro-3-methoxynaphtha-(2,3b)-oxirane by liquid chromatography: laboratory-scale elution chromatography and modelling of simulated moving bed
title Separation of enantiomers of 1a,2,7,7a-tetrahydro-3-methoxynaphtha-(2,3b)-oxirane by liquid chromatography: laboratory-scale elution chromatography and modelling of simulated moving bed
spellingShingle Separation of enantiomers of 1a,2,7,7a-tetrahydro-3-methoxynaphtha-(2,3b)-oxirane by liquid chromatography: laboratory-scale elution chromatography and modelling of simulated moving bed
Rodrigues, Alírio
Chiral epoxide
Chiral separation
title_short Separation of enantiomers of 1a,2,7,7a-tetrahydro-3-methoxynaphtha-(2,3b)-oxirane by liquid chromatography: laboratory-scale elution chromatography and modelling of simulated moving bed
title_full Separation of enantiomers of 1a,2,7,7a-tetrahydro-3-methoxynaphtha-(2,3b)-oxirane by liquid chromatography: laboratory-scale elution chromatography and modelling of simulated moving bed
title_fullStr Separation of enantiomers of 1a,2,7,7a-tetrahydro-3-methoxynaphtha-(2,3b)-oxirane by liquid chromatography: laboratory-scale elution chromatography and modelling of simulated moving bed
title_full_unstemmed Separation of enantiomers of 1a,2,7,7a-tetrahydro-3-methoxynaphtha-(2,3b)-oxirane by liquid chromatography: laboratory-scale elution chromatography and modelling of simulated moving bed
title_sort Separation of enantiomers of 1a,2,7,7a-tetrahydro-3-methoxynaphtha-(2,3b)-oxirane by liquid chromatography: laboratory-scale elution chromatography and modelling of simulated moving bed
author Rodrigues, Alírio
author_facet Rodrigues, Alírio
Lu, Z.P.
Loureiro, José M.
Pais, Luís S.
author_role author
author2 Lu, Z.P.
Loureiro, José M.
Pais, Luís S.
author2_role author
author
author
dc.contributor.none.fl_str_mv Biblioteca Digital do IPB
dc.contributor.author.fl_str_mv Rodrigues, Alírio
Lu, Z.P.
Loureiro, José M.
Pais, Luís S.
dc.subject.por.fl_str_mv Chiral epoxide
Chiral separation
topic Chiral epoxide
Chiral separation
description The separation of enantiomers of la,2,7,7a-tetrahydro-3-methoxynaphtha-(2,3b)-oxirane (Sandoz epoxide) on cellulose triacetate HPLC columns was investigated on the laboratory scale. The performance of the columns was calculated by HEPT measurements and the slopes of the adsorption equilibrium isotherms and effective diffusivities were calculated from elution chromatographic experiments. Multi-component adsorption equilibrium isotherms were calculated from single isotherms by using the ideal adsorbed solution (IAS) model. Simulation of continuous chromatographic separation of the racemic mixture of Sandoz epoxide in a simulated moving bed was carried out and the effect of mass transfer coefficient on process performance was analysed.
publishDate 1995
dc.date.none.fl_str_mv 1995
1995
1995-01-01T00:00:00Z
1995-01-01T00:00:00Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/10198/1146
url http://hdl.handle.net/10198/1146
dc.language.iso.fl_str_mv eng
eng
language eng
dc.relation.none.fl_str_mv Rodrigues, A.E.; Lu, Z.P.; Loureiro, J.M.; Pais, L.S. (1995). Separation of enantiomers of 1a,2,7,7a-tetrahydro-3-methoxynaphtha-(2,3b)-oxirane by liquid chromatography: laboratory-scale elution chromatography and modelling of simulated moving bed. Journal of Chromatography A. ISSN 0021-9673. 702:1-2, p.223-231
0021-9673
Journal of Chromatography A
10.1016/0021-9673(94)01037-F
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
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dc.publisher.none.fl_str_mv Elsevier
publisher.none.fl_str_mv Elsevier
dc.source.none.fl_str_mv reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
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instname_str Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron_str RCAAP
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reponame_str Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
collection Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
repository.name.fl_str_mv Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
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