Separation of enantiomers of 1a,2,7,7a-tetrahydro-3-methoxynaphtha-(2,3b)-oxirane by liquid chromatography: laboratory-scale elution chromatography and modelling of simulated moving bed
Autor(a) principal: | |
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Data de Publicação: | 1995 |
Outros Autores: | , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
Texto Completo: | http://hdl.handle.net/10198/1146 |
Resumo: | The separation of enantiomers of la,2,7,7a-tetrahydro-3-methoxynaphtha-(2,3b)-oxirane (Sandoz epoxide) on cellulose triacetate HPLC columns was investigated on the laboratory scale. The performance of the columns was calculated by HEPT measurements and the slopes of the adsorption equilibrium isotherms and effective diffusivities were calculated from elution chromatographic experiments. Multi-component adsorption equilibrium isotherms were calculated from single isotherms by using the ideal adsorbed solution (IAS) model. Simulation of continuous chromatographic separation of the racemic mixture of Sandoz epoxide in a simulated moving bed was carried out and the effect of mass transfer coefficient on process performance was analysed. |
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Separation of enantiomers of 1a,2,7,7a-tetrahydro-3-methoxynaphtha-(2,3b)-oxirane by liquid chromatography: laboratory-scale elution chromatography and modelling of simulated moving bedChiral epoxideChiral separationThe separation of enantiomers of la,2,7,7a-tetrahydro-3-methoxynaphtha-(2,3b)-oxirane (Sandoz epoxide) on cellulose triacetate HPLC columns was investigated on the laboratory scale. The performance of the columns was calculated by HEPT measurements and the slopes of the adsorption equilibrium isotherms and effective diffusivities were calculated from elution chromatographic experiments. Multi-component adsorption equilibrium isotherms were calculated from single isotherms by using the ideal adsorbed solution (IAS) model. Simulation of continuous chromatographic separation of the racemic mixture of Sandoz epoxide in a simulated moving bed was carried out and the effect of mass transfer coefficient on process performance was analysed.ElsevierBiblioteca Digital do IPBRodrigues, AlírioLu, Z.P.Loureiro, José M.Pais, Luís S.199519951995-01-01T00:00:00Z1995-01-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10198/1146engengRodrigues, A.E.; Lu, Z.P.; Loureiro, J.M.; Pais, L.S. (1995). Separation of enantiomers of 1a,2,7,7a-tetrahydro-3-methoxynaphtha-(2,3b)-oxirane by liquid chromatography: laboratory-scale elution chromatography and modelling of simulated moving bed. Journal of Chromatography A. ISSN 0021-9673. 702:1-2, p.223-2310021-9673Journal of Chromatography A10.1016/0021-9673(94)01037-Finfo:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-11-21T10:04:28Zoai:bibliotecadigital.ipb.pt:10198/1146Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T22:54:42.752835Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse |
dc.title.none.fl_str_mv |
Separation of enantiomers of 1a,2,7,7a-tetrahydro-3-methoxynaphtha-(2,3b)-oxirane by liquid chromatography: laboratory-scale elution chromatography and modelling of simulated moving bed |
title |
Separation of enantiomers of 1a,2,7,7a-tetrahydro-3-methoxynaphtha-(2,3b)-oxirane by liquid chromatography: laboratory-scale elution chromatography and modelling of simulated moving bed |
spellingShingle |
Separation of enantiomers of 1a,2,7,7a-tetrahydro-3-methoxynaphtha-(2,3b)-oxirane by liquid chromatography: laboratory-scale elution chromatography and modelling of simulated moving bed Rodrigues, Alírio Chiral epoxide Chiral separation |
title_short |
Separation of enantiomers of 1a,2,7,7a-tetrahydro-3-methoxynaphtha-(2,3b)-oxirane by liquid chromatography: laboratory-scale elution chromatography and modelling of simulated moving bed |
title_full |
Separation of enantiomers of 1a,2,7,7a-tetrahydro-3-methoxynaphtha-(2,3b)-oxirane by liquid chromatography: laboratory-scale elution chromatography and modelling of simulated moving bed |
title_fullStr |
Separation of enantiomers of 1a,2,7,7a-tetrahydro-3-methoxynaphtha-(2,3b)-oxirane by liquid chromatography: laboratory-scale elution chromatography and modelling of simulated moving bed |
title_full_unstemmed |
Separation of enantiomers of 1a,2,7,7a-tetrahydro-3-methoxynaphtha-(2,3b)-oxirane by liquid chromatography: laboratory-scale elution chromatography and modelling of simulated moving bed |
title_sort |
Separation of enantiomers of 1a,2,7,7a-tetrahydro-3-methoxynaphtha-(2,3b)-oxirane by liquid chromatography: laboratory-scale elution chromatography and modelling of simulated moving bed |
author |
Rodrigues, Alírio |
author_facet |
Rodrigues, Alírio Lu, Z.P. Loureiro, José M. Pais, Luís S. |
author_role |
author |
author2 |
Lu, Z.P. Loureiro, José M. Pais, Luís S. |
author2_role |
author author author |
dc.contributor.none.fl_str_mv |
Biblioteca Digital do IPB |
dc.contributor.author.fl_str_mv |
Rodrigues, Alírio Lu, Z.P. Loureiro, José M. Pais, Luís S. |
dc.subject.por.fl_str_mv |
Chiral epoxide Chiral separation |
topic |
Chiral epoxide Chiral separation |
description |
The separation of enantiomers of la,2,7,7a-tetrahydro-3-methoxynaphtha-(2,3b)-oxirane (Sandoz epoxide) on cellulose triacetate HPLC columns was investigated on the laboratory scale. The performance of the columns was calculated by HEPT measurements and the slopes of the adsorption equilibrium isotherms and effective diffusivities were calculated from elution chromatographic experiments. Multi-component adsorption equilibrium isotherms were calculated from single isotherms by using the ideal adsorbed solution (IAS) model. Simulation of continuous chromatographic separation of the racemic mixture of Sandoz epoxide in a simulated moving bed was carried out and the effect of mass transfer coefficient on process performance was analysed. |
publishDate |
1995 |
dc.date.none.fl_str_mv |
1995 1995 1995-01-01T00:00:00Z 1995-01-01T00:00:00Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://hdl.handle.net/10198/1146 |
url |
http://hdl.handle.net/10198/1146 |
dc.language.iso.fl_str_mv |
eng eng |
language |
eng |
dc.relation.none.fl_str_mv |
Rodrigues, A.E.; Lu, Z.P.; Loureiro, J.M.; Pais, L.S. (1995). Separation of enantiomers of 1a,2,7,7a-tetrahydro-3-methoxynaphtha-(2,3b)-oxirane by liquid chromatography: laboratory-scale elution chromatography and modelling of simulated moving bed. Journal of Chromatography A. ISSN 0021-9673. 702:1-2, p.223-231 0021-9673 Journal of Chromatography A 10.1016/0021-9673(94)01037-F |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.publisher.none.fl_str_mv |
Elsevier |
publisher.none.fl_str_mv |
Elsevier |
dc.source.none.fl_str_mv |
reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação instacron:RCAAP |
instname_str |
Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
instacron_str |
RCAAP |
institution |
RCAAP |
reponame_str |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
collection |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
repository.name.fl_str_mv |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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1817551277641433088 |