Angiogenesis as a therapeutic target in endometriosis

Detalhes bibliográficos
Autor(a) principal: Djokovic, Dusan
Data de Publicação: 2014
Outros Autores: Calhaz-Jorge, Carlos
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: http://hdl.handle.net/10451/51375
Resumo: Copyright © Ordem dos Médicos 2014
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spelling Angiogenesis as a therapeutic target in endometriosisAngiogénese como um alvo terapêutico para a endometrioseAngiogenesis InhibitorsTherapeutic useEndometriosisDrug therapyCopyright © Ordem dos Médicos 2014Introduction: Angiogenesis is a key factor for the successful establishment and growth of endometriotic lesions. Material and methods: We performed a literature search in PubMed and reviewed the most pertinent studies published until January 2014 and focused on the endometriosis-associated angiogenesis and/or anti-angiogenic strategies for the treatment of this gynecological disorder. Results: The present review provides a concise summary of the known molecular mechanisms that promote vascularization of endometriotic lesions and may serve as potential therapeutic targets. We also present a systematic overview of the inclusive and exclusive anti-angiogenic agents that have been already studied in cell cultures, animal models and/or endometriosis patients. Discussion and conclusion: The integration of anti-angiogenic approaches in the multimodal management strategies for endometriosis patients will be conditioned by the outcomes of future assessments regarding the effectiveness of such treatments, the risk of drug resistance development and the incidence of unacceptable side effects.Ordem dos MédicosRepositório da Universidade de LisboaDjokovic, DusanCalhaz-Jorge, Carlos2022-02-17T14:43:52Z20142014-01-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10451/51375engActa Med Port 2014 Jul-Aug;27(4):489-4970870-399X10.20344/amp.52441646-0758info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-11-08T16:56:00Zoai:repositorio.ul.pt:10451/51375Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T22:02:39.517477Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv Angiogenesis as a therapeutic target in endometriosis
Angiogénese como um alvo terapêutico para a endometriose
title Angiogenesis as a therapeutic target in endometriosis
spellingShingle Angiogenesis as a therapeutic target in endometriosis
Djokovic, Dusan
Angiogenesis Inhibitors
Therapeutic use
Endometriosis
Drug therapy
title_short Angiogenesis as a therapeutic target in endometriosis
title_full Angiogenesis as a therapeutic target in endometriosis
title_fullStr Angiogenesis as a therapeutic target in endometriosis
title_full_unstemmed Angiogenesis as a therapeutic target in endometriosis
title_sort Angiogenesis as a therapeutic target in endometriosis
author Djokovic, Dusan
author_facet Djokovic, Dusan
Calhaz-Jorge, Carlos
author_role author
author2 Calhaz-Jorge, Carlos
author2_role author
dc.contributor.none.fl_str_mv Repositório da Universidade de Lisboa
dc.contributor.author.fl_str_mv Djokovic, Dusan
Calhaz-Jorge, Carlos
dc.subject.por.fl_str_mv Angiogenesis Inhibitors
Therapeutic use
Endometriosis
Drug therapy
topic Angiogenesis Inhibitors
Therapeutic use
Endometriosis
Drug therapy
description Copyright © Ordem dos Médicos 2014
publishDate 2014
dc.date.none.fl_str_mv 2014
2014-01-01T00:00:00Z
2022-02-17T14:43:52Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/10451/51375
url http://hdl.handle.net/10451/51375
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv Acta Med Port 2014 Jul-Aug;27(4):489-497
0870-399X
10.20344/amp.5244
1646-0758
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Ordem dos Médicos
publisher.none.fl_str_mv Ordem dos Médicos
dc.source.none.fl_str_mv reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
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