Somatic stem cells and their dysfunction in endometriosis

Detalhes bibliográficos
Autor(a) principal: Djokovic, Dusan
Data de Publicação: 2015
Outros Autores: Calhaz-Jorge, Carlos
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: http://hdl.handle.net/10451/51757
Resumo: Copyright: © 2015 Djokovic and Calhaz-Jorge. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
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spelling Somatic stem cells and their dysfunction in endometriosisDrug targetEndometriosisEndometriosis markersPathogenesisSomatic stem cellsCopyright: © 2015 Djokovic and Calhaz-Jorge. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.Emerging evidence indicates that somatic stem cells (SSCs) of different types prominently contribute to endometrium-associated disorders such as endometriosis. We reviewed the pertinent studies available on PubMed, published in English language until December 2014 and focused on the involvement of SSCs in the pathogenesis of this common gynecological disease. A concise summary of the data obtained from in vitro experiments, animal models, and human tissue analyses provides insights into the SSC dysregulation in endometriotic lesions. In addition, a set of research results is presented supporting that SSC-targeting, in combination with hormonal therapy, may result in improved control of the disease, while a more in-depth characterization of endometriosis SSCs may contribute to the development of early-disease diagnostic tests with increased sensitivity and specificity. Key message: Seemingly essential for the establishment and progression of endometriotic lesions, dysregulated SSCs, and associated molecular alterations hold a promise as potential endometriosis markers and therapeutic targets.FrontiersRepositório da Universidade de LisboaDjokovic, DusanCalhaz-Jorge, Carlos2022-03-15T16:37:18Z20152015-01-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10451/51757engFront Surg. 2015 Jan 6;1:5110.3389/fsurg.2014.000512296-875Xinfo:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-11-08T16:56:39Zoai:repositorio.ul.pt:10451/51757Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T22:02:59.920063Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv Somatic stem cells and their dysfunction in endometriosis
title Somatic stem cells and their dysfunction in endometriosis
spellingShingle Somatic stem cells and their dysfunction in endometriosis
Djokovic, Dusan
Drug target
Endometriosis
Endometriosis markers
Pathogenesis
Somatic stem cells
title_short Somatic stem cells and their dysfunction in endometriosis
title_full Somatic stem cells and their dysfunction in endometriosis
title_fullStr Somatic stem cells and their dysfunction in endometriosis
title_full_unstemmed Somatic stem cells and their dysfunction in endometriosis
title_sort Somatic stem cells and their dysfunction in endometriosis
author Djokovic, Dusan
author_facet Djokovic, Dusan
Calhaz-Jorge, Carlos
author_role author
author2 Calhaz-Jorge, Carlos
author2_role author
dc.contributor.none.fl_str_mv Repositório da Universidade de Lisboa
dc.contributor.author.fl_str_mv Djokovic, Dusan
Calhaz-Jorge, Carlos
dc.subject.por.fl_str_mv Drug target
Endometriosis
Endometriosis markers
Pathogenesis
Somatic stem cells
topic Drug target
Endometriosis
Endometriosis markers
Pathogenesis
Somatic stem cells
description Copyright: © 2015 Djokovic and Calhaz-Jorge. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
publishDate 2015
dc.date.none.fl_str_mv 2015
2015-01-01T00:00:00Z
2022-03-15T16:37:18Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/10451/51757
url http://hdl.handle.net/10451/51757
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv Front Surg. 2015 Jan 6;1:51
10.3389/fsurg.2014.00051
2296-875X
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Frontiers
publisher.none.fl_str_mv Frontiers
dc.source.none.fl_str_mv reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron:RCAAP
instname_str Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron_str RCAAP
institution RCAAP
reponame_str Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
collection Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
repository.name.fl_str_mv Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
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