MRI assessment of superior temporal gyrus in Williams syndrome

Detalhes bibliográficos
Autor(a) principal: Sampaio, Adriana
Data de Publicação: 2008
Outros Autores: Sousa, Nuno, Férnandez, Montse, Vasconcelos, Cristiana, Shenton, Martha E., Gonçalves, Óscar F.
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: http://hdl.handle.net/1822/7917
Resumo: Prova tipográfica (In Press)
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spelling MRI assessment of superior temporal gyrus in Williams syndromeWilliams syndromeSTGLanguageNeurodevelopmentScience & TechnologyProva tipográfica (In Press)Objective: To evaluate volumes and asymmetry of superior temporal gyrus (STG) and correlate these measures with a neurocognitive evaluation of verbal performance in Williams syndrome (WS) and in a typically developing age-matched and sex-matched group. Background: Despite initial claims of language strength in WS, recent studies suggest delayed language milestones. The STG is implicated in linguistic processing and is a highly lateralized brain region. Method: Here, we examined STG volumes and asymmetry of STG in WS patients and in age-matched controls. We also correlated volume of STG with a subset of verbal measures. Magnetic resonance imaging scans were obtained on a GE 1.5-T magnet with 1.5-mm contiguous slices, and were used to measure whole gray matter, white matter, and cerebrospinal fluid volumes, and also STG volume. Results: Results revealed significantly reduced intracranial volume in WS patients, compared with controls. Right and left STG were also significantly smaller in WS patients. In addition, compared with normal controls, a lack of normal left >right STG asymmetry was evident in WS. Also of note was the finding that, in contrast to controls, WS patients did not reveal a positive correlation between verbal intelligence quotient and left STG volume, which further suggests a disruption in this region of the brain. Conclusions: In conclusion, atypical patterns of asymmetry and reduced STG volume in WS were observed, which may, in part, contribute to some of the linguistic impairments found in this cohort of WS patients.National Institutes of Health - (K05 MH 01110)Fundação para a Ciência e Tecnologia (FCT) - POCTI/PSI/58364/2004, RH/BD/16091/2004Lippincott, Williams & WilkinsUniversidade do MinhoSampaio, AdrianaSousa, NunoFérnandez, MontseVasconcelos, CristianaShenton, Martha E.Gonçalves, Óscar F.2008-06-062008-06-06T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/1822/7917eng1543-363310.1097/WNN.0b013e31817720e418797257info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-07-21T12:12:15Zoai:repositorium.sdum.uminho.pt:1822/7917Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T19:04:09.694523Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv MRI assessment of superior temporal gyrus in Williams syndrome
title MRI assessment of superior temporal gyrus in Williams syndrome
spellingShingle MRI assessment of superior temporal gyrus in Williams syndrome
Sampaio, Adriana
Williams syndrome
STG
Language
Neurodevelopment
Science & Technology
title_short MRI assessment of superior temporal gyrus in Williams syndrome
title_full MRI assessment of superior temporal gyrus in Williams syndrome
title_fullStr MRI assessment of superior temporal gyrus in Williams syndrome
title_full_unstemmed MRI assessment of superior temporal gyrus in Williams syndrome
title_sort MRI assessment of superior temporal gyrus in Williams syndrome
author Sampaio, Adriana
author_facet Sampaio, Adriana
Sousa, Nuno
Férnandez, Montse
Vasconcelos, Cristiana
Shenton, Martha E.
Gonçalves, Óscar F.
author_role author
author2 Sousa, Nuno
Férnandez, Montse
Vasconcelos, Cristiana
Shenton, Martha E.
Gonçalves, Óscar F.
author2_role author
author
author
author
author
dc.contributor.none.fl_str_mv Universidade do Minho
dc.contributor.author.fl_str_mv Sampaio, Adriana
Sousa, Nuno
Férnandez, Montse
Vasconcelos, Cristiana
Shenton, Martha E.
Gonçalves, Óscar F.
dc.subject.por.fl_str_mv Williams syndrome
STG
Language
Neurodevelopment
Science & Technology
topic Williams syndrome
STG
Language
Neurodevelopment
Science & Technology
description Prova tipográfica (In Press)
publishDate 2008
dc.date.none.fl_str_mv 2008-06-06
2008-06-06T00:00:00Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/1822/7917
url http://hdl.handle.net/1822/7917
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 1543-3633
10.1097/WNN.0b013e31817720e4
18797257
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Lippincott, Williams & Wilkins
publisher.none.fl_str_mv Lippincott, Williams & Wilkins
dc.source.none.fl_str_mv reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron:RCAAP
instname_str Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron_str RCAAP
institution RCAAP
reponame_str Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
collection Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
repository.name.fl_str_mv Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
repository.mail.fl_str_mv
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