MRI amygdala volume in Williams syndrome
Autor(a) principal: | |
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Data de Publicação: | 2011 |
Outros Autores: | , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
Texto Completo: | http://hdl.handle.net/1822/13811 |
Resumo: | One of the most intriguing characteristics of Williams Syndrome individuals is their hypersociability. The amygdala has been consistently implicated in the etiology of this social profile, particularly given its role in emotional and social behavior. This study examined amygdala volume and symmetry in WS individuals and in age and sex matched controls. Magnetic resonance imaging scans were obtained on a GE 1.5-T magnet with 1.5- mm contiguous slices and were used to measure whole gray matter, white matter and cerebrospinal fluid volumes, as well as amygdala volume (right and left). Results revealed significantly reduced intracranial volume in individuals with WS, compared with controls. There were no differences between groups in absolute amygdalae volume, although there was a relative increase in amygdalae volumes, when adjusted for total intracranial content. There were no inter-hemispheric differences in amygdalae volumes in both groups. These results suggest a relative increase in amygdala volume in WS compared with healthy controls that likely reflects abnormal neurodevelopmental processes of midline brain structures. |
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MRI amygdala volume in Williams syndromeWilliams syndromeHypersociabilityAmygdalaNeurodevelopmentSocial SciencesScience & TechnologyOne of the most intriguing characteristics of Williams Syndrome individuals is their hypersociability. The amygdala has been consistently implicated in the etiology of this social profile, particularly given its role in emotional and social behavior. This study examined amygdala volume and symmetry in WS individuals and in age and sex matched controls. Magnetic resonance imaging scans were obtained on a GE 1.5-T magnet with 1.5- mm contiguous slices and were used to measure whole gray matter, white matter and cerebrospinal fluid volumes, as well as amygdala volume (right and left). Results revealed significantly reduced intracranial volume in individuals with WS, compared with controls. There were no differences between groups in absolute amygdalae volume, although there was a relative increase in amygdalae volumes, when adjusted for total intracranial content. There were no inter-hemispheric differences in amygdalae volumes in both groups. These results suggest a relative increase in amygdala volume in WS compared with healthy controls that likely reflects abnormal neurodevelopmental processes of midline brain structures.This research was supported by the grants PIC/IC/83290/2007 from Fundac¸a˜o para a Cieˆncia e Tecnologia (Portugal) and Fundacio´n Alicia Koplowitz. (V convocatoria de 2009. Ayudas a la investigacio´n en psiquiatrı´a de la infancia y adolescencia enfermedades neurodegenerativas tempranas)ElsevierUniversidade do MinhoCapitão, LilianaSampaio, AdrianaSampaio, CassandraVasconcelos, CristianaFérnandez, MontseGarayzábal Heinze, ElenaShenton, Martha E.Gonçalves, Óscar F.20112011-01-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/1822/13811eng0891-422210.1016/j.ridd.2011.05.03321752593info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-07-21T12:47:50Zoai:repositorium.sdum.uminho.pt:1822/13811Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T19:45:57.772103Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse |
dc.title.none.fl_str_mv |
MRI amygdala volume in Williams syndrome |
title |
MRI amygdala volume in Williams syndrome |
spellingShingle |
MRI amygdala volume in Williams syndrome Capitão, Liliana Williams syndrome Hypersociability Amygdala Neurodevelopment Social Sciences Science & Technology |
title_short |
MRI amygdala volume in Williams syndrome |
title_full |
MRI amygdala volume in Williams syndrome |
title_fullStr |
MRI amygdala volume in Williams syndrome |
title_full_unstemmed |
MRI amygdala volume in Williams syndrome |
title_sort |
MRI amygdala volume in Williams syndrome |
author |
Capitão, Liliana |
author_facet |
Capitão, Liliana Sampaio, Adriana Sampaio, Cassandra Vasconcelos, Cristiana Férnandez, Montse Garayzábal Heinze, Elena Shenton, Martha E. Gonçalves, Óscar F. |
author_role |
author |
author2 |
Sampaio, Adriana Sampaio, Cassandra Vasconcelos, Cristiana Férnandez, Montse Garayzábal Heinze, Elena Shenton, Martha E. Gonçalves, Óscar F. |
author2_role |
author author author author author author author |
dc.contributor.none.fl_str_mv |
Universidade do Minho |
dc.contributor.author.fl_str_mv |
Capitão, Liliana Sampaio, Adriana Sampaio, Cassandra Vasconcelos, Cristiana Férnandez, Montse Garayzábal Heinze, Elena Shenton, Martha E. Gonçalves, Óscar F. |
dc.subject.por.fl_str_mv |
Williams syndrome Hypersociability Amygdala Neurodevelopment Social Sciences Science & Technology |
topic |
Williams syndrome Hypersociability Amygdala Neurodevelopment Social Sciences Science & Technology |
description |
One of the most intriguing characteristics of Williams Syndrome individuals is their hypersociability. The amygdala has been consistently implicated in the etiology of this social profile, particularly given its role in emotional and social behavior. This study examined amygdala volume and symmetry in WS individuals and in age and sex matched controls. Magnetic resonance imaging scans were obtained on a GE 1.5-T magnet with 1.5- mm contiguous slices and were used to measure whole gray matter, white matter and cerebrospinal fluid volumes, as well as amygdala volume (right and left). Results revealed significantly reduced intracranial volume in individuals with WS, compared with controls. There were no differences between groups in absolute amygdalae volume, although there was a relative increase in amygdalae volumes, when adjusted for total intracranial content. There were no inter-hemispheric differences in amygdalae volumes in both groups. These results suggest a relative increase in amygdala volume in WS compared with healthy controls that likely reflects abnormal neurodevelopmental processes of midline brain structures. |
publishDate |
2011 |
dc.date.none.fl_str_mv |
2011 2011-01-01T00:00:00Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://hdl.handle.net/1822/13811 |
url |
http://hdl.handle.net/1822/13811 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
0891-4222 10.1016/j.ridd.2011.05.033 21752593 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.publisher.none.fl_str_mv |
Elsevier |
publisher.none.fl_str_mv |
Elsevier |
dc.source.none.fl_str_mv |
reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação instacron:RCAAP |
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Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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RCAAP |
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RCAAP |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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1799133026582528000 |