Increased Intake of Both Caffeine and Non-Caffeine Coffee Components Is Associated with Reduced NAFLD Severity in Subjects with Type 2 Diabetes
| Autor(a) principal: | |
|---|---|
| Data de Publicação: | 2023 |
| Outros Autores: | , , , , , , , , , |
| Tipo de documento: | Artigo |
| Idioma: | eng |
| Título da fonte: | Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
| Texto Completo: | http://hdl.handle.net/10362/147813 |
Resumo: | Funding Information: This research was financed by a grant from the Institute for Scientific Information on Coffee (ISIC), by the European Regional Development Fund (ERDF), through the Centro 2020 Regional Operational Programme, the COMPETE 2020-Operational Programme for Competitiveness and Internationalization, and by Portuguese national funds via Fundação para a Ciência e Tecnologia (FCT): UIDB/04539/2020, UIDP/04539/2020, LA/P/0058/2020 and iNOVA4Health (UIDB/Multi/04462/2020). The National Mass Spectrometry Network (RNEM) provided funding under the contract POCI-01-0145-FEDER-402-022125 (ref.: ROTEIRO/0028/2013). M.C. was supported by PhD fellowship PD/BD/135178/2017, co-financed by the European Social Fund (ESF), through the POCH-Programa Operacional do Capital Humano, and national funds via FCT. Funding Information: The authors received funding from the Institute for Scientific Information on Coffee (ISIC), to perform the studies. Publisher Copyright: © 2022 by the authors. |
| id |
RCAP_570d0c2c7b0a06bd75490201ed36a107 |
|---|---|
| oai_identifier_str |
oai:run.unl.pt:10362/147813 |
| network_acronym_str |
RCAP |
| network_name_str |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
| repository_id_str |
7160 |
| spelling |
Increased Intake of Both Caffeine and Non-Caffeine Coffee Components Is Associated with Reduced NAFLD Severity in Subjects with Type 2 Diabetescaffeinefatty liver indexfibrosisnon-alcoholic fatty liver diseasetype 2 diabetesFood ScienceNutrition and DieteticsSDG 3 - Good Health and Well-beingFunding Information: This research was financed by a grant from the Institute for Scientific Information on Coffee (ISIC), by the European Regional Development Fund (ERDF), through the Centro 2020 Regional Operational Programme, the COMPETE 2020-Operational Programme for Competitiveness and Internationalization, and by Portuguese national funds via Fundação para a Ciência e Tecnologia (FCT): UIDB/04539/2020, UIDP/04539/2020, LA/P/0058/2020 and iNOVA4Health (UIDB/Multi/04462/2020). The National Mass Spectrometry Network (RNEM) provided funding under the contract POCI-01-0145-FEDER-402-022125 (ref.: ROTEIRO/0028/2013). M.C. was supported by PhD fellowship PD/BD/135178/2017, co-financed by the European Social Fund (ESF), through the POCH-Programa Operacional do Capital Humano, and national funds via FCT. Funding Information: The authors received funding from the Institute for Scientific Information on Coffee (ISIC), to perform the studies. Publisher Copyright: © 2022 by the authors.Coffee may protect against non-alcoholic fatty liver disease (NAFLD), but the roles of the caffeine and non-caffeine components are unclear. Coffee intake by 156 overweight subjects (87% with Type-2-Diabetes, T2D) was assessed via a questionnaire, with 98 subjects (all T2D) also providing a 24 h urine sample for quantification of coffee metabolites by LC–MS/MS. NAFLD was characterized by the fatty liver index (FLI) and by Fibroscan® assessment of fibrosis. No associations were found between self-reported coffee intake and NAFLD parameters; however, total urine caffeine metabolites, defined as Σcaffeine (caffeine + paraxanthine + theophylline), and adjusted for fat-free body mass, were significantly higher for subjects with no liver fibrosis than for those with fibrosis. Total non-caffeine metabolites, defined as Σncm (trigonelline + caffeic acid + p-coumaric acid), showed a significant negative association with the FLI. Multiple regression analyses for overweight/obese T2D subjects (n = 89) showed that both Σcaffeine and Σncm were negatively associated with the FLI, after adjusting for age, sex, HbA1c, ethanol intake and glomerular filtration rate. The theophylline fraction of Σcaffeine was significantly increased with both fibrosis and the FLI, possibly reflecting elevated CYP2E1 activity—a hallmark of NAFLD worsening. Thus, for overweight/obese T2D patients, higher intake of both caffeine and non-caffeine coffee components is associated with less severe NAFLD. Caffeine metabolites represent novel markers of NAFLD progression.NOVA Medical School|Faculdade de Ciências Médicas (NMS|FCM)iNOVA4Health - pólo NMSRUNCoelho, MargaridaPatarrão, Rita S.Sousa-Lima, InêsRibeiro, Rogério T.Meneses, Maria JoãoAndrade, RitaMendes, Vera M.Manadas, BrunoRaposo, João FilipeMacedo, M. PaulaJones, John G.2023-01-18T22:17:12Z2023-012023-01-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10362/147813eng1422-8599PURE: 50629749https://doi.org/10.3390/nu15010004info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2024-05-22T18:08:18Zoai:run.unl.pt:10362/147813Portal AgregadorONGhttps://www.rcaap.pt/oai/openairemluisa.alvim@gmail.comopendoar:71602024-05-22T18:08:18Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse |
| dc.title.none.fl_str_mv |
Increased Intake of Both Caffeine and Non-Caffeine Coffee Components Is Associated with Reduced NAFLD Severity in Subjects with Type 2 Diabetes |
| title |
Increased Intake of Both Caffeine and Non-Caffeine Coffee Components Is Associated with Reduced NAFLD Severity in Subjects with Type 2 Diabetes |
| spellingShingle |
Increased Intake of Both Caffeine and Non-Caffeine Coffee Components Is Associated with Reduced NAFLD Severity in Subjects with Type 2 Diabetes Coelho, Margarida caffeine fatty liver index fibrosis non-alcoholic fatty liver disease type 2 diabetes Food Science Nutrition and Dietetics SDG 3 - Good Health and Well-being |
| title_short |
Increased Intake of Both Caffeine and Non-Caffeine Coffee Components Is Associated with Reduced NAFLD Severity in Subjects with Type 2 Diabetes |
| title_full |
Increased Intake of Both Caffeine and Non-Caffeine Coffee Components Is Associated with Reduced NAFLD Severity in Subjects with Type 2 Diabetes |
| title_fullStr |
Increased Intake of Both Caffeine and Non-Caffeine Coffee Components Is Associated with Reduced NAFLD Severity in Subjects with Type 2 Diabetes |
| title_full_unstemmed |
Increased Intake of Both Caffeine and Non-Caffeine Coffee Components Is Associated with Reduced NAFLD Severity in Subjects with Type 2 Diabetes |
| title_sort |
Increased Intake of Both Caffeine and Non-Caffeine Coffee Components Is Associated with Reduced NAFLD Severity in Subjects with Type 2 Diabetes |
| author |
Coelho, Margarida |
| author_facet |
Coelho, Margarida Patarrão, Rita S. Sousa-Lima, Inês Ribeiro, Rogério T. Meneses, Maria João Andrade, Rita Mendes, Vera M. Manadas, Bruno Raposo, João Filipe Macedo, M. Paula Jones, John G. |
| author_role |
author |
| author2 |
Patarrão, Rita S. Sousa-Lima, Inês Ribeiro, Rogério T. Meneses, Maria João Andrade, Rita Mendes, Vera M. Manadas, Bruno Raposo, João Filipe Macedo, M. Paula Jones, John G. |
| author2_role |
author author author author author author author author author author |
| dc.contributor.none.fl_str_mv |
NOVA Medical School|Faculdade de Ciências Médicas (NMS|FCM) iNOVA4Health - pólo NMS RUN |
| dc.contributor.author.fl_str_mv |
Coelho, Margarida Patarrão, Rita S. Sousa-Lima, Inês Ribeiro, Rogério T. Meneses, Maria João Andrade, Rita Mendes, Vera M. Manadas, Bruno Raposo, João Filipe Macedo, M. Paula Jones, John G. |
| dc.subject.por.fl_str_mv |
caffeine fatty liver index fibrosis non-alcoholic fatty liver disease type 2 diabetes Food Science Nutrition and Dietetics SDG 3 - Good Health and Well-being |
| topic |
caffeine fatty liver index fibrosis non-alcoholic fatty liver disease type 2 diabetes Food Science Nutrition and Dietetics SDG 3 - Good Health and Well-being |
| description |
Funding Information: This research was financed by a grant from the Institute for Scientific Information on Coffee (ISIC), by the European Regional Development Fund (ERDF), through the Centro 2020 Regional Operational Programme, the COMPETE 2020-Operational Programme for Competitiveness and Internationalization, and by Portuguese national funds via Fundação para a Ciência e Tecnologia (FCT): UIDB/04539/2020, UIDP/04539/2020, LA/P/0058/2020 and iNOVA4Health (UIDB/Multi/04462/2020). The National Mass Spectrometry Network (RNEM) provided funding under the contract POCI-01-0145-FEDER-402-022125 (ref.: ROTEIRO/0028/2013). M.C. was supported by PhD fellowship PD/BD/135178/2017, co-financed by the European Social Fund (ESF), through the POCH-Programa Operacional do Capital Humano, and national funds via FCT. Funding Information: The authors received funding from the Institute for Scientific Information on Coffee (ISIC), to perform the studies. Publisher Copyright: © 2022 by the authors. |
| publishDate |
2023 |
| dc.date.none.fl_str_mv |
2023-01-18T22:17:12Z 2023-01 2023-01-01T00:00:00Z |
| dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
| dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
| format |
article |
| status_str |
publishedVersion |
| dc.identifier.uri.fl_str_mv |
http://hdl.handle.net/10362/147813 |
| url |
http://hdl.handle.net/10362/147813 |
| dc.language.iso.fl_str_mv |
eng |
| language |
eng |
| dc.relation.none.fl_str_mv |
1422-8599 PURE: 50629749 https://doi.org/10.3390/nu15010004 |
| dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
| eu_rights_str_mv |
openAccess |
| dc.format.none.fl_str_mv |
application/pdf |
| dc.source.none.fl_str_mv |
reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação instacron:RCAAP |
| instname_str |
Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
| instacron_str |
RCAAP |
| institution |
RCAAP |
| reponame_str |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
| collection |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
| repository.name.fl_str_mv |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
| repository.mail.fl_str_mv |
mluisa.alvim@gmail.com |
| _version_ |
1817545910296510464 |