Association between miR-146a and tumor necrosis factor alpha (TNF-α) in stable coronary artery disease

Detalhes bibliográficos
Autor(a) principal: Pereira-da-Silva, Tiago
Data de Publicação: 2021
Outros Autores: Napoleão, Patricia, Costa, Marina C., Gabriel, André F., Selas, Mafalda, Silva, Filipa, Enguita, Francisco J., Cruz Ferreira, Rui, Carmo, Miguel Mota
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: http://hdl.handle.net/10451/49586
Resumo: © 2021 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
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spelling Association between miR-146a and tumor necrosis factor alpha (TNF-α) in stable coronary artery diseaseInflammationmiR-146amicroRNAStable coronary artery diseaseTumor necrosis factor alpha© 2021 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).Background and Objectives: Tumor necrosis factor alpha (TNF-α) is proatherogenic and associated with the risk of acute ischemic events, although the mechanisms that regulate TNF-α expression in stable coronary artery disease (SCAD) are not fully understood. We investigated whether metabolic, inflammatory, and epigenetic (microRNA (miRNA)) markers are associated with TNF-α expression in SCAD. Materials and Methods: Patients with SCAD were prospectively recruited and their metabolic and inflammatory profiles were assessed. TNF-α levels were assessed using an enzyme-linked immunosorbent assay. The relative expression of six circulating miRNAs associated with the regulation of inflammation and/or atherosclerosis was determined. Results: Of the 24 included patients with the mean age of 65 (9) years, 88% were male, and 54% were diabetic. The TNF-α levels were (median (interquartile range)) 1.0 (0.7-1.1) pg/mL. The percentage of glycosylated hemoglobin (r = 0.418, p = 0.042), serum triglyceride levels (r = 0.429, p = 0.037), and C-reactive protein levels (r = 0.407, p = 0.048) were positively correlated with TNF-α levels. Of the candidate miRNAs, miR-146a expression levels were negatively correlated with TNF-α levels (as indicated by r = 0.500, p = 0.035 for correlation between delta cycle threshold (ΔCt) miR-146a and TNF-α levels). In multivariate analysis, serum triglyceride levels and miR-146a expression levels were independently associated with TNF-α levels. miR-146 expression levels were not associated with metabolic or other inflammatory parameters and were negatively correlated with the number of coronary vessels with obstructive disease (as indicated by r = 0.556, p = 0.017 for correlation between ΔCt miR-146a and number of diseased vessels). Conclusions: miR-146a expression levels were negatively correlated with TNF-α levels in patients with SCAD, irrespective of other metabolic or inflammatory markers, and with the severity of coronary artery disease. The results add to the knowledge on the role of miR-146a in TNF-α-based inflammation in SCAD and support future research on the potential therapeutic use of miR-146a in such a clinical scenario.MDPIRepositório da Universidade de LisboaPereira-da-Silva, TiagoNapoleão, PatriciaCosta, Marina C.Gabriel, André F.Selas, MafaldaSilva, FilipaEnguita, Francisco J.Cruz Ferreira, RuiCarmo, Miguel Mota2021-09-23T10:13:12Z20212021-01-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10451/49586engMedicina (Kaunas). 2021 Jun 4;57(6):57510.3390/medicina570605751648-9144info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-11-08T16:53:30Zoai:repositorio.ul.pt:10451/49586Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T22:01:13.153588Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv Association between miR-146a and tumor necrosis factor alpha (TNF-α) in stable coronary artery disease
title Association between miR-146a and tumor necrosis factor alpha (TNF-α) in stable coronary artery disease
spellingShingle Association between miR-146a and tumor necrosis factor alpha (TNF-α) in stable coronary artery disease
Pereira-da-Silva, Tiago
Inflammation
miR-146a
microRNA
Stable coronary artery disease
Tumor necrosis factor alpha
title_short Association between miR-146a and tumor necrosis factor alpha (TNF-α) in stable coronary artery disease
title_full Association between miR-146a and tumor necrosis factor alpha (TNF-α) in stable coronary artery disease
title_fullStr Association between miR-146a and tumor necrosis factor alpha (TNF-α) in stable coronary artery disease
title_full_unstemmed Association between miR-146a and tumor necrosis factor alpha (TNF-α) in stable coronary artery disease
title_sort Association between miR-146a and tumor necrosis factor alpha (TNF-α) in stable coronary artery disease
author Pereira-da-Silva, Tiago
author_facet Pereira-da-Silva, Tiago
Napoleão, Patricia
Costa, Marina C.
Gabriel, André F.
Selas, Mafalda
Silva, Filipa
Enguita, Francisco J.
Cruz Ferreira, Rui
Carmo, Miguel Mota
author_role author
author2 Napoleão, Patricia
Costa, Marina C.
Gabriel, André F.
Selas, Mafalda
Silva, Filipa
Enguita, Francisco J.
Cruz Ferreira, Rui
Carmo, Miguel Mota
author2_role author
author
author
author
author
author
author
author
dc.contributor.none.fl_str_mv Repositório da Universidade de Lisboa
dc.contributor.author.fl_str_mv Pereira-da-Silva, Tiago
Napoleão, Patricia
Costa, Marina C.
Gabriel, André F.
Selas, Mafalda
Silva, Filipa
Enguita, Francisco J.
Cruz Ferreira, Rui
Carmo, Miguel Mota
dc.subject.por.fl_str_mv Inflammation
miR-146a
microRNA
Stable coronary artery disease
Tumor necrosis factor alpha
topic Inflammation
miR-146a
microRNA
Stable coronary artery disease
Tumor necrosis factor alpha
description © 2021 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
publishDate 2021
dc.date.none.fl_str_mv 2021-09-23T10:13:12Z
2021
2021-01-01T00:00:00Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/10451/49586
url http://hdl.handle.net/10451/49586
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv Medicina (Kaunas). 2021 Jun 4;57(6):575
10.3390/medicina57060575
1648-9144
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv MDPI
publisher.none.fl_str_mv MDPI
dc.source.none.fl_str_mv reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron:RCAAP
instname_str Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron_str RCAAP
institution RCAAP
reponame_str Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
collection Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
repository.name.fl_str_mv Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
repository.mail.fl_str_mv
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