The origins of african Plasmodium vivax; insights from mitochondrial genome sequencing

Detalhes bibliográficos
Autor(a) principal: Culleton, Richard
Data de Publicação: 2011
Outros Autores: Coban, Cevayir, Zeyrek, Fadile Yildiz, Cravo, Pedro, Kaneko, Akira, Randrianarivelojosia, Milijaona, Andrianaranjaka, Voahangy, Kano, Shigeyuki, Farnert, Anna, Arez, Ana Paula, Sharp, Paul M., Carter, Richard, Tanabe, Kazuyuki
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: http://hdl.handle.net/10362/117134
Resumo: Plasmodium vivax, the second most prevalent of the human malaria parasites, is estimated to affect 75 million people annually. It is very rare, however, in west and central Africa, due to the high prevalence of the Duffy negative phenotype in the human population. Due to its rarity in Africa, previous studies on the phylogeny of world-wide P. vivax have suffered from insufficient samples of African parasites. Here we compare the mitochondrial sequence diversity of parasites from Africa with those from other areas of the world, in order to investigate the origin of present-day African P. vivax. Mitochondrial genome sequencing revealed relatively little polymorphism within the African population compared to parasites from the rest of the world. This, combined with sequence similarity with parasites from India, suggests that the present day African P. vivax population in humans may have been introduced relatively recently from the Indian subcontinent. Haplotype network analysis also raises the possibility that parasites currently found in Africa and South America may be the closest extant relatives of the ancestors of the current world population. Lines of evidence are adduced that this ancestral population may be from an ancient stock of P. vivax in Africa.
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spelling The origins of african Plasmodium vivax; insights from mitochondrial genome sequencingEcology, Evolution, Behavior and SystematicsParasitologyGeneticsSDG 3 - Good Health and Well-beingPlasmodium vivax, the second most prevalent of the human malaria parasites, is estimated to affect 75 million people annually. It is very rare, however, in west and central Africa, due to the high prevalence of the Duffy negative phenotype in the human population. Due to its rarity in Africa, previous studies on the phylogeny of world-wide P. vivax have suffered from insufficient samples of African parasites. Here we compare the mitochondrial sequence diversity of parasites from Africa with those from other areas of the world, in order to investigate the origin of present-day African P. vivax. Mitochondrial genome sequencing revealed relatively little polymorphism within the African population compared to parasites from the rest of the world. This, combined with sequence similarity with parasites from India, suggests that the present day African P. vivax population in humans may have been introduced relatively recently from the Indian subcontinent. Haplotype network analysis also raises the possibility that parasites currently found in Africa and South America may be the closest extant relatives of the ancestors of the current world population. Lines of evidence are adduced that this ancestral population may be from an ancient stock of P. vivax in Africa.Instituto de Higiene e Medicina Tropical (IHMT)Centro de Malária e outras Doenças Tropicais (CMDT)RUNCulleton, RichardCoban, CevayirZeyrek, Fadile YildizCravo, PedroKaneko, AkiraRandrianarivelojosia, MilijaonaAndrianaranjaka, VoahangyKano, ShigeyukiFarnert, AnnaArez, Ana PaulaSharp, Paul M.Carter, RichardTanabe, Kazuyuki2021-05-05T23:24:38Z2011-12-142011-12-14T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10362/117134eng1932-6203PURE: 26055916https://doi.org/10.1371/journal.pone.0029137info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2024-03-11T05:00:10Zoai:run.unl.pt:10362/117134Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-20T03:43:29.329159Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv The origins of african Plasmodium vivax; insights from mitochondrial genome sequencing
title The origins of african Plasmodium vivax; insights from mitochondrial genome sequencing
spellingShingle The origins of african Plasmodium vivax; insights from mitochondrial genome sequencing
Culleton, Richard
Ecology, Evolution, Behavior and Systematics
Parasitology
Genetics
SDG 3 - Good Health and Well-being
title_short The origins of african Plasmodium vivax; insights from mitochondrial genome sequencing
title_full The origins of african Plasmodium vivax; insights from mitochondrial genome sequencing
title_fullStr The origins of african Plasmodium vivax; insights from mitochondrial genome sequencing
title_full_unstemmed The origins of african Plasmodium vivax; insights from mitochondrial genome sequencing
title_sort The origins of african Plasmodium vivax; insights from mitochondrial genome sequencing
author Culleton, Richard
author_facet Culleton, Richard
Coban, Cevayir
Zeyrek, Fadile Yildiz
Cravo, Pedro
Kaneko, Akira
Randrianarivelojosia, Milijaona
Andrianaranjaka, Voahangy
Kano, Shigeyuki
Farnert, Anna
Arez, Ana Paula
Sharp, Paul M.
Carter, Richard
Tanabe, Kazuyuki
author_role author
author2 Coban, Cevayir
Zeyrek, Fadile Yildiz
Cravo, Pedro
Kaneko, Akira
Randrianarivelojosia, Milijaona
Andrianaranjaka, Voahangy
Kano, Shigeyuki
Farnert, Anna
Arez, Ana Paula
Sharp, Paul M.
Carter, Richard
Tanabe, Kazuyuki
author2_role author
author
author
author
author
author
author
author
author
author
author
author
dc.contributor.none.fl_str_mv Instituto de Higiene e Medicina Tropical (IHMT)
Centro de Malária e outras Doenças Tropicais (CMDT)
RUN
dc.contributor.author.fl_str_mv Culleton, Richard
Coban, Cevayir
Zeyrek, Fadile Yildiz
Cravo, Pedro
Kaneko, Akira
Randrianarivelojosia, Milijaona
Andrianaranjaka, Voahangy
Kano, Shigeyuki
Farnert, Anna
Arez, Ana Paula
Sharp, Paul M.
Carter, Richard
Tanabe, Kazuyuki
dc.subject.por.fl_str_mv Ecology, Evolution, Behavior and Systematics
Parasitology
Genetics
SDG 3 - Good Health and Well-being
topic Ecology, Evolution, Behavior and Systematics
Parasitology
Genetics
SDG 3 - Good Health and Well-being
description Plasmodium vivax, the second most prevalent of the human malaria parasites, is estimated to affect 75 million people annually. It is very rare, however, in west and central Africa, due to the high prevalence of the Duffy negative phenotype in the human population. Due to its rarity in Africa, previous studies on the phylogeny of world-wide P. vivax have suffered from insufficient samples of African parasites. Here we compare the mitochondrial sequence diversity of parasites from Africa with those from other areas of the world, in order to investigate the origin of present-day African P. vivax. Mitochondrial genome sequencing revealed relatively little polymorphism within the African population compared to parasites from the rest of the world. This, combined with sequence similarity with parasites from India, suggests that the present day African P. vivax population in humans may have been introduced relatively recently from the Indian subcontinent. Haplotype network analysis also raises the possibility that parasites currently found in Africa and South America may be the closest extant relatives of the ancestors of the current world population. Lines of evidence are adduced that this ancestral population may be from an ancient stock of P. vivax in Africa.
publishDate 2011
dc.date.none.fl_str_mv 2011-12-14
2011-12-14T00:00:00Z
2021-05-05T23:24:38Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/10362/117134
url http://hdl.handle.net/10362/117134
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 1932-6203
PURE: 26055916
https://doi.org/10.1371/journal.pone.0029137
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eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.source.none.fl_str_mv reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron:RCAAP
instname_str Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron_str RCAAP
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collection Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
repository.name.fl_str_mv Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
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