The origins of african Plasmodium vivax; insights from mitochondrial genome sequencing
Autor(a) principal: | |
---|---|
Data de Publicação: | 2011 |
Outros Autores: | , , , , , , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
Texto Completo: | http://hdl.handle.net/10362/117134 |
Resumo: | Plasmodium vivax, the second most prevalent of the human malaria parasites, is estimated to affect 75 million people annually. It is very rare, however, in west and central Africa, due to the high prevalence of the Duffy negative phenotype in the human population. Due to its rarity in Africa, previous studies on the phylogeny of world-wide P. vivax have suffered from insufficient samples of African parasites. Here we compare the mitochondrial sequence diversity of parasites from Africa with those from other areas of the world, in order to investigate the origin of present-day African P. vivax. Mitochondrial genome sequencing revealed relatively little polymorphism within the African population compared to parasites from the rest of the world. This, combined with sequence similarity with parasites from India, suggests that the present day African P. vivax population in humans may have been introduced relatively recently from the Indian subcontinent. Haplotype network analysis also raises the possibility that parasites currently found in Africa and South America may be the closest extant relatives of the ancestors of the current world population. Lines of evidence are adduced that this ancestral population may be from an ancient stock of P. vivax in Africa. |
id |
RCAP_575881ae1eee39bc7cb4c69717a058f4 |
---|---|
oai_identifier_str |
oai:run.unl.pt:10362/117134 |
network_acronym_str |
RCAP |
network_name_str |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
repository_id_str |
7160 |
spelling |
The origins of african Plasmodium vivax; insights from mitochondrial genome sequencingEcology, Evolution, Behavior and SystematicsParasitologyGeneticsSDG 3 - Good Health and Well-beingPlasmodium vivax, the second most prevalent of the human malaria parasites, is estimated to affect 75 million people annually. It is very rare, however, in west and central Africa, due to the high prevalence of the Duffy negative phenotype in the human population. Due to its rarity in Africa, previous studies on the phylogeny of world-wide P. vivax have suffered from insufficient samples of African parasites. Here we compare the mitochondrial sequence diversity of parasites from Africa with those from other areas of the world, in order to investigate the origin of present-day African P. vivax. Mitochondrial genome sequencing revealed relatively little polymorphism within the African population compared to parasites from the rest of the world. This, combined with sequence similarity with parasites from India, suggests that the present day African P. vivax population in humans may have been introduced relatively recently from the Indian subcontinent. Haplotype network analysis also raises the possibility that parasites currently found in Africa and South America may be the closest extant relatives of the ancestors of the current world population. Lines of evidence are adduced that this ancestral population may be from an ancient stock of P. vivax in Africa.Instituto de Higiene e Medicina Tropical (IHMT)Centro de Malária e outras Doenças Tropicais (CMDT)RUNCulleton, RichardCoban, CevayirZeyrek, Fadile YildizCravo, PedroKaneko, AkiraRandrianarivelojosia, MilijaonaAndrianaranjaka, VoahangyKano, ShigeyukiFarnert, AnnaArez, Ana PaulaSharp, Paul M.Carter, RichardTanabe, Kazuyuki2021-05-05T23:24:38Z2011-12-142011-12-14T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10362/117134eng1932-6203PURE: 26055916https://doi.org/10.1371/journal.pone.0029137info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2024-03-11T05:00:10Zoai:run.unl.pt:10362/117134Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-20T03:43:29.329159Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse |
dc.title.none.fl_str_mv |
The origins of african Plasmodium vivax; insights from mitochondrial genome sequencing |
title |
The origins of african Plasmodium vivax; insights from mitochondrial genome sequencing |
spellingShingle |
The origins of african Plasmodium vivax; insights from mitochondrial genome sequencing Culleton, Richard Ecology, Evolution, Behavior and Systematics Parasitology Genetics SDG 3 - Good Health and Well-being |
title_short |
The origins of african Plasmodium vivax; insights from mitochondrial genome sequencing |
title_full |
The origins of african Plasmodium vivax; insights from mitochondrial genome sequencing |
title_fullStr |
The origins of african Plasmodium vivax; insights from mitochondrial genome sequencing |
title_full_unstemmed |
The origins of african Plasmodium vivax; insights from mitochondrial genome sequencing |
title_sort |
The origins of african Plasmodium vivax; insights from mitochondrial genome sequencing |
author |
Culleton, Richard |
author_facet |
Culleton, Richard Coban, Cevayir Zeyrek, Fadile Yildiz Cravo, Pedro Kaneko, Akira Randrianarivelojosia, Milijaona Andrianaranjaka, Voahangy Kano, Shigeyuki Farnert, Anna Arez, Ana Paula Sharp, Paul M. Carter, Richard Tanabe, Kazuyuki |
author_role |
author |
author2 |
Coban, Cevayir Zeyrek, Fadile Yildiz Cravo, Pedro Kaneko, Akira Randrianarivelojosia, Milijaona Andrianaranjaka, Voahangy Kano, Shigeyuki Farnert, Anna Arez, Ana Paula Sharp, Paul M. Carter, Richard Tanabe, Kazuyuki |
author2_role |
author author author author author author author author author author author author |
dc.contributor.none.fl_str_mv |
Instituto de Higiene e Medicina Tropical (IHMT) Centro de Malária e outras Doenças Tropicais (CMDT) RUN |
dc.contributor.author.fl_str_mv |
Culleton, Richard Coban, Cevayir Zeyrek, Fadile Yildiz Cravo, Pedro Kaneko, Akira Randrianarivelojosia, Milijaona Andrianaranjaka, Voahangy Kano, Shigeyuki Farnert, Anna Arez, Ana Paula Sharp, Paul M. Carter, Richard Tanabe, Kazuyuki |
dc.subject.por.fl_str_mv |
Ecology, Evolution, Behavior and Systematics Parasitology Genetics SDG 3 - Good Health and Well-being |
topic |
Ecology, Evolution, Behavior and Systematics Parasitology Genetics SDG 3 - Good Health and Well-being |
description |
Plasmodium vivax, the second most prevalent of the human malaria parasites, is estimated to affect 75 million people annually. It is very rare, however, in west and central Africa, due to the high prevalence of the Duffy negative phenotype in the human population. Due to its rarity in Africa, previous studies on the phylogeny of world-wide P. vivax have suffered from insufficient samples of African parasites. Here we compare the mitochondrial sequence diversity of parasites from Africa with those from other areas of the world, in order to investigate the origin of present-day African P. vivax. Mitochondrial genome sequencing revealed relatively little polymorphism within the African population compared to parasites from the rest of the world. This, combined with sequence similarity with parasites from India, suggests that the present day African P. vivax population in humans may have been introduced relatively recently from the Indian subcontinent. Haplotype network analysis also raises the possibility that parasites currently found in Africa and South America may be the closest extant relatives of the ancestors of the current world population. Lines of evidence are adduced that this ancestral population may be from an ancient stock of P. vivax in Africa. |
publishDate |
2011 |
dc.date.none.fl_str_mv |
2011-12-14 2011-12-14T00:00:00Z 2021-05-05T23:24:38Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://hdl.handle.net/10362/117134 |
url |
http://hdl.handle.net/10362/117134 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
1932-6203 PURE: 26055916 https://doi.org/10.1371/journal.pone.0029137 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.source.none.fl_str_mv |
reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação instacron:RCAAP |
instname_str |
Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
instacron_str |
RCAAP |
institution |
RCAAP |
reponame_str |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
collection |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
repository.name.fl_str_mv |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
repository.mail.fl_str_mv |
|
_version_ |
1799138044549267456 |