Failure to detect Plasmodium vivax in West and Central Africa by PCR species typing

Detalhes bibliográficos
Autor(a) principal: Culleton, Richard L.
Data de Publicação: 2008
Outros Autores: Mita, Toshihiro, Ndounga, Mathieu, Unger, Holger, Cravo, Pedro V.L., Paganotti, Giacomo M., Takahashi, Nobuyuki, Kaneko, Akira, Eto, Hideaki, Tinto, Halidou, Karema, Corine, D'Alessandro, Umberto, Do Rosário, Virgilio, Kobayakawa, Takatoshi, Ntoumi, Francine, Carter, Richard, Tanabe, Kazuyuki
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: http://hdl.handle.net/10362/117259
Resumo: Background. Plasmodium vivax is estimated to affect 75 million people annually. It is reportedly absent, however, from west and central Africa due to the high prevalence of the Duffy negative phenotype in the indigenous populations. Despite this, non-African travellers consistently return to their own countries with P. vivax malaria after visiting this region. An attempt was made, therefore, to detect the presence of P. vivax parasites in blood samples collected from the indigenous populations of west and central Africa. Methods. Parasite species typing (for all four human malaria parasites) was carried out by PCR on 2,588 blood samples collected from individuals from nine African malaria-endemic countries. Results. Most infections (98.5%) were Plasmodium falciparum, Plasmodium malariae was identified in 8.5% of all infections, and Plasmodium ovale in 3.9%. The prevalence of both parasites varied greatly by country. Only one case of P. vivax was detected from Sao Tome, an island off the west coast of Africa, confirming the scarcity of this parasite in Africa. Conclusion. The prevalence of P. vivax in local populations in sub-Saharan Africa is very low, despite the frequent identification of this parasite in non-African travellers.
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spelling Failure to detect Plasmodium vivax in West and Central Africa by PCR species typingParasitologyInfectious DiseasesGeneticsSDG 3 - Good Health and Well-beingBackground. Plasmodium vivax is estimated to affect 75 million people annually. It is reportedly absent, however, from west and central Africa due to the high prevalence of the Duffy negative phenotype in the indigenous populations. Despite this, non-African travellers consistently return to their own countries with P. vivax malaria after visiting this region. An attempt was made, therefore, to detect the presence of P. vivax parasites in blood samples collected from the indigenous populations of west and central Africa. Methods. Parasite species typing (for all four human malaria parasites) was carried out by PCR on 2,588 blood samples collected from individuals from nine African malaria-endemic countries. Results. Most infections (98.5%) were Plasmodium falciparum, Plasmodium malariae was identified in 8.5% of all infections, and Plasmodium ovale in 3.9%. The prevalence of both parasites varied greatly by country. Only one case of P. vivax was detected from Sao Tome, an island off the west coast of Africa, confirming the scarcity of this parasite in Africa. Conclusion. The prevalence of P. vivax in local populations in sub-Saharan Africa is very low, despite the frequent identification of this parasite in non-African travellers.Instituto de Higiene e Medicina Tropical (IHMT)Centro de Malária e outras Doenças Tropicais (CMDT)RUNCulleton, Richard L.Mita, ToshihiroNdounga, MathieuUnger, HolgerCravo, Pedro V.L.Paganotti, Giacomo M.Takahashi, NobuyukiKaneko, AkiraEto, HideakiTinto, HalidouKarema, CorineD'Alessandro, UmbertoDo Rosário, VirgilioKobayakawa, TakatoshiNtoumi, FrancineCarter, RichardTanabe, Kazuyuki2021-05-06T22:43:20Z2008-09-262008-09-26T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10362/117259eng1475-2875PURE: 26056891https://doi.org/10.1186/1475-2875-7-174info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2024-03-11T05:00:22Zoai:run.unl.pt:10362/117259Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-20T03:43:34.031129Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv Failure to detect Plasmodium vivax in West and Central Africa by PCR species typing
title Failure to detect Plasmodium vivax in West and Central Africa by PCR species typing
spellingShingle Failure to detect Plasmodium vivax in West and Central Africa by PCR species typing
Culleton, Richard L.
Parasitology
Infectious Diseases
Genetics
SDG 3 - Good Health and Well-being
title_short Failure to detect Plasmodium vivax in West and Central Africa by PCR species typing
title_full Failure to detect Plasmodium vivax in West and Central Africa by PCR species typing
title_fullStr Failure to detect Plasmodium vivax in West and Central Africa by PCR species typing
title_full_unstemmed Failure to detect Plasmodium vivax in West and Central Africa by PCR species typing
title_sort Failure to detect Plasmodium vivax in West and Central Africa by PCR species typing
author Culleton, Richard L.
author_facet Culleton, Richard L.
Mita, Toshihiro
Ndounga, Mathieu
Unger, Holger
Cravo, Pedro V.L.
Paganotti, Giacomo M.
Takahashi, Nobuyuki
Kaneko, Akira
Eto, Hideaki
Tinto, Halidou
Karema, Corine
D'Alessandro, Umberto
Do Rosário, Virgilio
Kobayakawa, Takatoshi
Ntoumi, Francine
Carter, Richard
Tanabe, Kazuyuki
author_role author
author2 Mita, Toshihiro
Ndounga, Mathieu
Unger, Holger
Cravo, Pedro V.L.
Paganotti, Giacomo M.
Takahashi, Nobuyuki
Kaneko, Akira
Eto, Hideaki
Tinto, Halidou
Karema, Corine
D'Alessandro, Umberto
Do Rosário, Virgilio
Kobayakawa, Takatoshi
Ntoumi, Francine
Carter, Richard
Tanabe, Kazuyuki
author2_role author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
dc.contributor.none.fl_str_mv Instituto de Higiene e Medicina Tropical (IHMT)
Centro de Malária e outras Doenças Tropicais (CMDT)
RUN
dc.contributor.author.fl_str_mv Culleton, Richard L.
Mita, Toshihiro
Ndounga, Mathieu
Unger, Holger
Cravo, Pedro V.L.
Paganotti, Giacomo M.
Takahashi, Nobuyuki
Kaneko, Akira
Eto, Hideaki
Tinto, Halidou
Karema, Corine
D'Alessandro, Umberto
Do Rosário, Virgilio
Kobayakawa, Takatoshi
Ntoumi, Francine
Carter, Richard
Tanabe, Kazuyuki
dc.subject.por.fl_str_mv Parasitology
Infectious Diseases
Genetics
SDG 3 - Good Health and Well-being
topic Parasitology
Infectious Diseases
Genetics
SDG 3 - Good Health and Well-being
description Background. Plasmodium vivax is estimated to affect 75 million people annually. It is reportedly absent, however, from west and central Africa due to the high prevalence of the Duffy negative phenotype in the indigenous populations. Despite this, non-African travellers consistently return to their own countries with P. vivax malaria after visiting this region. An attempt was made, therefore, to detect the presence of P. vivax parasites in blood samples collected from the indigenous populations of west and central Africa. Methods. Parasite species typing (for all four human malaria parasites) was carried out by PCR on 2,588 blood samples collected from individuals from nine African malaria-endemic countries. Results. Most infections (98.5%) were Plasmodium falciparum, Plasmodium malariae was identified in 8.5% of all infections, and Plasmodium ovale in 3.9%. The prevalence of both parasites varied greatly by country. Only one case of P. vivax was detected from Sao Tome, an island off the west coast of Africa, confirming the scarcity of this parasite in Africa. Conclusion. The prevalence of P. vivax in local populations in sub-Saharan Africa is very low, despite the frequent identification of this parasite in non-African travellers.
publishDate 2008
dc.date.none.fl_str_mv 2008-09-26
2008-09-26T00:00:00Z
2021-05-06T22:43:20Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
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dc.identifier.uri.fl_str_mv http://hdl.handle.net/10362/117259
url http://hdl.handle.net/10362/117259
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 1475-2875
PURE: 26056891
https://doi.org/10.1186/1475-2875-7-174
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eu_rights_str_mv openAccess
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dc.source.none.fl_str_mv reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
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