Failure to detect Plasmodium vivax in West and Central Africa by PCR species typing
Autor(a) principal: | |
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Data de Publicação: | 2008 |
Outros Autores: | , , , , , , , , , , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
Texto Completo: | http://hdl.handle.net/10362/117259 |
Resumo: | Background. Plasmodium vivax is estimated to affect 75 million people annually. It is reportedly absent, however, from west and central Africa due to the high prevalence of the Duffy negative phenotype in the indigenous populations. Despite this, non-African travellers consistently return to their own countries with P. vivax malaria after visiting this region. An attempt was made, therefore, to detect the presence of P. vivax parasites in blood samples collected from the indigenous populations of west and central Africa. Methods. Parasite species typing (for all four human malaria parasites) was carried out by PCR on 2,588 blood samples collected from individuals from nine African malaria-endemic countries. Results. Most infections (98.5%) were Plasmodium falciparum, Plasmodium malariae was identified in 8.5% of all infections, and Plasmodium ovale in 3.9%. The prevalence of both parasites varied greatly by country. Only one case of P. vivax was detected from Sao Tome, an island off the west coast of Africa, confirming the scarcity of this parasite in Africa. Conclusion. The prevalence of P. vivax in local populations in sub-Saharan Africa is very low, despite the frequent identification of this parasite in non-African travellers. |
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Failure to detect Plasmodium vivax in West and Central Africa by PCR species typingParasitologyInfectious DiseasesGeneticsSDG 3 - Good Health and Well-beingBackground. Plasmodium vivax is estimated to affect 75 million people annually. It is reportedly absent, however, from west and central Africa due to the high prevalence of the Duffy negative phenotype in the indigenous populations. Despite this, non-African travellers consistently return to their own countries with P. vivax malaria after visiting this region. An attempt was made, therefore, to detect the presence of P. vivax parasites in blood samples collected from the indigenous populations of west and central Africa. Methods. Parasite species typing (for all four human malaria parasites) was carried out by PCR on 2,588 blood samples collected from individuals from nine African malaria-endemic countries. Results. Most infections (98.5%) were Plasmodium falciparum, Plasmodium malariae was identified in 8.5% of all infections, and Plasmodium ovale in 3.9%. The prevalence of both parasites varied greatly by country. Only one case of P. vivax was detected from Sao Tome, an island off the west coast of Africa, confirming the scarcity of this parasite in Africa. Conclusion. The prevalence of P. vivax in local populations in sub-Saharan Africa is very low, despite the frequent identification of this parasite in non-African travellers.Instituto de Higiene e Medicina Tropical (IHMT)Centro de Malária e outras Doenças Tropicais (CMDT)RUNCulleton, Richard L.Mita, ToshihiroNdounga, MathieuUnger, HolgerCravo, Pedro V.L.Paganotti, Giacomo M.Takahashi, NobuyukiKaneko, AkiraEto, HideakiTinto, HalidouKarema, CorineD'Alessandro, UmbertoDo Rosário, VirgilioKobayakawa, TakatoshiNtoumi, FrancineCarter, RichardTanabe, Kazuyuki2021-05-06T22:43:20Z2008-09-262008-09-26T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10362/117259eng1475-2875PURE: 26056891https://doi.org/10.1186/1475-2875-7-174info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2024-03-11T05:00:22Zoai:run.unl.pt:10362/117259Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-20T03:43:34.031129Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse |
dc.title.none.fl_str_mv |
Failure to detect Plasmodium vivax in West and Central Africa by PCR species typing |
title |
Failure to detect Plasmodium vivax in West and Central Africa by PCR species typing |
spellingShingle |
Failure to detect Plasmodium vivax in West and Central Africa by PCR species typing Culleton, Richard L. Parasitology Infectious Diseases Genetics SDG 3 - Good Health and Well-being |
title_short |
Failure to detect Plasmodium vivax in West and Central Africa by PCR species typing |
title_full |
Failure to detect Plasmodium vivax in West and Central Africa by PCR species typing |
title_fullStr |
Failure to detect Plasmodium vivax in West and Central Africa by PCR species typing |
title_full_unstemmed |
Failure to detect Plasmodium vivax in West and Central Africa by PCR species typing |
title_sort |
Failure to detect Plasmodium vivax in West and Central Africa by PCR species typing |
author |
Culleton, Richard L. |
author_facet |
Culleton, Richard L. Mita, Toshihiro Ndounga, Mathieu Unger, Holger Cravo, Pedro V.L. Paganotti, Giacomo M. Takahashi, Nobuyuki Kaneko, Akira Eto, Hideaki Tinto, Halidou Karema, Corine D'Alessandro, Umberto Do Rosário, Virgilio Kobayakawa, Takatoshi Ntoumi, Francine Carter, Richard Tanabe, Kazuyuki |
author_role |
author |
author2 |
Mita, Toshihiro Ndounga, Mathieu Unger, Holger Cravo, Pedro V.L. Paganotti, Giacomo M. Takahashi, Nobuyuki Kaneko, Akira Eto, Hideaki Tinto, Halidou Karema, Corine D'Alessandro, Umberto Do Rosário, Virgilio Kobayakawa, Takatoshi Ntoumi, Francine Carter, Richard Tanabe, Kazuyuki |
author2_role |
author author author author author author author author author author author author author author author author |
dc.contributor.none.fl_str_mv |
Instituto de Higiene e Medicina Tropical (IHMT) Centro de Malária e outras Doenças Tropicais (CMDT) RUN |
dc.contributor.author.fl_str_mv |
Culleton, Richard L. Mita, Toshihiro Ndounga, Mathieu Unger, Holger Cravo, Pedro V.L. Paganotti, Giacomo M. Takahashi, Nobuyuki Kaneko, Akira Eto, Hideaki Tinto, Halidou Karema, Corine D'Alessandro, Umberto Do Rosário, Virgilio Kobayakawa, Takatoshi Ntoumi, Francine Carter, Richard Tanabe, Kazuyuki |
dc.subject.por.fl_str_mv |
Parasitology Infectious Diseases Genetics SDG 3 - Good Health and Well-being |
topic |
Parasitology Infectious Diseases Genetics SDG 3 - Good Health and Well-being |
description |
Background. Plasmodium vivax is estimated to affect 75 million people annually. It is reportedly absent, however, from west and central Africa due to the high prevalence of the Duffy negative phenotype in the indigenous populations. Despite this, non-African travellers consistently return to their own countries with P. vivax malaria after visiting this region. An attempt was made, therefore, to detect the presence of P. vivax parasites in blood samples collected from the indigenous populations of west and central Africa. Methods. Parasite species typing (for all four human malaria parasites) was carried out by PCR on 2,588 blood samples collected from individuals from nine African malaria-endemic countries. Results. Most infections (98.5%) were Plasmodium falciparum, Plasmodium malariae was identified in 8.5% of all infections, and Plasmodium ovale in 3.9%. The prevalence of both parasites varied greatly by country. Only one case of P. vivax was detected from Sao Tome, an island off the west coast of Africa, confirming the scarcity of this parasite in Africa. Conclusion. The prevalence of P. vivax in local populations in sub-Saharan Africa is very low, despite the frequent identification of this parasite in non-African travellers. |
publishDate |
2008 |
dc.date.none.fl_str_mv |
2008-09-26 2008-09-26T00:00:00Z 2021-05-06T22:43:20Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://hdl.handle.net/10362/117259 |
url |
http://hdl.handle.net/10362/117259 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
1475-2875 PURE: 26056891 https://doi.org/10.1186/1475-2875-7-174 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.source.none.fl_str_mv |
reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação instacron:RCAAP |
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Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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RCAAP |
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RCAAP |
reponame_str |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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