Levels of circulating Fibroblast Growth Factor 23 (FGF23) and prognosis in cancer patients with bone metastases

Detalhes bibliográficos
Autor(a) principal: Mansinho, André
Data de Publicação: 2019
Outros Autores: Ferreira, Arlindo, Casimiro, Sandra, Alho, Irina, Vendrell, Ines, Costa, Ana Lúcia, Sousa, Rita, Marques, Catarina, Pulido, Catarina, Macedo, Daniela, Pacheco, Teresa, Correia, Lurdes, Costa, Luis
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: http://hdl.handle.net/10451/49209
Resumo: © 2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
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spelling Levels of circulating Fibroblast Growth Factor 23 (FGF23) and prognosis in cancer patients with bone metastasesFGF23Bone metastasesCancerPrognosis© 2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).The fibroblast growth factor (FGF) signaling pathway plays a key role in tumorigenesis and is recognized as a potential therapeutic target. In this study, the authors aimed to assess the impact of serum FGF23 levels in the prognosis of patients with cancer and bone metastases from solid tumors. A cohort of 112 patients with cancer and metastatic bone disease were treated with bone-targeted agents (BTA). Serum baseline FGF23 was quantified by ELISA and dichotomized in FGF23high and FGF23low groups. Additionally, the association between FGF23 and overall survival (OS) and time to skeletal-related events (TTSRE) was investigated. Baseline characteristics were balanced between groups, except for the median urinary N-terminal telopeptide (uNTX) level. After a median follow-up of 26.0 months, a median OS of 34.4 and 12.2 months was found in the FGF23low and FGF23high groups, respectively (multivariate HR 0.18, 95% CI 0.07⁻0.44, p = 0.001; univariate HR 0.27, p = 0.001). Additionally, TTSRE was significantly longer for patients with FGF23low (13.0 vs 2.0 months, p = 0.04). Overall, this study found that patients with FGF23low at baseline had longer OS and TTSRE. Further studies are warranted to define its role as a prognostic biomarker and in the use of drugs targeting the FGF axis.This research received funding from an anonymous non-pharma related individual in the form of donation. This study was supported by project UID/BIM/50005/2019 of Fundação para a Ciência e a Tecnologia (FCT)/Ministério da Ciência, Tecnologia e Ensino Superior (MCTES) through State Budget funding.MDPIRepositório da Universidade de LisboaMansinho, AndréFerreira, ArlindoCasimiro, SandraAlho, IrinaVendrell, InesCosta, Ana LúciaSousa, RitaMarques, CatarinaPulido, CatarinaMacedo, DanielaPacheco, TeresaCorreia, LurdesCosta, Luis2021-07-29T13:36:02Z2019-02-062019-02-06T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10451/49209engMansinho A, Ferreira AR, Casimiro S, Alho I, Vendrell I, Costa AL, Sousa R, Abreu C, Pulido C, Macedo D, Pacheco TR, Correia L, Costa L. Levels of circulating Fibroblast Growth Factor 23 (FGF23) and prognosis in cancer patients with bone metastases. Int J Mol Sci. 2019 Feb 6;20(3):6951661-659610.3390/ijms200306951422-0067info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2024-11-20T18:08:20Zoai:repositorio.ul.pt:10451/49209Portal AgregadorONGhttps://www.rcaap.pt/oai/openairemluisa.alvim@gmail.comopendoar:71602024-11-20T18:08:20Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv Levels of circulating Fibroblast Growth Factor 23 (FGF23) and prognosis in cancer patients with bone metastases
title Levels of circulating Fibroblast Growth Factor 23 (FGF23) and prognosis in cancer patients with bone metastases
spellingShingle Levels of circulating Fibroblast Growth Factor 23 (FGF23) and prognosis in cancer patients with bone metastases
Mansinho, André
FGF23
Bone metastases
Cancer
Prognosis
title_short Levels of circulating Fibroblast Growth Factor 23 (FGF23) and prognosis in cancer patients with bone metastases
title_full Levels of circulating Fibroblast Growth Factor 23 (FGF23) and prognosis in cancer patients with bone metastases
title_fullStr Levels of circulating Fibroblast Growth Factor 23 (FGF23) and prognosis in cancer patients with bone metastases
title_full_unstemmed Levels of circulating Fibroblast Growth Factor 23 (FGF23) and prognosis in cancer patients with bone metastases
title_sort Levels of circulating Fibroblast Growth Factor 23 (FGF23) and prognosis in cancer patients with bone metastases
author Mansinho, André
author_facet Mansinho, André
Ferreira, Arlindo
Casimiro, Sandra
Alho, Irina
Vendrell, Ines
Costa, Ana Lúcia
Sousa, Rita
Marques, Catarina
Pulido, Catarina
Macedo, Daniela
Pacheco, Teresa
Correia, Lurdes
Costa, Luis
author_role author
author2 Ferreira, Arlindo
Casimiro, Sandra
Alho, Irina
Vendrell, Ines
Costa, Ana Lúcia
Sousa, Rita
Marques, Catarina
Pulido, Catarina
Macedo, Daniela
Pacheco, Teresa
Correia, Lurdes
Costa, Luis
author2_role author
author
author
author
author
author
author
author
author
author
author
author
dc.contributor.none.fl_str_mv Repositório da Universidade de Lisboa
dc.contributor.author.fl_str_mv Mansinho, André
Ferreira, Arlindo
Casimiro, Sandra
Alho, Irina
Vendrell, Ines
Costa, Ana Lúcia
Sousa, Rita
Marques, Catarina
Pulido, Catarina
Macedo, Daniela
Pacheco, Teresa
Correia, Lurdes
Costa, Luis
dc.subject.por.fl_str_mv FGF23
Bone metastases
Cancer
Prognosis
topic FGF23
Bone metastases
Cancer
Prognosis
description © 2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
publishDate 2019
dc.date.none.fl_str_mv 2019-02-06
2019-02-06T00:00:00Z
2021-07-29T13:36:02Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/10451/49209
url http://hdl.handle.net/10451/49209
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv Mansinho A, Ferreira AR, Casimiro S, Alho I, Vendrell I, Costa AL, Sousa R, Abreu C, Pulido C, Macedo D, Pacheco TR, Correia L, Costa L. Levels of circulating Fibroblast Growth Factor 23 (FGF23) and prognosis in cancer patients with bone metastases. Int J Mol Sci. 2019 Feb 6;20(3):695
1661-6596
10.3390/ijms20030695
1422-0067
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv MDPI
publisher.none.fl_str_mv MDPI
dc.source.none.fl_str_mv reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron:RCAAP
instname_str Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron_str RCAAP
institution RCAAP
reponame_str Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
collection Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
repository.name.fl_str_mv Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
repository.mail.fl_str_mv mluisa.alvim@gmail.com
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