Crystallin fusion proteins improve the thermal properties of hair

Detalhes bibliográficos
Autor(a) principal: Tinoco, Ana
Data de Publicação: 2019
Outros Autores: Gonçalves, J. A., Silva, Carla, Cavaco-Paulo, Artur, Ribeiro, Artur
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: http://hdl.handle.net/1822/62173
Resumo: The Supplementary Material for this article can be found online at: https://www.frontiersin.org/articles/10.3389/fbioe. 2019.00298/full#supplementary-material
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spelling Crystallin fusion proteins improve the thermal properties of hairproteinsgamma D-crystallinhairthermal damageprotectionkeratin-based peptideγD-crystallinScience & TechnologyThe Supplementary Material for this article can be found online at: https://www.frontiersin.org/articles/10.3389/fbioe. 2019.00298/full#supplementary-materialStyling hair with straightening irons is a popular daily hair routine that significantly damage the hair keratin fiber due to the high temperature applied. In this study, we investigate the effect of two fusion proteins based on the human eye D-crystallin conjugated with a keratin-based peptide (KP-Cryst Wt and KP-Cryst Mut) on hair exposed to thermal damage. The mutant form was designed to improve protein stability and promote interaction with the hair. Through the study, it was demonstrated the protection of Asian and Caucasian virgin hair's structure by the pretreatments with the KP-Cryst fusion proteins. After hair thermal exposure, a higher water content was quantified by TGA on the hair fibers pretreated with the fusion proteins (about 38% for the KP-Cryst Wt and 44% for the KP-Cryst Mut). Also, negligible alterations in hair fibers' stiffness were observed after iron application, demonstrating the proteins capacity to effectively prevent the conversion of keratin -helix structure into -sheets. The results proved the capacity of the fusion proteins to bind to hair and protect it against high temperatures', supporting the development of new formulations based on the KP-Cryst proteins.This study was supported by the Portuguese Foundation for Science and Technology (FCT) under the scope of the strategic funding of UID/BIO/04469/2019 unit and BioTecNorte operation (NORTE-01-0145-FEDER-000004) funded by the European Regional Development Fund under the scope of Norte2020 - Programa Operacional Regional do Norte. AT and CS thanks FCT for funding the scholarships with the references SFRH/BD/114035/2015 and IF/00186/2015, respectively. JG thanks to the fellowship UMINHO/BI/424/2018.info:eu-repo/semantics/publishedVersionFrontiers Media S.A.Universidade do MinhoTinoco, AnaGonçalves, J. A.Silva, CarlaCavaco-Paulo, ArturRibeiro, Artur2019-10-252019-10-25T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/1822/62173engTinoco, Ana; Gonçalves, J. A.; Silva, Carla; Cavaco-Paulo, Artur; Ribeiro, Artur, Crystallin fusion proteins improve the thermal properties of hair. Frontiers in Bioengineering and Biotechnology, 7(298), 20192296-418510.3389/fbioe.2019.00298http://journal.frontiersin.org/journal/bioengineering-and-biotechnologyinfo:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-07-21T12:13:01Zoai:repositorium.sdum.uminho.pt:1822/62173Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T19:05:02.679364Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv Crystallin fusion proteins improve the thermal properties of hair
title Crystallin fusion proteins improve the thermal properties of hair
spellingShingle Crystallin fusion proteins improve the thermal properties of hair
Tinoco, Ana
proteins
gamma D-crystallin
hair
thermal damage
protection
keratin-based peptide
γD-crystallin
Science & Technology
title_short Crystallin fusion proteins improve the thermal properties of hair
title_full Crystallin fusion proteins improve the thermal properties of hair
title_fullStr Crystallin fusion proteins improve the thermal properties of hair
title_full_unstemmed Crystallin fusion proteins improve the thermal properties of hair
title_sort Crystallin fusion proteins improve the thermal properties of hair
author Tinoco, Ana
author_facet Tinoco, Ana
Gonçalves, J. A.
Silva, Carla
Cavaco-Paulo, Artur
Ribeiro, Artur
author_role author
author2 Gonçalves, J. A.
Silva, Carla
Cavaco-Paulo, Artur
Ribeiro, Artur
author2_role author
author
author
author
dc.contributor.none.fl_str_mv Universidade do Minho
dc.contributor.author.fl_str_mv Tinoco, Ana
Gonçalves, J. A.
Silva, Carla
Cavaco-Paulo, Artur
Ribeiro, Artur
dc.subject.por.fl_str_mv proteins
gamma D-crystallin
hair
thermal damage
protection
keratin-based peptide
γD-crystallin
Science & Technology
topic proteins
gamma D-crystallin
hair
thermal damage
protection
keratin-based peptide
γD-crystallin
Science & Technology
description The Supplementary Material for this article can be found online at: https://www.frontiersin.org/articles/10.3389/fbioe. 2019.00298/full#supplementary-material
publishDate 2019
dc.date.none.fl_str_mv 2019-10-25
2019-10-25T00:00:00Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/1822/62173
url http://hdl.handle.net/1822/62173
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv Tinoco, Ana; Gonçalves, J. A.; Silva, Carla; Cavaco-Paulo, Artur; Ribeiro, Artur, Crystallin fusion proteins improve the thermal properties of hair. Frontiers in Bioengineering and Biotechnology, 7(298), 2019
2296-4185
10.3389/fbioe.2019.00298
http://journal.frontiersin.org/journal/bioengineering-and-biotechnology
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Frontiers Media S.A.
publisher.none.fl_str_mv Frontiers Media S.A.
dc.source.none.fl_str_mv reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron:RCAAP
instname_str Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron_str RCAAP
institution RCAAP
reponame_str Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
collection Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
repository.name.fl_str_mv Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
repository.mail.fl_str_mv
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