Potential of human γD-crystallin for hair damage repair : insights into the mechanical properties and biocompatibility

• Autor(a) principal: Ribeiro, Artur J.
• Data de Publicação: 2013
• Outros Autores: Matamá, Maria Teresa, Cruz, Célia F., Gomes, A. C., Paulo, Artur Cavaco
• Tipo de documento: Artigo
• Idioma: eng
• Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
• Texto Completo: http://hdl.handle.net/1822/25932
• topic: Greek key motif; Hair treatment; Human crystallin; Mechanical properties improvement; Over bleached hair; Science & Technology

The objective of this work was to develop a new strategy to physically ‘repair’ chemically damaged hair. Hence the human eye γD-crystallin, a protein from the superfamily characterized structurally by the Greek key motif, was studied. The human γD-crystallin was chosen based on the ability of proteins belonging to this superfamily to be involved in the coating of specific structures. Two crystallins were used on the study, the wild type (Protein Data Bank ID: 1HK0) and the mutant protein. The mutant form was intended to induce a strong and quick protein polymerization as well to have new possible points of anchorage to hair.