Computational modeling of radiobiological effects in bone metastases for different radionuclides
Autor(a) principal: | |
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Data de Publicação: | 2017 |
Outros Autores: | , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
Texto Completo: | https://hdl.handle.net/10216/104258 |
Resumo: | : Computational simulation is a simple and practical way to study and to compare a variety of radioisotopes for different medical applications, including the palliative treatment of bone metastases. This study aimed to evaluate and compare cellular effects modelled for different radioisotopes currently in use or under research for treatment of bone metastases using computational methods. Methods: Computational models were used to estimate the radiation-induced cellular effects (Virtual Cell Radiobiology algorithm) post-irradiation with selected particles emitted by Strontium-89 (89Sr), Samarium-153 (153Sm), Lutetium-177 (177Lu), and Radium-223 (223Ra). Results: Cellular kinetics post-irradiation using 89Sr β- particles, 153 Sm β− particles, 177Lu β− particles and 223Ra α particles showed that the cell response was dose- and radio- nuclide-dependent. 177Lu beta minus particles and, in particular, 223Ra alpha particles, yielded the lowest survival fraction of all investigated particles. Conclusions: 223Ra alpha particles induced the highest cell death of all investigated particles on metastatic prostate cells in comparison to irradiation with β− radionuclides, two of the most frequently used radionuclides in the palliative treatment of bone metastases in clinical routine practice. Moreover, the data obtained suggest that the used computational methods might provide some perception about cellular effects following irradiation with different radionuclides. |
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Computational modeling of radiobiological effects in bone metastases for different radionuclidesCiências Tecnológicas, Ciências médicas e da saúdeTechnological sciences, Medical and Health sciences: Computational simulation is a simple and practical way to study and to compare a variety of radioisotopes for different medical applications, including the palliative treatment of bone metastases. This study aimed to evaluate and compare cellular effects modelled for different radioisotopes currently in use or under research for treatment of bone metastases using computational methods. Methods: Computational models were used to estimate the radiation-induced cellular effects (Virtual Cell Radiobiology algorithm) post-irradiation with selected particles emitted by Strontium-89 (89Sr), Samarium-153 (153Sm), Lutetium-177 (177Lu), and Radium-223 (223Ra). Results: Cellular kinetics post-irradiation using 89Sr β- particles, 153 Sm β− particles, 177Lu β− particles and 223Ra α particles showed that the cell response was dose- and radio- nuclide-dependent. 177Lu beta minus particles and, in particular, 223Ra alpha particles, yielded the lowest survival fraction of all investigated particles. Conclusions: 223Ra alpha particles induced the highest cell death of all investigated particles on metastatic prostate cells in comparison to irradiation with β− radionuclides, two of the most frequently used radionuclides in the palliative treatment of bone metastases in clinical routine practice. Moreover, the data obtained suggest that the used computational methods might provide some perception about cellular effects following irradiation with different radionuclides.20172017-01-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleimage/pngapplication/pdfhttps://hdl.handle.net/10216/104258eng0955-300210.1080/09553002.2017.1294274Francisco D. C. Guerra LiberalAdriana Alexandre S. TavaresJoão Manuel R. S. Tavaresinfo:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-11-29T12:44:56Zoai:repositorio-aberto.up.pt:10216/104258Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T23:25:57.840856Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse |
dc.title.none.fl_str_mv |
Computational modeling of radiobiological effects in bone metastases for different radionuclides |
title |
Computational modeling of radiobiological effects in bone metastases for different radionuclides |
spellingShingle |
Computational modeling of radiobiological effects in bone metastases for different radionuclides Francisco D. C. Guerra Liberal Ciências Tecnológicas, Ciências médicas e da saúde Technological sciences, Medical and Health sciences |
title_short |
Computational modeling of radiobiological effects in bone metastases for different radionuclides |
title_full |
Computational modeling of radiobiological effects in bone metastases for different radionuclides |
title_fullStr |
Computational modeling of radiobiological effects in bone metastases for different radionuclides |
title_full_unstemmed |
Computational modeling of radiobiological effects in bone metastases for different radionuclides |
title_sort |
Computational modeling of radiobiological effects in bone metastases for different radionuclides |
author |
Francisco D. C. Guerra Liberal |
author_facet |
Francisco D. C. Guerra Liberal Adriana Alexandre S. Tavares João Manuel R. S. Tavares |
author_role |
author |
author2 |
Adriana Alexandre S. Tavares João Manuel R. S. Tavares |
author2_role |
author author |
dc.contributor.author.fl_str_mv |
Francisco D. C. Guerra Liberal Adriana Alexandre S. Tavares João Manuel R. S. Tavares |
dc.subject.por.fl_str_mv |
Ciências Tecnológicas, Ciências médicas e da saúde Technological sciences, Medical and Health sciences |
topic |
Ciências Tecnológicas, Ciências médicas e da saúde Technological sciences, Medical and Health sciences |
description |
: Computational simulation is a simple and practical way to study and to compare a variety of radioisotopes for different medical applications, including the palliative treatment of bone metastases. This study aimed to evaluate and compare cellular effects modelled for different radioisotopes currently in use or under research for treatment of bone metastases using computational methods. Methods: Computational models were used to estimate the radiation-induced cellular effects (Virtual Cell Radiobiology algorithm) post-irradiation with selected particles emitted by Strontium-89 (89Sr), Samarium-153 (153Sm), Lutetium-177 (177Lu), and Radium-223 (223Ra). Results: Cellular kinetics post-irradiation using 89Sr β- particles, 153 Sm β− particles, 177Lu β− particles and 223Ra α particles showed that the cell response was dose- and radio- nuclide-dependent. 177Lu beta minus particles and, in particular, 223Ra alpha particles, yielded the lowest survival fraction of all investigated particles. Conclusions: 223Ra alpha particles induced the highest cell death of all investigated particles on metastatic prostate cells in comparison to irradiation with β− radionuclides, two of the most frequently used radionuclides in the palliative treatment of bone metastases in clinical routine practice. Moreover, the data obtained suggest that the used computational methods might provide some perception about cellular effects following irradiation with different radionuclides. |
publishDate |
2017 |
dc.date.none.fl_str_mv |
2017 2017-01-01T00:00:00Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
https://hdl.handle.net/10216/104258 |
url |
https://hdl.handle.net/10216/104258 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
0955-3002 10.1080/09553002.2017.1294274 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
image/png application/pdf |
dc.source.none.fl_str_mv |
reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação instacron:RCAAP |
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Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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RCAAP |
institution |
RCAAP |
reponame_str |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
repository.name.fl_str_mv |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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1799135565060243457 |