In silico comparasion of 11 different radioisotopes for palliative treatment of bone metastases

Detalhes bibliográficos
Autor(a) principal: F. Guerra Liberal
Data de Publicação: 2015
Outros Autores: Adriana Tavares, João Manuel R. S. Tavares
Tipo de documento: Livro
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: https://hdl.handle.net/10216/78718
Resumo: Throughout the years, the palliative treatment of bone metastases using bone seeking radiotracers has been part of the therapeutic resources used in oncology. However, the choice of which bone seeking agent to use is not consensual. Computer simulation is a simple and practical solution to study and to compare a variety of radioisotopes. This study aimed to compare 11 different radioisotopes currently in use or under research. Hence, computational models were used to estimate the percentage of deoxyribonucleic acid damage, the probability of correct DNA repair, and the radiation-induced cellular effects post-irradiation. 223Ra alpha particles, 177Lu beta minus particles, and 170Tm beta minus particles induced the highest cell death of all investigated particles and radioisotopes. The cell survival fraction measured post-irradiation with beta minus particles emitted by 89Sr and 153Sm, was higher than 177Lu beta minus particles and 223Ra alpha particles. Findings reported here may prompt future in vitro and in vivo experiments comparing different radionuclides for palliative treatment of bone metastases.
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spelling In silico comparasion of 11 different radioisotopes for palliative treatment of bone metastasesCiências Tecnológicas, Ciências da engenharia e tecnologiasTechnological sciences, Engineering and technologyThroughout the years, the palliative treatment of bone metastases using bone seeking radiotracers has been part of the therapeutic resources used in oncology. However, the choice of which bone seeking agent to use is not consensual. Computer simulation is a simple and practical solution to study and to compare a variety of radioisotopes. This study aimed to compare 11 different radioisotopes currently in use or under research. Hence, computational models were used to estimate the percentage of deoxyribonucleic acid damage, the probability of correct DNA repair, and the radiation-induced cellular effects post-irradiation. 223Ra alpha particles, 177Lu beta minus particles, and 170Tm beta minus particles induced the highest cell death of all investigated particles and radioisotopes. The cell survival fraction measured post-irradiation with beta minus particles emitted by 89Sr and 153Sm, was higher than 177Lu beta minus particles and 223Ra alpha particles. Findings reported here may prompt future in vitro and in vivo experiments comparing different radionuclides for palliative treatment of bone metastases.20152015-01-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/bookapplication/pdfhttps://hdl.handle.net/10216/78718eng10.1109/ENBENG.2015.7088832F. Guerra LiberalAdriana TavaresJoão Manuel R. S. Tavaresinfo:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-11-29T16:09:48Zoai:repositorio-aberto.up.pt:10216/78718Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-20T00:38:25.363941Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv In silico comparasion of 11 different radioisotopes for palliative treatment of bone metastases
title In silico comparasion of 11 different radioisotopes for palliative treatment of bone metastases
spellingShingle In silico comparasion of 11 different radioisotopes for palliative treatment of bone metastases
F. Guerra Liberal
Ciências Tecnológicas, Ciências da engenharia e tecnologias
Technological sciences, Engineering and technology
title_short In silico comparasion of 11 different radioisotopes for palliative treatment of bone metastases
title_full In silico comparasion of 11 different radioisotopes for palliative treatment of bone metastases
title_fullStr In silico comparasion of 11 different radioisotopes for palliative treatment of bone metastases
title_full_unstemmed In silico comparasion of 11 different radioisotopes for palliative treatment of bone metastases
title_sort In silico comparasion of 11 different radioisotopes for palliative treatment of bone metastases
author F. Guerra Liberal
author_facet F. Guerra Liberal
Adriana Tavares
João Manuel R. S. Tavares
author_role author
author2 Adriana Tavares
João Manuel R. S. Tavares
author2_role author
author
dc.contributor.author.fl_str_mv F. Guerra Liberal
Adriana Tavares
João Manuel R. S. Tavares
dc.subject.por.fl_str_mv Ciências Tecnológicas, Ciências da engenharia e tecnologias
Technological sciences, Engineering and technology
topic Ciências Tecnológicas, Ciências da engenharia e tecnologias
Technological sciences, Engineering and technology
description Throughout the years, the palliative treatment of bone metastases using bone seeking radiotracers has been part of the therapeutic resources used in oncology. However, the choice of which bone seeking agent to use is not consensual. Computer simulation is a simple and practical solution to study and to compare a variety of radioisotopes. This study aimed to compare 11 different radioisotopes currently in use or under research. Hence, computational models were used to estimate the percentage of deoxyribonucleic acid damage, the probability of correct DNA repair, and the radiation-induced cellular effects post-irradiation. 223Ra alpha particles, 177Lu beta minus particles, and 170Tm beta minus particles induced the highest cell death of all investigated particles and radioisotopes. The cell survival fraction measured post-irradiation with beta minus particles emitted by 89Sr and 153Sm, was higher than 177Lu beta minus particles and 223Ra alpha particles. Findings reported here may prompt future in vitro and in vivo experiments comparing different radionuclides for palliative treatment of bone metastases.
publishDate 2015
dc.date.none.fl_str_mv 2015
2015-01-01T00:00:00Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/book
format book
status_str publishedVersion
dc.identifier.uri.fl_str_mv https://hdl.handle.net/10216/78718
url https://hdl.handle.net/10216/78718
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 10.1109/ENBENG.2015.7088832
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dc.format.none.fl_str_mv application/pdf
dc.source.none.fl_str_mv reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron:RCAAP
instname_str Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
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reponame_str Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
collection Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
repository.name.fl_str_mv Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
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