PVA-Based Hydrogels Loaded with Diclofenac for Cartilage Replacement
Autor(a) principal: | |
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Data de Publicação: | 2022 |
Outros Autores: | , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
Texto Completo: | http://hdl.handle.net/10400.26/50033 |
Resumo: | Polyvinyl alcohol (PVA) hydrogels have been widely studied for cartilage replacement due to their biocompatibility, chemical stability, and ability to be modified such that they approximate natural tissue behavior. Additionally, they may also be used with advantages as local drug delivery systems. However, their properties are not yet the most adequate for such applications. This work aimed to develop new PVA-based hydrogels for this purpose, displaying improved tribomechani- cal properties with the ability to control the release of diclofenac (DFN). Four types of PVA-based hydrogels were prepared via freeze-thawing: PVA, PVA/PAA (by polyacrylic acid (PAA) addition), PVA/PAA+PEG (by polyethylene glycol (PEG) immersion), and PVA/PAA+PEG+A (by annealing). Their morphology, water uptake, mechanical and rheological properties, wettability, friction coef- ficient, and drug release behavior were accessed. The irritability of the best-performing material was investigated. The results showed that the PAA addition increased the swelling and drug release amount. PEG immersion led to a more compact structure and significantly improved the material’s tribomechanical performance. The annealing treatment led to the material with the most suitable properties: besides presenting a low friction coefficient, it further enhanced the mechanical properties and ensured a controlled DFN release for at least 3 days. Moreover, it did not reveal irritability potential for biological tissues. |
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PVA-Based Hydrogels Loaded with Diclofenac for Cartilage ReplacementPolyvinyl alcohol (PVA) hydrogels have been widely studied for cartilage replacement due to their biocompatibility, chemical stability, and ability to be modified such that they approximate natural tissue behavior. Additionally, they may also be used with advantages as local drug delivery systems. However, their properties are not yet the most adequate for such applications. This work aimed to develop new PVA-based hydrogels for this purpose, displaying improved tribomechani- cal properties with the ability to control the release of diclofenac (DFN). Four types of PVA-based hydrogels were prepared via freeze-thawing: PVA, PVA/PAA (by polyacrylic acid (PAA) addition), PVA/PAA+PEG (by polyethylene glycol (PEG) immersion), and PVA/PAA+PEG+A (by annealing). Their morphology, water uptake, mechanical and rheological properties, wettability, friction coef- ficient, and drug release behavior were accessed. The irritability of the best-performing material was investigated. The results showed that the PAA addition increased the swelling and drug release amount. PEG immersion led to a more compact structure and significantly improved the material’s tribomechanical performance. The annealing treatment led to the material with the most suitable properties: besides presenting a low friction coefficient, it further enhanced the mechanical properties and ensured a controlled DFN release for at least 3 days. Moreover, it did not reveal irritability potential for biological tissues.Repositório ComumBranco, Ana C.Oliveira, Andreia S.Monteiro, InêsNolasco, PedroSilva, Diana C.Figueiredo-Pina, CélioColaço, RogérioSerro, Ana P.2024-02-26T14:48:51Z20222022-01-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10400.26/50033engBranco, A. C., Oliveira, A. S., Monteiro, I., Nolasco, P., Silva, D. C., Figueiredo-Pina, C. G., Colaço, R., & Serro, A. P. (2022). PVA-Based Hydrogels Loaded with Diclofenac for Cartilage Replacement. Gels, 8(3), 143.2310-286110.3390/gels8030143info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2024-03-03T03:15:41Zoai:comum.rcaap.pt:10400.26/50033Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-20T03:12:23.426742Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse |
dc.title.none.fl_str_mv |
PVA-Based Hydrogels Loaded with Diclofenac for Cartilage Replacement |
title |
PVA-Based Hydrogels Loaded with Diclofenac for Cartilage Replacement |
spellingShingle |
PVA-Based Hydrogels Loaded with Diclofenac for Cartilage Replacement Branco, Ana C. |
title_short |
PVA-Based Hydrogels Loaded with Diclofenac for Cartilage Replacement |
title_full |
PVA-Based Hydrogels Loaded with Diclofenac for Cartilage Replacement |
title_fullStr |
PVA-Based Hydrogels Loaded with Diclofenac for Cartilage Replacement |
title_full_unstemmed |
PVA-Based Hydrogels Loaded with Diclofenac for Cartilage Replacement |
title_sort |
PVA-Based Hydrogels Loaded with Diclofenac for Cartilage Replacement |
author |
Branco, Ana C. |
author_facet |
Branco, Ana C. Oliveira, Andreia S. Monteiro, Inês Nolasco, Pedro Silva, Diana C. Figueiredo-Pina, Célio Colaço, Rogério Serro, Ana P. |
author_role |
author |
author2 |
Oliveira, Andreia S. Monteiro, Inês Nolasco, Pedro Silva, Diana C. Figueiredo-Pina, Célio Colaço, Rogério Serro, Ana P. |
author2_role |
author author author author author author author |
dc.contributor.none.fl_str_mv |
Repositório Comum |
dc.contributor.author.fl_str_mv |
Branco, Ana C. Oliveira, Andreia S. Monteiro, Inês Nolasco, Pedro Silva, Diana C. Figueiredo-Pina, Célio Colaço, Rogério Serro, Ana P. |
description |
Polyvinyl alcohol (PVA) hydrogels have been widely studied for cartilage replacement due to their biocompatibility, chemical stability, and ability to be modified such that they approximate natural tissue behavior. Additionally, they may also be used with advantages as local drug delivery systems. However, their properties are not yet the most adequate for such applications. This work aimed to develop new PVA-based hydrogels for this purpose, displaying improved tribomechani- cal properties with the ability to control the release of diclofenac (DFN). Four types of PVA-based hydrogels were prepared via freeze-thawing: PVA, PVA/PAA (by polyacrylic acid (PAA) addition), PVA/PAA+PEG (by polyethylene glycol (PEG) immersion), and PVA/PAA+PEG+A (by annealing). Their morphology, water uptake, mechanical and rheological properties, wettability, friction coef- ficient, and drug release behavior were accessed. The irritability of the best-performing material was investigated. The results showed that the PAA addition increased the swelling and drug release amount. PEG immersion led to a more compact structure and significantly improved the material’s tribomechanical performance. The annealing treatment led to the material with the most suitable properties: besides presenting a low friction coefficient, it further enhanced the mechanical properties and ensured a controlled DFN release for at least 3 days. Moreover, it did not reveal irritability potential for biological tissues. |
publishDate |
2022 |
dc.date.none.fl_str_mv |
2022 2022-01-01T00:00:00Z 2024-02-26T14:48:51Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://hdl.handle.net/10400.26/50033 |
url |
http://hdl.handle.net/10400.26/50033 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
Branco, A. C., Oliveira, A. S., Monteiro, I., Nolasco, P., Silva, D. C., Figueiredo-Pina, C. G., Colaço, R., & Serro, A. P. (2022). PVA-Based Hydrogels Loaded with Diclofenac for Cartilage Replacement. Gels, 8(3), 143. 2310-2861 10.3390/gels8030143 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.source.none.fl_str_mv |
reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação instacron:RCAAP |
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Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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RCAAP |
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RCAAP |
reponame_str |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
collection |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
repository.name.fl_str_mv |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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