Harmonized human biomonitoring in European children, teenagers and adults
Autor(a) principal: | |
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Data de Publicação: | 2023 |
Outros Autores: | , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , |
Tipo de documento: | Outros |
Idioma: | eng |
Título da fonte: | Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
Texto Completo: | http://hdl.handle.net/10362/149392 |
Resumo: | Funding Information: The authors would like to thank everybody who contributed to the HBM4EU Aligned Studies: the participating children, teenagers, adults and their families, the fieldworkers that collected the samples and database managers that made the information available to HBM4EU, the HBM4EU project partners, especially those from WP7 for developing all materials supporting the fieldwork, WP9 for organizing the QA/QC scheme under HBM4EU and all laboratories who performed the analytical measurements. We would like to acknowledge Sun Kyoung Jung from the National Institute of Environmental Research of South-Korea for providing the KoNEHS Cycle III results (crt adjusted). HBM4EU is co-financed under Horizon 2020 (grant agreement No 733032). The authors thank all principal investigators of the contributing studies for their participation and contribution to the HBM4EU Aligned Studies and the national program owners for their financial support. Further details on funding for all the participating studies can be found in the Supplemental Material, Table S12. |
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Harmonized human biomonitoring in European children, teenagers and adultsEU-wide exposure data of 11 chemical substance groups from the HBM4EU Aligned Studies (2014–2021)AdultsChildrenExposure biomarkersHBM4EUHuman biomonitoring (HBM)TeenagersPublic Health, Environmental and Occupational HealthSDG 3 - Good Health and Well-beingFunding Information: The authors would like to thank everybody who contributed to the HBM4EU Aligned Studies: the participating children, teenagers, adults and their families, the fieldworkers that collected the samples and database managers that made the information available to HBM4EU, the HBM4EU project partners, especially those from WP7 for developing all materials supporting the fieldwork, WP9 for organizing the QA/QC scheme under HBM4EU and all laboratories who performed the analytical measurements. We would like to acknowledge Sun Kyoung Jung from the National Institute of Environmental Research of South-Korea for providing the KoNEHS Cycle III results (crt adjusted). HBM4EU is co-financed under Horizon 2020 (grant agreement No 733032). The authors thank all principal investigators of the contributing studies for their participation and contribution to the HBM4EU Aligned Studies and the national program owners for their financial support. Further details on funding for all the participating studies can be found in the Supplemental Material, Table S12.As one of the core elements of the European Human Biomonitoring Initiative (HBM4EU) a human biomonitoring (HBM) survey was conducted in 23 countries to generate EU-wide comparable HBM data. This survey has built on existing HBM capacity in Europe by aligning national or regional HBM studies, referred to as the HBM4EU Aligned Studies. The HBM4EU Aligned Studies included a total of 10,795 participants of three age groups: (i) 3,576 children aged 6–12 years, (ii) 3,117 teenagers aged 12–18 years and (iii) 4,102 young adults aged 20–39 years. The participants were recruited between 2014 and 2021 in 11–12 countries per age group, geographically distributed across Europe. Depending on the age group, internal exposure to phthalates and the substitute DINCH, halogenated and organophosphorus flame retardants, per- and polyfluoroalkyl substances (PFASs), cadmium, bisphenols, polycyclic aromatic hydrocarbons (PAHs), arsenic species, acrylamide, mycotoxins (deoxynivalenol (total DON)), benzophenones and selected pesticides was assessed by measuring substance specific biomarkers subjected to stringent quality control programs for chemical analysis. For substance groups analyzed in different age groups higher average exposure levels were observed in the youngest age group, i.e., phthalates/DINCH in children versus teenagers, acrylamide and pesticides in children versus adults, benzophenones in teenagers versus adults. Many biomarkers in teenagers and adults varied significantly according to educational attainment, with higher exposure levels of bisphenols, phthalates, benzophenones, PAHs and acrylamide in participants (from households) with lower educational attainment, while teenagers from households with higher educational attainment have higher exposure levels for PFASs and arsenic. In children, a social gradient was only observed for the non-specific pyrethroid metabolite 3-PBA and di-isodecyl phthalate (DiDP), with higher levels in children from households with higher educational attainment. Geographical variations were seen for all exposure biomarkers. For 15 biomarkers, the available health-based HBM guidance values were exceeded with highest exceedance rates for toxicologically relevant arsenic in teenagers (40%), 3-PBA in children (36%), and between 11 and 14% for total DON, Σ (PFOA + PFNA + PFHxS + PFOS), bisphenol S and cadmium. The infrastructure and harmonized approach succeeded in obtaining comparable European wide internal exposure data for a prioritized set of 11 chemical groups. These data serve as a reference for comparison at the global level, provide a baseline to compare the efficacy of the European Commission's chemical strategy for sustainability and will give leverage to national policy makers for the implementation of targeted measures.NOVA Medical School|Faculdade de Ciências Médicas (NMS|FCM)RUNGovarts, EvaGilles, LieseRodriguez Martin, LauraSantonen, TiinaApel, PetraAlvito, PaulaAnastasi, ElenaAndersen, Helle RaunAndersson, Anna MariaAndryskova, LenkaAntignac, Jean PhilippeAppenzeller, BriceBarbone, FabioBarnett-Itzhaki, ZoharBarouki, RobertBerman, TamarBil, WienekeBorges, TeresaBuekers, JurgenCañas-Portilla, AnaCovaci, AdrianCsako, ZsofiaDen Hond, EllyDvorakova, DarinaFabelova, LuciaFletcher, TonyFrederiksen, HanneGabriel, CatherineGanzleben, CatherineGöen, ThomasHalldorsson, Thorhallur I.Haug, Line S.Horvat, MilenaHuuskonen, PasiImboden, MedeaJagodic Hudobivnik, MartaJanasik, BeataJanev Holcer, NatasaKarakitsios, SpyrosKatsonouri, AndromachiKlanova, JanaKokaraki, VenetiaKold Jensen, TinaKoponen, JaniLaeremans, MichelleLaguzzi, FedericaLange, RosaLemke, NoraLignell, SannaLindroos, Anna KarinLobo Vicente, JoanaLuijten, MirjamMakris, Konstantinos C.Mazej, DarjaMelymuk, LisaMeslin, MatthieuMol, HansMontazeri, ParisaMurawski, AlineNamorado, SóniaNiemann, LarsNübler, StefanieNunes, BaltazarOlafsdottir, KristinPalkovicova Murinova, LubicaPapaioannou, NafsikaPedraza-Diaz, SusanaPiler, PavelPlichta, VeronikaPoteser, MichaelProbst-Hensch, NicoleRambaud, LoïcRauscher-Gabernig, ElkeRausova, KatarinaRemy, SylvieRiou, MargauxRosolen, ValentinaRousselle, ChristopheRüther, MariaSarigiannis, DenisSilva, Maria J.Šlejkovec, ZdenkaSnoj Tratnik, JanjaStajnko, AnjaSzigeti, TamasTarazona, José V.Thomsen, CathrineTkalec, ŽigaTolonen, HannaTrnovec, TomasUhl, MariaVan Nieuwenhuyse, AnVasco, ElsaVerheyen, Veerle J.Viegas, SusanaVinggaard, Anne MarieVogel, NinaVorkamp, KatrinWasowicz, WojciechWeber, TillWimmerova, SonaWoutersen, MarjolijnZimmermann, PhilippZvonar, MartinKoch, HolgerKolossa-Gehring, MarikeEsteban López, MartaCastaño, ArgeliaStewart, LorraineSepai, OvnairSchoeters, Greet2023-02-17T22:23:09Z2023-042023-04-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/otherapplication/pdfhttp://hdl.handle.net/10362/149392eng1438-4639PURE: 53440375https://doi.org/10.1016/j.ijheh.2023.114119info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2024-05-22T18:09:19Zoai:run.unl.pt:10362/149392Portal AgregadorONGhttps://www.rcaap.pt/oai/openairemluisa.alvim@gmail.comopendoar:71602024-05-22T18:09:19Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse |
dc.title.none.fl_str_mv |
Harmonized human biomonitoring in European children, teenagers and adults EU-wide exposure data of 11 chemical substance groups from the HBM4EU Aligned Studies (2014–2021) |
title |
Harmonized human biomonitoring in European children, teenagers and adults |
spellingShingle |
Harmonized human biomonitoring in European children, teenagers and adults Govarts, Eva Adults Children Exposure biomarkers HBM4EU Human biomonitoring (HBM) Teenagers Public Health, Environmental and Occupational Health SDG 3 - Good Health and Well-being |
title_short |
Harmonized human biomonitoring in European children, teenagers and adults |
title_full |
Harmonized human biomonitoring in European children, teenagers and adults |
title_fullStr |
Harmonized human biomonitoring in European children, teenagers and adults |
title_full_unstemmed |
Harmonized human biomonitoring in European children, teenagers and adults |
title_sort |
Harmonized human biomonitoring in European children, teenagers and adults |
author |
Govarts, Eva |
author_facet |
Govarts, Eva Gilles, Liese Rodriguez Martin, Laura Santonen, Tiina Apel, Petra Alvito, Paula Anastasi, Elena Andersen, Helle Raun Andersson, Anna Maria Andryskova, Lenka Antignac, Jean Philippe Appenzeller, Brice Barbone, Fabio Barnett-Itzhaki, Zohar Barouki, Robert Berman, Tamar Bil, Wieneke Borges, Teresa Buekers, Jurgen Cañas-Portilla, Ana Covaci, Adrian Csako, Zsofia Den Hond, Elly Dvorakova, Darina Fabelova, Lucia Fletcher, Tony Frederiksen, Hanne Gabriel, Catherine Ganzleben, Catherine Göen, Thomas Halldorsson, Thorhallur I. Haug, Line S. Horvat, Milena Huuskonen, Pasi Imboden, Medea Jagodic Hudobivnik, Marta Janasik, Beata Janev Holcer, Natasa Karakitsios, Spyros Katsonouri, Andromachi Klanova, Jana Kokaraki, Venetia Kold Jensen, Tina Koponen, Jani Laeremans, Michelle Laguzzi, Federica Lange, Rosa Lemke, Nora Lignell, Sanna Lindroos, Anna Karin Lobo Vicente, Joana Luijten, Mirjam Makris, Konstantinos C. Mazej, Darja Melymuk, Lisa Meslin, Matthieu Mol, Hans Montazeri, Parisa Murawski, Aline Namorado, Sónia Niemann, Lars Nübler, Stefanie Nunes, Baltazar Olafsdottir, Kristin Palkovicova Murinova, Lubica Papaioannou, Nafsika Pedraza-Diaz, Susana Piler, Pavel Plichta, Veronika Poteser, Michael Probst-Hensch, Nicole Rambaud, Loïc Rauscher-Gabernig, Elke Rausova, Katarina Remy, Sylvie Riou, Margaux Rosolen, Valentina Rousselle, Christophe Rüther, Maria Sarigiannis, Denis Silva, Maria J. Šlejkovec, Zdenka Snoj Tratnik, Janja Stajnko, Anja Szigeti, Tamas Tarazona, José V. Thomsen, Cathrine Tkalec, Žiga Tolonen, Hanna Trnovec, Tomas Uhl, Maria Van Nieuwenhuyse, An Vasco, Elsa Verheyen, Veerle J. Viegas, Susana Vinggaard, Anne Marie Vogel, Nina Vorkamp, Katrin Wasowicz, Wojciech Weber, Till Wimmerova, Sona Woutersen, Marjolijn Zimmermann, Philipp Zvonar, Martin Koch, Holger Kolossa-Gehring, Marike Esteban López, Marta Castaño, Argelia Stewart, Lorraine Sepai, Ovnair Schoeters, Greet |
author_role |
author |
author2 |
Gilles, Liese Rodriguez Martin, Laura Santonen, Tiina Apel, Petra Alvito, Paula Anastasi, Elena Andersen, Helle Raun Andersson, Anna Maria Andryskova, Lenka Antignac, Jean Philippe Appenzeller, Brice Barbone, Fabio Barnett-Itzhaki, Zohar Barouki, Robert Berman, Tamar Bil, Wieneke Borges, Teresa Buekers, Jurgen Cañas-Portilla, Ana Covaci, Adrian Csako, Zsofia Den Hond, Elly Dvorakova, Darina Fabelova, Lucia Fletcher, Tony Frederiksen, Hanne Gabriel, Catherine Ganzleben, Catherine Göen, Thomas Halldorsson, Thorhallur I. Haug, Line S. Horvat, Milena Huuskonen, Pasi Imboden, Medea Jagodic Hudobivnik, Marta Janasik, Beata Janev Holcer, Natasa Karakitsios, Spyros Katsonouri, Andromachi Klanova, Jana Kokaraki, Venetia Kold Jensen, Tina Koponen, Jani Laeremans, Michelle Laguzzi, Federica Lange, Rosa Lemke, Nora Lignell, Sanna Lindroos, Anna Karin Lobo Vicente, Joana Luijten, Mirjam Makris, Konstantinos C. Mazej, Darja Melymuk, Lisa Meslin, Matthieu Mol, Hans Montazeri, Parisa Murawski, Aline Namorado, Sónia Niemann, Lars Nübler, Stefanie Nunes, Baltazar Olafsdottir, Kristin Palkovicova Murinova, Lubica Papaioannou, Nafsika Pedraza-Diaz, Susana Piler, Pavel Plichta, Veronika Poteser, Michael Probst-Hensch, Nicole Rambaud, Loïc Rauscher-Gabernig, Elke Rausova, Katarina Remy, Sylvie Riou, Margaux Rosolen, Valentina Rousselle, Christophe Rüther, Maria Sarigiannis, Denis Silva, Maria J. Šlejkovec, Zdenka Snoj Tratnik, Janja Stajnko, Anja Szigeti, Tamas Tarazona, José V. Thomsen, Cathrine Tkalec, Žiga Tolonen, Hanna Trnovec, Tomas Uhl, Maria Van Nieuwenhuyse, An Vasco, Elsa Verheyen, Veerle J. Viegas, Susana Vinggaard, Anne Marie Vogel, Nina Vorkamp, Katrin Wasowicz, Wojciech Weber, Till Wimmerova, Sona Woutersen, Marjolijn Zimmermann, Philipp Zvonar, Martin Koch, Holger Kolossa-Gehring, Marike Esteban López, Marta Castaño, Argelia Stewart, Lorraine Sepai, Ovnair Schoeters, Greet |
author2_role |
author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author |
dc.contributor.none.fl_str_mv |
NOVA Medical School|Faculdade de Ciências Médicas (NMS|FCM) RUN |
dc.contributor.author.fl_str_mv |
Govarts, Eva Gilles, Liese Rodriguez Martin, Laura Santonen, Tiina Apel, Petra Alvito, Paula Anastasi, Elena Andersen, Helle Raun Andersson, Anna Maria Andryskova, Lenka Antignac, Jean Philippe Appenzeller, Brice Barbone, Fabio Barnett-Itzhaki, Zohar Barouki, Robert Berman, Tamar Bil, Wieneke Borges, Teresa Buekers, Jurgen Cañas-Portilla, Ana Covaci, Adrian Csako, Zsofia Den Hond, Elly Dvorakova, Darina Fabelova, Lucia Fletcher, Tony Frederiksen, Hanne Gabriel, Catherine Ganzleben, Catherine Göen, Thomas Halldorsson, Thorhallur I. Haug, Line S. Horvat, Milena Huuskonen, Pasi Imboden, Medea Jagodic Hudobivnik, Marta Janasik, Beata Janev Holcer, Natasa Karakitsios, Spyros Katsonouri, Andromachi Klanova, Jana Kokaraki, Venetia Kold Jensen, Tina Koponen, Jani Laeremans, Michelle Laguzzi, Federica Lange, Rosa Lemke, Nora Lignell, Sanna Lindroos, Anna Karin Lobo Vicente, Joana Luijten, Mirjam Makris, Konstantinos C. Mazej, Darja Melymuk, Lisa Meslin, Matthieu Mol, Hans Montazeri, Parisa Murawski, Aline Namorado, Sónia Niemann, Lars Nübler, Stefanie Nunes, Baltazar Olafsdottir, Kristin Palkovicova Murinova, Lubica Papaioannou, Nafsika Pedraza-Diaz, Susana Piler, Pavel Plichta, Veronika Poteser, Michael Probst-Hensch, Nicole Rambaud, Loïc Rauscher-Gabernig, Elke Rausova, Katarina Remy, Sylvie Riou, Margaux Rosolen, Valentina Rousselle, Christophe Rüther, Maria Sarigiannis, Denis Silva, Maria J. Šlejkovec, Zdenka Snoj Tratnik, Janja Stajnko, Anja Szigeti, Tamas Tarazona, José V. Thomsen, Cathrine Tkalec, Žiga Tolonen, Hanna Trnovec, Tomas Uhl, Maria Van Nieuwenhuyse, An Vasco, Elsa Verheyen, Veerle J. Viegas, Susana Vinggaard, Anne Marie Vogel, Nina Vorkamp, Katrin Wasowicz, Wojciech Weber, Till Wimmerova, Sona Woutersen, Marjolijn Zimmermann, Philipp Zvonar, Martin Koch, Holger Kolossa-Gehring, Marike Esteban López, Marta Castaño, Argelia Stewart, Lorraine Sepai, Ovnair Schoeters, Greet |
dc.subject.por.fl_str_mv |
Adults Children Exposure biomarkers HBM4EU Human biomonitoring (HBM) Teenagers Public Health, Environmental and Occupational Health SDG 3 - Good Health and Well-being |
topic |
Adults Children Exposure biomarkers HBM4EU Human biomonitoring (HBM) Teenagers Public Health, Environmental and Occupational Health SDG 3 - Good Health and Well-being |
description |
Funding Information: The authors would like to thank everybody who contributed to the HBM4EU Aligned Studies: the participating children, teenagers, adults and their families, the fieldworkers that collected the samples and database managers that made the information available to HBM4EU, the HBM4EU project partners, especially those from WP7 for developing all materials supporting the fieldwork, WP9 for organizing the QA/QC scheme under HBM4EU and all laboratories who performed the analytical measurements. We would like to acknowledge Sun Kyoung Jung from the National Institute of Environmental Research of South-Korea for providing the KoNEHS Cycle III results (crt adjusted). HBM4EU is co-financed under Horizon 2020 (grant agreement No 733032). The authors thank all principal investigators of the contributing studies for their participation and contribution to the HBM4EU Aligned Studies and the national program owners for their financial support. Further details on funding for all the participating studies can be found in the Supplemental Material, Table S12. |
publishDate |
2023 |
dc.date.none.fl_str_mv |
2023-02-17T22:23:09Z 2023-04 2023-04-01T00:00:00Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/other |
format |
other |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://hdl.handle.net/10362/149392 |
url |
http://hdl.handle.net/10362/149392 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
1438-4639 PURE: 53440375 https://doi.org/10.1016/j.ijheh.2023.114119 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
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application/pdf |
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Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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RCAAP |
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RCAAP |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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mluisa.alvim@gmail.com |
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