Laser-induced graphene from paper for non-enzymatic uric acid electrochemical sensing in urine

Detalhes bibliográficos
Autor(a) principal: Kulyk, Bohdan
Data de Publicação: 2022
Outros Autores: Pereira, Sónia O., Fernandes, António J. S., Fortunato, Elvira, Costa, Florinda M., Santos, Nuno F.
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: http://hdl.handle.net/10362/150709
Resumo: This work was developed within the scope of project i3N (LA/P/0037/2020. I.P. N. F. Santos thanks i3N for the BPD Grant BPD/UI96/5177/2020. S. O. Pereira thanks i3N for the BPD Grant BPD/UI96/5808/2017. The authors also thank Jonas Deuermeier for the XPS measurements. Publisher Copyright: © 2022 Elsevier Ltd
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spelling Laser-induced graphene from paper for non-enzymatic uric acid electrochemical sensing in urineElectrochemical biosensorsFlexible electronicsGrapheneHuman urinePaper-LIGUric acidChemistry(all)Materials Science(all)SDG 3 - Good Health and Well-beingSDG 13 - Climate ActionThis work was developed within the scope of project i3N (LA/P/0037/2020. I.P. N. F. Santos thanks i3N for the BPD Grant BPD/UI96/5177/2020. S. O. Pereira thanks i3N for the BPD Grant BPD/UI96/5808/2017. The authors also thank Jonas Deuermeier for the XPS measurements. Publisher Copyright: © 2022 Elsevier LtdLaser-induced graphene from paper (paper-LIG) was applied in non-enzymatic electrochemical sensing of uric acid (UA) in human urine. Paper-LIG was formed by CO2 laser modification of paper into a 3D graphene arrangement. Kinetic analysis of paper-LIG electrodes returned effective heterogeneous electron transfer standard rate constants of 1.4 × 10−3 cm s−1 and 7.8 × 10−4 cm s−1 for [Ru(NH3)6]2+/3+ and [Fe(CN)6]4−/3− redox probes, respectively. These electrodes were able to detect and quantify uric acid in PBS within the 10–300 μM range at pH between 5.6 and 7.4. At pH 7.4, a linear response (R2 = 0.999) from 10 to 250 μM was achieved, with a limit of detection of 3.97 μM and a sensitivity of 0.363 μA cm−2 μM−1. Paper-LIG electrodes denoted adequate selectivity in synthetic urine as well as in ascorbic acid (AA) and dopamine (DA)-containing electrolytes. Determination of urinary UA content in human samples returned a concentration of c.a. 1.8–1.9 mM, within the range for healthy individuals. Recoveries of samples spiked with 50 and 100 μM UA were 100.6% and 95.4%, respectively, with satisfactory reproducibility and stability. These cheap, lightweight, flexible, and eco-friendly paper-LIG biosensors for non-enzymatic quantification of UA in human urine pave the way to widespread application in the detection of other important biomarkers.CENIMAT-i3N - Centro de Investigação de Materiais (Lab. Associado I3N)DCM - Departamento de Ciência dos MateriaisUNINOVA-Instituto de Desenvolvimento de Novas TecnologiasRUNKulyk, BohdanPereira, Sónia O.Fernandes, António J. S.Fortunato, ElviraCosta, Florinda M.Santos, Nuno F.2023-03-16T22:36:20Z2022-092022-09-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article11application/pdfhttp://hdl.handle.net/10362/150709engKulyk, B., Pereira, S. O., Fernandes, A. J. S., Fortunato, E., Costa, F. M., & Santos, N. F. (2022). Laser-induced graphene from paper for non-enzymatic uric acid electrochemical sensing in urine. Carbon, 197, 253-263. https://doi.org/10.1016/j.carbon.2022.06.0130008-6223PURE: 56058981https://doi.org/10.1016/j.carbon.2022.06.013info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2024-03-11T05:33:01Zoai:run.unl.pt:10362/150709Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-20T03:54:16.078934Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv Laser-induced graphene from paper for non-enzymatic uric acid electrochemical sensing in urine
title Laser-induced graphene from paper for non-enzymatic uric acid electrochemical sensing in urine
spellingShingle Laser-induced graphene from paper for non-enzymatic uric acid electrochemical sensing in urine
Kulyk, Bohdan
Electrochemical biosensors
Flexible electronics
Graphene
Human urine
Paper-LIG
Uric acid
Chemistry(all)
Materials Science(all)
SDG 3 - Good Health and Well-being
SDG 13 - Climate Action
title_short Laser-induced graphene from paper for non-enzymatic uric acid electrochemical sensing in urine
title_full Laser-induced graphene from paper for non-enzymatic uric acid electrochemical sensing in urine
title_fullStr Laser-induced graphene from paper for non-enzymatic uric acid electrochemical sensing in urine
title_full_unstemmed Laser-induced graphene from paper for non-enzymatic uric acid electrochemical sensing in urine
title_sort Laser-induced graphene from paper for non-enzymatic uric acid electrochemical sensing in urine
author Kulyk, Bohdan
author_facet Kulyk, Bohdan
Pereira, Sónia O.
Fernandes, António J. S.
Fortunato, Elvira
Costa, Florinda M.
Santos, Nuno F.
author_role author
author2 Pereira, Sónia O.
Fernandes, António J. S.
Fortunato, Elvira
Costa, Florinda M.
Santos, Nuno F.
author2_role author
author
author
author
author
dc.contributor.none.fl_str_mv CENIMAT-i3N - Centro de Investigação de Materiais (Lab. Associado I3N)
DCM - Departamento de Ciência dos Materiais
UNINOVA-Instituto de Desenvolvimento de Novas Tecnologias
RUN
dc.contributor.author.fl_str_mv Kulyk, Bohdan
Pereira, Sónia O.
Fernandes, António J. S.
Fortunato, Elvira
Costa, Florinda M.
Santos, Nuno F.
dc.subject.por.fl_str_mv Electrochemical biosensors
Flexible electronics
Graphene
Human urine
Paper-LIG
Uric acid
Chemistry(all)
Materials Science(all)
SDG 3 - Good Health and Well-being
SDG 13 - Climate Action
topic Electrochemical biosensors
Flexible electronics
Graphene
Human urine
Paper-LIG
Uric acid
Chemistry(all)
Materials Science(all)
SDG 3 - Good Health and Well-being
SDG 13 - Climate Action
description This work was developed within the scope of project i3N (LA/P/0037/2020. I.P. N. F. Santos thanks i3N for the BPD Grant BPD/UI96/5177/2020. S. O. Pereira thanks i3N for the BPD Grant BPD/UI96/5808/2017. The authors also thank Jonas Deuermeier for the XPS measurements. Publisher Copyright: © 2022 Elsevier Ltd
publishDate 2022
dc.date.none.fl_str_mv 2022-09
2022-09-01T00:00:00Z
2023-03-16T22:36:20Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/10362/150709
url http://hdl.handle.net/10362/150709
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv Kulyk, B., Pereira, S. O., Fernandes, A. J. S., Fortunato, E., Costa, F. M., & Santos, N. F. (2022). Laser-induced graphene from paper for non-enzymatic uric acid electrochemical sensing in urine. Carbon, 197, 253-263. https://doi.org/10.1016/j.carbon.2022.06.013
0008-6223
PURE: 56058981
https://doi.org/10.1016/j.carbon.2022.06.013
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv 11
application/pdf
dc.source.none.fl_str_mv reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron:RCAAP
instname_str Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron_str RCAAP
institution RCAAP
reponame_str Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
collection Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
repository.name.fl_str_mv Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
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