A Novel Ecological Approach Reveals Early Executive Function Impairments in Huntington's Disease

Detalhes bibliográficos
Autor(a) principal: Júlio, Filipa
Data de Publicação: 2019
Outros Autores: Ribeiro, Maria J., Patrício, Miguel, Malhão, Alexandre, Pedrosa, Fábio, Gonçalves, Hélio, Simões, Marco, van Asselen, Marieke, Simões, Mário R., Castelo-Branco, Miguel, Januário, Cristina
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: http://hdl.handle.net/10316/106990
https://doi.org/10.3389/fpsyg.2019.00585
Resumo: Introduction: Impairments in executive functions are common in neurogenetic disorders such as Huntington's disease (HD) and are thought to significantly influence the patient's functional status. Reliable tools with higher ecological validity that can assess and predict the impact of executive dysfunction in daily-life performance are needed. This study aimed to develop and validate a novel non-immersive virtual reality task ("EcoKitchen") created with the purpose of capturing cognitive and functional changes shown by HD carriers without clinical manifestations of the disease (Premanifest HD), in a more realistic setting. Materials and Methods: We designed a virtual reality task with three blocks of increasing executive load. The performance of three groups (Controls, CTRL; Premanifest HD individuals, HP; Early Manifest HD patients, HD) was compared in four main components of the study protocol: the EcoKitchen; a subjective (self-report) measure - "The Adults and Older Adults Functional Assessment Inventory (IAFAI)"; the "Behavioural Assessment of Dysexecutive Syndrome battery (BADS)"; and a conventional neuropsychological test battery. We also examined statistical associations between EcoKitchen and the other executive, functional and clinical measures used. Results: The HD group showed deficits in all the assessment methods used. In contrast, the HP group was only found to be impaired in the EcoKitchen task, particularly in the most cognitively demanding blocks, where they showed a higher number of errors compared to the CTRL group. Statistically significant correlations were identified between the EcoKitchen, measures of the other assessment tools, and HD clinical features. Discussion: The EcoKitchen task, developed as an ecological executive function assessment tool, was found to be sensitive to early deficits in this domain. Critically, in premanifest HD individuals, it identifies dysfunction prior to symptom onset. Further it adds a potential tool for diagnosis and management of the patients' real-life problems.
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spelling A Novel Ecological Approach Reveals Early Executive Function Impairments in Huntington's DiseaseHuntington’s diseaseexecutive functionsactivities of daily livingecological validityvirtual realityIntroduction: Impairments in executive functions are common in neurogenetic disorders such as Huntington's disease (HD) and are thought to significantly influence the patient's functional status. Reliable tools with higher ecological validity that can assess and predict the impact of executive dysfunction in daily-life performance are needed. This study aimed to develop and validate a novel non-immersive virtual reality task ("EcoKitchen") created with the purpose of capturing cognitive and functional changes shown by HD carriers without clinical manifestations of the disease (Premanifest HD), in a more realistic setting. Materials and Methods: We designed a virtual reality task with three blocks of increasing executive load. The performance of three groups (Controls, CTRL; Premanifest HD individuals, HP; Early Manifest HD patients, HD) was compared in four main components of the study protocol: the EcoKitchen; a subjective (self-report) measure - "The Adults and Older Adults Functional Assessment Inventory (IAFAI)"; the "Behavioural Assessment of Dysexecutive Syndrome battery (BADS)"; and a conventional neuropsychological test battery. We also examined statistical associations between EcoKitchen and the other executive, functional and clinical measures used. Results: The HD group showed deficits in all the assessment methods used. In contrast, the HP group was only found to be impaired in the EcoKitchen task, particularly in the most cognitively demanding blocks, where they showed a higher number of errors compared to the CTRL group. Statistically significant correlations were identified between the EcoKitchen, measures of the other assessment tools, and HD clinical features. Discussion: The EcoKitchen task, developed as an ecological executive function assessment tool, was found to be sensitive to early deficits in this domain. Critically, in premanifest HD individuals, it identifies dysfunction prior to symptom onset. Further it adds a potential tool for diagnosis and management of the patients' real-life problems.Frontiers Media S.A.2019info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articlehttp://hdl.handle.net/10316/106990http://hdl.handle.net/10316/106990https://doi.org/10.3389/fpsyg.2019.00585eng1664-1078Júlio, FilipaRibeiro, Maria J.Patrício, MiguelMalhão, AlexandrePedrosa, FábioGonçalves, HélioSimões, Marcovan Asselen, MariekeSimões, Mário R.Castelo-Branco, MiguelJanuário, Cristinainfo:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-05-08T10:23:51Zoai:estudogeral.uc.pt:10316/106990Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T21:23:22.423800Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv A Novel Ecological Approach Reveals Early Executive Function Impairments in Huntington's Disease
title A Novel Ecological Approach Reveals Early Executive Function Impairments in Huntington's Disease
spellingShingle A Novel Ecological Approach Reveals Early Executive Function Impairments in Huntington's Disease
Júlio, Filipa
Huntington’s disease
executive functions
activities of daily living
ecological validity
virtual reality
title_short A Novel Ecological Approach Reveals Early Executive Function Impairments in Huntington's Disease
title_full A Novel Ecological Approach Reveals Early Executive Function Impairments in Huntington's Disease
title_fullStr A Novel Ecological Approach Reveals Early Executive Function Impairments in Huntington's Disease
title_full_unstemmed A Novel Ecological Approach Reveals Early Executive Function Impairments in Huntington's Disease
title_sort A Novel Ecological Approach Reveals Early Executive Function Impairments in Huntington's Disease
author Júlio, Filipa
author_facet Júlio, Filipa
Ribeiro, Maria J.
Patrício, Miguel
Malhão, Alexandre
Pedrosa, Fábio
Gonçalves, Hélio
Simões, Marco
van Asselen, Marieke
Simões, Mário R.
Castelo-Branco, Miguel
Januário, Cristina
author_role author
author2 Ribeiro, Maria J.
Patrício, Miguel
Malhão, Alexandre
Pedrosa, Fábio
Gonçalves, Hélio
Simões, Marco
van Asselen, Marieke
Simões, Mário R.
Castelo-Branco, Miguel
Januário, Cristina
author2_role author
author
author
author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Júlio, Filipa
Ribeiro, Maria J.
Patrício, Miguel
Malhão, Alexandre
Pedrosa, Fábio
Gonçalves, Hélio
Simões, Marco
van Asselen, Marieke
Simões, Mário R.
Castelo-Branco, Miguel
Januário, Cristina
dc.subject.por.fl_str_mv Huntington’s disease
executive functions
activities of daily living
ecological validity
virtual reality
topic Huntington’s disease
executive functions
activities of daily living
ecological validity
virtual reality
description Introduction: Impairments in executive functions are common in neurogenetic disorders such as Huntington's disease (HD) and are thought to significantly influence the patient's functional status. Reliable tools with higher ecological validity that can assess and predict the impact of executive dysfunction in daily-life performance are needed. This study aimed to develop and validate a novel non-immersive virtual reality task ("EcoKitchen") created with the purpose of capturing cognitive and functional changes shown by HD carriers without clinical manifestations of the disease (Premanifest HD), in a more realistic setting. Materials and Methods: We designed a virtual reality task with three blocks of increasing executive load. The performance of three groups (Controls, CTRL; Premanifest HD individuals, HP; Early Manifest HD patients, HD) was compared in four main components of the study protocol: the EcoKitchen; a subjective (self-report) measure - "The Adults and Older Adults Functional Assessment Inventory (IAFAI)"; the "Behavioural Assessment of Dysexecutive Syndrome battery (BADS)"; and a conventional neuropsychological test battery. We also examined statistical associations between EcoKitchen and the other executive, functional and clinical measures used. Results: The HD group showed deficits in all the assessment methods used. In contrast, the HP group was only found to be impaired in the EcoKitchen task, particularly in the most cognitively demanding blocks, where they showed a higher number of errors compared to the CTRL group. Statistically significant correlations were identified between the EcoKitchen, measures of the other assessment tools, and HD clinical features. Discussion: The EcoKitchen task, developed as an ecological executive function assessment tool, was found to be sensitive to early deficits in this domain. Critically, in premanifest HD individuals, it identifies dysfunction prior to symptom onset. Further it adds a potential tool for diagnosis and management of the patients' real-life problems.
publishDate 2019
dc.date.none.fl_str_mv 2019
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
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status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/10316/106990
http://hdl.handle.net/10316/106990
https://doi.org/10.3389/fpsyg.2019.00585
url http://hdl.handle.net/10316/106990
https://doi.org/10.3389/fpsyg.2019.00585
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dc.relation.none.fl_str_mv 1664-1078
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dc.publisher.none.fl_str_mv Frontiers Media S.A.
publisher.none.fl_str_mv Frontiers Media S.A.
dc.source.none.fl_str_mv reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
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instname_str Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
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reponame_str Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
collection Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
repository.name.fl_str_mv Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
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