Bioengineered cell culture systems of central nervous system injury and disease

Detalhes bibliográficos
Autor(a) principal: Teixeira, Fábio Gabriel Rodrigues
Data de Publicação: 2016
Outros Autores: Vasconcelos, Natália L., Gomes, Eduardo Domingos Correia, Marques, Fernanda, Sousa, João Carlos, Sousa, Nuno, Silva, Nuno A., Silva, Rita Catarina Assunção Ribeiro, Lima, Rui Augusto Ribeiro, Salgado, A. J.
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: http://hdl.handle.net/1822/50294
Resumo: Cell culture systems, either 2D or explant based, have been pivotal to better understand the pathophysiology of several central nervous system (CNS) disorders. Recently, bioengineered cell culture systems have been proposed as an alternative to the traditional setups. These innovative systems often combine different cell populations in 3D environments that more closely recapitulate the different niches that exist within the developing or adult CNS. Given the importance of such systems for the future of CNS-related research, we discuss here the most recent advances in the field, particularly those dealing with neurodegeneration, neurodevelopmental disorders, and trauma.
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spelling Bioengineered cell culture systems of central nervous system injury and diseaseScience & TechnologyCell culture systems, either 2D or explant based, have been pivotal to better understand the pathophysiology of several central nervous system (CNS) disorders. Recently, bioengineered cell culture systems have been proposed as an alternative to the traditional setups. These innovative systems often combine different cell populations in 3D environments that more closely recapitulate the different niches that exist within the developing or adult CNS. Given the importance of such systems for the future of CNS-related research, we discuss here the most recent advances in the field, particularly those dealing with neurodegeneration, neurodevelopmental disorders, and trauma.Financial support is acknowledged from Prémios Santa Casa Neurociências – Prize Melo e Castro for Spinal Cord Injury Research; Portuguese Foundation for Science and Technology [Doctoral fellowship (SFRH/BD/103075/2014) to E.D.G.; IF Development Grant to A.J.S.; Starting Grant to F. Marques; PostDoctoral fellowship SFRH/BPD/97701/2013 to N.A.S.]; this work was co-funded by Programa Operacional Regional do Norte (ON.2 – O Novo Norte), ao abrigo do Quadro de Referência Estratégico Nacional (QREN), através do Fundo Europeu de Desenvolvimento Regional (FEDER).info:eu-repo/semantics/publishedVersionElsevierUniversidade do MinhoTeixeira, Fábio Gabriel RodriguesVasconcelos, Natália L.Gomes, Eduardo Domingos CorreiaMarques, FernandaSousa, João CarlosSousa, NunoSilva, Nuno A.Silva, Rita Catarina Assunção RibeiroLima, Rui Augusto RibeiroSalgado, A. J.20162016-01-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/1822/50294eng1359-64461878-583210.1016/j.drudis.2016.04.02027132519https://www.journals.elsevier.cominfo:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-07-21T12:44:27Zoai:repositorium.sdum.uminho.pt:1822/50294Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T19:42:07.982739Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv Bioengineered cell culture systems of central nervous system injury and disease
title Bioengineered cell culture systems of central nervous system injury and disease
spellingShingle Bioengineered cell culture systems of central nervous system injury and disease
Teixeira, Fábio Gabriel Rodrigues
Science & Technology
title_short Bioengineered cell culture systems of central nervous system injury and disease
title_full Bioengineered cell culture systems of central nervous system injury and disease
title_fullStr Bioengineered cell culture systems of central nervous system injury and disease
title_full_unstemmed Bioengineered cell culture systems of central nervous system injury and disease
title_sort Bioengineered cell culture systems of central nervous system injury and disease
author Teixeira, Fábio Gabriel Rodrigues
author_facet Teixeira, Fábio Gabriel Rodrigues
Vasconcelos, Natália L.
Gomes, Eduardo Domingos Correia
Marques, Fernanda
Sousa, João Carlos
Sousa, Nuno
Silva, Nuno A.
Silva, Rita Catarina Assunção Ribeiro
Lima, Rui Augusto Ribeiro
Salgado, A. J.
author_role author
author2 Vasconcelos, Natália L.
Gomes, Eduardo Domingos Correia
Marques, Fernanda
Sousa, João Carlos
Sousa, Nuno
Silva, Nuno A.
Silva, Rita Catarina Assunção Ribeiro
Lima, Rui Augusto Ribeiro
Salgado, A. J.
author2_role author
author
author
author
author
author
author
author
author
dc.contributor.none.fl_str_mv Universidade do Minho
dc.contributor.author.fl_str_mv Teixeira, Fábio Gabriel Rodrigues
Vasconcelos, Natália L.
Gomes, Eduardo Domingos Correia
Marques, Fernanda
Sousa, João Carlos
Sousa, Nuno
Silva, Nuno A.
Silva, Rita Catarina Assunção Ribeiro
Lima, Rui Augusto Ribeiro
Salgado, A. J.
dc.subject.por.fl_str_mv Science & Technology
topic Science & Technology
description Cell culture systems, either 2D or explant based, have been pivotal to better understand the pathophysiology of several central nervous system (CNS) disorders. Recently, bioengineered cell culture systems have been proposed as an alternative to the traditional setups. These innovative systems often combine different cell populations in 3D environments that more closely recapitulate the different niches that exist within the developing or adult CNS. Given the importance of such systems for the future of CNS-related research, we discuss here the most recent advances in the field, particularly those dealing with neurodegeneration, neurodevelopmental disorders, and trauma.
publishDate 2016
dc.date.none.fl_str_mv 2016
2016-01-01T00:00:00Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/1822/50294
url http://hdl.handle.net/1822/50294
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 1359-6446
1878-5832
10.1016/j.drudis.2016.04.020
27132519
https://www.journals.elsevier.com
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Elsevier
publisher.none.fl_str_mv Elsevier
dc.source.none.fl_str_mv reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
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collection Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
repository.name.fl_str_mv Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
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