Nuclear migration in mammalian brain development

Detalhes bibliográficos
Autor(a) principal: Bertipaglia, Chiara
Data de Publicação: 2018
Outros Autores: Gonçalves, João Carlos, Vallee, Richard Bert
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: https://hdl.handle.net/1822/58248
Resumo: During development of the mammalian brain, neural stem cells divide and give rise to adult stem cells, glia and neurons, which migrate to their final locations. Nuclear migration is an important feature of neural stem cell (radial glia progenitor) proliferation and subsequent postmitotic neuronal migration. Defects in nuclear migration contribute to severe neurodevelopmental disorders such as microcephaly and lissencephaly. In this review, we address the cellular and molecular mechanisms responsible for nuclear migration during the radial glia cell cycle and postmitotic neuronal migration, with a particular focus on the role of molecular motors and cytoskeleton dynamics in regulating nuclear behavior.
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spelling Nuclear migration in mammalian brain developmentCentrosomeCytoskeletonMicrotubulesMigrationMolecular motorsNuclear envelopeNucleusScience & TechnologyDuring development of the mammalian brain, neural stem cells divide and give rise to adult stem cells, glia and neurons, which migrate to their final locations. Nuclear migration is an important feature of neural stem cell (radial glia progenitor) proliferation and subsequent postmitotic neuronal migration. Defects in nuclear migration contribute to severe neurodevelopmental disorders such as microcephaly and lissencephaly. In this review, we address the cellular and molecular mechanisms responsible for nuclear migration during the radial glia cell cycle and postmitotic neuronal migration, with a particular focus on the role of molecular motors and cytoskeleton dynamics in regulating nuclear behavior.The authors thank Dr. Tiago Dantas and Dr. Aditi Falnikar for critical reading of the manuscript. This work was supported by grants R01 HD40182 to R.V., and the FCT MDPhD Scholarship PD/BD/113766/2015 to J.C.G.Elsevier LtdUniversidade do MinhoBertipaglia, ChiaraGonçalves, João CarlosVallee, Richard Bert2018-102018-10-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttps://hdl.handle.net/1822/58248eng1084-952110.1016/j.semcdb.2017.11.03329208348info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-07-21T12:29:56Zoai:repositorium.sdum.uminho.pt:1822/58248Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T19:25:02.362670Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv Nuclear migration in mammalian brain development
title Nuclear migration in mammalian brain development
spellingShingle Nuclear migration in mammalian brain development
Bertipaglia, Chiara
Centrosome
Cytoskeleton
Microtubules
Migration
Molecular motors
Nuclear envelope
Nucleus
Science & Technology
title_short Nuclear migration in mammalian brain development
title_full Nuclear migration in mammalian brain development
title_fullStr Nuclear migration in mammalian brain development
title_full_unstemmed Nuclear migration in mammalian brain development
title_sort Nuclear migration in mammalian brain development
author Bertipaglia, Chiara
author_facet Bertipaglia, Chiara
Gonçalves, João Carlos
Vallee, Richard Bert
author_role author
author2 Gonçalves, João Carlos
Vallee, Richard Bert
author2_role author
author
dc.contributor.none.fl_str_mv Universidade do Minho
dc.contributor.author.fl_str_mv Bertipaglia, Chiara
Gonçalves, João Carlos
Vallee, Richard Bert
dc.subject.por.fl_str_mv Centrosome
Cytoskeleton
Microtubules
Migration
Molecular motors
Nuclear envelope
Nucleus
Science & Technology
topic Centrosome
Cytoskeleton
Microtubules
Migration
Molecular motors
Nuclear envelope
Nucleus
Science & Technology
description During development of the mammalian brain, neural stem cells divide and give rise to adult stem cells, glia and neurons, which migrate to their final locations. Nuclear migration is an important feature of neural stem cell (radial glia progenitor) proliferation and subsequent postmitotic neuronal migration. Defects in nuclear migration contribute to severe neurodevelopmental disorders such as microcephaly and lissencephaly. In this review, we address the cellular and molecular mechanisms responsible for nuclear migration during the radial glia cell cycle and postmitotic neuronal migration, with a particular focus on the role of molecular motors and cytoskeleton dynamics in regulating nuclear behavior.
publishDate 2018
dc.date.none.fl_str_mv 2018-10
2018-10-01T00:00:00Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv https://hdl.handle.net/1822/58248
url https://hdl.handle.net/1822/58248
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 1084-9521
10.1016/j.semcdb.2017.11.033
29208348
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Elsevier Ltd
publisher.none.fl_str_mv Elsevier Ltd
dc.source.none.fl_str_mv reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron:RCAAP
instname_str Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron_str RCAAP
institution RCAAP
reponame_str Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
collection Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
repository.name.fl_str_mv Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
repository.mail.fl_str_mv
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