The roles of vitamin D and polyphenols in the management of age-related macular degeneration: a narrative review

Detalhes bibliográficos
Autor(a) principal: Fernandes, Nádia
Data de Publicação: 2023
Outros Autores: Araújo, Marta Castro, Lança, Carla
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: http://hdl.handle.net/10400.21/15931
Resumo: Age-related macular degeneration (AMD) is a chronic progressive ocular disease and the main cause of severe visual impairment in the elderly. Vitamin D deficiency may be a risk factor for AMD. Additionally, current evidence suggests dietary advice of increasing the consumption of polyphenols, which may have antioxidant and anti-inflammatory properties. The aim of this review was to describe the roles of vitamin D levels and polyphenols in the management of AMD. The results of this review showed mixed evidence regarding the protective effect of vitamin D against AMD. Polyphenols (flavonoids group, curcumin, and resveratrol) seem to play an important role as angiogenesis inhibitors, but their effect on AMD is still unclear. Vitamin D and polyphenols may both play an important role as nutritional modifiable protective factors that reduce the risk of AMD progression. However, more research is necessary to better understand the roles of vitamin D and polyphenols in different stages of the disease.
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spelling The roles of vitamin D and polyphenols in the management of age-related macular degeneration: a narrative reviewOphthalmologyAge macular degenerationVitamin D25-Hydroxyvitamin D serumPolyphenolsNutritionEye healthcareRetinaChoroidAge-related macular degeneration (AMD) is a chronic progressive ocular disease and the main cause of severe visual impairment in the elderly. Vitamin D deficiency may be a risk factor for AMD. Additionally, current evidence suggests dietary advice of increasing the consumption of polyphenols, which may have antioxidant and anti-inflammatory properties. The aim of this review was to describe the roles of vitamin D levels and polyphenols in the management of AMD. The results of this review showed mixed evidence regarding the protective effect of vitamin D against AMD. Polyphenols (flavonoids group, curcumin, and resveratrol) seem to play an important role as angiogenesis inhibitors, but their effect on AMD is still unclear. Vitamin D and polyphenols may both play an important role as nutritional modifiable protective factors that reduce the risk of AMD progression. However, more research is necessary to better understand the roles of vitamin D and polyphenols in different stages of the disease.MDPIRCIPLFernandes, NádiaAraújo, Marta CastroLança, Carla2023-04-21T11:41:10Z2023-032023-03-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10400.21/15931engFernandes N, Araújo MC, Lança C. The roles of vitamin D and polyphenols in the management of age-related macular degeneration: a narrative review. Future Pharmacol. 2023;3(1):317-28.10.3390/futurepharmacol3010020info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-08-03T10:14:02Zoai:repositorio.ipl.pt:10400.21/15931Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T20:23:31.046135Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv The roles of vitamin D and polyphenols in the management of age-related macular degeneration: a narrative review
title The roles of vitamin D and polyphenols in the management of age-related macular degeneration: a narrative review
spellingShingle The roles of vitamin D and polyphenols in the management of age-related macular degeneration: a narrative review
Fernandes, Nádia
Ophthalmology
Age macular degeneration
Vitamin D
25-Hydroxyvitamin D serum
Polyphenols
Nutrition
Eye healthcare
Retina
Choroid
title_short The roles of vitamin D and polyphenols in the management of age-related macular degeneration: a narrative review
title_full The roles of vitamin D and polyphenols in the management of age-related macular degeneration: a narrative review
title_fullStr The roles of vitamin D and polyphenols in the management of age-related macular degeneration: a narrative review
title_full_unstemmed The roles of vitamin D and polyphenols in the management of age-related macular degeneration: a narrative review
title_sort The roles of vitamin D and polyphenols in the management of age-related macular degeneration: a narrative review
author Fernandes, Nádia
author_facet Fernandes, Nádia
Araújo, Marta Castro
Lança, Carla
author_role author
author2 Araújo, Marta Castro
Lança, Carla
author2_role author
author
dc.contributor.none.fl_str_mv RCIPL
dc.contributor.author.fl_str_mv Fernandes, Nádia
Araújo, Marta Castro
Lança, Carla
dc.subject.por.fl_str_mv Ophthalmology
Age macular degeneration
Vitamin D
25-Hydroxyvitamin D serum
Polyphenols
Nutrition
Eye healthcare
Retina
Choroid
topic Ophthalmology
Age macular degeneration
Vitamin D
25-Hydroxyvitamin D serum
Polyphenols
Nutrition
Eye healthcare
Retina
Choroid
description Age-related macular degeneration (AMD) is a chronic progressive ocular disease and the main cause of severe visual impairment in the elderly. Vitamin D deficiency may be a risk factor for AMD. Additionally, current evidence suggests dietary advice of increasing the consumption of polyphenols, which may have antioxidant and anti-inflammatory properties. The aim of this review was to describe the roles of vitamin D levels and polyphenols in the management of AMD. The results of this review showed mixed evidence regarding the protective effect of vitamin D against AMD. Polyphenols (flavonoids group, curcumin, and resveratrol) seem to play an important role as angiogenesis inhibitors, but their effect on AMD is still unclear. Vitamin D and polyphenols may both play an important role as nutritional modifiable protective factors that reduce the risk of AMD progression. However, more research is necessary to better understand the roles of vitamin D and polyphenols in different stages of the disease.
publishDate 2023
dc.date.none.fl_str_mv 2023-04-21T11:41:10Z
2023-03
2023-03-01T00:00:00Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/10400.21/15931
url http://hdl.handle.net/10400.21/15931
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv Fernandes N, Araújo MC, Lança C. The roles of vitamin D and polyphenols in the management of age-related macular degeneration: a narrative review. Future Pharmacol. 2023;3(1):317-28.
10.3390/futurepharmacol3010020
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv MDPI
publisher.none.fl_str_mv MDPI
dc.source.none.fl_str_mv reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron:RCAAP
instname_str Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
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